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Article ; Online: ULTRAPETALAs in action: Unraveling their role in root development.

Ornelas-Ayala, Diego / Cortés-Quiñones, Carlos / Arciniega-González, J Arturo / Garay-Arroyo, Adriana / García-Ponce, Berenice / R Alvarez-Buylla, Elena / Sanchez, Maria De La Paz

Plant science : an international journal of experimental plant biology

2024 Volume 340, Page(s) 111975

Abstract: The epigenetic complex Trithorax (TrxG) regulates gene transcription through post-translational histone modifications and is involved in a wide range of developmental processes. ULTRAPETALA1 (ULT1) is a SAND domain plant-exclusive TrxG protein that ... ...

Abstract	The epigenetic complex Trithorax (TrxG) regulates gene transcription through post-translational histone modifications and is involved in a wide range of developmental processes. ULTRAPETALA1 (ULT1) is a SAND domain plant-exclusive TrxG protein that regulates the H3K4me3 active mark to counteract PcG repression. ULT1 has been identified to be involved in multiple tissue-specific processes. In the Arabidopsis root, ULT1 is required to maintain the stem cell niche, a role that is independent of the histone methyltransferase ATX1. Here we show the contribution of ULT2 in the maintenance of root stem cell niche. We also analyzed the gene expression in the ult1, ult2, and ult1ult2 mutants, evidencing three ways in which ULT1 and ULT2 regulate gene expression, one of them, where ULT1 or ULT2 regulate specific genes each, another where ULT1 and ULT2 act redundantly, as well as a regulation that requires of ULT1 and ULT2 together, supporting a coregulation, never reported. Furthermore, we also evidenced the participation of ULT1 in transcriptional repression synergically with CLF, a key histone methyltransferase of PcG.
MeSH term(s)	Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Transcription Factors/metabolism ; Arabidopsis/metabolism ; Plant Proteins/metabolism ; Histone Methyltransferases/metabolism
Chemical Substances	Arabidopsis Proteins ; Transcription Factors ; Plant Proteins ; Histone Methyltransferases (EC 2.1.1.-) ; ULT1 protein, Arabidopsis
Language	English
Publishing date	2024-01-03
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	742010-9
ISSN	1873-2259 ; 0168-9452
ISSN (online)	1873-2259
ISSN	0168-9452
DOI	10.1016/j.plantsci.2024.111975
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Article ; Online: BIOCLIMATIC DROUGHT AND ITS TRENDS IN CALIFORNIA STATE (U.S.)

A. González-Pérez / R. Álvarez-Esteban / Alejandro Velázquez / A. Penas / S. del Río

Ecological Indicators, Vol 153, Iss , Pp 110426- (2023)

2023

Abstract: Drought occurs naturally all over the world. Global warming has led an increase in the areas affected by this phenomenon. The study of drought involves the analysis of indicators and indices used to assess changes in the hydrological cycle of a region. A ...

Abstract	Drought occurs naturally all over the world. Global warming has led an increase in the areas affected by this phenomenon. The study of drought involves the analysis of indicators and indices used to assess changes in the hydrological cycle of a region. A large number of indices developed for drought monitoring are based on meteorological and hydrological variables. This research has applied the Ombroxeric Index for the first time in California. It is based on the concept of ombroxericity: a condition of the territory characterised from an ombrothermic point of view, which can develop in relatively humid areas/zones, depending on the time scale of the study (i.e. monthly, seasonal or annual basis). Temperatures and precipitation from 180 meteorological stations have been considered for a period of observation from 1980 to 2016. In order to know the evolution of this index, a modified trend analysis based on the Mann-Kendall test and a modified Sen slope analysis were used. Empirical Bayesian Kriging was applied as an interpolation technique. Results are presented in both surface and contour maps. California showed a wide range of ombroxeric levels that went from upper strong dry in northern zones, to lower weak arid. Trend results showed an increase in bioclimatic drought throughout the whole State. In addition, summer showed the highest levels on the Ombroxeric Index. An increase in drought trends was observed at the seasonal level, being more pronounced in summer and spring. In both cases are increases in the central (+5 and +3.6 units year−1 respectively) and the southern (+4 and +4.5 units year−1 respectively) areas of the State. Increasing frequency and severity of droughts could have implications for the management of water resources and the survival of Californian vegetation types, such as conifers.
Keywords	Bioclimatology ; Climate change ; Empirical Bayesian Kriging ; Ombroxeric Index ; Modified Mann-Kendall ; Modified Sen’s slope ; Ecology ; QH540-549.5
Subject code	910
Language	English
Publishing date	2023-09-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Insuficiencia hepática aguda y rabdomiólisis secundaria a «regenerador celular»

