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Article ; Online: Radiation treatment monitoring with DCE-US in CWR22 prostate tumor xenografts.

Arteaga-Marrero, Natalia / Mainou-Gomez, Jose F / Brekke Rygh, Cecilie / Lutay, Nataliya / Roehrich, Dieter / Reed, Rolf K / Olsen, Dag R

Acta radiologica (Stockholm, Sweden : 1987)

2018 Volume 60, Issue 6, Page(s) 788–797

Abstract: Background: Longitudinal monitoring of potential radiotherapy treatment effects can be determined by dynamic contrast-enhanced ultrasound (DCE-US).: Purpose: To assess functional parameters by means of DCE-US in a murine subcutaneous model of human ... ...

Abstract	Background: Longitudinal monitoring of potential radiotherapy treatment effects can be determined by dynamic contrast-enhanced ultrasound (DCE-US). Purpose: To assess functional parameters by means of DCE-US in a murine subcutaneous model of human prostate cancer, and their relationship to dose deposition and time-frame after treatment. A special focus has been placed to evaluate the vascular heterogeneity of the tumor and on the most suitable data analysis approach that reflects this heterogeneity. Material and methods: In vivo DCE-US was acquired 24 h and 48 h after radiation treatment with a single dose of 7.5 Gy and 10 Gy, respectively. Tumor vasculature was characterized pixelwise using the Brix pharmacokinetic analysis of the time-intensity curves. Results: Longitudinal changes were detected ( P < 0.001) at 24 h and 48 h after treatment. At 48 h, the eliminating rate constant of the contrast agent from the plasma, k Conclusion: DCE-US has been shown to detect vascular changes at a very early stage after radiotherapy, which is a great advantage since DCE-US is non-invasive, available at most hospitals, and is low in cost compared to other techniques used in clinical practice.
MeSH term(s)	Animals ; Cell Line, Tumor ; Contrast Media ; Disease Models, Animal ; Humans ; Image Enhancement/methods ; Male ; Mice ; Mice, Nude ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/radiotherapy ; Treatment Outcome ; Ultrasonography/methods
Chemical Substances	Contrast Media
Language	English
Publishing date	2018-09-19
Publishing country	England
Document type	Journal Article
ZDB-ID	105-3
ISSN	1600-0455 ; 0284-1851 ; 0349-652X
ISSN (online)	1600-0455
ISSN	0284-1851 ; 0349-652X
DOI	10.1177/0284185118798167
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Article ; Online: Multimodal approach to assess tumour vasculature and potential treatment effect with DCE-US and DCE-MRI quantification in CWR22 prostate tumour xenografts.

Arteaga-Marrero, N / Rygh, C B / Mainou-Gomez, J F / Nylund, K / Roehrich, D / Heggdal, J / Matulaniec, P / Gilja, O H / Reed, R K / Svensson, L / Lutay, N / Olsen, D R

Contrast media & molecular imaging

2015 Volume 10, Issue 6, Page(s) 428–437

Abstract: The aim of this study was to compare intratumoural heterogeneity and longitudinal changes assessed by dynamic contrast-enhanced ultrasound (DCE-US) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in prostate tumour xenografts. In vivo ... ...

Abstract	The aim of this study was to compare intratumoural heterogeneity and longitudinal changes assessed by dynamic contrast-enhanced ultrasound (DCE-US) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in prostate tumour xenografts. In vivo DCE-US and DCE-MRI were obtained 24 h pre- (day 0) and post- (day 2) radiation treatment with a single dose of 7.5 Gy. Characterization of the tumour vasculature was determined by Brix pharmacokinetic analysis of the time-intensity curves. Histogram analysis of voxels showed significant changes (p < 0.001) from day 0 to day 2 in both modalities for kep , the exchange rate constant from the extracellular extravascular space to the plasma, and kel , the elimination rate constant of the contrast. In addition, kep and kel values from DCE-US were significantly higher than those derived from DCE-MRI at day 0 (p < 0.0001) for both groups. At day 2, kel followed the same tendency for both groups, whereas kep showed this tendency only for the treated group in intermediate-enhancement regions. Regarding kep median values, longitudinal changes were not found for any modality. However, at day 2, kep linked to DCE-US was correlated to MVD in high-enhancement areas for the treated group (p = 0.05). In contrast, correlation to necrosis was detected for the control group in intermediate-enhancement areas (p < 0.1). Intratumoural heterogeneity and longitudinal changes in tumour vasculature were assessed for both modalities. Microvascular parameters derived from DCE-US seem to provide reliable biomarkers during radiotherapy as validated by histology. Furthermore, DCE-US could be a stand-alone or a complementary technique.
MeSH term(s)	Animals ; Biomarkers, Tumor/analysis ; Cell Line, Tumor ; Contrast Media/pharmacology ; Gadolinium/pharmacology ; Humans ; Image Enhancement/methods ; Magnetic Resonance Imaging/methods ; Male ; Mice ; Microvessels/diagnostic imaging ; Multimodal Imaging/methods ; Neoplasm Transplantation ; Prostatic Neoplasms/blood supply ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/radiotherapy ; Transplantation, Heterologous ; Tumor Burden ; Ultrasonography
Chemical Substances	Biomarkers, Tumor ; Contrast Media ; Gadolinium (AU0V1LM3JT)
Language	English
Publishing date	2015-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2232678-9
ISSN	1555-4317 ; 1555-4309
ISSN (online)	1555-4317
ISSN	1555-4309
DOI	10.1002/cmmi.1645
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Article ; Online: Image quality of list-mode proton imaging without front trackers.

