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  1. Article ; Online: Leptin (rs7799039) and solute carrier family 30 zinc transporter (rs13266634) polymorphisms in Euro-Brazilian pregnant women with gestational diabetes.

    Teleginski, A / Welter, M / Frigeri, H R / Réa, R R / Souza, E M / Alberton, D / Rego, F G M / Picheth, G

    Genetics and molecular research : GMR

    2017  Volume 16, Issue 1

    Abstract: Leptin (LEP), a protein that plays a fundamental role in the metabolism of energy reserves, and the solute carrier family 30 A8 zinc transporter (SLC30A8) have been consistently associated with diabetes. Women with gestational diabetes are at moderate ... ...

    Abstract Leptin (LEP), a protein that plays a fundamental role in the metabolism of energy reserves, and the solute carrier family 30 A8 zinc transporter (SLC30A8) have been consistently associated with diabetes. Women with gestational diabetes are at moderate risk of developing diabetes type 1 and 2 after pregnancy, in addition to complications to the fetus. We investigated the association of the polymorphisms rs7799039 (LEP) and rs13266634 (SLC30A8) in a case-control study in Euro-Brazilians with gestational diabetes (GDM, N = 134) and healthy pregnant women (control, N = 180). Real-time PCR with fluorescent probes (TaqMan system) was applied to genotyping. All polymorphisms were in Hardy-Weinberg equilibrium. The minor allele frequencies, for healthy and GDM, respectively, for the A-allele (LEP gene rs7799039) were 40.3% (95%CI = 35-45%) vs 36.6% (95%CI = 31-42%), P = 0.345; and for the T-allele (SLC30A8 gene rs13266634) were 27.8% (95%CI = 23-32%) vs 23.5% (95%CI = 18-29%), P = 0.227. Genotype comparisons for both polymorphisms showed no significant difference (P > 0.05). The polymorphisms rs7799039 and rs13266634 were not associated with GDM in the population studied (P > 0.05). The minor allele frequencies for both polymorphisms were similar to those of other Caucasian populations.
    MeSH term(s) Adult ; Alleles ; Brazil ; Carrier Proteins/genetics ; Carrier Proteins/metabolism ; Case-Control Studies ; Cation Transport Proteins/genetics ; Cation Transport Proteins/metabolism ; Diabetes, Gestational/genetics ; Diabetes, Gestational/metabolism ; Female ; Gene Frequency ; Genetic Association Studies ; Genetic Predisposition to Disease ; Humans ; Leptin/genetics ; Leptin/metabolism ; Polymorphism, Single Nucleotide ; Pregnancy
    Chemical Substances Carrier Proteins ; Cation Transport Proteins ; Leptin ; SLC30A1 protein, human ; zinc-binding protein
    Language English
    Publishing date 2017-03-30
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2114039-X
    ISSN 1676-5680 ; 1676-5680
    ISSN (online) 1676-5680
    ISSN 1676-5680
    DOI 10.4238/gmr16019515
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Low prevalence of glucokinase gene mutations in gestational diabetic patients with good glycemic control.

    Frigeri, H R / Santos, I C R / Réa, R R / Almeida, A C R / Fadel-Picheth, C M T / Pedrosa, F O / Souza, E M / Rego, F G M / Picheth, G

    Genetics and molecular research : GMR

    2012  Volume 11, Issue 2, Page(s) 1433–1441

    Abstract: Glucokinase (GCK) plays a key role in glucose homeostasis. Gestational diabetes mellitus increases the risk of gestational complications in pregnant women and fetuses. We screened for mutations in coding and flanking regions of the GCK gene in ... ...