Salvador Rocha-Quiroz / Erandy Montes de Oca-García / Randy R. Álvarez-Rangel

Anales Médicos, Vol 68, Iss

2023 Volume 3

Abstract: La insuficiencia hepática aguda es una enfermedad potencialmente mortal que ocurre con mayor frecuencia en pacientes sin enfermedad hepática preexistente. La presentación clínica incluye en general disfunción hepática, valores bioquímicos hepáticos ... ...

Abstract	La insuficiencia hepática aguda es una enfermedad potencialmente mortal que ocurre con mayor frecuencia en pacientes sin enfermedad hepática preexistente. La presentación clínica incluye en general disfunción hepática, valores bioquímicos hepáticos anormales y coagulopatía. El objetivo de este reporte es presentar el caso de un paciente de 58 años que acudió a nuestra unidad hospitalaria con datos de insuficiencia cardiaca congestiva descompensada y falla hepática aguda, con evidencia bioquímica de insuficiencia hepática que evoluciona con rabdomiólisis grave. Se destaca el hecho de referir la ingesta de un suplemento denominado «regenerador celular.»
Keywords	Insuficiencia cardiaca congestiva. Insuficiencia hepática aguda. Rabdomiólisis ; Medicine ; R
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	Publicaciones Permanyer
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Computational Model of the Endothelial to Mesenchymal Transition

Nathan Weinstein / Luis Mendoza / Elena R. Álvarez-Buylla

Frontiers in Genetics, Vol

2020 Volume 11

Abstract: Endothelial cells (ECs) form the lining of lymph and blood vessels. Changes in tissue requirements or wounds may cause ECs to behave as tip or stalk cells. Alternatively, they may differentiate into mesenchymal cells (MCs). These processes are known as ... ...

Abstract	Endothelial cells (ECs) form the lining of lymph and blood vessels. Changes in tissue requirements or wounds may cause ECs to behave as tip or stalk cells. Alternatively, they may differentiate into mesenchymal cells (MCs). These processes are known as EC activation and endothelial-to-mesenchymal transition (EndMT), respectively. EndMT, Tip, and Stalk EC behaviors all require SNAI1, SNAI2, and Matrix metallopeptidase (MMP) function. However, only EndMT inhibits the expression of VE-cadherin, PECAM1, and VEGFR2, and also leads to EC detachment. Physiologically, EndMT is involved in heart valve development, while a defective EndMT regulation is involved in the physiopathology of cardiovascular malformations, congenital heart disease, systemic and organ fibrosis, pulmonary arterial hypertension, and atherosclerosis. Therefore, the control of EndMT has many promising potential applications in regenerative medicine. Despite the fact that many molecular components involved in EC activation and EndMT have been characterized, the system-level molecular mechanisms involved in this process have not been elucidated. Toward this end, hereby we present Boolean network model of the molecular involved in the regulation of EC activation and EndMT. The simulated dynamic behavior of our model reaches fixed and cyclic patterns of activation that correspond to the expected EC and MC cell types and behaviors, recovering most of the specific effects of simple gain and loss-of-function mutations as well as the conditions associated with the progression of several diseases. Therefore, our model constitutes a theoretical framework that can be used to generate hypotheses and guide experimental inquiry to comprehend the regulatory mechanisms behind EndMT. Our main findings include that both the extracellular microevironment and the pattern of molecular activity within the cell regulate EndMT. EndMT requires a lack of VEGFA and sufficient oxygen in the extracellular microenvironment as well as no FLI1 and GATA2 activity within the cell. ...
Keywords	endothelial-mesenchymal transition ; systems biology ; angiogenesis ; Boolean network ; endothelial cell plasticity ; heart development ; Genetics ; QH426-470
Subject code	570
Language	English
Publishing date	2020-03-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Structural Analysis of SARS-CoV-2 ORF8 Protein

