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  1. Article ; Online: Dealing with Dual Challenges Posed by an Uncorrected Atrial Septal Defect with Poliomyelitis- Anaesthetic Considerations for a Non Cardiac Surgery

    R Chandhinie / M Raj / R Purushotham

    Journal of Clinical and Diagnostic Research, Vol 16, Iss 6, Pp UD01-UD

    2022  Volume 03

    Abstract: Atrial Septal Defect (ASD) is one of the most common congenital heart diseases. This is one such disease where patients largely remain asymptomatic throughout childhood and begin showing symptoms during adulthood. Here, the authors present a case of a 44- ...

    Abstract Atrial Septal Defect (ASD) is one of the most common congenital heart diseases. This is one such disease where patients largely remain asymptomatic throughout childhood and begin showing symptoms during adulthood. Here, the authors present a case of a 44-year-old male patient, with an uncorrected ASD and poliomyelitis, who presented with fracture femur. He was posted for Open Reduction Internal Fixation (ORIF) with plating of femur. The anaesthetic management was successfully done with general anaesthesia through endotracheal intubation along with fascia iliaca block. After the procedure and extubation, the patient was conscious, oriented, responded to commands, and had normal vital parameters. He was shifted to the Intensive Care Unit (ICU)for further observation and monitoring in view of his pre-existing co-morbid conditions. Postoperatively, cardiovascular surgeon advised a correction surgery for his ASD at a later date. The patient was discharged on Postoperative Day (POD) 12. Dealing with these two vastly different disease entities in the same patient certainly posed a unique aspect to the present case considering the fact that there was no prior literature regarding the same.
    Keywords congenital heart diseases ; fascia iliaca block ; femur ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher JCDR Research and Publications Private Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: A Cross-sectional Study on Adherence to Personal Protective Equipment among Healthcare Workers during COVID-19 Pandemic in a Tertiary Care Centre, Tamil Nadu, India

    R Purushotham / Veena Raja / SPJ Salim Javeedh / Balaji Ramraj Ramamurthy / Bhuvanamha Devi Ramamurthy

    Journal of Clinical and Diagnostic Research, Vol 16, Iss 5, Pp LC01-LC

    2022  Volume 08

    Abstract: Introduction: Personal Protective Equipment (PPE) provides physical barrier against hazardous injury or infectious agents. With the outbreak of COVID-19 pandemic, PPE plays a vital role with face mask and gloves are being most essential. The frontline ... ...

    Abstract Introduction: Personal Protective Equipment (PPE) provides physical barrier against hazardous injury or infectious agents. With the outbreak of COVID-19 pandemic, PPE plays a vital role with face mask and gloves are being most essential. The frontline Healthcare Workers (HCW) utilises them to minimise the risk of contaminated contact or infected droplet exposure. Aim: To evaluate the appropriate use of PPE among healthcare workers in tertiary care hospital. Materials and Methods: This cross-sectional study was conducted in SRM Medical College Hospital and Research Centre, Potheri, Chengalpet district, Chennai, Tamil Nadu, India, from February 2021 to May 2021, on utility of PPE among the healthcare workers. There were a total of 273 participants including doctors, residents (postgraduate)/interns, nurses and laboratory technicians. A predesigned questionnaire was utilised to collect information, apart from observation of their PPE practice and 360 degree observation from peers were also used to evaluate. Statistical analysis was done using Chi-square test, Fisher’s-exact test and logistic regression model. Results: Among 273 HCWs, there were 58 (21.24%) doctors, 163 (59.71%) residents and interns, 19 (6.96%) nurses and 33 (12.09%) technicians. There was no association in the frequency of mask with the type of HCW (p-value=0.217). However, the usage frequency of gloves (p-value=0.003), face shield/goggles (p-value=0.004), disposable gown (p-value=0.001) and doffing according to protocol (p-value=0.001) showed statistically significant difference between the category of HCWs. Conclusion: In this study, PPE adherence was high among HCW; however, there was a subtle difference in compliance across the varied groups of healthcare professional and type of PPE used. The PPE compliance among HCW cannot be assumed to be good blindly; frequent official training programs, availability of PPE logistics along with scrutinisation regarding its appropriate usage and discarding at regular intervals minimises the non compliance ...
    Keywords compliance ; coronavirus 2019 infection ; severe acute respiratory syndrome coronavirus-2 ; transmission ; Medicine ; R
    Subject code 360
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher JCDR Research and Publications Private Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Causality assessment: A brief insight into practices in pharmaceutical industry.

    Naidu, R Purushotham

    Perspectives in clinical research

    2013  Volume 4, Issue 4, Page(s) 233–236

    Abstract: Healthcare industry is flooded with multitude of drugs, and the list is increasing day by day. Consumption of medications has enormously increased due to life style changes, having safer drugs is the need of the hour. Regulators and other authorities to ... ...

