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  1. Article ; Online: A Nationwide Analysis of Head and Neck Fibromatoses.

    Raad, Richard A / Akers, Rachel / Al-Khudari, Samer / Stenson, Kerstin / Bhayani, Mihir K

    The Laryngoscope

    2023  Volume 134, Issue 5, Page(s) 2228–2235

    Abstract: Background: Head and neck fibromatoses (HNFs) are a rare, diverse group of soft tissue tumors characterized by an abnormal proliferation of fibroblasts. Available literature on these tumors is limited to case reports and small single-institutional ... ...

    Abstract Background: Head and neck fibromatoses (HNFs) are a rare, diverse group of soft tissue tumors characterized by an abnormal proliferation of fibroblasts. Available literature on these tumors is limited to case reports and small single-institutional studies.
    Objective: We aim to provide demographic, socioeconomic, tumor-related, and treatment characteristics of HNFs.
    Design: Retrospective cohort analysis using the National Cancer Database (NCDB).
    Methods: The NCDB was queried for fibromatosis-related histologic codes located within the head and neck region. Various factors were analyzed. Univariate and multivariate survival analyses were performed.
    Results: Between 2004 and 2016, 130 patients were included in the analyses. Average age was 57.4 years old with a predominance of White (83.6%) males (61.5%). Non-desmoid HNFs accounted for 60%-70% of the tumors. The salivary gland was the most common location (38.5%) and more than half of the tumors were high grade. The majority were treated surgically (90.8%) and 25% had positive margins. Mean and median overall survival (OS) were 98.9 and 135.4 months, respectively. Surgery is associated with better OS than nonsurgical alternatives. Addition of adjuvant treatments was not associated with differences in survival.
    Conclusion: In the largest study to date, we describe demographic, socioeconomic, tumor-related, and treatment patterns of patients with this rare disease. These tumors are most frequently present in middle-aged males with high-grade histology. Most are treated surgically and positive surgical margins are common. Surgery has better OS than nonsurgical alternatives. While adjuvant radiation has become more common, we found no difference in survival compared to surgery alone.
    Level of evidence: 4 Laryngoscope, 134:2228-2235, 2024.
    MeSH term(s) Male ; Middle Aged ; Humans ; Female ; Retrospective Studies ; Survival Analysis ; Cohort Studies ; Head ; Fibroma ; Head and Neck Neoplasms/therapy
    Language English
    Publishing date 2023-11-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.31153
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A nationwide analysis of salvage surgery for laryngeal cancer in the elderly.

    Raad, Richard A / Holland, Katie / Ritz, Ethan M / Tajudeen, Bobby A / Al-Khudari, Samer / Stenson, Kerstin / Teitcher, Joshua / Fidler, Mary Jo / Jelinek, Michael / Joshi, Nikhil / Bhayani, Mihir K

    Head & neck

    2023  Volume 45, Issue 11, Page(s) 2915–2924

    Abstract: Background: We aim to describe outcomes of elderly patients undergoing salvage surgery for laryngeal cancer and to characterize the interplay of age with various other factors in this growing population.: Methods: Using the National Cancer Database, ... ...

