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Artikel ; Online: International collaborative donor project.

Ríos Zambudio, Antonio

Cirugia espanola

2018 Band 96, Heft 2, Seite(n) 69–75

Abstract: The International Donor Collaborative Project (PCID) research group was created in 1996 in Spain with the aim of promoting research in the field of organ donation and transplantation, led by Spanish surgeons. During this period they have developed the ... ...

Titelübersetzung	Proyecto colaborativo internacional donante.
Abstract	The International Donor Collaborative Project (PCID) research group was created in 1996 in Spain with the aim of promoting research in the field of organ donation and transplantation, led by Spanish surgeons. During this period they have developed the questionnaires of the PCID, both the attitude towards cadaver and live donation, which are the most used questionnaires in publications in indexed journals. They have been the driving group of stratified studies representative of the populations under study, and of the performance of multivariate statistical analyzes in the field of psycho-social research in organ donation and transplantation. The main contributions of the group focus on the analysis of health center professionals and emerging migrant groups. In recent years, studies have been extended to the United States, Latin America (mainly Mexico) and Europe.
Mesh-Begriff(e)	Attitude to Health ; Humans ; International Cooperation ; Tissue and Organ Procurement/organization & administration
Sprache	Spanisch
Erscheinungsdatum	2018-02-07
Erscheinungsland	Spain
Dokumenttyp	Journal Article
ISSN	2173-5077
ISSN (online)	2173-5077
DOI	10.1016/j.ciresp.2017.11.009
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Cell-specific Extracellular Vesicles and Their miRNA Cargo Released Into the Organ Preservation Solution During Cold Ischemia Storage as Biomarkers for Liver Transplant Outcomes.

Vidal-Correoso, Daniel / Mateo, Sandra V / Muñoz-Morales, Ana M / Lucas-Ruiz, Fernando / Jover-Aguilar, Marta / Alconchel, Felipe / Martínez-Alarcón, Laura / Sánchez-Redondo, Sara / Santos, Vanesa / López-López, Víctor / Ríos-Zambudio, Antonio / Cascales, Pedro / Pons, José Antonio / Ramírez, Pablo / Pelegrín, Pablo / Peinado, Héctor / Baroja-Mazo, Alberto

Transplantation

2024

Abstract: Background: Liver transplantation (LT) is crucial for end-stage liver disease patients, but organ shortages persist. Donation after circulatory death (DCD) aims to broaden the donor pool but presents challenges. Complications like acute rejection, ... ...

Abstract	Background: Liver transplantation (LT) is crucial for end-stage liver disease patients, but organ shortages persist. Donation after circulatory death (DCD) aims to broaden the donor pool but presents challenges. Complications like acute rejection, hepatic artery thrombosis, and biliary issues still impact posttransplant prognosis. Biomarkers, including extracellular vesicles (EVs) and microRNAs (miRNAs), show promise in understanding and monitoring posttransplant events. This study explores the role of EVs and their miRNA cargo in LT, including their potential as diagnostic tools. Methods: EVs from intrahepatic end-ischemic organ preservation solution (eiOPS) in 79 donated livers were detected using different techniques (nanosight tracking analysis, transmission electron microscopy, and flow cytometry). EV-derived miRNAs were identified by quantitative real time-polymerase chain reaction. Bioinformatics analysis was performed using the R platform. Results: Different-sized and origin-specific EVs were found in eiOPS, with significantly higher concentrations in DCD compared with donation after brain death organs. Additionally, several EV-associated miRNAs, including let-7d-5p, miR-28-5p, miR-200a-3p, miR-200b-3p, miR-200c-3p, and miR-429, were overexpressed in DCD-derived eiOPS. These miRNAs also exhibited differential expression patterns in liver tissue biopsies. Pathway analysis revealed enrichment in signaling pathways involved in extracellular matrix organization and various cellular processes. Moreover, specific EVs and miRNAs correlated with clinical outcomes, including survival and early allograft dysfunction. A predictive model combining biomarkers and clinical variables showed promise in acute rejection detection after LT. Conclusions: These findings provide new insights into the use of EVs and miRNAs as biomarkers and their possible influence on posttransplantation outcomes, potentially contributing to improved diagnostic approaches and personalized treatment strategies in LT.
Sprache	Englisch
Erscheinungsdatum	2024-04-05
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	208424-7
ISSN	1534-6080 ; 0041-1337
ISSN (online)	1534-6080
ISSN	0041-1337
DOI	10.1097/TP.0000000000005008
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Endothelial cell activation mediated by cold ischemia-released mitochondria is partially inhibited by defibrotide and impacts on early allograft function following liver transplantation.

