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  1. Article ; Online: Methods and datasets for segmentation of minimally invasive surgical instruments in endoscopic images and videos: A review of the state of the art.

    Rueckert, Tobias / Rueckert, Daniel / Palm, Christoph

    Computers in biology and medicine

    2024  Volume 169, Page(s) 107929

    Abstract: In the field of computer- and robot-assisted minimally invasive surgery, enormous progress has been made in recent years based on the recognition of surgical instruments in endoscopic images and videos. In particular, the determination of the position ... ...

    Abstract In the field of computer- and robot-assisted minimally invasive surgery, enormous progress has been made in recent years based on the recognition of surgical instruments in endoscopic images and videos. In particular, the determination of the position and type of instruments is of great interest. Current work involves both spatial and temporal information, with the idea that predicting the movement of surgical tools over time may improve the quality of the final segmentations. The provision of publicly available datasets has recently encouraged the development of new methods, mainly based on deep learning. In this review, we identify and characterize datasets used for method development and evaluation and quantify their frequency of use in the literature. We further present an overview of the current state of research regarding the segmentation and tracking of minimally invasive surgical instruments in endoscopic images and videos. The paper focuses on methods that work purely visually, without markers of any kind attached to the instruments, considering both single-frame semantic and instance segmentation approaches, as well as those that incorporate temporal information. The publications analyzed were identified through the platforms Google Scholar, Web of Science, and PubMed. The search terms used were "instrument segmentation", "instrument tracking", "surgical tool segmentation", and "surgical tool tracking", resulting in a total of 741 articles published between 01/2015 and 07/2023, of which 123 were included using systematic selection criteria. A discussion of the reviewed literature is provided, highlighting existing shortcomings and emphasizing the available potential for future developments.
    MeSH term(s) Endoscopy ; Minimally Invasive Surgical Procedures ; Robotic Surgical Procedures/methods ; Surgery, Computer-Assisted/methods ; Surgical Instruments ; Image Processing, Computer-Assisted/methods
    Language English
    Publishing date 2024-01-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 127557-4
    ISSN 1879-0534 ; 0010-4825
    ISSN (online) 1879-0534
    ISSN 0010-4825
    DOI 10.1016/j.compbiomed.2024.107929
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Corrigendum to "Methods and datasets for segmentation of minimally invasive surgical instruments in endoscopic images and videos: A review of the state of the art" [Comput. Biol. Med. 169 (2024) 107929].

    Rueckert, Tobias / Rueckert, Daniel / Palm, Christoph

    Computers in biology and medicine

    2024  Volume 170, Page(s) 108027

    Language English
    Publishing date 2024-02-09
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 127557-4
    ISSN 1879-0534 ; 0010-4825
    ISSN (online) 1879-0534
    ISSN 0010-4825
    DOI 10.1016/j.compbiomed.2024.108027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Thesis: Auswirkungen einer Nadelakupunktur auf den respiratory burst neutrophiler Granulozyten

    Rückert, Tobias

    2004  

    Author's details vorgelegt von Tobias Rückert
    Language German
    Size 84 Bl. . graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Hannover, Univ., Diss., 2005
    HBZ-ID HT014528754
    Database Catalogue ZB MED Medicine, Health

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  4. Book ; Online: Methods and datasets for segmentation of minimally invasive surgical instruments in endoscopic images and videos

    Rueckert, Tobias / Rueckert, Daniel / Palm, Christoph

    A review of the state of the art

    2023  

    Abstract: In the field of computer- and robot-assisted minimally invasive surgery, enormous progress has been made in recent years based on the recognition of surgical instruments in endoscopic images and videos. In particular, the determination of the position ... ...