    Abstract Glucokinase (GCK) plays a key role in glucose homeostasis. Gestational diabetes mellitus increases the risk of gestational complications in pregnant women and fetuses. We screened for mutations in coding and flanking regions of the GCK gene in pregnant women with or without gestational diabetes in a Brazilian population. A sample of 200 pregnant women classified as healthy (control, N = 100) or with gestational diabetes (N = 100) was analyzed for mutations in the GCK gene. All gestational diabetes mellitus patients had good glycemic control maintained by diet alone and no complications during pregnancy. Mutations were detected by single-strand conformation polymorphism and DNA sequencing. Thirteen of the 200 subjects had GCK gene mutations. The mutations detected were in intron 3 (c.43331A>G, new), intron 6 (c.47702T>C, rs2268574), intron 9 (c.48935C>T, rs2908274), and exon 10 (c.49620G>A, rs13306388). None of these GCK mutations were found to be significantly associated with gestational diabetes mellitus. In summary, we report a low frequency of GCK mutations in a pregnant Brazilian population and describe a new intronic variation (c.43331A>G, intron 3). We conclude that mutations in GCK introns and in non-translatable regions of the GCK gene do not affect glycemic control and are not correlated with gestational diabetes mellitus.
    MeSH term(s) Blood Glucose/metabolism ; Diabetes, Gestational/blood ; Diabetes, Gestational/genetics ; Female ; Glucokinase/genetics ; Humans ; Mutation ; Polymerase Chain Reaction ; Polymorphism, Single-Stranded Conformational/genetics ; Pregnancy
    Chemical Substances Blood Glucose ; Glucokinase (EC 2.7.1.2)
    Language English
    Publishing date 2012-05-18
    Publishing country Brazil
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2114039-X
    ISSN 1676-5680 ; 1676-5680
    ISSN (online) 1676-5680
    ISSN 1676-5680
    DOI 10.4238/2012.May.18.2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: "Graveyard for Britons", West Florida, 1763-1781.

    Rea, R R

    The Florida historical quarterly

    1969  Volume 47, Page(s) 345–364

    MeSH term(s) Disease ; History, Modern 1601- ; Military Medicine/history ; United Kingdom ; United States
    Language English
    Publishing date 1969
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 2508716-2
    ISSN 0015-4113
    ISSN 0015-4113
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Butyrylcholinesterase and obesity in individuals with the CHE2 C5+ and CHE2 C5- phenotypes

    Alcantara, V.M / Oliveira, L.C / Rea, R.R / Suplicy, H.L / Chautard-Freire-Maia, E.A

    International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity. 2003 Dec., v. 27, no. 12

    2003  

    Abstract: OBJECTIVE: To investigate the association between butyrylcholinesterase (BChE) activities (total and band specific) and body mass index (BMI) in obese and nonobese individuals, considering other variables (anthropometric, biochemical and hormonal) and ... ...

    Abstract OBJECTIVE: To investigate the association between butyrylcholinesterase (BChE) activities (total and band specific) and body mass index (BMI) in obese and nonobese individuals, considering other variables (anthropometric, biochemical and hormonal) and the leanness process. SUBJECTS: Obese (BMI greater than or equal to 30 kg/m2; N=181) and nonobese individuals (N=265), classified according to the CHE2 locus phenotypes, with the obese patients being followed-up when submitted to a weight-loss program. MEASUREMENTS: Anthropometric (weight, height, BMI, waist, waist/hip ratio--WHR, triceps and subscapular skinfolds, percentage of body fat and arterial pressures), hormonal (insulin, estradiol--E2, triiodothyronine--T3 and thyroxine--T4) and biochemical (glucose, total cholesterol, HDL-C, triglycerides, uric acid, urea, creatinine, sodium, potassium and BChE activities) variables. RESULTS: Although obese CHE2 C5- individuals presented higher mean BChE activities than their CHE2 C5- controls and diminished mean activities with leanness, similar comparisons did not show any difference in the CHE2 C5+ group. Furthermore, the mean serum potassium values of obese individuals were significantly higher in the CHE2 C5+ than in the CHE2 C5- phenotype. The BChE activities were less related to BMI in obese CHE2 C5- individuals than in their controls. In the CHE2 C5- obese group, significant regression coefficients were found between BChE activity variables and BMI (+), ethnic origin (higher in Euro-Brazilians), sex (higher in males), diastolic pressure (-), triceps skinfold (+), total cholesterol (+), T3 (+) and E2 (-). The main findings in the CHE2 C5+ obese group: mean insulin levels decreased with leanness and a significant correlation was detected between the C5 complex activity and creatinine (+), insulin (-) and WHR (-); a significantly higher frequency of weight loss occurred compared to the CHE2 C5- group. CONCLUSION: In the present study, different relations between obesity and some of the studied variables were found when CHE2 C5+ and CHE2 C5- individuals were compared.
    Keywords obesity ; body mass index ; cholinesterase ; enzyme activity ; phenotype ; loci ; lean body mass ; blood serum ; potassium ; Whites ; Blacks ; men ; women ; cholesterol ; skinfold thickness ; blood pressure ; waist-to-hip ratio ; insulin ; creatinine ; human diseases ; Brazil
    Language English
    Dates of publication 2003-12
    Size p. 1557-1564.
    Document type Article
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: The functional polymorphisms -429T>C and -374T>A of the RAGE gene promoter are not associated with gestational diabetes in Euro-Brazilians.