    Abstract Background: We aim to describe outcomes of elderly patients undergoing salvage surgery for laryngeal cancer and to characterize the interplay of age with various other factors in this growing population.
    Methods: Using the National Cancer Database, we identified cases of salvage laryngectomy in patients who failed chemoradiation. An age cutoff of 70 years was used to separate subjects into two groups. Various factors were compared.
    Results: Of the 825 patients included, 166 (20.1%) were elderly. Elderly patients had worse overall survival (p = 0.001), higher 30-day and 90-day mortality (p = 0.006, p < 0.001), and a longer length of stay (LOS) (p = 0.015). LOS over 1 week was associated with worse survival (p = 0.032).
    Conclusion: Elderly patients had worse overall perioperative survival than their younger counterparts. LOS and 30-day readmissions were associated with higher risk of mortality in this group. We provide a contemporary set of relevant information for head and neck cancer providers to consider in this growing population.
    MeSH term(s) Humans ; Aged ; Laryngeal Neoplasms/surgery ; Laryngeal Neoplasms/drug therapy ; Retrospective Studies ; Head and Neck Neoplasms/surgery ; Chemoradiotherapy ; Length of Stay ; Salvage Therapy ; Laryngectomy
    Language English
    Publishing date 2023-09-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645165-2
    ISSN 1097-0347 ; 0148-6403 ; 1043-3074
    ISSN (online) 1097-0347
    ISSN 0148-6403 ; 1043-3074
    DOI 10.1002/hed.27525
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Improved sinonasal symptom and endoscopy sinus scores with dose-escalated intranasal mometasone irrigation in patients with refractory chronic rhinosinusitis.

    Papagiannopoulos, Peter / Brown, Hannah J / Kim, Young Jae / Houser, Thomas K / Ganti, Ashwin / Raad, Richard A / Kuan, Edward C / Losavio, Phillip / Batra, Pete S / Tajudeen, Bobby A

    International forum of allergy & rhinology

    2022  Volume 12, Issue 7, Page(s) 955–957

    MeSH term(s) Chronic Disease ; Endoscopy ; Humans ; Mometasone Furoate/therapeutic use ; Paranasal Sinuses/surgery ; Rhinitis/diagnosis ; Rhinitis/drug therapy ; Sinusitis/diagnosis ; Sinusitis/drug therapy ; Treatment Outcome
    Chemical Substances Mometasone Furoate (04201GDN4R)
    Language English
    Publishing date 2022-01-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2625826-2
    ISSN 2042-6984 ; 2042-6976
    ISSN (online) 2042-6984
    ISSN 2042-6976
    DOI 10.1002/alr.22940
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  4. Article ; Online: Aggregate Prevalence of Chemosensory and Sinonasal Dysfunction in SARS-CoV-2 and Related Coronaviruses.

    Lehrich, Brandon M / Goshtasbi, Khodayar / Raad, Richard A / Ganti, Ashwin / Papagiannopoulos, Peter / Tajudeen, Bobby A / Kuan, Edward C

    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

    2020  Volume 163, Issue 1, Page(s) 156–161

    Abstract: Much of the published literature regarding the novel coronavirus disease 2019 (COVID-19) constitutes lower respiratory system symptomatology, while there exists a paucity of data describing the complicated sequelae of the upper respiratory system, ... ...

    Abstract Much of the published literature regarding the novel coronavirus disease 2019 (COVID-19) constitutes lower respiratory system symptomatology, while there exists a paucity of data describing the complicated sequelae of the upper respiratory system, including chemosensory and/or sinonasal dysfunction. This study utilized the National Library of Medicine's PubMed/MEDLINE database to query for articles describing COVID-19, SARS-CoV-2, SARS-CoV-1, MERS-CoV, and other coronaviruses, with any mention of smell, taste, or other chemosensory or sinonasal dysfunction. Aggregate analysis demonstrated an incidence of 49.6% (n = 497 of 1002; 95% CI, 46.5%-52.7%), 47.9% (n = 480 of 1002; 95% CI, 44.8%-51.0%), and 17.9% (n = 880 of 4909; 95% CI, 16.9%-19.0%) for smell loss, taste loss, and smell or taste loss, respectively, in patients infected with SARS-CoV-2. Additionally, there were significantly higher incidences of runny nose/rhinorrhea/rhinitis and nasal congestion/obstruction/blockage in other coronaviruses as compared with SARS-CoV-2 (
    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/epidemiology ; Coronavirus Infections/virology ; Global Health ; Humans ; Olfaction Disorders/epidemiology ; Olfaction Disorders/etiology ; Olfaction Disorders/physiopathology ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/epidemiology ; Prevalence ; SARS-CoV-2 ; Smell
    Keywords covid19
    Language English
    Publishing date 2020-05-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 392085-9
    ISSN 1097-6817 ; 0161-6439 ; 0194-5998
    ISSN (online) 1097-6817
    ISSN 0161-6439 ; 0194-5998
    DOI 10.1177/0194599820929278
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  5. Article ; Online: Temporal patterns of nasal symptoms in patients with mild severity SARS-CoV-2 infection.

