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Article ; Online: Radiation treatment monitoring with DCE-US in CWR22 prostate tumor xenografts.

Arteaga-Marrero, Natalia / Mainou-Gomez, Jose F / Brekke Rygh, Cecilie / Lutay, Nataliya / Roehrich, Dieter / Reed, Rolf K / Olsen, Dag R

Acta radiologica (Stockholm, Sweden : 1987)

2018 Volume 60, Issue 6, Page(s) 788–797

Abstract: Background: Longitudinal monitoring of potential radiotherapy treatment effects can be determined by dynamic contrast-enhanced ultrasound (DCE-US).: Purpose: To assess functional parameters by means of DCE-US in a murine subcutaneous model of human ... ...

Abstract	Background: Longitudinal monitoring of potential radiotherapy treatment effects can be determined by dynamic contrast-enhanced ultrasound (DCE-US). Purpose: To assess functional parameters by means of DCE-US in a murine subcutaneous model of human prostate cancer, and their relationship to dose deposition and time-frame after treatment. A special focus has been placed to evaluate the vascular heterogeneity of the tumor and on the most suitable data analysis approach that reflects this heterogeneity. Material and methods: In vivo DCE-US was acquired 24 h and 48 h after radiation treatment with a single dose of 7.5 Gy and 10 Gy, respectively. Tumor vasculature was characterized pixelwise using the Brix pharmacokinetic analysis of the time-intensity curves. Results: Longitudinal changes were detected ( P < 0.001) at 24 h and 48 h after treatment. At 48 h, the eliminating rate constant of the contrast agent from the plasma, k Conclusion: DCE-US has been shown to detect vascular changes at a very early stage after radiotherapy, which is a great advantage since DCE-US is non-invasive, available at most hospitals, and is low in cost compared to other techniques used in clinical practice.
MeSH term(s)	Animals ; Cell Line, Tumor ; Contrast Media ; Disease Models, Animal ; Humans ; Image Enhancement/methods ; Male ; Mice ; Mice, Nude ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/radiotherapy ; Treatment Outcome ; Ultrasonography/methods
Chemical Substances	Contrast Media
Language	English
Publishing date	2018-09-19
Publishing country	England
Document type	Journal Article
ZDB-ID	105-3
ISSN	1600-0455 ; 0284-1851 ; 0349-652X
ISSN (online)	1600-0455
ISSN	0284-1851 ; 0349-652X
DOI	10.1177/0284185118798167
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Article ; Online: Image quality of list-mode proton imaging without front trackers.

Rambo Sølie, Jarle / Volz, Lennart / Egil Seime Pettersen, Helge / Piersimoni, Pierluigi / Harald Odland, Odd / Röhrich, Dieter / Helstrup, Håvard / Peitzmann, Thomas / Ullaland, Kjetil / Varga-Kofarago, Monika / Mehendale, Shruti / Slettevoll Grøttvik, Ola / Nilsen Eikeland, Viljar / Meric, Ilker / Seco, Joao

Physics in medicine and biology

2020 Volume 65, Issue 13, Page(s) 135012

Abstract: List mode proton imaging relies on accurate reconstruction of the proton most likely path (MLP) through the patient. This typically requires two sets of position sensitive detector systems, one upstream (front) and one downstream (rear) of the patient. ... ...

Abstract	List mode proton imaging relies on accurate reconstruction of the proton most likely path (MLP) through the patient. This typically requires two sets of position sensitive detector systems, one upstream (front) and one downstream (rear) of the patient. However, for a clinical implementation it can be preferable to omit the front trackers (single-sided proton imaging). For such a system, the MLP can be computed from information available through the beam delivery system and the remaining rear tracker set. In this work, we use Monte Carlo simulations to compare a conventional double-sided (using both front and rear detector systems) with a single-sided system (only rear detector system) by evaluating the spatial resolution of proton radiographs (pRad) and proton CT images (pCT) acquired with these set-ups. Both the pencil beam spot size, as well as the spacing between spots was also adjusted to identify the impact of these beam parameters on the image quality. Relying only on the pencil beam central position for computing the MLP resulted in severe image artifacts both in pRad and pCT. Using the recently extended-MLP formalism that incorporate pencil beam uncertainty removed these image artifacts. However, using a more focused pencil beam with this algorithm induced image artifacts when the spot spacing was the same as the beam spot size. The spatial resolution tested with a sharp edge gradient technique was reduced by 40% for single-sided (MTF
MeSH term(s)	Algorithms ; Child ; Head/diagnostic imaging ; Humans ; Image Processing, Computer-Assisted ; Monte Carlo Method ; Phantoms, Imaging ; Protons ; Quality Control ; Tomography, X-Ray Computed/methods
Chemical Substances	Protons
Language	English
Publishing date	2020-07-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	208857-5
ISSN	1361-6560 ; 0031-9155
ISSN (online)	1361-6560
ISSN	0031-9155
DOI	10.1088/1361-6560/ab8ddb
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Book ; Online: Remote Configuration of the ProASIC3 on the ALICE Inner Tracking System Readout Unit

