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  1. Article ; Online: Immunohematological testing and transfusion management of the prenatal patient.

    Quraishy, NurJehan / Sapatnekar, Suneeti

    Advances in clinical chemistry

    2023  Volume 117, Page(s) 163–208

    Abstract: The primary indication for immunohematological testing in the prenatal patient is to detect and identify maternal red cell antibodies. If there are antibodies that are expected to hemolyze the fetus' red cells, their strength of reactivity must be tested, ...

    Abstract The primary indication for immunohematological testing in the prenatal patient is to detect and identify maternal red cell antibodies. If there are antibodies that are expected to hemolyze the fetus' red cells, their strength of reactivity must be tested, and the fetus' antigen status determined. After delivery, testing is performed to assess the extent of fetomaternal hemorrhage, as a large hemorrhage may require other therapeutic interventions. Another major role for immunohematological testing is to select blood components appropriately when intrauterine transfusion is required for fetal anemia resulting from maternal alloimmunization or some other cause. Supplementation with molecular methods has transformed the practice of immunohematology, particularly as it applies to typing for the D antigen of the Rh blood group system. Notwithstanding the advances in testing, close coordination and communication between the transfusion service and the obstetrics service are the foundation for ensuring the finest care for prenatal patients, and for new mothers and their infants. This review describes testing and transfusion practices for prenatal patients, using case presentations to highlight the management of selected immunohematological findings. It also includes a discussion of key patient management topics that are currently unresolved.
    MeSH term(s) Pregnancy ; Female ; Humans ; Erythroblastosis, Fetal/diagnosis ; Erythroblastosis, Fetal/therapy ; Isoantibodies ; Blood Transfusion ; Erythrocytes ; Anemia, Hemolytic, Autoimmune
    Chemical Substances Isoantibodies
    Language English
    Publishing date 2023-09-19
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 210505-6
    ISSN 2162-9471 ; 0065-2423
    ISSN (online) 2162-9471
    ISSN 0065-2423
    DOI 10.1016/bs.acc.2023.08.002
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  2. Article ; Online: Convalescent plasma for COVID-19: Promising, not proven.

    Mucha, Simon R / Quraishy, NurJehan

    Cleveland Clinic journal of medicine

    2020  Volume 87, Issue 11, Page(s) 664–670

    Abstract: While promising, convalescent plasma remains experimental and is not proven effective for COVID-19. In addition, many questions remain regarding the accuracy and predictive value of antibody testing of donors and patients, optimal donor selection, ... ...

    Abstract While promising, convalescent plasma remains experimental and is not proven effective for COVID-19. In addition, many questions remain regarding the accuracy and predictive value of antibody testing of donors and patients, optimal donor selection, optimal timing, and selection of patients most likely to benefit. Until these questions are answered, convalescent plasma should ideally be used in the context of well-designed clinical trials.
    MeSH term(s) Betacoronavirus/immunology ; Betacoronavirus/isolation & purification ; Clinical Laboratory Techniques/methods ; Clinical Trials as Topic ; Coronavirus Infections/diagnosis ; Coronavirus Infections/genetics ; Coronavirus Infections/immunology ; Coronavirus Infections/therapy ; Donor Selection ; Humans ; Immunization, Passive/adverse effects ; Immunization, Passive/methods ; Pandemics ; Patient Selection ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/genetics ; Pneumonia, Viral/immunology ; Pneumonia, Viral/therapy ; Predictive Value of Tests ; Reproducibility of Results ; Risk Assessment ; Time-to-Treatment ; Treatment Outcome
    Keywords covid19
    Language English
    Publishing date 2020-11-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639116-3
    ISSN 1939-2869 ; 0891-1150
    ISSN (online) 1939-2869
    ISSN 0891-1150
    DOI 10.3949/ccjm.87a.ccc056
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Convalescent plasma for COVID-19: Promising, not proven

    Mucha, Simon R / Quraishy, NurJehan

    Cleve Clin J Med

    Abstract: While promising, convalescent plasma remains experimental and is not proven effective for COVID-19. In addition, many questions remain regarding the accuracy and predictive value of antibody testing of donors and patients, optimal donor selection, ... ...