    Abstract In the field of computer- and robot-assisted minimally invasive surgery, enormous progress has been made in recent years based on the recognition of surgical instruments in endoscopic images and videos. In particular, the determination of the position and type of instruments is of great interest. Current work involves both spatial and temporal information, with the idea that predicting the movement of surgical tools over time may improve the quality of the final segmentations. The provision of publicly available datasets has recently encouraged the development of new methods, mainly based on deep learning. In this review, we identify and characterize datasets used for method development and evaluation and quantify their frequency of use in the literature. We further present an overview of the current state of research regarding the segmentation and tracking of minimally invasive surgical instruments in endoscopic images and videos. The paper focuses on methods that work purely visually, without markers of any kind attached to the instruments, considering both single-frame semantic and instance segmentation approaches, as well as those that incorporate temporal information. The publications analyzed were identified through the platforms Google Scholar, Web of Science, and PubMed. The search terms used were "instrument segmentation", "instrument tracking", "surgical tool segmentation", and "surgical tool tracking", resulting in a total of 741 articles published between 01/2015 and 07/2023, of which 123 were included using systematic selection criteria. A discussion of the reviewed literature is provided, highlighting existing shortcomings and emphasizing the available potential for future developments.

    Comment: 30 pages, 10 figures
    Keywords Computer Science - Computer Vision and Pattern Recognition
    Publishing date 2023-04-25
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Influence of artificial intelligence on the diagnostic performance of endoscopists in the assessment of Barrett's esophagus: a tandem randomized and video trial.

    Meinikheim, Michael / Mendel, Robert / Palm, Christoph / Probst, Andreas / Muzalyova, Anna / Scheppach, Markus W / Nagl, Sandra / Schnoy, Elisabeth / Römmele, Christoph / Schulz, Dominik A H / Schlottmann, Jakob / Prinz, Friederike / Rauber, David / Rückert, Tobias / Matsumura, Tomoaki / Fernández-Esparrach, Glòria / Parsa, Nasim / Byrne, Michael F / Messmann, Helmut /
    Ebigbo, Alanna

    Endoscopy

    2024  

    Abstract: Background: This study evaluated the effect of an artificial intelligence (AI)-based clinical decision support system on the performance and diagnostic confidence of endoscopists in their assessment of Barrett's esophagus (BE).: Methods: 96 ... ...

    Abstract Background: This study evaluated the effect of an artificial intelligence (AI)-based clinical decision support system on the performance and diagnostic confidence of endoscopists in their assessment of Barrett's esophagus (BE).
    Methods: 96 standardized endoscopy videos were assessed by 22 endoscopists with varying degrees of BE experience from 12 centers. Assessment was randomized into two video sets: group A (review first without AI and second with AI) and group B (review first with AI and second without AI). Endoscopists were required to evaluate each video for the presence of Barrett's esophagus-related neoplasia (BERN) and then decide on a spot for a targeted biopsy. After the second assessment, they were allowed to change their clinical decision and confidence level.
    Results: AI had a stand-alone sensitivity, specificity, and accuracy of 92.2%, 68.9%, and 81.3%, respectively. Without AI, BE experts had an overall sensitivity, specificity, and accuracy of 83.3%, 58.1%, and 71.5%, respectively. With AI, BE nonexperts showed a significant improvement in sensitivity and specificity when videos were assessed a second time with AI (sensitivity 69.8% [95%CI 65.2%-74.2%] to 78.0% [95%CI 74.0%-82.0%]; specificity 67.3% [95%CI 62.5%-72.2%] to 72.7% [95%CI 68.2%-77.3%]). In addition, the diagnostic confidence of BE nonexperts improved significantly with AI.
    Conclusion: BE nonexperts benefitted significantly from additional AI. BE experts and nonexperts remained significantly below the stand-alone performance of AI, suggesting that there may be other factors influencing endoscopists' decisions to follow or discard AI advice.
    Language English
    Publishing date 2024-05-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/a-2296-5696
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: An artificial intelligence algorithm is highly accurate for detecting endoscopic features of eosinophilic esophagitis.