Villalba-López, Francisco / García-Bernal, David / Mateo, Sandra V / Vidal-Correoso, Daniel / Jover-Aguilar, Marta / Alconchel, Felipe / Martínez-Alarcón, Laura / López-López, Víctor / Ríos-Zambudio, Antonio / Cascales, Pedro / Pons, José A / Ramírez, Pablo / Pelegrín, Pablo / Baroja-Mazo, Alberto

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2023 Band 167, Seite(n) 115529

Abstract: DAMPs (danger-associated molecular patterns) are self-molecules of the organism that appear after damage. The endothelium plays several roles in organ rejection, such as presenting alloantigens to T cells and contributing to the development of ... ...

Abstract	DAMPs (danger-associated molecular patterns) are self-molecules of the organism that appear after damage. The endothelium plays several roles in organ rejection, such as presenting alloantigens to T cells and contributing to the development of inflammation and thrombosis. This study aimed to assess whether DAMPs present in the organ preservation solution (OPS) after cold ischemic storage (CIS) contribute to exacerbating the endothelial response to an inflammatory challenge and whether defibrotide treatment could counteract this effect. The activation of cultured human umbilical vein endothelial cells (HUVECs) was analyzed after challenging with end-ischemic OPS (eiOPS) obtained after CIS. Additionally, transwell assays were performed to study the ability of eiOPS to attract lymphocytes across the endothelium. The study revealed that eiOPS upregulated the expression of MCP-1 and IL-6 in HUVECs. Moreover, eiOPS increased the membrane expression of ICAM-1and HLA-DR, which facilitated leukocyte migration toward a chemokine gradient. Furthermore, eiOPS demonstrated its chemoattractant ability. This activation was mediated by free mitochondria. Defibrotide was found to partially inhibit the eiOPS-mediated activation. Moreover, the eiOPS-mediated activation of endothelial cells (ECs) correlated with early allograft dysfunction in liver transplant patients. Our finding provide support for the hypothesis that mitochondria released during cold ischemia could trigger EC activation, leading to complications in graft outcomes. Therefore, the analysis and quantification of free mitochondria in the eiOPS samples obtained after CIS could provide a predictive value for monitoring the progression of transplantation. Moreover, defibrotide emerges as a promising therapeutic agent to mitigate the damage induced by ischemia in donated organs.
Sprache	Englisch
Erscheinungsdatum	2023-09-18
Erscheinungsland	France
Dokumenttyp	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2023.115529
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Danger signals released during cold ischemia storage activate NLRP3 inflammasome in myeloid cells and influence early allograft function in liver transplantation.

Lucas-Ruiz, Fernando / Mateo, Sandra V / Jover-Aguilar, Marta / Alconchel, Felipe / Martínez-Alarcón, Laura / de Torre-Minguela, Carlos / Vidal-Correoso, Daniel / Villalba-López, Francisco / López-López, Víctor / Ríos-Zambudio, Antonio / Pons, José A / Ramírez, Pablo / Pelegrín, Pablo / Baroja-Mazo, Alberto

EBioMedicine

2022 Band 87, Seite(n) 104419

Abstract: Background: Innate immunity plays a fundamental role in solid organ transplantation. Myeloid cells can sense danger signals or DAMPs released after tissue or cell damage, such as during ischemia processes. This study aimed to identify DAMPs released ... ...