Rambo Sølie, Jarle / Volz, Lennart / Egil Seime Pettersen, Helge / Piersimoni, Pierluigi / Harald Odland, Odd / Röhrich, Dieter / Helstrup, Håvard / Peitzmann, Thomas / Ullaland, Kjetil / Varga-Kofarago, Monika / Mehendale, Shruti / Slettevoll Grøttvik, Ola / Nilsen Eikeland, Viljar / Meric, Ilker / Seco, Joao

Physics in medicine and biology

2020 Volume 65, Issue 13, Page(s) 135012

Abstract: List mode proton imaging relies on accurate reconstruction of the proton most likely path (MLP) through the patient. This typically requires two sets of position sensitive detector systems, one upstream (front) and one downstream (rear) of the patient. ... ...

Abstract	List mode proton imaging relies on accurate reconstruction of the proton most likely path (MLP) through the patient. This typically requires two sets of position sensitive detector systems, one upstream (front) and one downstream (rear) of the patient. However, for a clinical implementation it can be preferable to omit the front trackers (single-sided proton imaging). For such a system, the MLP can be computed from information available through the beam delivery system and the remaining rear tracker set. In this work, we use Monte Carlo simulations to compare a conventional double-sided (using both front and rear detector systems) with a single-sided system (only rear detector system) by evaluating the spatial resolution of proton radiographs (pRad) and proton CT images (pCT) acquired with these set-ups. Both the pencil beam spot size, as well as the spacing between spots was also adjusted to identify the impact of these beam parameters on the image quality. Relying only on the pencil beam central position for computing the MLP resulted in severe image artifacts both in pRad and pCT. Using the recently extended-MLP formalism that incorporate pencil beam uncertainty removed these image artifacts. However, using a more focused pencil beam with this algorithm induced image artifacts when the spot spacing was the same as the beam spot size. The spatial resolution tested with a sharp edge gradient technique was reduced by 40% for single-sided (MTF
MeSH term(s)	Algorithms ; Child ; Head/diagnostic imaging ; Humans ; Image Processing, Computer-Assisted ; Monte Carlo Method ; Phantoms, Imaging ; Protons ; Quality Control ; Tomography, X-Ray Computed/methods
Chemical Substances	Protons
Language	English
Publishing date	2020-07-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	208857-5
ISSN	1361-6560 ; 0031-9155
ISSN (online)	1361-6560
ISSN	0031-9155
DOI	10.1088/1361-6560/ab8ddb
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Zs.A 199: Show issues

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Journal: Kuehlen mit Sonne - Klimatisierung von Buerogebaeuden

Roehrich, Dagmar

Betrieb und Energie (Sonderteil der Zeitschriften 'Betriebstechnik' und 'Energie Spektrum') : Energie- und Umwelttechnik fuer die betriebliche Praxis

1995 , Page(s) 29–30, 32

Abstract: Die alte Erkenntnis, dass man mit Waerme kuehlen kann, eroeffnet der Solarenergienutzung neue Anwendungsbereiche. An der praktischen Umsetzung dieses Gedankens arbeiten das Freiburger Fraunhofer Institut fuer Solare Energiesysteme sowie der Anlagenbauer ... ...