    Abstract While promising, convalescent plasma remains experimental and is not proven effective for COVID-19. In addition, many questions remain regarding the accuracy and predictive value of antibody testing of donors and patients, optimal donor selection, optimal timing, and selection of patients most likely to benefit. Until these questions are answered, convalescent plasma should ideally be used in the context of well-designed clinical trials.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #711331
    Database COVID19

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  4. Article: Heat elution: a modification of the Landsteiner-Miller method.

    Dean-El, Celeste / Quraishy, NurJehan

    Immunohematology

    2019  Volume 35, Issue 2, Page(s) 45–47

    Abstract: Conclusions: Elution removes antibodies coating red blood cells and allows for serologic testing of the recovered antibodies. Heat elution may be used in the investigation of ABO hemolytic disease of the fetus and newborn, in the detection of weak A and ...

    Abstract Conclusions: Elution removes antibodies coating red blood cells and allows for serologic testing of the recovered antibodies. Heat elution may be used in the investigation of ABO hemolytic disease of the fetus and newborn, in the detection of weak A and B antigens in combination with adsorption-elution using polyclonal antibodies, and for the resolution of interfering IgM agglutinating antibodies.
    MeSH term(s) ABO Blood-Group System ; Antibodies ; Blood Group Antigens ; Blood Group Incompatibility ; Erythroblastosis, Fetal ; Hot Temperature ; Humans ; Infant, Newborn
    Chemical Substances ABO Blood-Group System ; Antibodies ; Blood Group Antigens
    Language English
    Publishing date 2019-07-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1146978-x
    ISSN 0894-203X
    ISSN 0894-203X
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  5. Article ; Online: Implementation of a Standardized Prenatal Testing Protocol in an Integrated, Multihospital Health System.

    Sapatnekar, Suneeti / Lu, Wen / Bakdash, Suzanne / Quraishy, NurJehan

    American journal of clinical pathology

    2020  Volume 155, Issue 1, Page(s) 133–140

    Abstract: Objectives: When our institution grew into an integrated multihospital health system, we were faced with the need to standardize laboratory processes, including blood bank processes, across all locations. The purpose of this article is to describe our ... ...

    Abstract Objectives: When our institution grew into an integrated multihospital health system, we were faced with the need to standardize laboratory processes, including blood bank processes, across all locations. The purpose of this article is to describe our experience of standardizing the protocols for prenatal testing.
    Methods: For each hospital in the system, we established service tiers to define tests offered on site or referred to another location. For each prenatal test, we examined the related processes for ways to improve uniformity, efficiency, and reliability. Throughout this process of standardization, we collaborated with the clinical services to gain concurrence on the interpretation and reporting of results.
    Results: We created and implemented a uniform protocol for testing prenatal patients. The protocol standardized the definition of critical titer, instituted criteria to identify passively acquired anti-D, and established a process for the follow-up of women with inconsistent serologic results on Rh(D) typing.
    Conclusions: Close collaboration with the clinical services ensured that our testing protocol is aligned with the needs of the integrated obstetrics service in the health system. The approach described in this article may provide a plan outline for pathologists facing similar challenges at other integrated health systems.
    MeSH term(s) Delivery of Health Care/standards ; Female ; Humans ; Pregnancy ; Prenatal Diagnosis/methods ; Prenatal Diagnosis/standards
    Language English
    Publishing date 2020-09-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2944-0
    ISSN 1943-7722 ; 0002-9173
    ISSN (online) 1943-7722
    ISSN 0002-9173
    DOI 10.1093/ajcp/aqaa120
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  6. Book: A compendium of transfusion practice guidelines