    Santos, I C R / Daga, D R / Frigeri, H R / Réa, R R / Almeida, A C R / Souza, E M / Pedrosa, F O / Fadel-Picheth, C M T / Picheth, G

    Genetics and molecular research : GMR

    2010  Volume 9, Issue 2, Page(s) 1130–1135

    Abstract: The receptor for advanced glycation end products (RAGE or AGER) is a multiligand member of the immunoglobulin superfamily. RAGE is expressed in several tissues, including human myometrium, chorionic villi and placenta. Advanced glycation end products are ...

    Abstract The receptor for advanced glycation end products (RAGE or AGER) is a multiligand member of the immunoglobulin superfamily. RAGE is expressed in several tissues, including human myometrium, chorionic villi and placenta. Advanced glycation end products are the best studied ligands of RAGE; they have pro-inflammatory actions in human gestational tissues, increasing oxidative stress and the release of cytokines and prostaglandins. We investigated the association of RAGE gene promoter polymorphisms -429T>C (rs1800625) and -374T>A (rs1800624) with gestational diabetes. A sample of 750 unrelated European origin pregnant Brazilian women were classified as nondiabetic (control group, N = 600) or having gestational diabetes (N = 150) according to American Diabetes Association 2009 criteria. Genotyping was performed by PCR-RFLP. The frequencies of the rare alleles -429C (6.3 versus 9.1%) and -374A (26 versus 30%) were not significantly different between the gestational diabetes patients and healthy pregnant women. Also, the -429T>C and -374T>A polymorphisms were not associated with body mass index, lipid profile, fasting glycemia, HbA1C, or insulin requirement. We found that functional promoter polymorphisms of the RAGE gene were not associated with gestational diabetes or its complications in these Euro-Brazilian patients.
    MeSH term(s) Adult ; Brazil ; Diabetes, Gestational/ethnology ; Diabetes, Gestational/genetics ; Europe ; Female ; Glycated Hemoglobin A/genetics ; Humans ; Immunoglobulins/metabolism ; Insulin/metabolism ; Ligands ; Polymerase Chain Reaction/methods ; Polymorphism, Genetic ; Polymorphism, Restriction Fragment Length ; Pregnancy ; Promoter Regions, Genetic ; Receptor for Advanced Glycation End Products/genetics
    Chemical Substances Glycated Hemoglobin A ; Immunoglobulins ; Insulin ; Ligands ; Receptor for Advanced Glycation End Products ; hemoglobin A1c protein, human
    Language English
    Publishing date 2010-06-15
    Publishing country Brazil
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2114039-X
    ISSN 1676-5680 ; 1676-5680
    ISSN (online) 1676-5680
    ISSN 1676-5680
    DOI 10.4238/vol9-2gmr817
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Variant K of butyrylcholinesterase and types 1 and 2 of diabetes mellitus.

