Article: Gyógyszerek okozta fényérzékenységi reakciók és gyógyszerészi kémiai háitterük.
2015 Volume 85, Issue 2, Page(s) 51–70
Abstract: The photosensitivity originated from drugs is a common problem in medical and pharmaceutical practice. It is of prominent importance in drug development and in regulatory issues. The photosensitizer effect of drug substances is determined by their ... ...
Title translation | Pharmaceutical chemistry of drug-initiated photosensitivity. |
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Abstract | The photosensitivity originated from drugs is a common problem in medical and pharmaceutical practice. It is of prominent importance in drug development and in regulatory issues. The photosensitizer effect of drug substances is determined by their chemical structures, and it mainly originates from aromatic chromophore systems and photo-dissociable bonds forming free radicals. The photodegradation may happen in many different types of chemical reaction pathways. Our aim is to demonstrate in this review the interrelations between structure and photodegradation. We show examples for the different reaction types, with drugs from different pharmacologic therapeutic classes. The in vivo chemical reactivity of photodegradates of pharmaceutical substances, the in vitro methods of investigation for testing photoreactivity and phototoxicity, and briefly the clinical tests for photosensitivity disorders are also discussed. |
MeSH term(s) | Chemistry, Pharmaceutical/methods ; Dermatitis, Phototoxic/prevention & control ; Humans ; Photolysis/drug effects ; Photosensitivity Disorders/chemically induced ; Photosensitivity Disorders/diagnosis ; Photosensitivity Disorders/prevention & control ; Photosensitizing Agents/adverse effects ; Photosensitizing Agents/chemistry ; Structure-Activity Relationship ; Ultraviolet Rays/adverse effects |
Chemical Substances | Photosensitizing Agents |
Language | Hungarian |
Publishing date | 2015 |
Publishing country | Hungary |
Document type | English Abstract ; Journal Article ; Review |
ZDB-ID | 392228-5 |
ISSN | 0001-6659 |
ISSN | 0001-6659 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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