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  1. Article ; Online: Survey of Respiratory Care Professionals' Knowledge in Early Mobilization: A Pilot Study.

    Qutub, Hatem Othman / Matani, Abdelaziz Smiah / Farooqi, Faraz Ahmed

    Journal of epidemiology and global health

    2019  Volume 8, Issue 3-4, Page(s) 208–212

    Abstract: Early mobilization (EM) is practiced for intensive care unit (ICU) patients in many hospitals in the Eastern Province in Saudi Arabia. Respiratory care professionals' knowledge about using EM was, therefore, surveyed and investigated to improve and ... ...

    Abstract Early mobilization (EM) is practiced for intensive care unit (ICU) patients in many hospitals in the Eastern Province in Saudi Arabia. Respiratory care professionals' knowledge about using EM was, therefore, surveyed and investigated to improve and update its practice and ultimately to develop related regulations and policies. A survey including 156 respiratory care professionals was conducted using a validated questionnaire. The focus was on collecting information on participants' relevant backgrounds and on proper use of EM. Knowledge and proper use of EM were calculated in relation to participants' demographic and professional characteristics. The statistical analysis using analysis of variance and Student
    MeSH term(s) Adult ; Attitude of Health Personnel ; Clinical Competence ; Early Ambulation/methods ; Early Ambulation/standards ; Female ; Health Care Surveys ; Health Knowledge, Attitudes, Practice ; Health Personnel/psychology ; Health Personnel/standards ; Humans ; Male ; Middle Aged ; Respiratory Care Units/methods ; Respiratory Care Units/standards ; Respiratory Therapy/methods ; Respiratory Therapy/standards ; Saudi Arabia/epidemiology
    Language English
    Publishing date 2019-03-13
    Publishing country France
    Document type Journal Article
    ZDB-ID 2645324-1
    ISSN 2210-6014 ; 2210-6006
    ISSN (online) 2210-6014
    ISSN 2210-6006
    DOI 10.2991/j.jegh.2018.06.100
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Gender Differences in Prevalence of Sleepy Driving Among Young Drivers in Saudi Arabia.

    Alqurashi, Yousef D / Alqarni, Abdullah S / Albukhamsin, Faisal Maher / Alfaris, Abdullah Abdulaziz / Alhassan, Bader Ibrahim / Ghazwani, Waleed Khalid / Altammar, Abdulaziz Abdulrahman / Aleid, Mutlaq Eid / Almutary, Hayfa / Aldhahir, Abdulelah M / Alessy, Saleh A / Almusally, Rayyan / Alsaid, Abir / Mahmoud, Mahmoud Ibrahim / Qutub, Hatem Othman / Sebastian, Tunny / Alghnam, Suliman / Polkey, Michael I

    Nature and science of sleep

    2024  Volume 16, Page(s) 53–62

    Abstract: Introduction: Sleepy driving is associated with Motor Vehicles Accidents (MVAs). In Saudi Arabia, previous studies have addressed this association among men only. Therefore, the aim of this study was to compare the prevalence of sleepy driving and ... ...

    Abstract Introduction: Sleepy driving is associated with Motor Vehicles Accidents (MVAs). In Saudi Arabia, previous studies have addressed this association among men only. Therefore, the aim of this study was to compare the prevalence of sleepy driving and associated factors between genders.
    Methods: In a cross-sectional study design, we offered a self-administered online questionnaire to 3272 participants from different regions of Saudi Arabia. The questionnaire included 46 questions covering sociodemographics, driving habits, sleeping habits, Epworth Sleepiness Scale, and Berlin questionnaire to assess the risk of sleep apnea. Univariable and multivariable logistic regression analyses were used to determine the significant factors associated with self-reported sleepy driving, defined as operating a motor vehicle while feeling sleepy in the preceding six months.
    Results: Of the 3272 invitees, 2958 (90%) completed the questionnaire, of which 1414 (48%) were women. The prevalence of sleepy driving in the preceding six months was 42% (men: 50% and women 32%, p<0.001). Specifically, participants reported the following: 12% had had to stop their vehicle due to sleepiness (men: 16.2% and women 7%, p<0.001), 12.4% reported near-miss accidents (men: 16.2% and women: 8.2%, p<0.001) and 4.2% reported an accident due to sleepiness (men: 4.3% and women: 4%, p=0.645). In multivariable analysis, being male, younger age, use of any type of medications, shift working, working more than 12 hours per day, driving duration of 3-5 hours per day, driving experience of more than 2 years, excessive daytime sleepiness and risk of having obstructive sleep apnea were all associated with increased likelihood of falling asleep while driving in the preceding 6 months.
    Conclusion: Sleepy driving and MVA are prevalent in both gender but was higher in men. Future public health initiatives should particularly focus on men, since men reported a greater likelihood of both sleep-related MVA and "near miss" events.
    Language English
    Publishing date 2024-02-01
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2587468-8
    ISSN 1179-1608
    ISSN 1179-1608
    DOI 10.2147/NSS.S439161
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Association Between FeNO, Total Blood IgE, Peripheral Blood Eosinophil and Inflammatory Cytokines in Partly Controlled Asthma.

