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Article ; Online: International collaborative donor project.

Ríos Zambudio, Antonio

Cirugia espanola

2018 Volume 96, Issue 2, Page(s) 69–75

Abstract: The International Donor Collaborative Project (PCID) research group was created in 1996 in Spain with the aim of promoting research in the field of organ donation and transplantation, led by Spanish surgeons. During this period they have developed the ... ...

Title translation	Proyecto colaborativo internacional donante.
Abstract	The International Donor Collaborative Project (PCID) research group was created in 1996 in Spain with the aim of promoting research in the field of organ donation and transplantation, led by Spanish surgeons. During this period they have developed the questionnaires of the PCID, both the attitude towards cadaver and live donation, which are the most used questionnaires in publications in indexed journals. They have been the driving group of stratified studies representative of the populations under study, and of the performance of multivariate statistical analyzes in the field of psycho-social research in organ donation and transplantation. The main contributions of the group focus on the analysis of health center professionals and emerging migrant groups. In recent years, studies have been extended to the United States, Latin America (mainly Mexico) and Europe.
MeSH term(s)	Attitude to Health ; Humans ; International Cooperation ; Tissue and Organ Procurement/organization & administration
Language	Spanish
Publishing date	2018-02-07
Publishing country	Spain
Document type	Journal Article
ISSN	2173-5077
ISSN (online)	2173-5077
DOI	10.1016/j.ciresp.2017.11.009
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Article ; Online: Papillary thyroid microcarcinoma with minimal extrathyroidal extension. Is its course so indolent that it requires a less aggressive treatment?

Ruiz Pardo, J / Ríos Zambudio, A / Rodríguez González, J M / Paredes Quiles, M / Soriano Giménez, V / Oviedo Ramírez, M I / Hernández Martínez, A M / Parrilla Paricio, P

Revista clinica espanola

2021 Volume 221, Issue 3, Page(s) 131–138

Abstract: Background: Although the incidence of papillary thyroid microcarcinoma (PTMC) has increased in recent decades, the role played by minimal extrathyroidal extension (mETE) in the prognosis of PTMC is still unclear. The aim of this study is to analyze the ... ...

Abstract	Background: Although the incidence of papillary thyroid microcarcinoma (PTMC) has increased in recent decades, the role played by minimal extrathyroidal extension (mETE) in the prognosis of PTMC is still unclear. The aim of this study is to analyze the factors associated with PTMC with mETE and its long-term prognosis. Material and methods: We conducted a retrospective study on patients with a histological diagnosis of PTMC. We excluded patients who had previously undergone thyroid surgery, those who had other synchronous malignancies, those with an ectopic location of the PTMC, and those lost to follow-up within two years. We compared group 1 (PTMC without extrathyroidal extension) to group 2 (PTMC with mETE) and performed a multivariate analysis. Results: We observed PTMC with mETE in 11.2% (n = 18) of patients. On the multivariate analysis, mETE was associated with an age ≥45 years (OR: 4.383; 95% CI: 1.051-18.283, p = .043), tumor size ≥8 mm (OR: 5.913; 95% CI: 1.795-19.481; p = .003), bilaterality (OR: 4.430; 95% CI: 1.294-15.173; p = .018) and metastatic lymph nodes (OR: 12.588; 95% CI: 2.919-54.280; p = .001). Over the mean follow-up period of 119.8 ± 65 months, one case of recurrence was detected in group 2 (0% vs. 5.6%; p = .112). No patients died of the disease. Disease-free survival was lower in group 2 (124.9 ± 5.6 vs. 97.4 ± 10.3 months; p = .034). Conclusions: The mETE of PTMC is a factor of worse prognosis associated with the presence of metastatic lymph nodes and a lower rate of disease-free survival.
MeSH term(s)	Carcinoma, Papillary/epidemiology ; Humans ; Lymphatic Metastasis ; Middle Aged ; Retrospective Studies ; Risk Factors ; Thyroid Neoplasms/epidemiology
Language	English
Publishing date	2021-02-15
Publishing country	Spain
Document type	Journal Article
ISSN	2254-8874
ISSN (online)	2254-8874
DOI	10.1016/j.rceng.2019.12.012
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Article ; Online: Papillary thyroid microcarcinoma with minimal extrathyroidal extension. Is its course so indolent that it requires a less aggressive treatment?

