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Buch ; Dissertation / Habilitation: Monozytäre Eigenschaften endothelialer Vorläuferzellen und ihre Bedeutung im Rahmen der Transplantatvaskulopathie

Rämer, Patrick Claudius

2009

Verfasserangabe	vorgelegt von Patrick Claudius Rämer
Sprache	Deutsch
Umfang	VI, 77 Bl. : Ill., graph. Darst., 30 cm
Erscheinungsland	Deutschland
Dokumenttyp	Buch ; Dissertation / Habilitation
Dissertation / Habilitation	Heidelberg, Univ., Diss., 2010
HBZ-ID	HT016677333
Datenquelle	Katalog ZB MED Medizin, Gesundheit

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2011 E 350	bestellbar zur Ausleihe	Magazin

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Artikel ; Online: Erratum for Rothe et al., "Are enterococcal bloodstream infections an independent risk factor for a poorer 5-year survival or just a marker for severity of illness?-The Munich multicentric enterococci cohort".

Rothe, Kathrin / Bachfischer, Tobias / Karapetyan, Siranush / Hapfelmeier, Alexander / Wurst, Milena / Gleich, Sabine / Dichtl, Karl / Schmid, Roland M / Triebelhorn, Julian / Wagner, Laura / Erber, Johanna / Voit, Florian / Burgkart, Rainer / Obermeier, Andreas / Seybold, Ulrich / Busch, Dirk H / Rämer, Patrick C / Spinner, Christoph D / Schneider, Jochen

Microbiology spectrum

2024 , Seite(n) e0095124

Sprache	Englisch
Erscheinungsdatum	2024-05-07
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Published Erratum
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.00951-24
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Are enterococcal bloodstream infections an independent risk factor for a poorer 5-year survival or just a marker for severity of illness?-The Munich multicentric enterococci cohort.

Rothe, Kathrin / Bachfischer, Tobias / Karapetyan, Siranush / Hapfelmeier, Alexander / Wurst, Milena / Gleich, Sabine / Dichtl, Karl / Schmid, Roland M / Triebelhorn, Julian / Wagner, Laura / Erber, Johanna / Voit, Florian / Burgkart, Rainer / Obermeier, Andreas / Seibold, Ulrich / Busch, Dirk H / Rämer, Patrick C / Spinner, Christoph D / Schneider, Jochen

Microbiology spectrum

2023 Band 11, Heft 6, Seite(n) e0258523

Abstract: Importance: The present study provides a substantial contribution to literature, showing that patients with enterococcal bloodstream infections (BSI) have a lower survival rate than those ... ...

Abstract	Importance: The present study provides a substantial contribution to literature, showing that patients with enterococcal bloodstream infections (BSI) have a lower survival rate than those with
Mesh-Begriff(e)	Humans ; Enterococcus ; Prospective Studies ; Escherichia coli ; Bacteremia/epidemiology ; Gram-Positive Bacterial Infections/diagnosis ; Gram-Positive Bacterial Infections/epidemiology ; Risk Factors ; Sepsis ; Escherichia coli Infections/epidemiology ; Patient Acuity ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use
Chemische Substanzen	Anti-Bacterial Agents
Sprache	Englisch
Erscheinungsdatum	2023-10-04
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.02585-23
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Targeting Beclin 1 for viral subversion of macroautophagy.

Gannagé, Monique / Rämer, Patrick C / Münz, Christian

Autophagy

2010 Band 6, Heft 1, Seite(n) 166–167

Abstract: We have recently characterized that influenza A virus blocks autophagosome degradation via its matrix protein 2. Matrix protein 2 seems to achieve this macroautophagy inhibition not by its well-characterized proton channel function, but possibly due to ... ...

