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Article ; Online: Pilot study of longterm low fat diet in relapsing-remitting multiple sclerosis.

Dean, Zuzana / Penesova, Adela / Radikova, Zofia / Kollar, Branislav

2022 Volume 43, Issue 3, Page(s) 135–139

Abstract: Background and objective: To assess longterm feasibility of low saturated fat diet (less than 15 g of saturated fat per day) in patients with relapsing remitting multiple sclerosis (RRMS) and its effect on the course of the disease.: Materials and ... ...

Abstract	Background and objective: To assess longterm feasibility of low saturated fat diet (less than 15 g of saturated fat per day) in patients with relapsing remitting multiple sclerosis (RRMS) and its effect on the course of the disease. Materials and methods: Patients were enrolled into a single arm, prospective study. The eligibility criteria included the diagnosis of RRMS according to the McDonald criteria 2010 and the ability to comply with the diet. Patients were allowed to receive disease modifying therapy (DMT) and to take food supplements. Diet adherence was monitored by food diaries. Number of attacks, brain magnetic resonance imaging (MRI) characteristics, Expanded disability status scale (EDSS) and Body mass index (BMI) were recorded. Results: Twelve patients with RRMS were enrolled. Six patients (50%) continued with the diet for the median duration of 37 months. The high drop-out of patients was caused mainly by patients' inability to strictly adhere to the diet. In six patients who were able to follow the diet - their mean EDSS of 1.30 decreased to 1.17. None of the patients experienced an attack, 5 of 6 patients had stable disease on yearly magnetic resonance imaging (MRI) scans with no new lesions identified. Conclusion: The low fat diet is safe and seems to be effective in preventing clinical attacks/new MRI lesions. The main drawback is the problem of adhering to the diet longterm in the western-style diet environment.
Language	English
Publishing date	2022-09-16
Publishing country	Sweden
Document type	Journal Article
ZDB-ID	135951-4
ISSN	2354-4716 ; 0172-780X
ISSN (online)	2354-4716
ISSN	0172-780X
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Article ; Online: Nutritional interventions for patients with alkaptonuria: A minireview.

Imrich, Richard / Zatkova, Andrea / Lukacova, Olga / Sedlakova, Jana / Zanova, Elizabeth / Vlcek, Miroslav / Penesova, Adela / Radikova, Zofia / Havranova, Andrea / Ranganath, Lakshminarayan

Endocrine regulations

2023 Volume 57, Issue 1, Page(s) 61–67

Abstract: Alkaptonuria (AKU, OMIM, No. 203500) is a rare, slow-progressing, irreversible, multisystemic disease resulting from a deficiency of the homogentisate 1,2-dioxygenase enzyme, which leads to the accumulation of homogentisic acid (HGA) and subsequent ... ...

Abstract	Alkaptonuria (AKU, OMIM, No. 203500) is a rare, slow-progressing, irreversible, multisystemic disease resulting from a deficiency of the homogentisate 1,2-dioxygenase enzyme, which leads to the accumulation of homogentisic acid (HGA) and subsequent deposition as pigment in connective tissues called ochronosis. As a result, severe arthropathy of large joints and spondyloarthropathy with frequent fractures, ligament ruptures, and osteoporosis develops in AKU patients. Since 2020, the first-time treatment with nitisinone has become available in the European Union. Nitisinone significantly reduces HGA production and arrests ochronosis in AKU patients. However, blocking of the tyrosine metabolic pathway by the drug leads to tyrosine plasma and tissue concentrations increase. The nitisinone-induced hypertyrosinemia can lead to the development of corneal keratopathy, and once it develops, the treatment needs to be interrupted. A decrease in overall protein intake reduces the risk of the keratopathy during nitisinone-induced hypertyrosinemia in AKU patients. The low-protein diet is not only poorly tolerated by patients, but over longer periods, leads to a severe muscle loss and weight gain due to increased energy intake from carbohydrates and fats. Therefore, the development of novel nutritional approaches is required to prevent the adverse events due to nitisinone-induced hypertyrosinemia and the negative impact on skeletal muscle metabolism in AKU patients.
MeSH term(s)	Humans ; Alkaptonuria/drug therapy ; Alkaptonuria/metabolism ; Ochronosis/drug therapy ; Tyrosinemias ; Tyrosine/therapeutic use ; Homogentisic Acid/metabolism
Chemical Substances	nitisinone (K5BN214699) ; Tyrosine (42HK56048U) ; Homogentisic Acid (NP8UE6VF08)
Language	English
Publishing date	2023-03-26
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1082213-6
ISSN	1336-0329 ; 0013-7200 ; 1210-0668
ISSN (online)	1336-0329
ISSN	0013-7200 ; 1210-0668
DOI	10.2478/enr-2023-0008
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Article ; Online: Gut Microbiota and Serum Metabolites in Individuals with Class III Obesity Without Type 2 Diabetes Mellitus: Pilot Analysis.