Antonio Valcarcel / Antonio Bensussen / Elena R. Álvarez-Buylla / José Díaz

Frontiers in Genetics, Vol

Pathogenic and Therapeutic Implications

2021 Volume 12

Abstract: Current therapeutic strategies and vaccines against SARS-CoV-2 are mainly focused on the Spike protein despite there are other viral proteins with important roles in COVID-19 pathogenicity. For example, ORF8 restructures vesicular trafficking in the host ...

Abstract	Current therapeutic strategies and vaccines against SARS-CoV-2 are mainly focused on the Spike protein despite there are other viral proteins with important roles in COVID-19 pathogenicity. For example, ORF8 restructures vesicular trafficking in the host cell, impacts intracellular immunity through the IFN-I signaling, and growth pathways through the mitogen-activated protein kinases (MAPKs). In this mini-review, we analyze the main structural similarities of ORF8 with immunological molecules such as IL−1, contributing to the immunological deregulation observed in COVID-19. We also propose that the blockage of some effector functions of ORF8 with Rapamycin, such as the mTORC1 activation through MAPKs 40 pathway, with Rapamycin, can be a promising approach to reduce COVID-19 mortality.
Keywords	SARS-CoV-2 ; COVID-19 ; ORF8 ; structural biology ; COVID-19 therapeutics ; Genetics ; QH426-470
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: An adipose lncRAP2-Igf2bp2 complex enhances adipogenesis and energy expenditure by stabilizing target mRNAs

Juan R. Alvarez-Dominguez / Sally Winther / Jacob B. Hansen / Harvey F. Lodish / Marko Knoll

iScience, Vol 25, Iss 1, Pp 103680- (2022)

2022

Abstract: Summary: lncRAP2 is a conserved cytoplasmic lncRNA enriched in adipose tissue and required for adipogenesis. Using purification and in vivo interactome analyses, we show that lncRAP2 forms complexes with proteins that stabilize mRNAs and modulate ... ...

Abstract	Summary: lncRAP2 is a conserved cytoplasmic lncRNA enriched in adipose tissue and required for adipogenesis. Using purification and in vivo interactome analyses, we show that lncRAP2 forms complexes with proteins that stabilize mRNAs and modulate translation, among them Igf2bp2. Surveying transcriptome-wide Igf2bp2 client mRNAs in white adipocytes reveals selective binding to mRNAs encoding adipogenic regulators and energy expenditure effectors, including adiponectin. These same target proteins are downregulated when either Igf2bp2 or lncRAP2 is downregulated, hindering adipocyte lipolysis. Proteomics and ribosome profiling show this occurs predominantly through mRNA accumulation, as lncRAP2-Igf2bp2 complex binding does not impact translation efficiency. Phenome-wide association studies reveal specific associations of genetic variants within both lncRAP2 and Igf2bp2 with body mass and type 2 diabetes, and both lncRAP2 and Igf2bp2 are suppressed in adipose depots of obese and diabetic individuals. Thus, the lncRAP2-Igf2bp2 complex potentiates adipose development and energy expenditure and is associated with susceptibility to obesity-linked diabetes.
Keywords	Biological sciences ; Molecular physiology ; Molecular biology ; Omics ; Science ; Q
Subject code	571
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Todo sobre una entidad poco conocida

Jimena Mariano / Marcos R. Álvarez / Marcelo Sabbione / María L. Juana / Eric Yaniunas / Matías N. Gómez

Revista Argentina de Radiología, Vol 87, Iss

el síndrome linfoproliferativo postrasplante

2023 Volume 2

Abstract: El síndrome linfoproliferativo postrasplante (SLPT o PTLD por sus siglas en inglés, posttransplantation lymphoproliferative disorder) consiste en un grupo heterogéneo de enfermedades linfoproliferativas que ocurren en el marco de la inmunosupresión ... ...