Abstract	We have recently characterized that influenza A virus blocks autophagosome degradation via its matrix protein 2. Matrix protein 2 seems to achieve this macroautophagy inhibition not by its well-characterized proton channel function, but possibly due to its binding to Atg6/Beclin 1, thereby enhancing the death of its host cell. Here we discuss several viruses that now have been described to compromise macroautophagy via binding to Atg6/Beclin 1 with different outcomes for their replication, and how interaction with one and the same protein could inhibit autophagosome generation or degradation.
Mesh-Begriff(e)	Animals ; Apoptosis Regulatory Proteins/genetics ; Apoptosis Regulatory Proteins/physiology ; Autophagy/genetics ; Autophagy/immunology ; Autophagy/physiology ; Beclin-1 ; Gene Targeting/methods ; HIV-1/immunology ; HIV-1/physiology ; Humans ; Immunity, Innate/genetics ; Influenza A virus/immunology ; Influenza A virus/physiology ; Membrane Proteins/genetics ; Membrane Proteins/physiology ; Models, Biological ; Virus Diseases/genetics ; Virus Diseases/immunology ; Virus Diseases/therapy ; Viruses/immunology
Chemische Substanzen	Apoptosis Regulatory Proteins ; BECN1 protein, human ; Beclin-1 ; Membrane Proteins
Sprache	Englisch
Erscheinungsdatum	2010-01-13
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2454135-7
ISSN	1554-8635 ; 1554-8627
ISSN (online)	1554-8635
ISSN	1554-8627
DOI	10.4161/auto.6.1.10624
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Statins inhibit NK-cell cytotoxicity by interfering with LFA-1-mediated conjugate formation

Raemer, Patrick C / Kohl, Kristine / Watzl, Carsten

European journal of immunology. 2009 June, v. 39, no. 6

2009

Abstract: Inhibitors of the 3-hydroxy-3-methylglutaryl coenzyme A reductase, commonly referred to as statins, are inhibitors of cholesterol biosynthesis. They are broadly used for treating hypercholesterolemia and for prevention of cardio- and cerebrovascular ... ...

Abstract	Inhibitors of the 3-hydroxy-3-methylglutaryl coenzyme A reductase, commonly referred to as statins, are inhibitors of cholesterol biosynthesis. They are broadly used for treating hypercholesterolemia and for prevention of cardio- and cerebrovascular diseases. Recent publications show that statins also act as immunomodulatory drugs. Here, we show that lipophilic statins inhibit NK-cell degranulation and cytotoxicity. This effect was reversible by addition of substrates of isoprenylation, but not by addition of cholesterol. In NK-target cell conjugates intracellular Ca²⁺ flux was unaffected by statin treatment. However, statins strongly reduced the amount of conjugate formation between NK and target cells. This inhibition was paralleled by a statin-dependent inhibition of LFA-1-mediated adhesion and a reduction of NK-cell polarization. This demonstrates that statins impair the formation of effector-target cell conjugates resulting in the disruption of early signaling and the loss of NK-cell cytotoxicity.
Sprache	Englisch
Erscheinungsverlauf	2009-06
Umfang	p. 1456-1465.
Erscheinungsort	Wiley-VCH Verlag
Dokumenttyp	Artikel
ZDB-ID	120108-6
ISSN	1521-4141 ; 0014-2980
ISSN (online)	1521-4141
ISSN	0014-2980
DOI	10.1002/eji.200838863
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel ; Online: Integrated IT Platform for Coordination of Diagnosis, Treatment, and Aftercare of Prosthetic Joint Infections.

Suren, Christian / Feihl, Susanne / Querbach, Christiane / Rämer, Patrick / Pohlig, Florian / Thurner, Jakob / Bernard, Rudolf / Busch, Dirk / VON Eisenhart-Rothe, Rüdiger / Mühlhofer, Heinrich Maria Laurentius

In vivo (Athens, Greece)

2019 Band 33, Heft 5, Seite(n) 1625–1633

Abstract: Background/aim: Prosthetic joint infections (PJI) are difficult to diagnose and treat. For a correct diagnosis, an array of information has to be processed and weighted. Successful treatment depends on the diagnosis, timing, and surgical strategy paired ...

