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  1. Article ; Online: Asymptomatic and symptomatic SARS-CoV-2 infections elicit polyfunctional antibodies

    Jérémy Dufloo / Ludivine Grzelak / Isabelle Staropoli / Yoann Madec / Laura Tondeur / François Anna / Stéphane Pelleau / Aurélie Wiedemann / Cyril Planchais / Julian Buchrieser / Rémy Robinot / Marie-Noelle Ungeheuer / Hugo Mouquet / Pierre Charneau / Michael White / Yves Lévy / Bruno Hoen / Arnaud Fontanet / Olivier Schwartz /
    Timothée Bruel

    Cell Reports Medicine, Vol 2, Iss 5, Pp 100275- (2021)

    2021  

    Abstract: Summary: Many SARS-CoV-2-infected individuals remain asymptomatic. Little is known about the extent and quality of their antiviral humoral response. Here, we analyze antibody functions in 52 asymptomatic infected individuals, 119 mildly symptomatic, and ... ...

    Abstract Summary: Many SARS-CoV-2-infected individuals remain asymptomatic. Little is known about the extent and quality of their antiviral humoral response. Here, we analyze antibody functions in 52 asymptomatic infected individuals, 119 mildly symptomatic, and 21 hospitalized patients with COVID-19. We measure anti-spike immunoglobulin G (IgG), IgA, and IgM levels with the S-Flow assay and map IgG-targeted epitopes with a Luminex assay. We also evaluate neutralization, complement deposition, and antibody-dependent cellular cytotoxicity (ADCC) using replication-competent SARS-CoV-2 or reporter cell systems. We show that COVID-19 sera mediate complement deposition and kill infected cells by ADCC. Sera from asymptomatic individuals neutralize the virus, activate ADCC, and trigger complement deposition. Antibody levels and functions are lower in asymptomatic individuals than they are in symptomatic cases. Antibody functions are correlated, regardless of disease severity. Longitudinal samplings show that antibody functions follow similar kinetics of induction and contraction. Overall, asymptomatic SARS-CoV-2 infection elicits polyfunctional antibodies neutralizing the virus and targeting infected cells.
    Keywords SARS-CoV-2 ; ADCC ; complement ; asymptomatic ; antibody ; Medicine (General) ; R5-920
    Subject code 570
    Language English
    Publishing date 2021-05-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Low CCR5 expression protects HIV-specific CD4+ T cells of elite controllers from viral entry

    Mathieu Claireaux / Rémy Robinot / Jérôme Kervevan / Mandar Patgaonkar / Isabelle Staropoli / Anne Brelot / Alexandre Nouël / Stacy Gellenoncourt / Xian Tang / Mélanie Héry / Stevenn Volant / Emeline Perthame / Véronique Avettand-Fenoël / Julian Buchrieser / Thomas Cokelaer / Christiane Bouchier / Laurence Ma / Faroudy Boufassa / Samia Hendou /
    Valentina Libri / Milena Hasan / David Zucman / Pierre de Truchis / Olivier Schwartz / Olivier Lambotte / Lisa A. Chakrabarti

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Volume 19

    Abstract: Here, Claireaux et al. show that people who naturally control HIV infection express lower levels of the viral co-receptor CCR5 in specific CD4+ T cells, and that this results from mutations or receptor internalization by CD4+ T cell-produced chemokines. ...

    Abstract Here, Claireaux et al. show that people who naturally control HIV infection express lower levels of the viral co-receptor CCR5 in specific CD4+ T cells, and that this results from mutations or receptor internalization by CD4+ T cell-produced chemokines.
    Keywords Science ; Q
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: SARS-CoV-2 infection induces the dedifferentiation of multiciliated cells and impairs mucociliary clearance

    Rémy Robinot / Mathieu Hubert / Guilherme Dias de Melo / Françoise Lazarini / Timothée Bruel / Nikaïa Smith / Sylvain Levallois / Florence Larrous / Julien Fernandes / Stacy Gellenoncourt / Stéphane Rigaud / Olivier Gorgette / Catherine Thouvenot / Céline Trébeau / Adeline Mallet / Guillaume Duménil / Samy Gobaa / Raphaël Etournay / Pierre-Marie Lledo /
    Marc Lecuit / Hervé Bourhy / Darragh Duffy / Vincent Michel / Olivier Schwartz / Lisa A. Chakrabarti

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Volume 16

    Abstract: SARS-CoV-2 infection damages the airways. Here the authors show that SARS-CoV-2 infection induces the rapid loss of airway motile cilia, resulting in altered cilia clearance function. Cilia loss is preceded by reduced expression of the ciliogenesis ... ...

    Abstract SARS-CoV-2 infection damages the airways. Here the authors show that SARS-CoV-2 infection induces the rapid loss of airway motile cilia, resulting in altered cilia clearance function. Cilia loss is preceded by reduced expression of the ciliogenesis regulator Foxj1.
    Keywords Science ; Q
    Language English
    Publishing date 2021-07-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Seroprevalence and Cross-reactivity of Human Polyomavirus 9

    Jérôme T.J. Nicol / Antoine Touzé / Rémy Robinot / Francoise Arnold / Elisa Mazzoni / Mauro Tognon / Pierre Coursaget

    Emerging Infectious Diseases, Vol 18, Iss 8, Pp 1329-

    2012  Volume 1332

    Abstract: Many humans have antibodies against simian lymphotropic polyomavirus (LPyV), but its DNA has not been found in humans. Identification of human polyomavirus 9 (HPyV9) led us to compare the seroprevalence and cross-reactivity of LPyV and HpyV9. Results ... ...

    Abstract Many humans have antibodies against simian lymphotropic polyomavirus (LPyV), but its DNA has not been found in humans. Identification of human polyomavirus 9 (HPyV9) led us to compare the seroprevalence and cross-reactivity of LPyV and HpyV9. Results could indicate that humans who have antibodies against LPyV are infected by HPyV9.
    Keywords HPyV9 ; LPyV ; MCPyV ; seroprevalence ; viruses ; polyomavirus ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
    Language English
    Publishing date 2012-08-01T00:00:00Z
    Publisher Centers for Disease Control and Prevention
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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