    Raad, Richard A / Ganti, Ashwin / Goshtasbi, Khodayar / Lehrich, Brandon M / Papagiannopoulos, Peter / LoSavio, Phillip / Mahdavinia, Mahboobeh / Kuan, Edward C / Batra, Pete S / Tajudeen, Bobby A

    American journal of otolaryngology

    2021  Volume 42, Issue 6, Page(s) 103076

    Abstract: Background: No study to date has analyzed the progression of sinonasal symptoms over time in COVID-19 patients. The purpose of this study is to analyze the progression of sinonasal symptoms and risk factors for olfactory dysfunction in the mild severity ...

    Abstract Background: No study to date has analyzed the progression of sinonasal symptoms over time in COVID-19 patients. The purpose of this study is to analyze the progression of sinonasal symptoms and risk factors for olfactory dysfunction in the mild severity COVID-19 patient.
    Methods: An internet survey was used to assess sinonasal symptoms in patients with COVID-19. Changes in rhinologic domain and symptom-specific Sinonasal Outcome Test (SNOT-22) scores were compared at five time points: two weeks before diagnosis, at diagnosis, two weeks after diagnosis, four weeks after diagnosis, and six months after diagnosis.
    Results: 521 responses were collected. Rhinologic domain SNOT-22 scores increased significantly (p < 0.001) to 8.94 at the time of diagnosis, remained elevated two weeks post-diagnosis (5.14, p = 0.004), and decreased significantly four weeks post-diagnosis (3.14, p = 0.004). Smell-specific SNOT-22 scores peaked at the time of diagnosis (2.05, p < 0.001), remained elevated two weeks after diagnosis (1.19, p < 0.001), and returned to baseline four weeks post-diagnosis (0.64, p > 0.999). Taste-specific SNOT-22 scores also peaked at diagnosis (2.06, p < 0.001), remained elevated two weeks after diagnosis (1.19, p < 0.001), and returned to baseline four weeks after diagnosis (0.71, p > 0.999). There were no significant differences in sense of smell or taste between 1-month and 6-month timepoints.
    Conclusion: Sinonasal symptoms, particularly loss of smell and taste, may be important presenting symptoms in the mild severity COVID-19 patient. Our findings support incorporating these symptoms into screening protocols.
    Level of evidence: 4.
    MeSH term(s) Adult ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19/physiopathology ; COVID-19/virology ; Female ; Humans ; Male ; Middle Aged ; Olfaction Disorders/etiology ; Paranasal Sinuses/physiopathology ; Risk Factors ; SARS-CoV-2 ; Severity of Illness Index ; Sino-Nasal Outcome Test ; Taste Disorders/etiology ; Time Factors
    Language English
    Publishing date 2021-04-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604541-8
    ISSN 1532-818X ; 0196-0709
    ISSN (online) 1532-818X
    ISSN 0196-0709
    DOI 10.1016/j.amjoto.2021.103076
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    Zs.A 1637: Show issues Location:
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  6. Article: Aggregate Prevalence of Chemosensory and Sinonasal Dysfunction in SARS-CoV-2 and Related Coronaviruses

    Lehrich, Brandon M / Goshtasbi, Khodayar / Raad, Richard A / Ganti, Ashwin / Papagiannopoulos, Peter / Tajudeen, Bobby A / Kuan, Edward C

    Otolaryngol Head Neck Surg

    Abstract: Much of the published literature regarding the novel coronavirus disease 2019 (COVID-19) constitutes lower respiratory system symptomatology, while there exists a paucity of data describing the complicated sequelae of the upper respiratory system, ... ...