    Abstract Healthcare industry is flooded with multitude of drugs, and the list is increasing day by day. Consumption of medications has enormously increased due to life style changes, having safer drugs is the need of the hour. Regulators and other authorities to have a check have put in stringent regulations and pharmacovigilance system in place. Eventhough there has been increase in adverse drug reactions (ADR) reporting in the last decade, causality assessment has been the greater challenge for academicians and even industry. Causality is crucial for risk benefit assessment, particularly when it involves post marketing safety signals. Pharmaceutical companies have put in efforts to have a standardized approach for causality assessment. This article will provide some insight into the approaches for causality assessment from a pharma industry perspective.
    Language English
    Publishing date 2013-08-20
    Publishing country India
    Document type Journal Article
    ZDB-ID 2593231-7
    ISSN 2229-5488 ; 2229-3485
    ISSN (online) 2229-5488
    ISSN 2229-3485
    DOI 10.4103/2229-3485.120173
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Causality assessment

    R Purushotham Naidu

    Perspectives in Clinical Research, Vol 4, Iss 4, Pp 233-

    A brief insight into practices in pharmaceutical industry

    2013  Volume 236

    Abstract: Healthcare industry is flooded with multitude of drugs, and the list is increasing day by day. Consumption of medications has enormously increased due to life style changes, having safer drugs is the need of the hour. Regulators and other authorities to ... ...

    Abstract Healthcare industry is flooded with multitude of drugs, and the list is increasing day by day. Consumption of medications has enormously increased due to life style changes, having safer drugs is the need of the hour. Regulators and other authorities to have a check have put in stringent regulations and pharmacovigilance system in place. Eventhough there has been increase in adverse drug reactions (ADR) reporting in the last decade, causality assessment has been the greater challenge for academicians and even industry. Causality is crucial for risk benefit assessment, particularly when it involves post marketing safety signals. Pharmaceutical companies have put in efforts to have a standardized approach for causality assessment. This article will provide some insight into the approaches for causality assessment from a pharma industry perspective.
    Keywords Adverse drug reactions ; causality ; pharmacovigilance ; Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2013-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Increasing Full Child Immunization Rates by Government Using an Innovative Computerized Immunization Due List in Rural India.

    Ganguly, Enakshi / Gupta, Rahul / Widge, Alik / Reddy, R Purushotham / Balasubramanian, K / Reddy, P S

    Inquiry : a journal of medical care organization, provision and financing

    2018  Volume 55, Page(s) 46958017751292

    Abstract: Increasing child vaccination coverage to 85% or more in rural India from the current level of 50% holds great promise for reducing infant and child mortality and improving health of children. We have tested a novel strategy called Rural Effective ... ...

    Abstract Increasing child vaccination coverage to 85% or more in rural India from the current level of 50% holds great promise for reducing infant and child mortality and improving health of children. We have tested a novel strategy called Rural Effective Affordable Comprehensive Health Care (REACH) in a rural population of more than 300 000 in Rajasthan and succeeded in achieving full immunization coverage of 88.7% among children aged 12 to 23 months in a short span of less than 2 years. The REACH strategy was first developed and successfully implemented in a demonstration project by SHARE INDIA in Medchal region of Andhra Pradesh, and was then replicated in Rajgarh block of Rajasthan in cooperation with Bhoruka Charitable Trust (private partners of Integrated Child Development Services and National Rural Health Mission health workers in Rajgarh). The success of the REACH strategy in both Andhra Pradesh and Rajasthan suggests that it could be successfully adopted as a model to enhance vaccination coverage dramatically in other areas of rural India.
    MeSH term(s) Female ; Humans ; Immunization Programs/organization & administration ; India ; Infant ; Information Systems/organization & administration ; Male ; Rural Population/statistics & numerical data ; Vaccination Coverage/organization & administration ; Vaccination Coverage/statistics & numerical data
    Language English
    Publishing date 2018-02-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 42153-4
    ISSN 1945-7243 ; 0046-9580
    ISSN (online) 1945-7243
    ISSN 0046-9580
    DOI 10.1177/0046958017751292
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Rational Design of Protein-Specific Folding Modifiers.

    Das, Anirban / Yadav, Anju / Gupta, Mona / R, Purushotham / Terse, Vishram L / Vishvakarma, Vicky / Singh, Sameer / Nandi, Tathagata / Banerjee, Arkadeep / Mandal, Kalyaneswar / Gosavi, Shachi / Das, Ranabir / Ainavarapu, Sri Rama Koti / Maiti, Sudipta

    Journal of the American Chemical Society

    2021  Volume 143, Issue 44, Page(s) 18766–18776

    Abstract: Protein-folding can go ... ...