Ruiz Pardo, J / Ríos Zambudio, A / Rodríguez González, J M / Paredes Quiles, M / Soriano Giménez, V / Oviedo Ramírez, M I / Hernández Martínez, A M / Parrilla Paricio, P

Revista clinica espanola

2020 Volume 221, Issue 3, Page(s) 131–138

Title translation	Microcarcinoma papilar de tiroides con extensión extratiroidea mínima. ¿Tiene un curso tan indolente para precisar un tratamiento menos intensivo?
Abstract	Background: Although the incidence of papillary thyroid microcarcinoma (PTMC) has increased in recent decades, the role played by minimal extrathyroidal extension (mETE) in the prognosis of PTMC is still unclear. The aim of this study is to analyze the factors associated with PTMC with mETE and its long-term prognosis. Material and methods: We conducted a retrospective study on patients with a histological diagnosis of PTMC. We excluded patients who had previously undergone thyroid surgery, those who had other synchronous malignancies, those with an ectopic location of the PTMC, and those lost to follow-up within 2years. We compared group 1 (PTMC without extrathyroidal extension) to group 2 (PTMC with mETE) and performed a multivariate analysis. Results: We observed PTMC with mETE in 11.2% (n=18) of patients. On the multivariate analysis, mETE was associated with age ≥45 years (OR: 4.383; 95% CI: 1.051-18.283, p = .043), tumor size ≥8mm (OR: 5.913; 95% CL: 1.795-19.481; p = .003), bilaterality (OR: 4.430; 95% CI: 1.294-15.173; p = .018) and metastatic lymph nodes (OR: 12.588; 95% CI: 2.919-54.280; p = .001). During a mean follow-up of 119.8±65 months, one recurrence was detected in group 2 (0% vs. 5.6%; p = .112). No patients died of the disease. Disease-free survival was lower in group 2 (124.9±5.6 vs. 97.4±10.3 months; p = .034). Conclusions: The mETE of PTMC is a factor of worse prognosis associated with the presence of metastatic lymph nodes and a lower rate of disease-free survival.
Language	Spanish
Publishing date	2020-03-23
Publishing country	Spain
Document type	Journal Article
ZDB-ID	123597-7
ISSN	1578-1860 ; 0014-2565 ; 0014-2565
ISSN (online)	1578-1860 ; 0014-2565
ISSN	0014-2565
DOI	10.1016/j.rce.2019.12.010
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Article ; Online: Cell-specific Extracellular Vesicles and Their miRNA Cargo Released Into the Organ Preservation Solution During Cold Ischemia Storage as Biomarkers for Liver Transplant Outcomes.

Vidal-Correoso, Daniel / Mateo, Sandra V / Muñoz-Morales, Ana M / Lucas-Ruiz, Fernando / Jover-Aguilar, Marta / Alconchel, Felipe / Martínez-Alarcón, Laura / Sánchez-Redondo, Sara / Santos, Vanesa / López-López, Víctor / Ríos-Zambudio, Antonio / Cascales, Pedro / Pons, José Antonio / Ramírez, Pablo / Pelegrín, Pablo / Peinado, Héctor / Baroja-Mazo, Alberto

Transplantation

2024

Abstract: Background: Liver transplantation (LT) is crucial for end-stage liver disease patients, but organ shortages persist. Donation after circulatory death (DCD) aims to broaden the donor pool but presents challenges. Complications like acute rejection, ... ...

