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Article ; Online: SARS-CoV-2 vaccination in IBD: more pros than cons.

D'Amico, Ferdinando / Rabaud, Christian / Peyrin-Biroulet, Laurent / Danese, Silvio

Nature reviews. Gastroenterology & hepatology

2021 Volume 18, Issue 4, Page(s) 211–213

MeSH term(s)	COVID-19/prevention & control ; COVID-19 Vaccines/therapeutic use ; Humans ; Immunosuppressive Agents/therapeutic use ; Inflammatory Bowel Diseases/drug therapy ; Inflammatory Bowel Diseases/immunology ; SARS-CoV-2
Chemical Substances	COVID-19 Vaccines ; Immunosuppressive Agents
Language	English
Publishing date	2021-01-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2493722-8
ISSN	1759-5053 ; 1759-5045
ISSN (online)	1759-5053
ISSN	1759-5045
DOI	10.1038/s41575-021-00420-w
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Article ; Online: SARS-CoV-2 seroprevalence in healthcare workers and risk factors.

Weber, Stéphanie / Didelot, Alice / Agrinier, Nelly / Peyrin-Biroulet, Laurent / Schvoerer, Evelyne / Rabaud, Christian / Jeulin, Hélène

Infection, disease & health

2022 Volume 27, Issue 4, Page(s) 203–210

Abstract: Background: Exposure of healthcare workers (HCW) to SARS-CoV-2 is a public health concern. Not only are HCWs particularly exposed to SARS-CoV-2, but their contamination can also weaken the healthcare system.: Methods: We analyzed exposure of French ... ...

Abstract	Background: Exposure of healthcare workers (HCW) to SARS-CoV-2 is a public health concern. Not only are HCWs particularly exposed to SARS-CoV-2, but their contamination can also weaken the healthcare system. Methods: We analyzed exposure of French University Hospital HCWs to SARS-CoV-2 through history of positive RT-PCR test and SARS-CoV-2 seroprevalence. Potential risk factors, such as age, BMI, having children or not, working in a COVID-19 unit, or smoking were explored. Results: From May to June 2020, among the 8960 employees of the University Hospital of Nancy, a serological test was performed in 4696 HCWs. The average (SD) age was 40.4 (11.4) years, and the sample included 3926 women (83.6%). Of the 4696 HCWs, 1050 were smokers (22.4%). Among them, 2231 HCWs had a history of COVID-19 symptoms and/or flu-like syndrome (47.5%) and 238 were seropositive (5.1%). Neither gender, sex, BMI, nor having children were associated with a history of positive RT-PCR test or seropositive status. Previous work in a COVID-19 unit was associated with a history of positive RT-PCR test (p = 0.045), but not with seroprevalence (p = 0.215). As expected, history of COVID-19 clinical manifestations was more frequent in HCWs with positive serology than in HCWs with negative serology (adjusted OR = 1.9, 95%CI [1.4-2.5], p < 0.001). Less expected, smoking was associated with a reduced risk of seropositivity among HCWs (adjusted OR = 0.6, 95%CI [0.4-0.9], p = 0.019). Conclusion: HCW are patently exposed to SARS-CoV-2. Care to COVID-19 patients was not associated with a higher SARS-CoV-2 seroprevalence. Smoking appears here associated to a lower seroprevalence.
MeSH term(s)	Child ; Female ; Humans ; Adult ; SARS-CoV-2 ; Seroepidemiologic Studies ; COVID-19/epidemiology ; Health Personnel ; Risk Factors
Language	English
Publishing date	2022-05-17
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2902143-1
ISSN	2468-0869 ; 2468-0451
ISSN (online)	2468-0869
ISSN	2468-0451
DOI	10.1016/j.idh.2022.05.002
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Article ; Online: Incidence and characteristics of COVID-19 in French professional football players during the 2020-2021 season.

Luque-Paz, David / Orhant, Emmanuel / Michel, Fabrice / Kuentz, Philippe / Chapellier, Jean-François / Rolland, Eric / Rabaud, Christian / Tattevin, Pierre

Infectious diseases now

2022 Volume 52, Issue 6, Page(s) 371–373

Abstract: Objectives: To describe the epidemiology of COVID-19 in French professional football players, and to compare the infection incidence with the general population across the first three waves.: Methods: During the 2020-2021 season, all professional ... ...