Kubáňová, Libuša / Bielik, Viktor / Hric, Ivan / Ugrayová, Simona / Šoltys, Katarína / Rádiková, Žofia / Baranovičová, Eva / Grendár, Marián / Kolisek, Martin / Penesová, Adela

Metabolic syndrome and related disorders

2023 Volume 21, Issue 5, Page(s) 243–253

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Humans ; Diabetes Mellitus, Type 2 ; Gastrointestinal Microbiome ; Cross-Sectional Studies ; Prospective Studies ; Obesity ; Bacteria/genetics ; Citrates
Chemical Substances	Citrates
Language	English
Publishing date	2023-04-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2151220-6
ISSN	1557-8518 ; 1540-4196
ISSN (online)	1557-8518
ISSN	1540-4196
DOI	10.1089/met.2022.0071
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Article: The Interplay of Dyslipidemia, Oxidative Stress, and Clinical Outcomes in Acute Ischemic Stroke Patients with and without Coronary Artery Disease.

Kollar, Branislav / Siarnik, Pavel / Konarikova, Katarina / Oravec, Stanislav / Klobucka, Stanislava / Klobucnikova, Katarina / Poddany, Michal / Radikova, Zofia / Janubova, Maria / Turcani, Peter / Gajdosova, Livia / Zitnanova, Ingrid

Biomedicines

2024 Volume 12, Issue 2

Abstract: We assessed lipid and lipoprotein profiles, along with oxidative stress (OS) parameters, in patients within the crucial 24 h period following an acute ischemic stroke (AIS), comparing those with and without coronary artery disease (CAD). We aimed to ... ...

Abstract	We assessed lipid and lipoprotein profiles, along with oxidative stress (OS) parameters, in patients within the crucial 24 h period following an acute ischemic stroke (AIS), comparing those with and without coronary artery disease (CAD). We aimed to correlate these measures with clinical condition scales (NIHSS, mRS) post-AIS. This study included 27 AIS patients without CAD (AIS group) and 37 AIS patients with CAD (CAD-AIS group). Using polyacrylamide gel electrophoresis (Lipoprint system), we determined plasma LDL and HDL subfractions. Spectrophotometric methods were used to assess plasma antioxidant capacity, lipoperoxides, homocysteine (HC) levels, paraoxonase1, and catalase activities. We also measured urine isoprostanes and the activities of antioxidant enzymes (SOD, GPx) with commercial kits. CAD-AIS patients had notably higher HC levels, while there were no significant differences in lipoprotein subfractions and OS parameters between both groups. In the AIS group, mRS scores showed negative correlations with catalase, GPx activities, and total cholesterol. In the CAD-AIS group, atherogenic lipoproteins (IDLC, LDL2, LDL3-7) exhibited a significant positive correlation with mRS. This study underscores the role of dyslipidemia and OS in the development of AIS and CAD. It emphasizes the complex connections between specific biomarkers and post-stroke clinical outcomes. Our results suggest a significant impact of CAD treatment on lipid profile but not on homocysteine levels. The traditional narrative associating high cholesterol as the ultimate risk factor for cardiovascular diseases needs to be challenged, at least with respect to neurological outcomes. These insights may guide more targeted therapeutic approaches.
Language	English
Publishing date	2024-02-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines12020332
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Article: Seroprevalence of SARS-CoV-2 antibodies in the county town of Slovakia - a pilot study from the Trencin city.