Abstract	Die alte Erkenntnis, dass man mit Waerme kuehlen kann, eroeffnet der Solarenergienutzung neue Anwendungsbereiche. An der praktischen Umsetzung dieses Gedankens arbeiten das Freiburger Fraunhofer Institut fuer Solare Energiesysteme sowie der Anlagenbauer J. Wolfferts, eine Koelner Firma. Waehrend erstere eine kleine Demonstrationsanlage bauen, die als Vorbild fuer die Klimatisierung des neuen Technologiezentrums im saechsischen Riesa dient, ist die im August 1995 in Betrieb gegangen Koelner Pilotanlage ein Praxisbeispiel fuer die Nachruestung aelterer Buerohaeuser.
Keywords	Nachruestung ; Versuchsanlage ; Gebaeude ; Energiegewinnung ; Solarenergie ; Solarenergieanlage ; Klimatisierung ; Hochhaus ; Gebaeudetechnik ; Energietechnik ; Kuehlung ; Solarkollektor ; Verfahrensvergleich
Language	German
Document type	Journal
Database	OPAC and Environmental database (ULIDAT) of The Federal Environment Agency (UBA)

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Book ; Online: Remote Configuration of the ProASIC3 on the ALICE Inner Tracking System Readout Unit

Yuan, Shiming / Alme, Johan / Röhrich, Dieter / Richter, Matthias / Ersdal, Magnus Rentsch / Giubilato, Piero / Rinella, Gianluca Aglieri / Velure, Arild / Lupi, Matteo / Schambach, Johann Joachim

2020

Abstract: A Large Ion Collider Experiment (ALICE) is one of the four major experiments conducted at the CERN Large Hadron Collider (LHC). The ALICE detector is currently undergoing an upgrade for the upcoming Run 3 at the LHC. The new Inner Tracking System (ITS) ... ...

Abstract	A Large Ion Collider Experiment (ALICE) is one of the four major experiments conducted at the CERN Large Hadron Collider (LHC). The ALICE detector is currently undergoing an upgrade for the upcoming Run 3 at the LHC. The new Inner Tracking System (ITS) sub-detector is part of this upgrade. The front-end electronics of the ITS is composed by 192 Readout Units, installed in a radiation environment. Single Event Upsets (SEUs) in the SRAM-based Xilinx Kintex Ultrascale FPGAs used in the ITS readout represent a real concern. To clear SEUs affecting the Kintex configuration memory, a secondary Flash-based Microsemi ProASIC3E (PA3) FPGA is used. This device configures and continuously scrubs the Xilinx FPGA while data-taking is ongoing, which avoids accumulation of SEUs. The communication path to the RUs is via the radiation hard Gigabit Transceiver (GBT) system on 100 m long optical links. The PA3 is reachable via the GBT Slow Control Adapter (GBT-SCA) ASIC using a dedicated JTAG bus driving channel. During the course of Run 3, it is foreseeable that the FPGA design of the PA3 will require upgrades to correct possible issues and add new functionality. It is therefore mandatory that the PA3 itself can be configured remotely, for which a dedicated software tool is needed. This paper presents the design and implementation of the distributed tools to re-configure remotely the PA3 FPGAs.
Keywords	Physics - Instrumentation and Detectors ; Electrical Engineering and Systems Science - Systems and Control ; High Energy Physics - Experiment
Subject code	600
Publishing date	2020-11-07
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Exploration of differentiability in a proton computed tomography simulation framework.

Aehle, Max / Alme, Johan / Gábor Barnaföldi, Gergely / Blühdorn, Johannes / Bodova, Tea / Borshchov, Vyacheslav / van den Brink, Anthony / Eikeland, Viljar / Feofilov, Gregory / Garth, Christoph / Gauger, Nicolas R / Grøttvik, Ola / Helstrup, Håvard / Igolkin, Sergey / Keidel, Ralf / Kobdaj, Chinorat / Kortus, Tobias / Kusch, Lisa / Leonhardt, Viktor /

Mehendale, Shruti / Ningappa Mulawade, Raju / Harald Odland, Odd / O'Neill, George / Papp, Gábor / Peitzmann, Thomas / Pettersen, Helge Egil Seime / Piersimoni, Pierluigi / Pochampalli, Rohit / Protsenko, Maksym / Rauch, Max / Ur Rehman, Attiq / Richter, Matthias / Röhrich, Dieter / Sagebaum, Max / Santana, Joshua / Schilling, Alexander / Seco, Joao / Songmoolnak, Arnon / Sudár, Ákos / Tambave, Ganesh / Tymchuk, Ihor / Ullaland, Kjetil / Varga-Kofarago, Monika / Volz, Lennart / Wagner, Boris / Wendzel, Steffen / Wiebel, Alexander / Xiao, RenZheng / Yang, Shiming / Zillien, Sebastian

Physics in medicine and biology

2023 Volume 68, Issue 24

Abstract: Objective. ...