    Abstract Protein-folding can go wrong
    MeSH term(s) Models, Molecular ; Protein Conformation ; Protein Folding ; Ubiquitin/chemistry ; Ubiquitin/metabolism
    Chemical Substances Ubiquitin
    Language English
    Publishing date 2021-11-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.1c09611
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  7. Article: Rational Design of Protein-Specific Folding Modifiers

    Das, Anirban / Yadav, Anju / Gupta, Mona / R, Purushotham / Terse, Vishram L. / Vishvakarma, Vicky / Singh, Sameer / Nandi, Tathagata / Banerjee, Arkadeep / Mandal, Kalyaneswar / Gosavi, Shachi / Das, Ranabir / Ainavarapu, Sri Rama Koti / Maiti, Sudipta

    Journal of the American Chemical Society. 2021 Nov. 01, v. 143, no. 44

    2021  

    Abstract: Protein-folding can go wrong in vivo and in vitro, with significant consequences for the living organism and the pharmaceutical industry, respectively. Here we propose a design principle for small-peptide-based protein-specific folding modifiers. The ... ...

    Abstract Protein-folding can go wrong in vivo and in vitro, with significant consequences for the living organism and the pharmaceutical industry, respectively. Here we propose a design principle for small-peptide-based protein-specific folding modifiers. The principle is based on constructing a “xenonucleus”, which is a prefolded peptide that mimics the folding nucleus of a protein. Using stopped-flow kinetics, NMR spectroscopy, Förster resonance energy transfer, single-molecule force measurements, and molecular dynamics simulations, we demonstrate that a xenonucleus can make the refolding of ubiquitin faster by 33 ± 5%, while variants of the same peptide have little or no effect. Our approach provides a novel method for constructing specific, genetically encodable folding catalysts for suitable proteins that have a well-defined contiguous folding nucleus.
    Keywords energy transfer ; molecular dynamics ; nuclear magnetic resonance spectroscopy ; peptides ; pharmaceutical industry ; protein folding ; ubiquitin
    Language English
    Dates of publication 2021-1101
    Size p. 18766-18776.
    Publishing place American Chemical Society
    Document type Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.1c09611
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Increasing Full Child Immunization Rates by Government Using an Innovative Computerized Immunization Due List in Rural India

    Enakshi Ganguly MD / Rahul Gupta MStat / Alik Widge MD, PhD / R. Purushotham Reddy MBA / K. Balasubramanian PhD / P. S. Reddy MD.

    Inquiry: The Journal of Health Care Organization, Provision, and Financing, Vol

    2018  Volume 55

    Abstract: Increasing child vaccination coverage to 85% or more in rural India from the current level of 50% holds great promise for reducing infant and child mortality and improving health of children. We have tested a novel strategy called Rural Effective ... ...

    Abstract Increasing child vaccination coverage to 85% or more in rural India from the current level of 50% holds great promise for reducing infant and child mortality and improving health of children. We have tested a novel strategy called Rural Effective Affordable Comprehensive Health Care (REACH) in a rural population of more than 300 000 in Rajasthan and succeeded in achieving full immunization coverage of 88.7% among children aged 12 to 23 months in a short span of less than 2 years. The REACH strategy was first developed and successfully implemented in a demonstration project by SHARE INDIA in Medchal region of Andhra Pradesh, and was then replicated in Rajgarh block of Rajasthan in cooperation with Bhoruka Charitable Trust (private partners of Integrated Child Development Services and National Rural Health Mission health workers in Rajgarh). The success of the REACH strategy in both Andhra Pradesh and Rajasthan suggests that it could be successfully adopted as a model to enhance vaccination coverage dramatically in other areas of rural India.
    Keywords Public aspects of medicine ; RA1-1270
    Subject code 360
    Language English
    Publishing date 2018-01-01T00:00:00Z
    Publisher SAGE Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: "Mixed germ cell testicular tumor" in an adult female

    Udasimath Shivakumarswamy / R Purushotham / H K Kumar Naik / K R Nagesha

    Journal of Human Reproductive Sciences, Vol 5, Iss 1, Pp 64-

    2012  Volume 66

    Abstract: The androgen insensitivity (testicular feminization) syndrome was described by Morris in phenotypic females with 46XY karyotype, presenting with primary amenorrhea, adequate breast development, and absent or scanty pubic or axillary hair. Gonads consist ... ...

    Abstract The androgen insensitivity (testicular feminization) syndrome was described by Morris in phenotypic females with 46XY karyotype, presenting with primary amenorrhea, adequate breast development, and absent or scanty pubic or axillary hair. Gonads consist usually of seminiferous tubules without spermatogenesis. These patients have a 5-10% risk of developing germ cell tumors, usually after the complete development of secondary female sexual characteristics. We hereby report a case considered as a female with married life of 15 years, who was operated for severe abdominal pain. Phenotype characters were that of female. Microscopic examination of the tumor from the abdomen revealed germinoma and yolk sac tumor with adjacent seminiferous tubules. Karyotyping showed 46XY. Final diagnosis of malignant mixed germ cell tumor in androgen insensitivity syndrome was made. Surveillance may be the most appropriate option when these conditions are initially diagnosed in adulthood to prevent development of germ cell tumors.
    Keywords Androgen insensitivity ; germ cell tumors ; karyotype ; Gynecology and obstetrics ; RG1-991 ; Medicine ; R
    Language English
    Publishing date 2012-01-01T00:00:00Z
    Publisher Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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