Abstract	Background: Innate immunity plays a fundamental role in solid organ transplantation. Myeloid cells can sense danger signals or DAMPs released after tissue or cell damage, such as during ischemia processes. This study aimed to identify DAMPs released during cold ischemia storage of human liver and analyze their ability to activate the inflammasome in myeloid cells and the possible implications in terms of short-term outcomes of liver transplantation. Methods: 79 samples of organ preservation solution (OPS) from 79 deceased donors were collected after cold static storage. We used different analytical methods to measure DAMPs in these end-ischemic OPS (eiOPS) samples. We also used eiOPS in the human macrophage THP-1 cell line and primary monocyte cultures to study inflammasome activation. Findings: Different DAMPs were identified in eiOPS, several of which induced both priming and activation of the NLRP3 inflammasome in human myeloid cells. Cold ischemia time and donation after circulatory death negatively influenced the DAMP signature. Moreover, the presence of oligomeric inflammasomes and interleukin-18 in eiOPS correlated with early allograft dysfunction in liver transplant patients. Interpretation: DAMPs released during cold ischemia storage prime and activate the NLRP3 inflammasome in liver macrophages after transplantation, inducing a pro-inflammatory environment that will complicate the outcome of the graft. The use of pharmacological blockers targeting DAMPs or the NLRP3 inflammasome in liver ischemia during static cold storage or through extracorporeal organ support could be a suitable strategy to increase the success of liver transplantation. Funding: Fundación Mutua Madrileña and Instituto de Salud Carlos III, Madrid, Spain.
Mesh-Begriff(e)	Humans ; Allografts ; Cold Ischemia/adverse effects ; Inflammasomes/metabolism ; Ischemia ; Liver Transplantation/adverse effects ; Macrophages/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism
Chemische Substanzen	Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; NLRP3 protein, human
Sprache	Englisch
Erscheinungsdatum	2022-12-19
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article
ZDB-ID	2851331-9
ISSN	2352-3964
ISSN (online)	2352-3964
DOI	10.1016/j.ebiom.2022.104419
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Hiperparatiroidismo asociado al litio.

Ruiz Pardo, José / Ríos Zambudio, Antonio / Rodríguez González, José Manuel / Parrilla Paricio, Pascual

Medicina clinica

2016 Band 146, Heft 8, Seite(n) e43–4

Titelübersetzung	Lithium-associated hyperparathyroidism.
Mesh-Begriff(e)	Adult ; Aged ; Antimanic Agents/adverse effects ; Antimanic Agents/therapeutic use ; Bipolar Disorder/drug therapy ; Female ; Humans ; Hyperparathyroidism/chemically induced ; Hyperparathyroidism/diagnosis ; Lithium Compounds/adverse effects ; Lithium Compounds/therapeutic use ; Middle Aged
Chemische Substanzen	Antimanic Agents ; Lithium Compounds
Sprache	Spanisch
Erscheinungsdatum	2016-04-15
Erscheinungsland	Spain
Dokumenttyp	Case Reports ; Letter
ZDB-ID	411607-0
ISSN	1578-8989 ; 0025-7753
ISSN (online)	1578-8989
ISSN	0025-7753
DOI	10.1016/j.medcli.2015.10.007
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Results of treatment of papillary thyroid microcarcinoma adapted to risk of recurrence.

Ruiz-Pardo, José / Ríos-Zambudio, Antonio / Rodríguez-González, José M / Paredes-Quiles, Miriam / Soriano-Giménez, Víctor / Oviedo-Ramírez, M Isabel / Hernández-Martínez, Antonio M / Parrilla-Paricio, Pascual

Cirugia y cirujanos

2020 Band 88, Heft 5, Seite(n) 576–583

Abstract: Background: The incidence of papillary thyroid microcarcinoma (PTMC) is increasing.: Objective: To analyze the long-term prognosis of PTMC.: Method: Study population: patients with a histopathological diagnosis of PTMC (size ≤ 1 cm) treated ... ...