Abstract	Objective.
MeSH term(s)	Computer Simulation ; Protons ; Phantoms, Imaging ; Tomography, X-Ray Computed/methods ; Software ; Algorithms ; Monte Carlo Method
Chemical Substances	Protons
Language	English
Publishing date	2023-12-15
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	208857-5
ISSN	1361-6560 ; 0031-9155
ISSN (online)	1361-6560
ISSN	0031-9155
DOI	10.1088/1361-6560/ad0bdd
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Article ; Online: Uncertainty-aware spot rejection rate as quality metric for proton therapy using a digital tracking calorimeter.

Schilling, Alexander / Aehle, Max / Alme, Johan / Barnaföldi, Gergely Gábor / Bodova, Tea / Borshchov, Vyacheslav / van den Brink, Anthony / Eikeland, Viljar / Feofilov, Gregory / Garth, Christoph / Gauger, Nicolas R / Grøttvik, Ola / Helstrup, Håvard / Igolkin, Sergey / Keidel, Ralf / Kobdaj, Chinorat / Kortus, Tobias / Leonhardt, Viktor / Mehendale, Shruti /

Ningappa Mulawade, Raju / Harald Odland, Odd / O'Neill, George / Papp, Gábor / Peitzmann, Thomas / Pettersen, Helge Egil Seime / Piersimoni, Pierluigi / Protsenko, Maksym / Rauch, Max / Ur Rehman, Attiq / Richter, Matthias / Röhrich, Dieter / Santana, Joshua / Seco, Joao / Songmoolnak, Arnon / Sudár, Ákos / Tambave, Ganesh / Tymchuk, Ihor / Ullaland, Kjetil / Varga-Kofarago, Monika / Volz, Lennart / Wagner, Boris / Wendzel, Steffen / Wiebel, Alexander / Xiao, RenZheng / Yang, Shiming / Zillien, Sebastian

Physics in medicine and biology

2023 Volume 68, Issue 19

Abstract: Objective. ...

Abstract	Objective.
MeSH term(s)	Proton Therapy ; Uncertainty ; Protons ; Machine Learning ; Neural Networks, Computer
Chemical Substances	Protons
Language	English
Publishing date	2023-09-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	208857-5
ISSN	1361-6560 ; 0031-9155
ISSN (online)	1361-6560
ISSN	0031-9155
DOI	10.1088/1361-6560/acf5c2
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Book ; Thesis: Computeranalyse von Teilchenspurbildern hochenergetischer Kern-Kern-Stösse

Röhrich, Dieter

1986

Language	Undetermined
Size	109 S, Ill, 21 cm
Document type	Book ; Thesis
Thesis / German Habilitation thesis	@Marburg, Univ., Diss. : 1986
Database	Former special subject collection: coastal and deep sea fishing

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Book ; Thesis: Computeranalyse von Teilchenspurbildern hochenergetischer Kern-Kern-Stöße

Röhrich, Dieter

1986

Author's details	von Dieter Röhrich
Language	German
Size	109 S, Ill., graph. Darst
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Univ., Diss.--Marburg, 1986
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Book ; Online: Development of Wireless Techniques in Data and Power Transmission - Application for Particle Physics Detectors

Brenner, R. / Ceuterickx, S. / Dehos, C. / De Lurgio, P. / Djurcic, Z. / Drake, G. / Gimenez, J. L. Gonzalez / Gustafsson, L. / Kim, D. W. / Locci, E. / Roehrich, D. / Schoening, A. / Siligaris, A. / Soltveit, H. K. / Ullaland, K. / Vincent, P. / Wiednert, D. / Yang, S.

2015

Abstract: Wireless techniques have developed extremely fast over the last decade and using them for data and power transmission in particle physics detectors is not science- fiction any more. During the last years several research groups have independently thought ...

Abstract	Wireless techniques have developed extremely fast over the last decade and using them for data and power transmission in particle physics detectors is not science- fiction any more. During the last years several research groups have independently thought of making it a reality. Wireless techniques became a mature field for research and new developments might have impact on future particle physics experiments. The Instrumentation Frontier was set up as a part of the SnowMass 2013 Community Summer Study [1] to examine the instrumentation R&D for the particle physics research over the coming decades: {\guillemotleft} To succeed we need to make technical and scientific innovation a priority in the field {\guillemotright}. Wireless data transmission was identified as one of the innovations that could revolutionize the transmission of data out of the detector. Power delivery was another challenge mentioned in the same report. We propose a collaboration to identify the specific needs of different projects that might benefit from wireless techniques. The objective is to provide a common platform for research and development in order to optimize effectiveness and cost, with the aim of designing and testing wireless demonstrators for large instrumentation systems.
Keywords	Physics - Instrumentation and Detectors ; Computer Science - Networking and Internet Architecture ; High Energy Physics - Experiment
Subject code	306
Publishing date	2015-11-18
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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