Abstract	El síndrome linfoproliferativo postrasplante (SLPT o PTLD por sus siglas en inglés, posttransplantation lymphoproliferative disorder) consiste en un grupo heterogéneo de enfermedades linfoproliferativas que ocurren en el marco de la inmunosupresión postrasplante, que pueden abarcar desde una simple hiperplasia linfoidea hasta un linfoma maligno de alto grado, con eventual evolución fatal. Se estima su desarrollo entre el 1 y el 20% de los pacientes trasplantados. Los principales factores asociados con el desarrollo de SLPT son el grado de inmunosupresión y el virus de Epstein Barr (VEB). La mayoría suceden dentro del primer año postrasplante, pero el riesgo de desarrollarlo continúa hasta los 10 años. Su presentación es variable, puede ser asintomático o con manifestaciones inespecíficas (fiebre, linfadenopatías), lo que dificulta su diagnóstico desde el punto de vista clínico. Por este motivo, los métodos de imagen cumplen un rol fundamental en su diagnóstico, siendo la tomografía computada (TC) el más utilizado. Se deberá sospechar desde las imágenes en todo paciente trasplantado con afección nodal, principalmente en retroperitoneo y mesenterio; y/o extranodal, como el tracto gastrointestinal, órganos y el sistema nervioso central. El objetivo del presente trabajo consiste en realizar una revisión sobre el SLPT mediante las imágenes y conocer la importancia de su sospecha y diagnóstico.
Keywords	Trasplante. Síndrome linfoproliferativo postrasplante. Oncología ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	Publicaciones Permanyer
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: The Epigenetic Faces of ULTRAPETALA1.

Ornelas-Ayala, Diego / Garay-Arroyo, Adriana / García-Ponce, Berenice / R Álvarez-Buylla, Elena / Sanchez, María de la Paz

Frontiers in plant science

2021 Volume 12, Page(s) 637244

Abstract: ULTRAPETALA1 (ULT1) is a versatile plant-exclusive protein, initially described as a trithorax group (TrxG) factor that regulates transcriptional activation and counteracts polycomb group (PcG) repressor function. As part of TrxG, ULT1 interacts with ... ...

Abstract	ULTRAPETALA1 (ULT1) is a versatile plant-exclusive protein, initially described as a trithorax group (TrxG) factor that regulates transcriptional activation and counteracts polycomb group (PcG) repressor function. As part of TrxG, ULT1 interacts with ARABIDOPSIS TRITHORAX1 (ATX1) to regulate H3K4me3 activation mark deposition. However, our recent studies indicate that ULT1 can also act independently of ATX1. Moreover, the ULT1 ability to interact with transcription factors (TFs) and PcG proteins indicates that it is a versatile protein with other roles. Therefore, in this work we revised recent information about the function of Arabidopsis ULT1 to understand the roles of ULT1 in plant development. Furthermore, we discuss the molecular mechanisms of ULT1, highlighting its epigenetic role, in which ULT1 seems to have characteristics of an epigenetic molecular switch that regulates repression and activation processes via TrxG and PcG complexes.
Language	English
Publishing date	2021-02-25
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2711035-7
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2021.637244
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Article ; Online: Dynamical modeling predicts an inflammation-inducible CXCR7+ B cell precursor with potential implications in lymphoid blockage pathologies

Jennifer Enciso / Luis Mendoza / Elena R. Álvarez-Buylla / Rosana Pelayo

PeerJ, Vol 8, p e

2020 Volume 9902

Abstract: Background The blockage at the early B lymphoid cell development pathway within the bone marrow is tightly associated with hematopoietic and immune diseases, where the disruption of basal regulatory networks prevents the continuous replenishment of ... ...