    Quraishy, NurJehan

    2010  

    Institution American Red Cross
    Author's details [NurJehan Quraishy ... et al.]
    MeSH term(s) Blood Transfusion/standards
    Keywords United States
    Language English
    Size 111 p. :, ill.
    Edition 1st ed.
    Publisher American Red Cross
    Publishing place Washington, D.C.
    Document type Book
    Note "Authors: NurJehan Quraishy ... [et al.]" --P. 2 of cover.
    Database Catalogue of the US National Library of Medicine (NLM)

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  7. Article ; Online: Blood management during the COVID-19 pandemic.

    Tolich, Deborah / Auron, Moises / McCoy, Kelly / Dargis, Marni / Quraishy, NurJehan

    Cleveland Clinic journal of medicine

    2020  

    Abstract: The worldwide COVID-19 pandemic has required healthcare systems to implement strategies for effective healthcare delivery while managing blood supply chain disruptions and shortages created by infection-limiting practices that have reduced blood ... ...

    Abstract The worldwide COVID-19 pandemic has required healthcare systems to implement strategies for effective healthcare delivery while managing blood supply chain disruptions and shortages created by infection-limiting practices that have reduced blood donations. At Cleveland Clinic, we have made multiple synchronous efforts: a call for increased blood collection, alignment of efforts among transfusion medicine departments (blood banks), enhanced monitoring and triage of blood product use, and increased education on patient blood management practices regarding blood utilization and anemia management. In addition, we created an algorithm to assess anemia risks in patients whose elective surgery was cancelled to optimize preoperative hemoglobin levels.
    Keywords covid19
    Language English
    Publishing date 2020-08-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639116-3
    ISSN 1939-2869 ; 0891-1150
    ISSN (online) 1939-2869
    ISSN 0891-1150
    DOI 10.3949/ccjm.87a.ccc053
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  8. Article: Blood management during the COVID-19 pandemic

    Tolich, Deborah / Auron, Moises / McCoy, Kelly / Dargis, Marni / Quraishy, NurJehan

    Clevel. clin. j. med

    Abstract: The worldwide COVID-19 pandemic has required healthcare systems to implement strategies for effective healthcare delivery while managing blood supply chain disruptions and shortages created by infection-limiting practices that have reduced blood ... ...

    Abstract The worldwide COVID-19 pandemic has required healthcare systems to implement strategies for effective healthcare delivery while managing blood supply chain disruptions and shortages created by infection-limiting practices that have reduced blood donations. At Cleveland Clinic, we have made multiple synchronous efforts: a call for increased blood collection, alignment of efforts among transfusion medicine departments (blood banks), enhanced monitoring and triage of blood product use, and increased education on patient blood management practices regarding blood utilization and anemia management. In addition, we created an algorithm to assess anemia risks in patients whose elective surgery was cancelled to optimize preoperative hemoglobin levels.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #696819
    Database COVID19

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  9. Article ; Online: Adherence to blood product transfusion guidelines-An observational study of the current transfusion practice in a medical intensive care unit.

    Sadana, Divyajot / Kummangal, Basheer / Moghekar, Ajit / Banerjee, Kinjal / Kaur, Simrat / Balasubramanian, Shailesh / Tolich, Deborah / Han, Xiaozhen / Wang, Xiaofeng / Hanane, Tarik / Mireles-Cabodevila, Eduardo / Quraishy, NurJehan / Duggal, Abhijit / Krishnan, Sudhir

    Transfusion medicine (Oxford, England)

    2021  Volume 31, Issue 4, Page(s) 227–235

    Abstract: Background: Blood transfusions though life-saving are not entirely benign. They are the most overused procedure in the hospital and have been under scrutiny by the 'Choosing Wisely campaign'. The strict adoption of restrictive transfusion guidelines ... ...