Abstract	Background: Liver transplantation (LT) is crucial for end-stage liver disease patients, but organ shortages persist. Donation after circulatory death (DCD) aims to broaden the donor pool but presents challenges. Complications like acute rejection, hepatic artery thrombosis, and biliary issues still impact posttransplant prognosis. Biomarkers, including extracellular vesicles (EVs) and microRNAs (miRNAs), show promise in understanding and monitoring posttransplant events. This study explores the role of EVs and their miRNA cargo in LT, including their potential as diagnostic tools. Methods: EVs from intrahepatic end-ischemic organ preservation solution (eiOPS) in 79 donated livers were detected using different techniques (nanosight tracking analysis, transmission electron microscopy, and flow cytometry). EV-derived miRNAs were identified by quantitative real time-polymerase chain reaction. Bioinformatics analysis was performed using the R platform. Results: Different-sized and origin-specific EVs were found in eiOPS, with significantly higher concentrations in DCD compared with donation after brain death organs. Additionally, several EV-associated miRNAs, including let-7d-5p, miR-28-5p, miR-200a-3p, miR-200b-3p, miR-200c-3p, and miR-429, were overexpressed in DCD-derived eiOPS. These miRNAs also exhibited differential expression patterns in liver tissue biopsies. Pathway analysis revealed enrichment in signaling pathways involved in extracellular matrix organization and various cellular processes. Moreover, specific EVs and miRNAs correlated with clinical outcomes, including survival and early allograft dysfunction. A predictive model combining biomarkers and clinical variables showed promise in acute rejection detection after LT. Conclusions: These findings provide new insights into the use of EVs and miRNAs as biomarkers and their possible influence on posttransplantation outcomes, potentially contributing to improved diagnostic approaches and personalized treatment strategies in LT.
Language	English
Publishing date	2024-04-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	208424-7
ISSN	1534-6080 ; 0041-1337
ISSN (online)	1534-6080
ISSN	0041-1337
DOI	10.1097/TP.0000000000005008
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Zs.A 488: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Endothelial cell activation mediated by cold ischemia-released mitochondria is partially inhibited by defibrotide and impacts on early allograft function following liver transplantation.

Villalba-López, Francisco / García-Bernal, David / Mateo, Sandra V / Vidal-Correoso, Daniel / Jover-Aguilar, Marta / Alconchel, Felipe / Martínez-Alarcón, Laura / López-López, Víctor / Ríos-Zambudio, Antonio / Cascales, Pedro / Pons, José A / Ramírez, Pablo / Pelegrín, Pablo / Baroja-Mazo, Alberto

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2023 Volume 167, Page(s) 115529

Abstract: DAMPs (danger-associated molecular patterns) are self-molecules of the organism that appear after damage. The endothelium plays several roles in organ rejection, such as presenting alloantigens to T cells and contributing to the development of ... ...

Abstract	DAMPs (danger-associated molecular patterns) are self-molecules of the organism that appear after damage. The endothelium plays several roles in organ rejection, such as presenting alloantigens to T cells and contributing to the development of inflammation and thrombosis. This study aimed to assess whether DAMPs present in the organ preservation solution (OPS) after cold ischemic storage (CIS) contribute to exacerbating the endothelial response to an inflammatory challenge and whether defibrotide treatment could counteract this effect. The activation of cultured human umbilical vein endothelial cells (HUVECs) was analyzed after challenging with end-ischemic OPS (eiOPS) obtained after CIS. Additionally, transwell assays were performed to study the ability of eiOPS to attract lymphocytes across the endothelium. The study revealed that eiOPS upregulated the expression of MCP-1 and IL-6 in HUVECs. Moreover, eiOPS increased the membrane expression of ICAM-1and HLA-DR, which facilitated leukocyte migration toward a chemokine gradient. Furthermore, eiOPS demonstrated its chemoattractant ability. This activation was mediated by free mitochondria. Defibrotide was found to partially inhibit the eiOPS-mediated activation. Moreover, the eiOPS-mediated activation of endothelial cells (ECs) correlated with early allograft dysfunction in liver transplant patients. Our finding provide support for the hypothesis that mitochondria released during cold ischemia could trigger EC activation, leading to complications in graft outcomes. Therefore, the analysis and quantification of free mitochondria in the eiOPS samples obtained after CIS could provide a predictive value for monitoring the progression of transplantation. Moreover, defibrotide emerges as a promising therapeutic agent to mitigate the damage induced by ischemia in donated organs.
Language	English
Publishing date	2023-09-18
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2023.115529
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Article ; Online: Establishing the Number of Procedures for Optimal Renal Transplantation Training With the Use of a Canine Model.

Ayala-Garcia, M A / Soel-Encalada, J M / Rios Zambudio, A / Rodea-Montero, E R / Gonzalez-Yebra, B

Transplantation proceedings

2016 Volume 48, Issue 9, Page(s) 3053–3058

Abstract: Background: The training of surgeons that perform renal transplantations can be diverse. For example, the training profile can vary greatly, involving urologists to general surgeons. The efficacy of training programs directed at transplantation surgeons ...