Abstract	Background/aim: Prosthetic joint infections (PJI) are difficult to diagnose and treat. For a correct diagnosis, an array of information has to be processed and weighted. Successful treatment depends on the diagnosis, timing, and surgical strategy paired with treatment of the infectious agent. The complexity and interdisciplinarity needed cause difficulties concerning decision-making, the communication between disciplines, and the execution of a treatment strategy. The aim of this study was to develop a software platform to enhance the collection of information for the diagnosis of PJI, the interdisciplinary decision-making process, the communication between team members, and continuous evaluation of treatment. Patients and methods: In regular planning sessions with an information technology (IT) specialist, a concept for an IT solution was chosen and the tool was designed in an interdisciplinary approach. Results: The tool has been used as a trial version since June 2017. It consists of 14 user interfaces with 431 items. A total of 117 patients with 118 infections have been entered and the strategy decided upon and communicated using 298 infection board documents outlining the treatment. The tool is now being used to organize the infections board agenda, schedule patient case discussions, document the relevant data and treatment plan, as well as communicate with the other teams involved in the treatment. Conclusion: Using the developed tool enables the infections team to work collaboratively and under division of labor on each case, rendering the work flow more efficient for each team member.
Mesh-Begriff(e)	Aftercare ; Arthritis, Infectious/diagnosis ; Arthritis, Infectious/therapy ; Data Interpretation, Statistical ; Database Management Systems ; Disease Management ; Health Information Management/methods ; Humans ; Male ; Medical Informatics/methods ; Prosthesis-Related Infections/diagnosis ; Prosthesis-Related Infections/therapy
Sprache	Englisch
Erscheinungsdatum	2019-09-02
Erscheinungsland	Greece
Dokumenttyp	Journal Article
ZDB-ID	807031-3
ISSN	1791-7549 ; 0258-851X
ISSN (online)	1791-7549
ISSN	0258-851X
DOI	10.21873/invivo.11647
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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ab Jg. 2022: Lesesaal (EG)

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Artikel ; Online: Statins inhibit NK-cell cytotoxicity by interfering with LFA-1-mediated conjugate formation.

Raemer, Patrick C / Kohl, Kristine / Watzl, Carsten

European journal of immunology

2009 Band 39, Heft 6, Seite(n) 1456–1465

Abstract	Inhibitors of the 3-hydroxy-3-methylglutaryl coenzyme A reductase, commonly referred to as statins, are inhibitors of cholesterol biosynthesis. They are broadly used for treating hypercholesterolemia and for prevention of cardio- and cerebrovascular diseases. Recent publications show that statins also act as immunomodulatory drugs. Here, we show that lipophilic statins inhibit NK-cell degranulation and cytotoxicity. This effect was reversible by addition of substrates of isoprenylation, but not by addition of cholesterol. In NK-target cell conjugates intracellular Ca(2+) flux was unaffected by statin treatment. However, statins strongly reduced the amount of conjugate formation between NK and target cells. This inhibition was paralleled by a statin-dependent inhibition of LFA-1-mediated adhesion and a reduction of NK-cell polarization. This demonstrates that statins impair the formation of effector-target cell conjugates resulting in the disruption of early signaling and the loss of NK-cell cytotoxicity.
Mesh-Begriff(e)	Calcium Signaling/drug effects ; Cell Adhesion/drug effects ; Cell Adhesion/immunology ; Cell Communication/drug effects ; Cell Communication/immunology ; Cell Degranulation/drug effects ; Cell Degranulation/immunology ; Cell Line, Tumor ; Cell Polarity/drug effects ; Cytotoxicity, Immunologic/drug effects ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology ; Intercellular Adhesion Molecule-1/metabolism ; K562 Cells ; Killer Cells, Natural/cytology ; Killer Cells, Natural/drug effects ; Killer Cells, Natural/immunology ; Killer Cells, Natural/metabolism ; Lymphocyte Function-Associated Antigen-1/metabolism ; Mevalonic Acid/pharmacology ; Phospholipase C gamma/metabolism ; Phosphorylation/drug effects ; Polyisoprenyl Phosphates/pharmacology ; Prenylation/drug effects ; Protein Binding/drug effects ; Receptors, Natural Killer Cell/metabolism
Chemische Substanzen	Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Lymphocyte Function-Associated Antigen-1 ; Polyisoprenyl Phosphates ; Receptors, Natural Killer Cell ; Intercellular Adhesion Molecule-1 (126547-89-5) ; Phospholipase C gamma (EC 3.1.4.3) ; geranylgeranyl pyrophosphate (N21T0D88LX) ; Mevalonic Acid (S5UOB36OCZ)
Sprache	Englisch
Erscheinungsdatum	2009-06
Erscheinungsland	Germany
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120108-6
ISSN	1521-4141 ; 0014-2980
ISSN (online)	1521-4141
ISSN	0014-2980
DOI	10.1002/eji.200838863
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Konferenzbeitrag: Entwicklung einer prospektiven Datenbank zur Erfassung periprothetischer Infektionen zur integrierten Therapieplanung und -kontrolle

Suren, Christian / Querbach, Christiane / Rämer, Patrick / Thurner, Jakob / Feihl, Susanne / Schauwecker, Johannes / von Eisenhart-Rothe, Rüdiger / Mühlhofer, Heinrich