    Abstract Background: Blood transfusions though life-saving are not entirely benign. They are the most overused procedure in the hospital and have been under scrutiny by the 'Choosing Wisely campaign'. The strict adoption of restrictive transfusion guidelines could improve patient outcomes while reducing cost.
    Objectives: In this study, we evaluate adherence to restrictive transfusion guidelines, along with hospital mortality and length of stay (LOS) in transfusion events with a pre-transfusion haemoglobin (Hb) ≥7 g/dl. Additionally, we evaluated associated costs accrued due to unnecessary transfusions.
    Methods: We conducted a retrospective observational study in a 64-bed medical intensive care unit (MICU) of an academic medical centre involving all adult patients (N = 957) requiring packed red blood cell transfusion between January 2015 and December 2015.
    Results: In total, 3140 units were transfused with a mean pre-transfusion Hb of 6.75 ± 0.86 g/dl. Nine hundred forty-four (30%) transfusion events occurred with a pre-transfusion Hb ≥7 g/dl, and 385 (12.3%) of these occurred in patients without hypotension, tachycardia, use of vasopressors, or coronary artery disease. Forgoing them could have led to a savings of approximately 0.3 million dollars. Transfusion events with pre-transfusion Hb ≥7 g/dl were associated with an increased mortality in patients with acute blood loss (odds ratio [OR] 2.08, 95% confidence interval [CI] 1.11-3.88; p = 0.02) and LOS in patients with chronic blood loss (β
    Conclusion: A subset of anaemic patients in the MICU still receive red blood cell transfusions against restrictive guidelines offering hospitals the potential for effective intervention that has both economic and clinical implications.
    MeSH term(s) Blood Transfusion ; Erythrocyte Transfusion ; Hemoglobins/analysis ; Humans ; Intensive Care Units ; Length of Stay
    Chemical Substances Hemoglobins
    Language English
    Publishing date 2021-03-21
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 1067989-3
    ISSN 1365-3148 ; 0958-7578
    ISSN (online) 1365-3148
    ISSN 0958-7578
    DOI 10.1111/tme.12771
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  10. Article ; Online: Clotting during autologous hematopoietic progenitor cells collection.

    Gokhale, Amit / Quraishy, NurJehan / Veemara, Viva / Howdyshell, Heather / Murray, Lynn / Royer, Jennifer / Salmi, Linda / Ricci, Kristin / Liu, Hien

    Journal of clinical apheresis

    2017  Volume 32, Issue 6, Page(s) 560–561

    Abstract: Autologous hematopoietic progenitor cell (HPC) transplant through peripheral blood mobilization and leukapheresis is a standard treatment for many patients with hematopoietic malignancies. Although leukapheresis is usually completed with no complications, ...

    Abstract Autologous hematopoietic progenitor cell (HPC) transplant through peripheral blood mobilization and leukapheresis is a standard treatment for many patients with hematopoietic malignancies. Although leukapheresis is usually completed with no complications, we present a case in which the hematopoietic progenitor cells clotted during collection. The patient had no history of hypercoagulopathy. It was identified that the anticoagulant infusion line was partially constricted by a blood warmer clamp. The machine did not alarm. Most of the multiple Food and Drug Administration reports of clotting occurring during apheresis procedures were due to the patients' preexisting hypercoagulopathy or insufficient anticoagulant solution being used. The machine alarmed in most of these cases. Our case demonstrates that inadequate anticoagulation can occur during an HPC collection procedure without activation of an alarm.
    MeSH term(s) Blood Coagulation ; Clinical Alarms ; Equipment Failure ; Female ; Hematopoietic Stem Cell Transplantation ; Hematopoietic Stem Cells/cytology ; Humans ; Leukapheresis ; Middle Aged ; Transplantation, Autologous
    Language English
    Publishing date 2017-12
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 604912-6
    ISSN 1098-1101 ; 0733-2459
    ISSN (online) 1098-1101
    ISSN 0733-2459
    DOI 10.1002/jca.21539
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