    Römmele, Christoph / Mendel, Robert / Barrett, Caroline / Kiesl, Hans / Rauber, David / Rückert, Tobias / Kraus, Lisa / Heinkele, Jakob / Dhillon, Christine / Grosser, Bianca / Prinz, Friederike / Wanzl, Julia / Fleischmann, Carola / Nagl, Sandra / Schnoy, Elisabeth / Schlottmann, Jakob / Dellon, Evan S / Messmann, Helmut / Palm, Christoph /
    Ebigbo, Alanna

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 11115

    Abstract: The endoscopic features associated with eosinophilic esophagitis (EoE) may be missed during routine endoscopy. We aimed to develop and evaluate an Artificial Intelligence (AI) algorithm for detecting and quantifying the endoscopic features of EoE in ... ...

    Abstract The endoscopic features associated with eosinophilic esophagitis (EoE) may be missed during routine endoscopy. We aimed to develop and evaluate an Artificial Intelligence (AI) algorithm for detecting and quantifying the endoscopic features of EoE in white light images, supplemented by the EoE Endoscopic Reference Score (EREFS). An AI algorithm (AI-EoE) was constructed and trained to differentiate between EoE and normal esophagus using endoscopic white light images extracted from the database of the University Hospital Augsburg. In addition to binary classification, a second algorithm was trained with specific auxiliary branches for each EREFS feature (AI-EoE-EREFS). The AI algorithms were evaluated on an external data set from the University of North Carolina, Chapel Hill (UNC), and compared with the performance of human endoscopists with varying levels of experience. The overall sensitivity, specificity, and accuracy of AI-EoE were 0.93 for all measures, while the AUC was 0.986. With additional auxiliary branches for the EREFS categories, the AI algorithm (AI-EoE-EREFS) performance improved to 0.96, 0.94, 0.95, and 0.992 for sensitivity, specificity, accuracy, and AUC, respectively. AI-EoE and AI-EoE-EREFS performed significantly better than endoscopy beginners and senior fellows on the same set of images. An AI algorithm can be trained to detect and quantify endoscopic features of EoE with excellent performance scores. The addition of the EREFS criteria improved the performance of the AI algorithm, which performed significantly better than endoscopists with a lower or medium experience level.
    MeSH term(s) Artificial Intelligence ; Eosinophilic Esophagitis/diagnosis ; Esophagoscopy/methods ; Humans ; Severity of Illness Index
    Language English
    Publishing date 2022-07-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-14605-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Vessel and tissue recognition during third-space endoscopy using a deep learning algorithm.

    Ebigbo, Alanna / Mendel, Robert / Scheppach, Markus W / Probst, Andreas / Shahidi, Neal / Prinz, Friederike / Fleischmann, Carola / Römmele, Christoph / Goelder, Stefan Karl / Braun, Georg / Rauber, David / Rueckert, Tobias / de Souza, Luis A / Papa, Joao / Byrne, Michael / Palm, Christoph / Messmann, Helmut

    Gut

    2022  Volume 71, Issue 12, Page(s) 2388–2390

    Abstract: In this study, we aimed to develop an artificial intelligence clinical decision support solution to mitigate operator-dependent limitations during complex endoscopic procedures such as endoscopic submucosal dissection and peroral endoscopic myotomy, for ... ...

    Abstract In this study, we aimed to develop an artificial intelligence clinical decision support solution to mitigate operator-dependent limitations during complex endoscopic procedures such as endoscopic submucosal dissection and peroral endoscopic myotomy, for example, bleeding and perforation. A DeepLabv3-based model was trained to delineate vessels, tissue structures and instruments on endoscopic still images from such procedures. The mean cross-validated Intersection over Union and Dice Score were 63% and 76%, respectively. Applied to standardised video clips from third-space endoscopic procedures, the algorithm showed a mean vessel detection rate of 85% with a false-positive rate of 0.75/min. These performance statistics suggest a potential clinical benefit for procedure safety, time and also training.
    MeSH term(s) Humans ; Artificial Intelligence ; Deep Learning ; Endoscopy, Gastrointestinal ; Endoscopic Mucosal Resection
    Language English
    Publishing date 2022-09-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gutjnl-2021-326470
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Influence of artificial intelligence on the diagnostic performance of endoscopists in the assessment of Barrett’s esophagus: a tandem randomized and video trial