    Abstract Much of the published literature regarding the novel coronavirus disease 2019 (COVID-19) constitutes lower respiratory system symptomatology, while there exists a paucity of data describing the complicated sequelae of the upper respiratory system, including chemosensory and/or sinonasal dysfunction. This study utilized the National Library of Medicine's PubMed/MEDLINE database to query for articles describing COVID-19, SARS-CoV-2, SARS-CoV-1, MERS-CoV, and other coronaviruses, with any mention of smell, taste, or other chemosensory or sinonasal dysfunction. Aggregate analysis demonstrated an incidence of 49.6% (n = 497 of 1002; 95% CI, 46.5%-52.7%), 47.9% (n = 480 of 1002; 95% CI, 44.8%-51.0%), and 17.9% (n = 880 of 4909; 95% CI, 16.9%-19.0%) for smell loss, taste loss, and smell or taste loss, respectively, in patients infected with SARS-CoV-2. Additionally, there were significantly higher incidences of runny nose/rhinorrhea/rhinitis and nasal congestion/obstruction/blockage in other coronaviruses as compared with SARS-CoV-2 (P < .001). Understanding these less well-characterized symptoms may help develop measures for estimating early markers of disease prevalence and/or resolution. Level of evidence: 4.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #306072
    Database COVID19

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  7. Article ; Online: Aggregate Prevalence of Chemosensory and Sinonasal Dysfunction in SARS-CoV-2 and Related Coronaviruses

    Lehrich, Brandon M. / Goshtasbi, Khodayar / Raad, Richard A. / Ganti, Ashwin / Papagiannopoulos, Peter / Tajudeen, Bobby A. / Kuan, Edward C.

    Otolaryngology–Head and Neck Surgery

    2020  Volume 163, Issue 1, Page(s) 156–161

    Abstract: Much of the published literature regarding the novel coronavirus disease 2019 (COVID-19) constitutes lower respiratory system symptomatology, while there exists a paucity of data describing the complicated sequelae of the upper respiratory system, ... ...

    Abstract Much of the published literature regarding the novel coronavirus disease 2019 (COVID-19) constitutes lower respiratory system symptomatology, while there exists a paucity of data describing the complicated sequelae of the upper respiratory system, including chemosensory and/or sinonasal dysfunction. This study utilized the National Library of Medicine’s PubMed/MEDLINE database to query for articles describing COVID-19, SARS-CoV-2, SARS-CoV-1, MERS-CoV, and other coronaviruses, with any mention of smell, taste, or other chemosensory or sinonasal dysfunction. Aggregate analysis demonstrated an incidence of 49.6% (n = 497 of 1002; 95% CI, 46.5%-52.7%), 47.9% (n = 480 of 1002; 95% CI, 44.8%-51.0%), and 17.9% (n = 880 of 4909; 95% CI, 16.9%-19.0%) for smell loss, taste loss, and smell or taste loss, respectively, in patients infected with SARS-CoV-2. Additionally, there were significantly higher incidences of runny nose/rhinorrhea/rhinitis and nasal congestion/obstruction/blockage in other coronaviruses as compared with SARS-CoV-2 ( P < .001). Understanding these less well-characterized symptoms may help develop measures for estimating early markers of disease prevalence and/or resolution. Level of evidence: 4.
    Keywords Surgery ; Otorhinolaryngology ; covid19
    Language English
    Publisher SAGE Publications
    Publishing country us
    Document type Article ; Online
    ZDB-ID 392085-9
    ISSN 1097-6817 ; 0161-6439 ; 0194-5998
    ISSN (online) 1097-6817
    ISSN 0161-6439 ; 0194-5998
    DOI 10.1177/0194599820929278
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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