Titelübersetzung	Resultados del tratamiento del microcarcinoma papilar de tiroides adaptado al riesgo de recurrencia.
Abstract	Background: The incidence of papillary thyroid microcarcinoma (PTMC) is increasing. Objective: To analyze the long-term prognosis of PTMC. Method: Study population: patients with a histopathological diagnosis of PTMC (size ≤ 1 cm) treated according to the risk of recurrence of the Latin American Thyroid Society. Inclusion criteria: minimum follow-up of 2 years, availability of histopathological samples, and treatment compliance. Exclusion criteria: previous thyroid surgery, other synchronous malignancies or ectopic location of the PTMC. Study variables: persistences, recurrences and mortality. Results: Based on the risk of recurrence, PTMC has very low risk in 65.2% (n = 105), low risk in 17.4% (n = 28) and high risk in 17.4% (n = 28). In high risk patients, total thyroidectomy was performed in all cases, cervical lymphadenectomy in 57,1% (n = 16) and metabolic therapy with I Conclusions: PTMC treated based on its risk of recurrence has a good long-term prognosis, without persistences, with a low number of recurrences and absence of disease-associated mortality.
Mesh-Begriff(e)	Carcinoma, Papillary/epidemiology ; Carcinoma, Papillary/surgery ; Humans ; Recurrence ; Thyroid Neoplasms/epidemiology ; Thyroid Neoplasms/surgery ; Thyroidectomy
Sprache	Englisch
Erscheinungsdatum	2020-10-16
Erscheinungsland	Mexico
Dokumenttyp	Journal Article
ZDB-ID	730699-4
ISSN	2444-054X ; 0009-7411
ISSN (online)	2444-054X
ISSN	0009-7411
DOI	10.24875/CIRU.20001560
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Lethal infection by Streptococcus group A in thyroid surgery: the importance of an early diagnosis.

López-López, Víctor / Ríos Zambudio, Antonio / Rodríguez González, José Manuel / Segura Rodriguez, Javier / Parrilla, Pascual

Cirugia espanola

2017 Band 96, Heft 6, Seite(n) 385–387

Titelübersetzung	Infección letal por Streptococcus del grupo A en cirugía tiroidea: la importancia de un diagnóstico precoz.
Mesh-Begriff(e)	Adult ; Early Diagnosis ; Fatal Outcome ; Female ; Humans ; Streptococcal Infections/diagnosis ; Streptococcus pyogenes ; Surgical Wound Infection/diagnosis ; Thyroidectomy
Sprache	Spanisch
Erscheinungsdatum	2017-11-10
Erscheinungsland	Spain
Dokumenttyp	Case Reports ; Letter
ISSN	2173-5077
ISSN (online)	2173-5077
DOI	10.1016/j.ciresp.2017.09.017
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Attitudes of Latin American Immigrants Resident in Florida (United States) Toward Related Living Kidney Donation.

Ríos Zambudio, Antonio / López-Navas, Ana Isabel / Garrido, Gregorio / Ayala-García, Marco Antonio / Sebastián, María José / Hernández, Antonio Miguel / Ramírez, Pablo / Parrilla, Pascual

Progress in transplantation (Aliso Viejo, Calif.)

2018 Band 29, Heft 1, Seite(n) 11–17

Abstract: Introduction: Latin American immigrants comprise an important population group in the United States. The purpose of this study was to analyze the attitude toward living kidney donation found among Latin American citizens who are residents in Florida and ...

Abstract	Introduction: Latin American immigrants comprise an important population group in the United States. The purpose of this study was to analyze the attitude toward living kidney donation found among Latin American citizens who are residents in Florida and to identify the psychosocial variables affecting their attitude. Material and methods: A sample of Latin American residents in the state of Florida was randomly obtained and stratified by nationality, age, and sex (n = 1524). Attitude was assessed through a validated questionnaire that was self-administered and completed anonymously. Descriptive, Student Results: The questionnaire completion rate was 94% (N = 1433), with 59% (n = 845) in favor of related living donation, 40% (n = 571) were opposed to donation, with the remaining 1% (n = 17) undecided. The following variables were related to attitude toward living donation: country of origin ( Conclusions: The attitude toward related living kidney donation of Latin American residents in Florida is not very favorable (only 59%).
Mesh-Begriff(e)	Adult ; Cultural Characteristics ; Emigrants and Immigrants ; Family ; Female ; Florida ; Health Knowledge, Attitudes, Practice ; Hispanic Americans/psychology ; Humans ; Latin America/ethnology ; Living Donors/psychology ; Male ; Religion ; Surveys and Questionnaires ; Tissue and Organ Harvesting
Sprache	Englisch
Erscheinungsdatum	2018-12-30
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	2864264-8
ISSN	2164-6708 ; 1526-9248
ISSN (online)	2164-6708
ISSN	1526-9248
DOI	10.1177/1526924818817073
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Knowledge and attitude towards organ donation of medicine students of a Northwestern Mexico public university