Kajanova, Ivana / Grossmannova, Katarina / Jelenska, Lenka / Lukacikova, Lubomira / Radikova, Zofia / Knutova, Nikola / Nahlikova, Jana / Belisova, Martina / Pastorekova, Silvia / Kopacek, Juraj

Acta virologica

2022 Volume 66, Issue 3, Page(s) 228–237

Abstract: Slovakia is a country with only 5.45 million inhabitants. However, the past two years of the COVID-19 pandemic have shown huge inter-regional differences. These were represented by different numbers of diagnosed SARS-CoV-2 cases and the vaccination rates ...

Abstract	Slovakia is a country with only 5.45 million inhabitants. However, the past two years of the COVID-19 pandemic have shown huge inter-regional differences. These were represented by different numbers of diagnosed SARS-CoV-2 cases and the vaccination rates in the regions, as well as by the willingness of the inhabitants to comply with anti-pandemic measures or to undergo testing. The occurrence of such regional disparities provided a rational basis for monitoring the epidemic situation within smaller areas, e.g. at city level. Trencin is a medium-sized Slovak county town with about 55 000 inhabitants. The city administration gave its residents the opportunity to assess their current level of antibodies against the SARS-CoV-2 virus, and received an additional benefit in the form of data on the real epidemic situation in the city, which helped in further management of anti-pandemic measures. The primary aim of the study, conducted in January and February 2022, was to determine the levels of antibodies against the SARS-CoV-2 virus in the inhabitants of Trencin. The results showed that 75% of the study participants, representing the adult population of the city, had detectable IgG antibodies against the SARS-CoV-2 spike protein. Noteworthy, at the time of the study, 13% of the Trencin city population who were unaware of overcoming COVID-19 had specific antibodies against the virus. Furthermore, the antibody levels in recovered unvaccinated subjects increased not only with the severity of their COVID-19 symptoms, but also after multiple recoveries from the disease. On the other hand, the severity of side effects after vaccination did not influence the antibody levels. The results of the study are in line with the current view that hybrid immunity (vaccination plus SARS-CoV-2 infection in any order) offers greater protection than immunity elicited by vaccination or COVID-19 separately. Keywords: SARS-CoV-2 coronavirus; COVID-19; ELISA; seroprevalence; antibodies; vaccination.
MeSH term(s)	Adult ; Antibodies, Viral ; COVID-19/epidemiology ; Humans ; Immunoglobulin G ; Pandemics ; Pilot Projects ; SARS-CoV-2 ; Seroepidemiologic Studies ; Slovakia/epidemiology ; Spike Glycoprotein, Coronavirus
Chemical Substances	Antibodies, Viral ; Immunoglobulin G ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
Language	English
Publishing date	2022-08-26
Publishing country	Slovakia
Document type	Journal Article
ZDB-ID	210452-0
ISSN	1336-2305 ; 0001-723X
ISSN (online)	1336-2305
ISSN	0001-723X
DOI	10.4149/av_2022_301
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Article ; Online: Endothelial Function in Patients with Multiple Sclerosis: The Role of GLP-1 Agonists, Lipoprotein Subfractions, and Redox Balance.

Hardonova, Miroslava / Siarnik, Pavel / Sivakova, Monika / Sucha, Bianka / Penesova, Adela / Radikova, Zofia / Havranova, Andrea / Imrich, Richard / Vlcek, Miroslav / Zitnanova, Ingrid / Krastev, Georgi / Kiacikova, Maria / Kollar, Branislav / Turcani, Peter

International journal of molecular sciences

2023 Volume 24, Issue 13

Abstract: Introduction: Epidemiological studies have suggested an increased vascular risk in patients with multiple sclerosis (MS). There is increasing evidence of the beneficial effects of GLP-1 agonists (GLP-1a) in preventing vascular complications and slowing ... ...