    Meinikheim, Michael / Mendel, Robert / Palm, Christoph / Probst, Andreas / Muzalyova, Anna / Scheppach, Markus W. / Nagl, Sandra / Schnoy, Elisabeth / Römmele, Christoph / Schulz, Dominik A. H. / Schlottmann, Jakob / Prinz, Friederike / Rauber, David / Rückert, Tobias / Matsumura, Tomoaki / Fernández-Esparrach, Glòria / Parsa, Nasim / Byrne, Michael F. / Messmann, Helmut /
    Ebigbo, Alanna

    Endoscopy

    2024  

    Abstract: Background: This study evaluated the effect of an artificial intelligence (AI)-based clinical decision support system on the performance and diagnostic confidence of endoscopists in their assessment of Barrett’s esophagus (BE).: Methods: 96 ... ...

    Abstract Background: This study evaluated the effect of an artificial intelligence (AI)-based clinical decision support system on the performance and diagnostic confidence of endoscopists in their assessment of Barrett’s esophagus (BE).
    Methods: 96 standardized endoscopy videos were assessed by 22 endoscopists with varying degrees of BE experience from 12 centers. Assessment was randomized into two video sets: group A (review first without AI and second with AI) and group B (review first with AI and second without AI). Endoscopists were required to evaluate each video for the presence of Barrett’s esophagus-related neoplasia (BERN) and then decide on a spot for a targeted biopsy. After the second assessment, they were allowed to change their clinical decision and confidence level.
    Results: AI had a stand-alone sensitivity, specificity, and accuracy of 92.2%, 68.9%, and 81.3%, respectively. Without AI, BE experts had an overall sensitivity, specificity, and accuracy of 83.3%, 58.1%, and 71.5%, respectively. With AI, BE nonexperts showed a significant improvement in sensitivity and specificity when videos were assessed a second time with AI (sensitivity 69.8% [95%CI 65.2%–74.2%] to 78.0% [95%CI 74.0%–82.0%]; specificity 67.3% [95%CI 62.5%–72.2%] to 72.7% [95%CI 68.2%–77.3%]). In addition, the diagnostic confidence of BE nonexperts improved significantly with AI.
    Conclusion: BE nonexperts benefitted significantly from additional AI. BE experts and nonexperts remained significantly below the stand-alone performance of AI, suggesting that there may be other factors influencing endoscopists’ decisions to follow or discard AI advice.
    Language English
    Publishing date 2024-03-28
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/a-2296-5696
    Database Thieme publisher's database

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  9. Article ; Online: Endoscopic prediction of submucosal invasion in Barrett's cancer with the use of artificial intelligence: a pilot study.

    Ebigbo, Alanna / Mendel, Robert / Rückert, Tobias / Schuster, Laurin / Probst, Andreas / Manzeneder, Johannes / Prinz, Friederike / Mende, Matthias / Steinbrück, Ingo / Faiss, Siegbert / Rauber, David / de Souza, Luis A / Papa, João P / Deprez, Pierre H / Oyama, Tsuneo / Takahashi, Akiko / Seewald, Stefan / Sharma, Prateek / Byrne, Michael F /
    Palm, Christoph / Messmann, Helmut

    Endoscopy

    2021  Volume 53, Issue 9, Page(s) 878–883

    Abstract: Background: The accurate differentiation between T1a and T1b Barrett's-related cancer has both therapeutic and prognostic implications but is challenging even for experienced physicians. We trained an artificial intelligence (AI) system on the basis of ... ...