Abstract	Background: The training of surgeons that perform renal transplantations can be diverse. For example, the training profile can vary greatly, involving urologists to general surgeons. The efficacy of training programs directed at transplantation surgeons is influenced by numerous factors, including the specialist profile who is trained, the number of procedures available to trainees in a given teaching hospital, and the duration of training. Here we determine the number of procedures necessary to consolidate and contribute to proficiency in renal transplantation technique. Methods: We used a canine model, comparing 32 renal transplantations performed by a urologist and by a general surgeon who had completed their respective training in renal transplantation. Results: Our results demonstrated that with 12 surgical procedures, surgeons were able to consolidate their skills in renal transplantation, regardless of their educational background. Conclusions: This is an initial effort in the establishment of a system for targeted training of transplantation surgeons directed specifically at correcting deficiencies and consolidating skills acquired during training programs. These efforts should contribute to the improvement of patient safety in public and private health systems.
MeSH term(s)	Animals ; Clinical Competence/standards ; Dogs ; Education, Medical, Continuing/methods ; General Surgery/education ; General Surgery/standards ; Humans ; Kidney Transplantation/education ; Kidney Transplantation/standards ; Kidney Transplantation/statistics & numerical data ; Male ; Models, Animal ; Operative Time ; Prospective Studies ; Urologists/education ; Urologists/standards
Language	English
Publishing date	2016-11
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	82046-5
ISSN	1873-2623 ; 0041-1345
ISSN (online)	1873-2623
ISSN	0041-1345
DOI	10.1016/j.transproceed.2016.07.032
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Article ; Online: Danger signals released during cold ischemia storage activate NLRP3 inflammasome in myeloid cells and influence early allograft function in liver transplantation.

Lucas-Ruiz, Fernando / Mateo, Sandra V / Jover-Aguilar, Marta / Alconchel, Felipe / Martínez-Alarcón, Laura / de Torre-Minguela, Carlos / Vidal-Correoso, Daniel / Villalba-López, Francisco / López-López, Víctor / Ríos-Zambudio, Antonio / Pons, José A / Ramírez, Pablo / Pelegrín, Pablo / Baroja-Mazo, Alberto

EBioMedicine

2022 Volume 87, Page(s) 104419

Abstract: Background: Innate immunity plays a fundamental role in solid organ transplantation. Myeloid cells can sense danger signals or DAMPs released after tissue or cell damage, such as during ischemia processes. This study aimed to identify DAMPs released ... ...

Abstract	Background: Innate immunity plays a fundamental role in solid organ transplantation. Myeloid cells can sense danger signals or DAMPs released after tissue or cell damage, such as during ischemia processes. This study aimed to identify DAMPs released during cold ischemia storage of human liver and analyze their ability to activate the inflammasome in myeloid cells and the possible implications in terms of short-term outcomes of liver transplantation. Methods: 79 samples of organ preservation solution (OPS) from 79 deceased donors were collected after cold static storage. We used different analytical methods to measure DAMPs in these end-ischemic OPS (eiOPS) samples. We also used eiOPS in the human macrophage THP-1 cell line and primary monocyte cultures to study inflammasome activation. Findings: Different DAMPs were identified in eiOPS, several of which induced both priming and activation of the NLRP3 inflammasome in human myeloid cells. Cold ischemia time and donation after circulatory death negatively influenced the DAMP signature. Moreover, the presence of oligomeric inflammasomes and interleukin-18 in eiOPS correlated with early allograft dysfunction in liver transplant patients. Interpretation: DAMPs released during cold ischemia storage prime and activate the NLRP3 inflammasome in liver macrophages after transplantation, inducing a pro-inflammatory environment that will complicate the outcome of the graft. The use of pharmacological blockers targeting DAMPs or the NLRP3 inflammasome in liver ischemia during static cold storage or through extracorporeal organ support could be a suitable strategy to increase the success of liver transplantation. Funding: Fundación Mutua Madrileña and Instituto de Salud Carlos III, Madrid, Spain.
MeSH term(s)	Humans ; Allografts ; Cold Ischemia/adverse effects ; Inflammasomes/metabolism ; Ischemia ; Liver Transplantation/adverse effects ; Macrophages/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism
Chemical Substances	Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; NLRP3 protein, human
Language	English
Publishing date	2022-12-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2851331-9
ISSN	2352-3964
ISSN (online)	2352-3964
DOI	10.1016/j.ebiom.2022.104419
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Article ; Online: Hiperparatiroidismo asociado al litio.