Abstract	Introduction: Epidemiological studies have suggested an increased vascular risk in patients with multiple sclerosis (MS). There is increasing evidence of the beneficial effects of GLP-1 agonists (GLP-1a) in preventing vascular complications and slowing the progression of neurodegeneration. Our objective was to explore the changes in the endothelial function of MS patients after 12 months of GLP-1a therapy. We also explored the role of lipoprotein subfractions and the antioxidant capacity of plasma. Methods: MS patients were enrolled in a prospective, unicentric study. GLP-1a (dulaglutide) was administered to 13 patients. The control population consisted of 12 subjects. Endothelial function was determined by peripheral arterial tonometry and expressed as reperfusion hyperemia index (RHI). Trolox equivalent antioxidant capacity (TEAC) was used to assess the total antioxidant capacity of the plasma. The levels of lipoprotein subfractions were evaluated. Results: The GLP-1a group did not have a significant change in their RHIs after 12 months (2.1 ± 0.6 vs. 2.1 ± 0.7; Conclusion: Our results suggest that the application of additional GLP-1a therapy may have atheroprotective and antioxidant effects in MS patients with high MS activity and thus may prospectively mitigate their vascular risk. However, the lipoprotein profile may also play an important role in the atherogenic risk of MS subjects.
MeSH term(s)	Humans ; Multiple Sclerosis/drug therapy ; Antioxidants ; Prospective Studies ; Cholesterol, LDL ; Lipoproteins ; Hyperemia ; Oxidation-Reduction ; Glucagon-Like Peptide 1 ; Lipoproteins, LDL
Chemical Substances	Antioxidants ; Cholesterol, LDL ; Lipoproteins ; Glucagon-Like Peptide 1 (89750-14-1) ; Lipoproteins, LDL
Language	English
Publishing date	2023-07-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241311162
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Article ; Online: Association of lipoprotein levels with sleep apnea: role of autonomic dysfunction.

Siarnik, Pavel / Penesova, Adela / Radikova, Zofia / Hluchanova, Alzbeta / Hanus, Oto / Klobucnikova, Katarina / Turcani, Peter / Kollar, Branislav

Endocrine regulations

2021 Volume 55, Issue 1, Page(s) 22–29

Abstract: Objectives. ...

Abstract	Objectives.
MeSH term(s)	Adult ; Autonomic Nervous System Diseases/blood ; Baroreflex ; Cholesterol, HDL/blood ; Female ; Humans ; Hypercholesterolemia/physiopathology ; Hypertriglyceridemia/physiopathology ; Lipoproteins/blood ; Male ; Middle Aged ; Oxygen/blood ; Polysomnography ; Sleep Apnea Syndromes/blood ; Snoring ; Triglycerides/blood
Chemical Substances	Cholesterol, HDL ; Lipoproteins ; Triglycerides ; Oxygen (S88TT14065)
Language	English
Publishing date	2021-01-29
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1082213-6
ISSN	1336-0329 ; 0013-7200 ; 1210-0668
ISSN (online)	1336-0329
ISSN	0013-7200 ; 1210-0668
DOI	10.2478/enr-2021-0004
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Article: Assessment of insulin sensitivity/resistance in epidemiological studies.

Radikova, Zofia

Endocrine regulations

2003 Volume 37, Issue 3, Page(s) 189–194

Abstract: Hyperinsulinemic euglycemic clamp is known to be the "gold standard" in measurement insulin sensitivity. However, its time and financially consuming realization led to a simplified approach in quantification of insulin sensitivity. Various indices of ... ...