    Badar, Ahmed / Salem, Ayad Mohammed / Bamosa, Abdullah Omar / Qutub, Hatem Othman / Gupta, Rakesh Kumar / Siddiqui, Intisar Ahmad

    Journal of asthma and allergy

    2020  Volume 13, Page(s) 533–543

    Abstract: Background: Fractional exhaled nitric oxide (FeNO) is a convenient to use biomarker of airway inflammation. However, the mutual relationship between FeNO, peripheral blood eosinophil, total immunoglobulin E (IgE) and inflammatory cytokines showed some ... ...

    Abstract Background: Fractional exhaled nitric oxide (FeNO) is a convenient to use biomarker of airway inflammation. However, the mutual relationship between FeNO, peripheral blood eosinophil, total immunoglobulin E (IgE) and inflammatory cytokines showed some controversy.
    Objective: This study was carried out to determine the accuracy of peripheral blood eosinophil and total IgE to detect eosinophilic airway inflammation as determined by two FeNO cutoff points. The correlation between FeNO, peripheral blood eosinophil, total IgE and certain inflammatory cytokines was also examined.
    Methods: Seventy-six patients with partly controlled asthma performed the following tests on the same day: FeNO, pulmonary function tests (PFTs), peripheral blood eosinophils, total IgE, and inflammatory cytokine assay. The correlation between these markers was investigated and the diagnostic accuracy of peripheral blood eosinophils and total IgE to identify eosinophilic asthma phenotype was calculated using receiver operating characteristics area under the curve (ROC AUC).
    Results: FeNO was positively correlated with percentage of blood eosinophils (
    Conclusion: In patients with partly controlled asthma, peripheral blood eosinophil and total IgE showed equal useful accuracy in predicting eosinophilic airways. However, higher predictive values were reported at FeNO level >50 ppb. FeNO was positively correlated with peripheral blood eosinophil, total IgE but not with any of the studied cytokines.
    Language English
    Publishing date 2020-10-29
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2494877-9
    ISSN 1178-6965
    ISSN 1178-6965
    DOI 10.2147/JAA.S274022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Effect of Nigella sativa supplementation on lung function and inflammatory mediatorsin partly controlled asthma: a randomized controlled trial.

    Salem, Ayad Mohammed / Bamosa, Abdullah Omar / Qutub, Hatem Othman / Gupta, Rakesh Kumar / Badar, Ahmed / Elnour, Abdelsalam / Afzal, Muhammad Nasir

    Annals of Saudi medicine

    2017  Volume 37, Issue 1, Page(s) 64–71

    Abstract: Background: Nigella sativa and its derivatives have been reported to have anti-inflammatory and bronchodilator effects, but the effects have been evaluated in only a few clinical studies.: Objectives: To determine the effect of N sativa ... ...