2017 , Seite(n) WI26–575

Veranstaltung/Kongress	Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2017); Berlin; ; Berufsverband der Fachärzte für Orthopädie; 2017
Schlagwörter	Medizin, Gesundheit ; Infektion ; periprothetisch ; periimplantär ; Implantatinfekt ; Datenbank ; interdisziplinär ; Antibiotika ; antiinfektiv ; prospektiv ; Erfassung ; data mining
Erscheinungsdatum	2017-10-23
Verlag	German Medical Science GMS Publishing House; Düsseldorf
Dokumenttyp	Konferenzbeitrag
DOI	10.3205/17dkou242
Datenquelle	German Medical Science

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Artikel ; Online: Correction: Immunosuppressive FK506 treatment leads to more frequent EBV-associated lymphoproliferative disease in humanized mice.

PLoS pathogens

2020 Band 16, Heft 12, Seite(n) e1009167

Abstract: This corrects the article DOI: 10.1371/journal.ppat.1008477.]. ...

Abstract	[This corrects the article DOI: 10.1371/journal.ppat.1008477.].
Sprache	Englisch
Erscheinungsdatum	2020-12-21
Erscheinungsland	United States
Dokumenttyp	Published Erratum
ZDB-ID	2205412-1
ISSN	1553-7374 ; 1553-7366
ISSN (online)	1553-7374
ISSN	1553-7366
DOI	10.1371/journal.ppat.1009167
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Immunosuppressive FK506 treatment leads to more frequent EBV-associated lymphoproliferative disease in humanized mice.

PLoS pathogens

2020 Band 16, Heft 4, Seite(n) e1008477

Abstract: Post-transplant lymphoproliferative disorder (PTLD) is a potentially fatal complication after organ transplantation frequently associated with the Epstein-Barr virus (EBV). Immunosuppressive treatment is thought to allow the expansion of EBV-infected B ... ...

Abstract	Post-transplant lymphoproliferative disorder (PTLD) is a potentially fatal complication after organ transplantation frequently associated with the Epstein-Barr virus (EBV). Immunosuppressive treatment is thought to allow the expansion of EBV-infected B cells, which often express all eight oncogenic EBV latent proteins. Here, we assessed whether HLA-A2 transgenic humanized NSG mice treated with the immunosuppressant FK506 could be used to model EBV-PTLD. We found that FK506 treatment of EBV-infected mice led to an elevated viral burden, more frequent tumor formation and diminished EBV-induced T cell responses, indicative of reduced EBV-specific immune control. EBV latency III and lymphoproliferation-associated cellular transcripts were up-regulated in B cells from immunosuppressed animals, akin to the viral and host gene expression pattern found in EBV-PTLD. Utilizing an unbiased gene expression profiling approach, we identified genes differentially expressed in B cells of EBV-infected animals with and without FK506 treatment. Upon investigating the most promising candidates, we validated sCD30 as a marker of uncontrolled EBV proliferation in both humanized mice and in pediatric patients with EBV-PTLD. High levels of sCD30 have been previously associated with EBV-PTLD in patients. As such, we believe that humanized mice can indeed model aspects of EBV-PTLD development and may prove useful for the safety assessment of immunomodulatory therapies.
Mesh-Begriff(e)	Animals ; B-Lymphocytes/metabolism ; DNA, Viral ; Disease Models, Animal ; Epstein-Barr Virus Infections/virology ; Female ; Gene Expression Profiling/methods ; HLA-A2 Antigen ; Herpesvirus 4, Human/genetics ; Herpesvirus 4, Human/metabolism ; Herpesvirus 4, Human/pathogenicity ; Humans ; Immunocompromised Host ; Immunosuppressive Agents/pharmacology ; Lymphoproliferative Disorders/immunology ; Lymphoproliferative Disorders/virology ; Male ; Mice ; Mice, Inbred NOD ; Mice, Transgenic ; Organ Transplantation/adverse effects ; Tacrolimus/pharmacology ; Transcriptome/genetics ; Viral Load
Chemische Substanzen	DNA, Viral ; HLA-A2 Antigen ; Immunosuppressive Agents ; Tacrolimus (WM0HAQ4WNM)
Sprache	Englisch
Erscheinungsdatum	2020-04-06
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2205412-1
ISSN	1553-7374 ; 1553-7366
ISSN (online)	1553-7374
ISSN	1553-7366
DOI	10.1371/journal.ppat.1008477
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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