Sebastián-Ruiz, María José / Guerra-Sáenz, Elda Karina / Vargas-Yamanaka, Anna Karen / Barboza-Quintana, Oralia / Ríos-Zambudio, Antonio / García-Cabello, Ricardo / Palacios-Saucedo, Gerardo Del Carmen

Gaceta medica de Mexico

2017 Band 153, Heft 4, Seite(n) 430–440

Abstract: Objective: To evaluate the knowledge and attitude towards organ donation of medicine students of a Northwestern Mexico public university.: Materials and methods: A prolective, descriptive, observational, and cross-sectional study. A 34 items cross- ... ...

Titelübersetzung	Actitud y conocimiento sobre donación de órganos de estudiantes de medicina de una universidad pública del noreste de México
Abstract	Objective: To evaluate the knowledge and attitude towards organ donation of medicine students of a Northwestern Mexico public university. Materials and methods: A prolective, descriptive, observational, and cross-sectional study. A 34 items cross-sectional survey evaluating knowledge and attitude towards organ donation in 3,056 medicine students during 2013-2015. Descriptive statistics were used as absolute frequencies, percentages, mean and standard deviation, as well as the Chi-square test. A p < 0.05 was considered significant. Results: 74% of students would donate their own organs, mainly due to reciprocity (41%). 26% of students would not donate, 48% of them because of fear that their organs could be taken before death. 86% would donate organs from a relative. 64% have spoken about organ donation and transplantation with their family and 67% with friends. 50% said they had received no information about it. 68% understand the concept of brain death. Conclusion: Students received little information about organ donation during college. Despite that, most of them showed a positive attitude and are willing to donate.
Sprache	Spanisch
Erscheinungsdatum	2017
Erscheinungsland	Mexico
Dokumenttyp	Journal Article
ZDB-ID	425456-9
ISSN	0016-3813
ISSN	0016-3813
DOI	10.24875/GMM.17002573
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Fístula quilosa cervical tras linfadenectomía por carcinoma papilar de tiroides tratada con análogos de la somatostatina.

Cascales Campos, Pedro Antonio / Ríos Zambudio, Antonio / Rodríguez González, José Manuel / Parrilla Paricio, Pascual

Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion

2011 Band 58, Heft 3, Seite(n) 150–151

Titelübersetzung	Cervical chylous fistula after lymphadenectomy for papillary thyroid carcinoma treated with somatostatin analogs.
Mesh-Begriff(e)	Adult ; Carcinoma, Papillary/secondary ; Carcinoma, Papillary/surgery ; Combined Modality Therapy ; Dietary Fats/therapeutic use ; Fatty Acids/therapeutic use ; Female ; Fistula/diet therapy ; Fistula/drug therapy ; Fistula/etiology ; Fistula/surgery ; Humans ; Intraoperative Complications/etiology ; Lymphatic Diseases/diet therapy ; Lymphatic Diseases/drug therapy ; Lymphatic Diseases/etiology ; Lymphatic Diseases/surgery ; Neck Dissection/adverse effects ; Octreotide/therapeutic use ; Postoperative Complications/diet therapy ; Postoperative Complications/drug therapy ; Postoperative Complications/etiology ; Suction ; Thoracic Duct/injuries ; Thyroid Neoplasms/surgery ; Thyroidectomy
Chemische Substanzen	Dietary Fats ; Fatty Acids ; Octreotide (RWM8CCW8GP)
Sprache	Spanisch
Erscheinungsdatum	2011-03
Erscheinungsland	Spain
Dokumenttyp	Case Reports ; Letter
ZDB-ID	1469349-5
ISSN	1579-2021 ; 0211-2299 ; 1575-0922
ISSN (online)	1579-2021
ISSN	0211-2299 ; 1575-0922
DOI	10.1016/j.endonu.2010.10.007
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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