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  1. Book ; Online ; Thesis: Das musikalische Aufführungsrecht in Deutschland im 19. Jahrhundert

    Rasch, Felix [Verfasser]

    2019  

    Author's details Felix Rasch
    Keywords Recht ; Law
    Subject code sg340
    Language German
    Publisher Peter Lang GmbH, Internationaler Verlag der Wissenschaften
    Publishing place Frankfurt a.M.
    Document type Book ; Online ; Thesis
    ISBN 978-3-631-80452-0 ; 3-631-80452-0
    Database Digital theses on the web

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  2. Book ; Online ; Thesis: The role of 4E-T in translational regulation and mRNA decay

    Räsch, Felix Alexander Paul [Verfasser]

    2020  

    Author's details Felix Alexander Paul Räsch
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Universitätsbibliothek Tübingen
    Publishing place Tübingen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  3. Article ; Online: 4E-T-bound mRNAs are stored in a silenced and deadenylated form.

    Räsch, Felix / Weber, Ramona / Izaurralde, Elisa / Igreja, Cátia

    Genes & development

    2020  Volume 34, Issue 11-12, Page(s) 847–860

    Abstract: Human 4E-T is an eIF4E-binding protein (4E-BP) present in processing (P)-bodies that represses translation and regulates decay of mRNAs destabilized by AU-rich elements and microRNAs (miRNAs). However, the underlying regulatory mechanisms are still ... ...

    Abstract Human 4E-T is an eIF4E-binding protein (4E-BP) present in processing (P)-bodies that represses translation and regulates decay of mRNAs destabilized by AU-rich elements and microRNAs (miRNAs). However, the underlying regulatory mechanisms are still unclear. Here, we show that upon mRNA binding 4E-T represses translation and promotes deadenylation via the recruitment of the CCR4-NOT deadenylase complex. The interaction with CCR4-NOT is mediated by previously uncharacterized sites in the middle region of 4E-T. Importantly, mRNA decapping and decay are inhibited by 4E-T and the deadenylated target is stored in a repressed form. Inhibition of mRNA decapping requires the interaction of 4E-T with the cap-binding proteins eIF4E/4EHP. We further show that regulation of decapping by 4E-T participates in mRNA repression by the miRNA effector protein TNRC6B and that 4E-T overexpression interferes with tristetraprolin (TTP)- and NOT1-mediated mRNA decay. Thus, we postulate that 4E-T modulates 5'-to-3' decay by swapping the fate of a deadenylated mRNA from complete degradation to storage. Our results provide insight into the mechanism of mRNA storage that controls localized translation and mRNA stability in P-bodies.
    MeSH term(s) Gene Expression Regulation/genetics ; Gene Silencing/physiology ; Nucleocytoplasmic Transport Proteins/genetics ; Nucleocytoplasmic Transport Proteins/metabolism ; Protein Binding/genetics ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA-Binding Proteins/metabolism ; Transcription Factors/metabolism
    Chemical Substances EIF4ENIF1 protein, human ; Nucleocytoplasmic Transport Proteins ; RNA, Messenger ; RNA-Binding Proteins ; TNRC6B protein, human ; Transcription Factors
    Language English
    Publishing date 2020-04-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 806684-x
    ISSN 1549-5477 ; 0890-9369
    ISSN (online) 1549-5477
    ISSN 0890-9369
    DOI 10.1101/gad.336073.119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2292: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 54: Show issues

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  4. Article ; Online: HELZ directly interacts with CCR4-NOT and causes decay of bound mRNAs.

    Hanet, Aoife / Räsch, Felix / Weber, Ramona / Ruscica, Vincenzo / Fauser, Maria / Raisch, Tobias / Kuzuoğlu-Öztürk, Duygu / Chang, Chung-Te / Bhandari, Dipankar / Igreja, Cátia / Wohlbold, Lara

    Life science alliance

    2019  Volume 2, Issue 5

    Abstract: Eukaryotic superfamily (SF) 1 helicases have been implicated in various aspects of RNA metabolism, including transcription, processing, translation, and degradation. Nevertheless, until now, most human SF1 helicases remain poorly understood. Here, we ... ...

    Abstract Eukaryotic superfamily (SF) 1 helicases have been implicated in various aspects of RNA metabolism, including transcription, processing, translation, and degradation. Nevertheless, until now, most human SF1 helicases remain poorly understood. Here, we have functionally and biochemically characterized the role of a putative SF1 helicase termed "helicase with zinc-finger," or HELZ. We discovered that HELZ associates with various mRNA decay factors, including components of the carbon catabolite repressor 4-negative on TATA box (CCR4-NOT) deadenylase complex in human and
    MeSH term(s) Animals ; Cell Line ; Drosophila melanogaster ; Gene Expression Profiling ; Gene Expression Regulation, Developmental ; HEK293 Cells ; Humans ; Nervous System/growth & development ; Nervous System/metabolism ; Protein Binding ; Protein Biosynthesis ; RNA Helicases/genetics ; RNA Helicases/metabolism ; RNA Stability ; Receptors, CCR4/chemistry ; Receptors, CCR4/metabolism ; TATA Box
    Chemical Substances Receptors, CCR4 ; RNA Helicases (EC 3.6.4.13)
    Language English
    Publishing date 2019-09-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2575-1077
    ISSN (online) 2575-1077
    DOI 10.26508/lsa.201900405
    Database MEDical Literature Analysis and Retrieval System OnLINE

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