Ruiz Pardo, José / Ríos Zambudio, Antonio / Rodríguez González, José Manuel / Parrilla Paricio, Pascual

Medicina clinica

2016 Volume 146, Issue 8, Page(s) e43–4

Title translation	Lithium-associated hyperparathyroidism.
MeSH term(s)	Adult ; Aged ; Antimanic Agents/adverse effects ; Antimanic Agents/therapeutic use ; Bipolar Disorder/drug therapy ; Female ; Humans ; Hyperparathyroidism/chemically induced ; Hyperparathyroidism/diagnosis ; Lithium Compounds/adverse effects ; Lithium Compounds/therapeutic use ; Middle Aged
Chemical Substances	Antimanic Agents ; Lithium Compounds
Language	Spanish
Publishing date	2016-04-15
Publishing country	Spain
Document type	Case Reports ; Letter
ZDB-ID	411607-0
ISSN	1578-8989 ; 0025-7753
ISSN (online)	1578-8989
ISSN	0025-7753
DOI	10.1016/j.medcli.2015.10.007
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Article ; Online: Results of treatment of papillary thyroid microcarcinoma adapted to risk of recurrence.

Ruiz-Pardo, José / Ríos-Zambudio, Antonio / Rodríguez-González, José M / Paredes-Quiles, Miriam / Soriano-Giménez, Víctor / Oviedo-Ramírez, M Isabel / Hernández-Martínez, Antonio M / Parrilla-Paricio, Pascual

Cirugia y cirujanos

2020 Volume 88, Issue 5, Page(s) 576–583

Abstract: Background: The incidence of papillary thyroid microcarcinoma (PTMC) is increasing.: Objective: To analyze the long-term prognosis of PTMC.: Method: Study population: patients with a histopathological diagnosis of PTMC (size ≤ 1 cm) treated ... ...

Title translation	Resultados del tratamiento del microcarcinoma papilar de tiroides adaptado al riesgo de recurrencia.
Abstract	Background: The incidence of papillary thyroid microcarcinoma (PTMC) is increasing. Objective: To analyze the long-term prognosis of PTMC. Method: Study population: patients with a histopathological diagnosis of PTMC (size ≤ 1 cm) treated according to the risk of recurrence of the Latin American Thyroid Society. Inclusion criteria: minimum follow-up of 2 years, availability of histopathological samples, and treatment compliance. Exclusion criteria: previous thyroid surgery, other synchronous malignancies or ectopic location of the PTMC. Study variables: persistences, recurrences and mortality. Results: Based on the risk of recurrence, PTMC has very low risk in 65.2% (n = 105), low risk in 17.4% (n = 28) and high risk in 17.4% (n = 28). In high risk patients, total thyroidectomy was performed in all cases, cervical lymphadenectomy in 57,1% (n = 16) and metabolic therapy with I Conclusions: PTMC treated based on its risk of recurrence has a good long-term prognosis, without persistences, with a low number of recurrences and absence of disease-associated mortality.
MeSH term(s)	Carcinoma, Papillary/epidemiology ; Carcinoma, Papillary/surgery ; Humans ; Recurrence ; Thyroid Neoplasms/epidemiology ; Thyroid Neoplasms/surgery ; Thyroidectomy
Language	English
Publishing date	2020-10-16
Publishing country	Mexico
Document type	Journal Article
ZDB-ID	730699-4
ISSN	2444-054X ; 0009-7411
ISSN (online)	2444-054X
ISSN	0009-7411
DOI	10.24875/CIRU.20001560
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Article: La cirugía en las metástasis pulmonares.

Torres Lanzas, J / Ríos Zambudio, A

Archivos de bronconeumologia

2002 Volume 38, Issue 9, Page(s) 403–405

Title translation	Surgery for lung metastasis.
MeSH term(s)	Humans ; Lung Neoplasms/secondary ; Lung Neoplasms/surgery ; Pneumonectomy/methods ; Prognosis ; Registries/statistics & numerical data ; Sternum/surgery ; Survival Rate ; Thoracotomy/methods ; Treatment Outcome
Language	Spanish
Publishing date	2002-07-10
Publishing country	Spain
Document type	Editorial
ZDB-ID	733126-5
ISSN	0300-2896
ISSN	0300-2896
DOI	10.1016/s0300-2896(02)75251-4
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