Abstract	Background The blockage at the early B lymphoid cell development pathway within the bone marrow is tightly associated with hematopoietic and immune diseases, where the disruption of basal regulatory networks prevents the continuous replenishment of functional B cells. Dynamic computational models may be instrumental for the comprehensive understanding of mechanisms underlying complex differentiation processes and provide novel prediction/intervention platforms to reinvigorate the system. Methods By reconstructing a three-module regulatory network including genetic transcription, intracellular transduction, and microenvironment communication, we have investigated the early B lineage cell fate decisions in normal and pathological settings. The early B cell differentiation network was simulated as a Boolean model and then transformed, using fuzzy logic, to a continuous model. We tested null and overexpression mutants to analyze the emergent behavior of the network. Due to its importance in inflammation, we investigated the effect of NFkB induction at different early B cell differentiation stages. Results While the exhaustive synchronous and asynchronous simulation of the early B cell regulatory network (eBCRN) reproduced the configurations of the hematopoietic progenitors and early B lymphoid precursors of the pathway, its simulation as a continuous model with fuzzy logics suggested a transient IL-7R+ ProB-to-Pre-B subset expressing pre-BCR and a series of dominant B-cell transcriptional factors. This conspicuous differentiating cell population up-regulated CXCR7 and reduced CXCR4 and FoxO1 expression levels. Strikingly, constant but intermediate NFkB signaling at specific B cell differentiation stages allowed stabilization of an aberrant CXCR7+ pre-B like phenotype with apparent affinity to proliferative signals, while under constitutive overactivation of NFkB, such cell phenotype was aberrantly exacerbated from the earliest stage of common lymphoid progenitors. Our mutant models revealed an abnormal delay in the ...
Keywords	B cell development ; Hematopoietic microenvironment ; Bone marrow ; Lymphoid niche ; Boolean networks ; Dynamical modeling ; Medicine ; R ; Biology (General) ; QH301-705.5
Subject code	570
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	PeerJ Inc.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Submarine topography and faulting in Bahía de Banderas, Mexico

R. Alvarez

Geofísica Internacional, Vol 46, Iss 2, Pp 93-

2007 Volume 116

Abstract: A digital elevation model of Bahía de Banderas and its offshore continuation to the Middle America Trench (MAT) is built from a data set of 6872 bathymetric soundings. Two new, offshore basins and several, previously unknown faults within the bay are ... ...

Abstract	A digital elevation model of Bahía de Banderas and its offshore continuation to the Middle America Trench (MAT) is built from a data set of 6872 bathymetric soundings. Two new, offshore basins and several, previously unknown faults within the bay are also identified. The south flank of Banderas canyon is considerably steeper than the north one. This asymmetry and the seismic activity present lead to propose that Banderas Canyon has a half-graben structure of the fault growth type, and reverse drag geometry, which originates in an extensional basin oriented N-S. The canyon is divided in two sections that trend in different directions. The older section of the canyon, trending E-W, is probably Late Miocene; the associated Banderas Fault is suggested to extend westward, down to the MAT along a section that complements that of the half-graben. The section of Banderas Canyon trending NE and continuing into Banderas Valley is identified as a younger portion of the structure. The older and the younger portions of the canyon appear to be active presently. A group of faults also trending NE seem to be associated with the change in direction of the canyon. These results support the hypothesis that the structure of Banderas Canyon is a half-graben, and strengthen the idea that it is the limit between the region to the north that underwent extension in the Miocene, and the region to the south that did not experienced it.
Keywords	Bahía de Banderas ; half-graben structure ; Banderas canyon ; submarine DEM ; extensional basin ; Geophysics. Cosmic physics ; QC801-809 ; Physics ; QC1-999 ; Science ; Q ; DOAJ:Geophysics and Geomagnetism ; DOAJ:Earth and Environmental Sciences
Subject code	550
Language	English
Publishing date	2007-05-01T00:00:00Z
Publisher	Universidad Nacional Autónoma de México
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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