Yuan, Shiming / Alme, Johan / Röhrich, Dieter / Richter, Matthias / Ersdal, Magnus Rentsch / Giubilato, Piero / Rinella, Gianluca Aglieri / Velure, Arild / Lupi, Matteo / Schambach, Johann Joachim

2020

Abstract: A Large Ion Collider Experiment (ALICE) is one of the four major experiments conducted at the CERN Large Hadron Collider (LHC). The ALICE detector is currently undergoing an upgrade for the upcoming Run 3 at the LHC. The new Inner Tracking System (ITS) ... ...

Abstract	A Large Ion Collider Experiment (ALICE) is one of the four major experiments conducted at the CERN Large Hadron Collider (LHC). The ALICE detector is currently undergoing an upgrade for the upcoming Run 3 at the LHC. The new Inner Tracking System (ITS) sub-detector is part of this upgrade. The front-end electronics of the ITS is composed by 192 Readout Units, installed in a radiation environment. Single Event Upsets (SEUs) in the SRAM-based Xilinx Kintex Ultrascale FPGAs used in the ITS readout represent a real concern. To clear SEUs affecting the Kintex configuration memory, a secondary Flash-based Microsemi ProASIC3E (PA3) FPGA is used. This device configures and continuously scrubs the Xilinx FPGA while data-taking is ongoing, which avoids accumulation of SEUs. The communication path to the RUs is via the radiation hard Gigabit Transceiver (GBT) system on 100 m long optical links. The PA3 is reachable via the GBT Slow Control Adapter (GBT-SCA) ASIC using a dedicated JTAG bus driving channel. During the course of Run 3, it is foreseeable that the FPGA design of the PA3 will require upgrades to correct possible issues and add new functionality. It is therefore mandatory that the PA3 itself can be configured remotely, for which a dedicated software tool is needed. This paper presents the design and implementation of the distributed tools to re-configure remotely the PA3 FPGAs.
Keywords	Physics - Instrumentation and Detectors ; Electrical Engineering and Systems Science - Systems and Control ; High Energy Physics - Experiment
Subject code	600
Publishing date	2020-11-07
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Exploration of differentiability in a proton computed tomography simulation framework.

Aehle, Max / Alme, Johan / Gábor Barnaföldi, Gergely / Blühdorn, Johannes / Bodova, Tea / Borshchov, Vyacheslav / van den Brink, Anthony / Eikeland, Viljar / Feofilov, Gregory / Garth, Christoph / Gauger, Nicolas R / Grøttvik, Ola / Helstrup, Håvard / Igolkin, Sergey / Keidel, Ralf / Kobdaj, Chinorat / Kortus, Tobias / Kusch, Lisa / Leonhardt, Viktor /

Mehendale, Shruti / Ningappa Mulawade, Raju / Harald Odland, Odd / O'Neill, George / Papp, Gábor / Peitzmann, Thomas / Pettersen, Helge Egil Seime / Piersimoni, Pierluigi / Pochampalli, Rohit / Protsenko, Maksym / Rauch, Max / Ur Rehman, Attiq / Richter, Matthias / Röhrich, Dieter / Sagebaum, Max / Santana, Joshua / Schilling, Alexander / Seco, Joao / Songmoolnak, Arnon / Sudár, Ákos / Tambave, Ganesh / Tymchuk, Ihor / Ullaland, Kjetil / Varga-Kofarago, Monika / Volz, Lennart / Wagner, Boris / Wendzel, Steffen / Wiebel, Alexander / Xiao, RenZheng / Yang, Shiming / Zillien, Sebastian

Physics in medicine and biology

2023 Volume 68, Issue 24

Abstract: Objective. ...