    Abstract Background: Nigella sativa and its derivatives have been reported to have anti-inflammatory and bronchodilator effects, but the effects have been evaluated in only a few clinical studies.
    Objectives: To determine the effect of N sativa supplementation on inflammation of the airways and limitation of airflow in partly controlled asthma patients.
    Design: Single-blind, placebo-controlled, randomized study.
    Setting: Asthma and allergy clinic of a university hospital in eastern Saudi Arabia.
    Patients and methods: Patients were divided into three groups. A control group (n=24) received the placebo, while NS-1 and NS-2 groups (n=26 each) received 1 and 2 g/day of N sativa, respectively, for 3 months along with maintenance inhaled therapy.
    Main outcome measure(s): Asthma control test (ACT) score, fractional exhaled nitric oxide (FeNO), peak expiratory flow (PEF) variability and other pulmonary function tests, IgE, serum cytokines, and frequency of exacerbations.
    Results: FEF25-75% and FEV1 (% predicted) increased significantly (P < .05) at both 6 and 12 weeks in the NS-2 group. PEF variability significantly improved in both NS-1 and NS-2 groups at 6 and 12 weeks as compared with the controls (P < .05). FeNO and serum IgE decreased significantly after 12 weeks in both the NS-1 and NS-2 groups vs baseline (P < .05). Both doses of N sativa produced a significant increase in the serum IFN-gamma at 12 weeks vs baseline (P < .05) as well as a significant improvement in the ACT score at 6 and 12 weeks vs baseline (P < .001, < .01). Significantly fewer patients had exacerbations in the NS-1 group (P < .05).
    Conclusion: N sativa supplementation with inhaled maintenance therapy improves some measures of pulmonary function and inflammation in partly controlled asthma.
    Limitations: No bronchoalveolar lavage or sputum samples taken for measurement of asthma markers. ISRCTN registry: ISRCTN48853858 DOI 10.1186/ISRCTN48853858.
    MeSH term(s) Adult ; Asthma/blood ; Asthma/drug therapy ; Asthma/physiopathology ; Bronchodilator Agents/pharmacology ; Cytokines/blood ; Dietary Supplements ; Disease Progression ; Exhalation/drug effects ; Female ; Humans ; Immunoglobulin E/blood ; Inflammation Mediators/blood ; Male ; Middle Aged ; Nigella sativa ; Nitric Oxide/analysis ; Peak Expiratory Flow Rate/drug effects ; Phytotherapy ; Plant Extracts/pharmacology ; Respiratory Function Tests ; Single-Blind Method
    Chemical Substances Bronchodilator Agents ; Cytokines ; Inflammation Mediators ; Plant Extracts ; Nitric Oxide (31C4KY9ESH) ; Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2017-03-16
    Publishing country Saudi Arabia
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 639014-6
    ISSN 0975-4466 ; 0256-4947
    ISSN (online) 0975-4466
    ISSN 0256-4947
    DOI 10.5144/0256-4947.2017.64
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 3022: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  5. Article: Metformin-related acidosis in a woman while performing Haj: a conservative approach.

    Ansari, Riyazuddin S H / Mady, Ahmed Fouad / Qutub, Hatem Othman / Althomaly, Eidah / Alzayer, Zainab Abdulaziz / Moulana, Amna A R

    Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia

    2015  Volume 26, Issue 1, Page(s) 125–127

    Abstract: Metformin is a first-line oral anti-hyperglycemic agent. It decreases insulin resistance, decreases hepatic glucose output and enhances peripheral glucose uptake. Metformin is used as a monotherapy in combination with other oral hypoglycemic agents. A ... ...

    Abstract Metformin is a first-line oral anti-hyperglycemic agent. It decreases insulin resistance, decreases hepatic glucose output and enhances peripheral glucose uptake. Metformin is used as a monotherapy in combination with other oral hypoglycemic agents. A major side-effect of metformin is lactic acidosis. The elimination of metformin is mainly through the kidneys, and raised plasma concentrations can cause lactic acidosis. Provided there is no overdose, metformin associated lactic acidosis rarely develops in patients without co-morbidities such as renal or hepatic insufficiency, acute infection or severe dehydration. Herein, we report a case of metformin-induced metabolic acidosis occurring in a woman who was severely dehydrated after performing Haj and treated conservatively.
    MeSH term(s) Acidosis, Lactic/chemically induced ; Acidosis, Lactic/therapy ; Dehydration/complications ; Diabetes Mellitus, Type 2/drug therapy ; Female ; Humans ; Hypoglycemic Agents/adverse effects ; Islam ; Metformin/adverse effects ; Middle Aged ; Travel
    Chemical Substances Hypoglycemic Agents ; Metformin (9100L32L2N)
    Language English
    Publishing date 2015-01-12
    Publishing country Saudi Arabia
    Document type Case Reports ; Journal Article
    ZDB-ID 1379955-1
    ISSN 1319-2442
    ISSN 1319-2442
    DOI 10.4103/1319-2442.148759
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4735: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Collaboration between a medical school and the provincial government health system in effective implementation of a problem-based curriculum: An experience from Saudi Arabia.