    Lepienski, L M / Alcântara, V M / Souza, R L R / Réa, R R / Chautard-Freire-Maia, E A

    Chemico-biological interactions

    2005  Volume 157-158, Page(s) 374–375

    MeSH term(s) Adolescent ; Age of Onset ; Alleles ; Butyrylcholinesterase/genetics ; Child ; Diabetes Mellitus, Type 1/enzymology ; Diabetes Mellitus, Type 1/genetics ; Diabetes Mellitus, Type 2/enzymology ; Diabetes Mellitus, Type 2/genetics ; Genetic Predisposition to Disease ; Genetic Variation/genetics ; Humans
    Chemical Substances Butyrylcholinesterase (EC 3.1.1.8)
    Language English
    Publishing date 2005-12-27
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 218799-1
    ISSN 1872-7786 ; 0009-2797
    ISSN (online) 1872-7786
    ISSN 0009-2797
    DOI 10.1016/j.cbi.2005.10.060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 686: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  7. Article: Butyrylcholinesterase and obesity in individuals with the CHE2 C5+ and CHE2 C5- phenotypes.

    Alcântara, V M / Oliveira, L C / Réa, R R / Suplicy, H L / Chautard-Freire-Maia, E A

    International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity

    2003  Volume 27, Issue 12, Page(s) 1557–1564

    Abstract: Objective: To investigate the association between butyrylcholinesterase (BChE) activities (total and band specific) and body mass index (BMI) in obese and nonobese individuals, considering other variables (anthropometric, biochemical and hormonal) and ... ...

    Abstract Objective: To investigate the association between butyrylcholinesterase (BChE) activities (total and band specific) and body mass index (BMI) in obese and nonobese individuals, considering other variables (anthropometric, biochemical and hormonal) and the leanness process.
    Subjects: Obese (BMI> or =30 kg/m(2); N=181) and nonobese individuals (N=265), classified according to the CHE2 locus phenotypes, with the obese patients being followed-up when submitted to a weight-loss program.
    Measurements: Anthropometric (weight, height, BMI, waist, waist/hip ratio-WHR, triceps and subscapular skinfolds, percentage of body fat and arterial pressures), hormonal (insulin, estradiol-E(2), triiodothyronine-T(3) and thyroxine-T(4)) and biochemical (glucose, total cholesterol, HDL-C, triglycerides, uric acid, urea, creatinine, sodium, potassium and BChE activities) variables.
    Results: Although obese CHE2 C5- individuals presented higher mean BChE activities than their CHE2 C5- controls and diminished mean activities with leanness, similar comparisons did not show any difference in the CHE2 C5+ group. Furthermore, the mean serum potassium values of obese individuals were significantly higher in the CHE2 C5+ than in the CHE2 C5- phenotype. The BChE activities were less related to BMI in obese CHE2 C5- individuals than in their controls. In the CHE2 C5- obese group, significant regression coefficients were found between BChE activity variables and BMI (+), ethnic origin (higher in Euro-Brazilians), sex (higher in males), diastolic pressure (-), triceps skinfold (+), total cholesterol (+), T(3) (+) and E(2) (-). The main findings in the CHE2 C5+ obese group: mean insulin levels decreased with leanness and a significant correlation was detected between the C(5) complex activity and creatinine (+), insulin (-) and WHR (-); a significantly higher frequency of weight loss occurred compared to the CHE2 C5- group.
    Conclusion: In the present study, different relations between obesity and some of the studied variables were found when CHE2 C5+ and CHE2 C5- individuals were compared.
    MeSH term(s) Adolescent ; Adult ; Aged ; Anthropometry ; Body Mass Index ; Butyrylcholinesterase/blood ; Cholinesterases/genetics ; Female ; Follow-Up Studies ; Humans ; Insulin/blood ; Male ; Middle Aged ; Obesity/enzymology ; Obesity/genetics ; Obesity/physiopathology ; Phenotype ; Regression Analysis ; Weight Loss
    Chemical Substances Insulin ; cholinesterase 2 (EC 3.1.1.-) ; Butyrylcholinesterase (EC 3.1.1.8) ; Cholinesterases (EC 3.1.1.8)
    Language English
    Publishing date 2003-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1103255-8
    ISSN 0307-0565
    ISSN 0307-0565
    DOI 10.1038/sj.ijo.0802464
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1325: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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