Abstract	Hyperinsulinemic euglycemic clamp is known to be the "gold standard" in measurement insulin sensitivity. However, its time and financially consuming realization led to a simplified approach in quantification of insulin sensitivity. Various indices of insulin sensitivity/resistance using the data from an oral glucose tolerance test were proposed in last 20 years. The aim of this review is to evaluate critically the use of some of the proposed indices in insulin sensitivity estimation. There are two groups of insulin sensitivity indices: 1. indices calculated by using fasting plasma concentrations of insulin, glucose and triglycerides, 2. indices calculated by using plasma concentrations of insulin and glucose obtained during 120 min of a standard (75 g glucose) oral glucose tolerance test. Some authors used demographic parameters (BMI, age, weight) in their formulas to achieve the best correlation with euglycemic clamp data. These indices are conveniently used in epidemiological and clinical studies to predict diabetes development in a non-diabetic population. Their use in clinical practice is limited because of the absence of reference values for normal and impaired insulin sensitivity.
MeSH term(s)	Glucose/metabolism ; Glucose Clamp Technique/standards ; Glucose Tolerance Test/standards ; Humans ; Insulin/metabolism ; Insulin Resistance/physiology
Chemical Substances	Insulin ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2003-09
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1082213-6
ISSN	1336-0329 ; 1210-0668 ; 0013-7200
ISSN (online)	1336-0329
ISSN	1210-0668 ; 0013-7200
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Article: The Efficacy of Short-Term Weight Loss Programs and Consumption of Natural Probiotic Bryndza Cheese on Gut Microbiota Composition in Women

Hric, Ivan / Ugrayová, Simona / Penesová, Adela / Rádiková, Žofia / Kubáňová, Libuša / Šardzíková, Sára / Baranovičová, Eva / Klučár, Ľuboš / Beke, Gábor / Grendar, Marian / Kolisek, Martin / Šoltys, Katarína / Bielik, Viktor

Nutrients. 2021 May 21, v. 13, no. 6

2021

Abstract: Weight loss interventions with probiotics have favourable effects on gut microbiota composition and derived metabolites. However, little is known about whether the consumption of natural probiotics, such as Bryndza cheeses, brings similar benefits. The ... ...

Abstract	Weight loss interventions with probiotics have favourable effects on gut microbiota composition and derived metabolites. However, little is known about whether the consumption of natural probiotics, such as Bryndza cheeses, brings similar benefits. The purpose of the study was to find the effect of short-term weight loss programs and Bryndza cheese consumption on the structure of the gut microbiota, microbiota-derived metabolites and body composition in middle-aged women. We conducted a randomised controlled intervention study. Twenty-two female participants with a body fat percentage ≥25% underwent a short weight loss program (4 weeks). Subjects were randomised to either the control or intervention group according to diet. The intervention group comprised 13 participants, whose diet contained 30 g of “Bryndza” cheese daily (WLPB). The control group comprised nine participants without the regular consumption of Bryndza cheese (WLP) in their diet. Both interventions lead to a significant and favourable change of BMI, body fat, waist circumference and muscle mass. Moreover, the relative abundance of Erysipelotrichales significantly increased in both groups. However, the relative abundance of lactic acid bacteria (Lactobacillales, Streptococcaceae, Lactococcus and Streptococcus) significantly increased only in the WLPB group. Furthermore, short-chain fatty acid producers Phascolarctobacterium and Butyricimonas increased significantly in the WLPB group. A short-term weight loss program combined with Bryndza cheese consumption improves body composition and increases the abundance of lactic acid bacteria and short-chain fatty acid producers in middle-aged women.
Keywords	Erysipelotrichales ; Lactococcus ; Phascolarctobacterium ; Streptococcus ; body fat ; cheeses ; clinical trials ; dairy consumption ; females ; intestinal microorganisms ; lactic acid ; metabolites ; muscle tissues ; probiotics ; short chain fatty acids ; waist circumference ; weight loss
Language	English
Dates of publication	2021-0521
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu13061753
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Lipoprotein profiling in early multiple sclerosis patients: effect of chronic inflammation?