Abstract	Objective.
MeSH term(s)	Computer Simulation ; Protons ; Phantoms, Imaging ; Tomography, X-Ray Computed/methods ; Software ; Algorithms ; Monte Carlo Method
Chemical Substances	Protons
Language	English
Publishing date	2023-12-15
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	208857-5
ISSN	1361-6560 ; 0031-9155
ISSN (online)	1361-6560
ISSN	0031-9155
DOI	10.1088/1361-6560/ad0bdd
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Article ; Online: Uncertainty-aware spot rejection rate as quality metric for proton therapy using a digital tracking calorimeter.

Schilling, Alexander / Aehle, Max / Alme, Johan / Barnaföldi, Gergely Gábor / Bodova, Tea / Borshchov, Vyacheslav / van den Brink, Anthony / Eikeland, Viljar / Feofilov, Gregory / Garth, Christoph / Gauger, Nicolas R / Grøttvik, Ola / Helstrup, Håvard / Igolkin, Sergey / Keidel, Ralf / Kobdaj, Chinorat / Kortus, Tobias / Leonhardt, Viktor / Mehendale, Shruti /

Ningappa Mulawade, Raju / Harald Odland, Odd / O'Neill, George / Papp, Gábor / Peitzmann, Thomas / Pettersen, Helge Egil Seime / Piersimoni, Pierluigi / Protsenko, Maksym / Rauch, Max / Ur Rehman, Attiq / Richter, Matthias / Röhrich, Dieter / Santana, Joshua / Seco, Joao / Songmoolnak, Arnon / Sudár, Ákos / Tambave, Ganesh / Tymchuk, Ihor / Ullaland, Kjetil / Varga-Kofarago, Monika / Volz, Lennart / Wagner, Boris / Wendzel, Steffen / Wiebel, Alexander / Xiao, RenZheng / Yang, Shiming / Zillien, Sebastian

Physics in medicine and biology

2023 Volume 68, Issue 19

Abstract: Objective. ...

Abstract	Objective.
MeSH term(s)	Proton Therapy ; Uncertainty ; Protons ; Machine Learning ; Neural Networks, Computer
Chemical Substances	Protons
Language	English
Publishing date	2023-09-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	208857-5
ISSN	1361-6560 ; 0031-9155
ISSN (online)	1361-6560
ISSN	0031-9155
DOI	10.1088/1361-6560/acf5c2
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Book ; Thesis: Computeranalyse von Teilchenspurbildern hochenergetischer Kern-Kern-Stösse

Röhrich, Dieter

1986

Language	Undetermined
Size	109 S, Ill, 21 cm
Document type	Book ; Thesis
Thesis / German Habilitation thesis	@Marburg, Univ., Diss. : 1986
Database	Former special subject collection: coastal and deep sea fishing

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Book ; Thesis: Computeranalyse von Teilchenspurbildern hochenergetischer Kern-Kern-Stöße

Röhrich, Dieter

1986

Author's details	von Dieter Röhrich
Language	German
Size	109 S, Ill., graph. Darst
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Univ., Diss.--Marburg, 1986
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: Estimated risk of radiation-induced cancer following paediatric cranio-spinal irradiation with electron, photon and proton therapy.

Stokkevåg, Camilla H / Engeseth, Grete-May / Ytre-Hauge, Kristian S / Röhrich, Dieter / Odland, Odd Harald / Muren, Ludvig P / Brydøy, Marianne / Hysing, Liv B / Szostak, Artur / Palmer, Matthew B / Petersen, Jørgen B B

Acta oncologica (Stockholm, Sweden)

2014 Volume 53, Issue 8, Page(s) 1048–1057

Abstract: Background: Improvement in radiotherapy during the past decades has made the risk of developing a radiation-induced secondary cancer as a result of dose to normal tissue a highly relevant survivorship issue. Important factors expected to influence ... ...