    Ahmed, Hatim Sid / Alabdulaali, Mohammed K / Qutub, Hatem Othman / Kaliyadan, Feroze / Almulhim, Abdulmohsen N / Albuali, Waleed Hamad / Al Gharib, Fahad / Al Otaibi, Fatma Huzam

    Education for health (Abingdon, England)

    2017  Volume 30, Issue 1, Page(s) 99–100

    MeSH term(s) Curriculum ; Education, Medical, Undergraduate/methods ; Education, Medical, Undergraduate/organization & administration ; Humans ; Problem-Based Learning ; Saudi Arabia ; Schools, Medical/organization & administration ; State Medicine/organization & administration
    Language English
    Publishing date 2017-06-27
    Publishing country India
    Document type Letter
    ZDB-ID 1318454-4
    ISSN 1469-5804 ; 1357-6283
    ISSN (online) 1469-5804
    ISSN 1357-6283
    DOI 10.4103/efh.EfH_154_16
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 3294: Show issues Location:
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  7. Article ; Online: A candidate transacting modulator of fetal hemoglobin gene expression in the Arab-Indian haplotype of sickle cell anemia.

    Vathipadiekal, Vinod / Farrell, John J / Wang, Shuai / Edward, Heather L / Shappell, Heather / Al-Rubaish, A M / Al-Muhanna, Fahad / Naserullah, Z / Alsuliman, A / Qutub, Hatem Othman / Simkin, Irene / Farrer, Lindsay A / Jiang, Zhihua / Luo, Hong-Yuan / Huang, Shengwen / Mostoslavsky, Gustavo / Murphy, George J / Patra, Pradeep K / Chui, David H K /
    Alsultan, Abdulrahman / Al-Ali, Amein K / Sebastiani, Paola / Steinberg, Martin H

    American journal of hematology

    2016  Volume 91, Issue 11, Page(s) 1118–1122

    Abstract: Fetal hemoglobin (HbF) levels are higher in the Arab-Indian (AI) β-globin gene haplotype of sickle cell anemia compared with African-origin haplotypes. To study genetic elements that effect HbF expression in the AI haplotype we completed whole genome ... ...

    Abstract Fetal hemoglobin (HbF) levels are higher in the Arab-Indian (AI) β-globin gene haplotype of sickle cell anemia compared with African-origin haplotypes. To study genetic elements that effect HbF expression in the AI haplotype we completed whole genome sequencing in 14 Saudi AI haplotype sickle hemoglobin homozygotes-seven selected for low HbF (8.2% ± 1.3%) and seven selected for high HbF (23.5% ± 2.6%). An intronic single nucleotide polymorphism (SNP) in ANTXR1, an anthrax toxin receptor (chromosome 2p13), was associated with HbF. These results were replicated in two independent Saudi AI haplotype cohorts of 120 and 139 patients, but not in 76 Saudi Benin haplotype, 894 African origin haplotype and 44 AI haplotype patients of Indian origin, suggesting that this association is effective only in the Saudi AI haplotype background. ANTXR1 variants explained 10% of the HbF variability compared with 8% for BCL11A. These two genes had independent, additive effects on HbF and together explained about 15% of HbF variability in Saudi AI sickle cell anemia patients. ANTXR1 was expressed at mRNA and protein levels in erythroid progenitors derived from induced pluripotent stem cells (iPSCs) and CD34
    MeSH term(s) Adolescent ; Adult ; Anemia, Sickle Cell/genetics ; Arabs/genetics ; Carrier Proteins/genetics ; Child ; Child, Preschool ; European Continental Ancestry Group/genetics ; Female ; Fetal Hemoglobin/genetics ; Gene Expression ; Haplotypes ; Humans ; Male ; Neoplasm Proteins/genetics ; Nuclear Proteins/genetics ; Polymorphism, Single Nucleotide ; Receptors, Cell Surface/genetics ; Young Adult ; beta-Globins/genetics
    Chemical Substances ANTXR1 protein, human ; BCL11A protein, human ; Carrier Proteins ; Neoplasm Proteins ; Nuclear Proteins ; Receptors, Cell Surface ; beta-Globins ; Fetal Hemoglobin (9034-63-3)
    Language English
    Publishing date 2016-08-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.24527
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1251: Show issues Location:
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