    Abstract Background: The accurate differentiation between T1a and T1b Barrett's-related cancer has both therapeutic and prognostic implications but is challenging even for experienced physicians. We trained an artificial intelligence (AI) system on the basis of deep artificial neural networks (deep learning) to differentiate between T1a and T1b Barrett's cancer on white-light images.
    Methods: Endoscopic images from three tertiary care centers in Germany were collected retrospectively. A deep learning system was trained and tested using the principles of cross validation. A total of 230 white-light endoscopic images (108 T1a and 122 T1b) were evaluated using the AI system. For comparison, the images were also classified by experts specialized in endoscopic diagnosis and treatment of Barrett's cancer.
    Results: The sensitivity, specificity, F1 score, and accuracy of the AI system in the differentiation between T1a and T1b cancer lesions was 0.77, 0.64, 0.74, and 0.71, respectively. There was no statistically significant difference between the performance of the AI system and that of experts, who showed sensitivity, specificity, F1, and accuracy of 0.63, 0.78, 0.67, and 0.70, respectively.
    Conclusion: This pilot study demonstrates the first multicenter application of an AI-based system in the prediction of submucosal invasion in endoscopic images of Barrett's cancer. AI scored equally to international experts in the field, but more work is necessary to improve the system and apply it to video sequences and real-life settings. Nevertheless, the correct prediction of submucosal invasion in Barrett's cancer remains challenging for both experts and AI.
    MeSH term(s) Adenocarcinoma/diagnostic imaging ; Artificial Intelligence ; Barrett Esophagus/diagnostic imaging ; Esophageal Neoplasms/diagnostic imaging ; Esophagoscopy ; Humans ; Pilot Projects ; Retrospective Studies
    Language English
    Publishing date 2021-02-11
    Publishing country Germany
    Document type Journal Article ; Multicenter Study
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/a-1311-8570
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Endoscopic prediction of submucosal invasion in Barrett’s cancer with the use of artificial intelligence: a pilot study

    Ebigbo, Alanna / Mendel, Robert / Rückert, Tobias / Schuster, Laurin / Probst, Andreas / Manzeneder, Johannes / Prinz, Friederike / Mende, Matthias / Steinbrück, Ingo / Faiss, Siegbert / Rauber, David / de Souza, Luis A. / Papa, João P. / Deprez, Pierre H. / Oyama, Tsuneo / Takahashi, Akiko / Seewald, Stefan / Sharma, Prateek / Byrne, Michael F. /
    Palm, Christoph / Messmann, Helmut

    Endoscopy

    2020  Volume 53, Issue 09, Page(s) 878–883

    Abstract: Background: The accurate differentiation between T1a and T1b Barrett’s-related cancer has both therapeutic and prognostic implications but is challenging even for experienced physicians. We trained an artificial intelligence (AI) system on the basis of ... ...

    Abstract Background: The accurate differentiation between T1a and T1b Barrett’s-related cancer has both therapeutic and prognostic implications but is challenging even for experienced physicians. We trained an artificial intelligence (AI) system on the basis of deep artificial neural networks (deep learning) to differentiate between T1a and T1b Barrett’s cancer on white-light images.
    Methods: Endoscopic images from three tertiary care centers in Germany were collected retrospectively. A deep learning system was trained and tested using the principles of cross validation. A total of 230 white-light endoscopic images (108 T1a and 122 T1b) were evaluated using the AI system. For comparison, the images were also classified by experts specialized in endoscopic diagnosis and treatment of Barrett’s cancer.
    Results: The sensitivity, specificity, F1 score, and accuracy of the AI system in the differentiation between T1a and T1b cancer lesions was 0.77, 0.64, 0.74, and 0.71, respectively. There was no statistically significant difference between the performance of the AI system and that of experts, who showed sensitivity, specificity, F1, and accuracy of 0.63, 0.78, 0.67, and 0.70, respectively.
    Conclusion: This pilot study demonstrates the first multicenter application of an AI-based system in the prediction of submucosal invasion in endoscopic images of Barrett’s cancer. AI scored equally to international experts in the field, but more work is necessary to improve the system and apply it to video sequences and real-life settings. Nevertheless, the correct prediction of submucosal invasion in Barrett’s cancer remains challenging for both experts and AI.
    Language English
    Publishing date 2020-11-16
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/a-1311-8570
    Database Thieme publisher's database

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