Abstract	Background: Improvement in radiotherapy during the past decades has made the risk of developing a radiation-induced secondary cancer as a result of dose to normal tissue a highly relevant survivorship issue. Important factors expected to influence secondary cancer risk include dose level and dose heterogeneity, as well as gender and type of tissue irradiated. The elevated radio-sensitivity in children calls for models particularly tailored to paediatric cancer patients. Material and methods: Treatment plans of six paediatric medulloblastoma patients were analysed with respect to secondary cancer risk following cranio-spinal irradiation (CSI), using either: 1) electrons and photons combined; 2) conformal photons; 3) double-scattering (DS) protons; or 4) intensity-modulated proton therapy (IMPT). The relative organ equivalent dose (OED) concept was applied in three dose-risk scenarios: a linear response model, a plateau response and an organ specific linear-exponential response. Life attributable risk (LAR) was calculated based on the BEIR VII committee's preferred models for estimating age- and site-specific solid cancer incidence. Uncertainties in the model input parameters were evaluated by error propagation using a Monte Carlo sampling procedure. Results: Both DS protons and IMPT achieved a significantly better dose conformity compared to the photon and electron irradiation techniques resulting in a six times lower overall risk of radiation-induced cancer. Secondary cancer risk in the thyroid and lungs contributed most to the overall risk in all compared modalities, while no significant difference was observed for the bones. Variations between DS protons and IMPT were small, as were differences between electrons and photons. Conclusion: Regardless of technique, using protons decreases the estimated risk of secondary cancer following paediatric CSI compared to conventional photon and electron techniques. Substantial uncertainties in the LAR estimates support relative risk comparisons by OED.
MeSH term(s)	Bone Neoplasms/etiology ; Cerebellar Neoplasms/radiotherapy ; Child ; Child, Preschool ; Colonic Neoplasms/etiology ; Craniospinal Irradiation/adverse effects ; Dose-Response Relationship, Radiation ; Electrons/adverse effects ; Female ; Humans ; Lung Neoplasms/etiology ; Male ; Medulloblastoma/radiotherapy ; Neoplasms, Radiation-Induced/etiology ; Neoplasms, Second Primary/etiology ; Organs at Risk/radiation effects ; Photons/adverse effects ; Proton Therapy/adverse effects ; Radiotherapy Dosage ; Radiotherapy, Intensity-Modulated/adverse effects ; Radiotherapy, Intensity-Modulated/methods ; Risk Assessment ; Sex Factors ; Thyroid Neoplasms/etiology
Language	English
Publishing date	2014-08
Publishing country	England
Document type	Journal Article
ZDB-ID	896449-x
ISSN	1651-226X ; 0349-652X ; 0284-186X ; 1100-1704
ISSN (online)	1651-226X
ISSN	0349-652X ; 0284-186X ; 1100-1704
DOI	10.3109/0284186X.2014.928420
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Article ; Online: Investigating particle track topology for range telescopes in particle radiography using convolutional neural networks.

Pettersen, Helge Egil Seime / Aehle, Max / Alme, Johan / Barnaföldi, Gergely Gábor / Borshchov, Vyacheslav / van den Brink, Anthony / Chaar, Mamdouh / Eikeland, Viljar / Feofilov, Grigory / Garth, Christoph / Gauger, Nicolas R / Genov, Georgi / Grøttvik, Ola / Helstrup, Håvard / Igolkin, Sergey / Keidel, Ralf / Kobdaj, Chinorat / Kortus, Tobias / Leonhardt, Viktor /

Mehendale, Shruti / Mulawade, Raju Ningappa / Odland, Odd Harald / Papp, Gábor / Peitzmann, Thomas / Piersimoni, Pierluigi / Protsenko, Maksym / Rehman, Attiq Ur / Richter, Matthias / Santana, Joshua / Schilling, Alexander / Seco, Joao / Songmoolnak, Arnon / Sølie, Jarle Rambo / Tambave, Ganesh / Tymchuk, Ihor / Ullaland, Kjetil / Varga-Kofarago, Monika / Volz, Lennart / Wagner, Boris / Wendzel, Steffen / Wiebel, Alexander / Xiao, RenZheng / Yang, Shiming / Yokoyama, Hiroki / Zillien, Sebastian / Röhrich, Dieter

Acta oncologica (Stockholm, Sweden)

2021 Volume 60, Issue 11, Page(s) 1413–1418

Abstract: Background: Proton computed tomography (pCT) and radiography (pRad) are proposed modalities for improved treatment plan accuracy and : Material and methods: The CNN was trained by simulation and reconstruction of tens of millions of proton and helium ...