Rádiková, Žofia / Penesová, Adela / Vlček, Miroslav / Havranová, Andrea / Siváková, Monika / Šiarnik, Pavel / Žitňanová, Ingrid / Imrich, Richard / Turčáni, Peter / Kollár, Branislav

Lipids in health and disease

2020 Volume 19, Issue 1, Page(s) 49

Abstract: Background: Inflammatory cytokines contribute to proatherogenic changes in lipid metabolism by reduction of HDL-cholesterol (HDL-C) levels, impairment of its antiinflammatory and antioxidant functions. Therefore, the protective actions of HDL-C can be ... ...

Abstract	Background: Inflammatory cytokines contribute to proatherogenic changes in lipid metabolism by reduction of HDL-cholesterol (HDL-C) levels, impairment of its antiinflammatory and antioxidant functions. Therefore, the protective actions of HDL-C can be limited in chronic inflammatory diseases such as multiple sclerosis (MS). The aim of this study was to assess the association between lipoprotein subfractions and inflammatory status in early stages of multiple sclerosis. Methods: Polyacrylamide gel electrophoresis Lipoprint© System was used for lipoprotein profile analysis in 19 newly diagnosed MS patients, and in matched 19 healthy controls. Serum levels of interleukin (IL) 1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12 (p70), IL-13, IL-17, granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor, interferon-γ and TNF-α were measured by multiplex bead assay. Results: Concentrations of the measured cytokines and lipoprotein subclasses were comparable between MS patients and controls. Male, but not female MS patients had significantly higher total HDL-C and small HDL-C subfraction than healthy controls. Large HDL-C negatively correlated with all measured cytokines except IL-17 in MS but not in controls. Intermediate HDL-C subfractions correlated positively with all measured cytokines except G-CSF in MS females but not in MS males or controls. Conclusion: Our results of higher HDL-C and mainly its small HDL-C subfraction suggest that male MS patients are at higher risk of atherosclerosis and the subtle dyslipidemia is present in early stages of the disease. The correlations between specific HDL-C subfractions and the inflammatory cytokines demonstrate mutual links between systemic inflammation and lipid metabolism in MS. Trial registration: ClinicalTrials.gov, Identifier: NCT03052595 Registered on Feb 14, 2017.
MeSH term(s)	Adult ; Cholesterol, HDL/blood ; Cholesterol, HDL/metabolism ; Electrophoresis, Polyacrylamide Gel ; Female ; Humans ; Inflammation/blood ; Inflammation/immunology ; Inflammation/metabolism ; Interleukin-10/blood ; Interleukin-10/metabolism ; Interleukin-17/blood ; Interleukin-17/metabolism ; Interleukin-1beta/blood ; Interleukin-1beta/metabolism ; Interleukin-2/blood ; Interleukin-2/metabolism ; Interleukin-4/blood ; Interleukin-4/metabolism ; Interleukin-6/blood ; Interleukin-6/metabolism ; Interleukin-7/blood ; Interleukin-7/metabolism ; Lipoproteins, HDL/blood ; Lipoproteins, HDL/metabolism ; Lipoproteins, LDL/blood ; Lipoproteins, LDL/metabolism ; Male ; Middle Aged ; Multiple Sclerosis/blood ; Multiple Sclerosis/immunology ; Multiple Sclerosis/metabolism
Chemical Substances	Cholesterol, HDL ; IL10 protein, human ; Interleukin-17 ; Interleukin-1beta ; Interleukin-2 ; Interleukin-6 ; Interleukin-7 ; Lipoproteins, HDL ; Lipoproteins, LDL ; Interleukin-10 (130068-27-8) ; Interleukin-4 (207137-56-2)
Language	English
Publishing date	2020-03-17
Publishing country	England
Document type	Journal Article
ISSN	1476-511X
ISSN (online)	1476-511X
DOI	10.1186/s12944-020-01221-x
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