Abstract	Background: Proton computed tomography (pCT) and radiography (pRad) are proposed modalities for improved treatment plan accuracy and Material and methods: The CNN was trained by simulation and reconstruction of tens of millions of proton and helium tracks. The CNN filter was then compared to simple energy loss threshold methods using the Area Under the Receiver Operating Characteristics curve (AUROC), and by comparing the image quality and Water Equivalent Path Length (WEPL) error of proton and helium radiographs filtered with the same methods. Results: The CNN method led to a considerable improvement of the AUROC, from 74.3% to 97.5% with protons and from 94.2% to 99.5% with helium. The CNN filtering reduced the WEPL error in the helium radiograph from 1.03 mm to 0.93 mm while no improvement was seen in the CNN filtered pRads. Conclusion: The CNN improved the filtering of proton and helium tracks. Only in the helium radiograph did this lead to improved image quality.
MeSH term(s)	Humans ; Image Processing, Computer-Assisted ; Monte Carlo Method ; Neural Networks, Computer ; Phantoms, Imaging ; Radiography ; Telescopes
Language	English
Publishing date	2021-07-14
Publishing country	England
Document type	Journal Article
ZDB-ID	896449-x
ISSN	1651-226X ; 0349-652X ; 0284-186X ; 1100-1704
ISSN (online)	1651-226X
ISSN	0349-652X ; 0284-186X ; 1100-1704
DOI	10.1080/0284186X.2021.1949037
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Article ; Online: Helium radiography with a digital tracking calorimeter-a Monte Carlo study for secondary track rejection.

Pettersen, Helge Egil Seime / Volz, Lennart / Sølie, Jarle Rambo / Alme, Johan / Barnaföldi, Gergely Gábor / Barthel, Rene / van den Brink, Anthony / Borshchov, Vyacheslav / Chaar, Mamdouh / Eikeland, Viljar / Genov, Georgi / Grøttvik, Ola / Helstrup, Håvard / Keidel, Ralf / Kobdaj, Chinorat / van der Kolk, Naomi / Mehendale, Shruti / Meric, Ilker / Harald Odland, Odd /

Papp, Gábor / Peitzmann, Thomas / Piersimoni, Pierluigi / Protsenko, Maksym / Ur Rehman, Attiq / Richter, Matthias / Tefre Samnøy, Andreas / Seco, Joao / Shafiee, Hesam / Songmoolnak, Arnon / Tambave, Ganesh / Tymchuk, Ihor / Ullaland, Kjetil / Varga-Kofarago, Monika / Wagner, Boris / Xiao, RenZheng / Yang, Shiming / Yokoyama, Hiroki / Röhrich, Dieter

Physics in medicine and biology

2021 Volume 66, Issue 3, Page(s) 35004

Abstract: Radiation therapy using protons and heavier ions is a fast-growing therapeutic option for cancer patients. A clinical system for particle imaging in particle therapy would enable online patient position verification, estimation of the dose deposition ... ...

Abstract	Radiation therapy using protons and heavier ions is a fast-growing therapeutic option for cancer patients. A clinical system for particle imaging in particle therapy would enable online patient position verification, estimation of the dose deposition through range monitoring and a reduction of uncertainties in the calculation of the relative stopping power of the patient. Several prototype imaging modalities offer radiography and computed tomography using protons and heavy ions. A Digital Tracking Calorimeter (DTC), currently under development, has been proposed as one such detector. In the DTC 43 longitudinal layers of laterally stacked ALPIDE CMOS monolithic active pixel sensor chips are able to reconstruct a large number of simultaneously recorded proton tracks. In this study, we explored the capability of the DTC for helium imaging which offers favorable spatial resolution over proton imaging. Helium ions exhibit a larger cross section for inelastic nuclear interactions, increasing the number of produced secondaries in the imaged object and in the detector itself. To that end, a filtering process able to remove a large fraction of the secondaries was identified, and the track reconstruction process was adapted for helium ions. By filtering on the energy loss along the tracks, on the incoming angle and on the particle ranges, 97.5% of the secondaries were removed. After passing through 16 cm water, 50.0% of the primary helium ions survived; after the proposed filtering 42.4% of the primaries remained; finally after subsequent image reconstruction 31% of the primaries remained. Helium track reconstruction leads to more track matching errors compared to protons due to the increased available focus strength of the helium beam. In a head phantom radiograph, the Water Equivalent Path Length error envelope was 1.0 mm for helium and 1.1 mm for protons. This accuracy is expected to be sufficient for helium imaging for pre-treatment verification purposes.
MeSH term(s)	Calorimetry/instrumentation ; Helium ; Humans ; Monte Carlo Method ; Phantoms, Imaging ; Protons ; Radiography
Chemical Substances	Protons ; Helium (206GF3GB41)
Language	English
Publishing date	2021-01-26
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	208857-5
ISSN	1361-6560 ; 0031-9155
ISSN (online)	1361-6560
ISSN	0031-9155
DOI	10.1088/1361-6560/abca03
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