Abstract	Objectives: To describe the epidemiology of COVID-19 in French professional football players, and to compare the infection incidence with the general population across the first three waves. Methods: During the 2020-2021 season, all professional football players (n = 1217) in the two primary French leagues underwent weekly testing for SARS-CoV-2 infection by nasopharyngeal PCR, in combination with rigorous infection control measures. Results: Among all players, 572 (47%) tested positive at least once, with no COVID-19-related death or hospital admission. Monthly incidence estimates in players ranged from 1486 to 6731 per 100,000 individuals, i.e. 2-17 times higher than incidence estimates in the general population in France during the study period. Conclusion: Almost 50% of professional football players developed SARS-CoV-2 infection during the 2020-2021 season in France, with no severe complication.
MeSH term(s)	Humans ; COVID-19/epidemiology ; Incidence ; SARS-CoV-2 ; Seasons ; Soccer/statistics & numerical data ; France/epidemiology
Language	English
Publishing date	2022-07-08
Publishing country	France
Document type	Journal Article
ISSN	2666-9919
ISSN (online)	2666-9919
DOI	10.1016/j.idnow.2022.07.001
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Article: Diarrhée aiguë chez l'enfant et chez l'adulte (avec le traitement). 2e partie: chez l'adulte.

Rabaud, Christian

La Revue du praticien

2004 Volume 54, Issue 4, Page(s) 427–434

Title translation	Acute diarrhoea in the child and in the adult (with treatment).
MeSH term(s)	Acute Disease ; Adult ; Anti-Bacterial Agents/therapeutic use ; Dehydration/etiology ; Dehydration/prevention & control ; Diarrhea/drug therapy ; Diarrhea/etiology ; Diarrhea/pathology ; Fluid Therapy ; Gastrointestinal Diseases/complications ; Hemodynamics ; Humans
Chemical Substances	Anti-Bacterial Agents
Language	French
Publishing date	2004-02-29
Publishing country	France
Document type	Journal Article
ZDB-ID	205365-2
ISSN	2101-017X ; 0035-2640
ISSN (online)	2101-017X
ISSN	0035-2640
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Article: Perceptions, Representations, and Experiences of Patients Presenting Nonspecific Symptoms in the Context of Suspected Lyme Borreliosis.

Raffetin, Alice / Barquin, Aude / Nguala, Steve / Paoletti, Giulia / Rabaud, Christian / Chassany, Olivier / Caraux-Paz, Pauline / Covasso, Sarah / Partouche, Henri

Microorganisms

2021 Volume 9, Issue 7

Abstract: Background: Some subjective symptoms may be reported at all stages of Lyme borreliosis (LB) and may persist for several months after treatment. Nonspecific symptoms without any objective manifestation of LB are sometimes attributed by patients to a ... ...

Abstract	Background: Some subjective symptoms may be reported at all stages of Lyme borreliosis (LB) and may persist for several months after treatment. Nonspecific symptoms without any objective manifestation of LB are sometimes attributed by patients to a possible tick bite. The aim of our study was to explore the perceptions, representations, and experiences that these patients had of their disease and care paths. Methods: We performed a qualitative study through individual interviews (October 2017-May 2018), based on grounded theory, following the COREQ checklist. A balanced sample of patients with diverse profiles was recruited at consultations with general practitioners and infectious disease physicians. Results: Twelve patients were interviewed. Data saturation was reached at the twelfth interview. For codes, 293 were identified, and classified into 5 themes: (1) the experience of disabling nonspecific symptoms, especially pain, causing confusion and fear, (2) long and difficult care paths for the majority of the patients, experienced as an obstacle course, (3) a break with the previous state of health, causing a negative impact on every sphere of the patient's life, (4) empowerment of the patients and the self-management of their disease, and (5) the strong expression of a desire for change, with better listening, greater recognition of the symptoms, and simpler care paths. Conclusions: This study allows for the understanding of a patient's behaviours and the obstacles encountered, the way they are perceived, and the necessary solutions. The patients' expectations identified here could help physicians better understand the doctor-patient relationship in these complex management situations, which would reduce the burden of the disease. The current development of specialised reference centres could help meet the patients' demands and those of family physicians.
Language	English
Publishing date	2021-07-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms9071515
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Article ; Online: Beta SARS-CoV-2 variant and BNT162b2 vaccine effectiveness in long-term care facilities in France.

Lefèvre, Benjamin / Tondeur, Laura / Madec, Yoann / Grant, Rebecca / Lina, Bruno / van der Werf, Sylvie / Rabaud, Christian / Fontanet, Arnaud

The Lancet. Healthy longevity

2021 Volume 2, Issue 11, Page(s) e685–e687

MeSH term(s)	BNT162 Vaccine ; COVID-19 ; Humans ; Long-Term Care ; SARS-CoV-2 ; Vaccine Efficacy
Chemical Substances	BNT162 Vaccine (N38TVC63NU)
Language	English
Publishing date	2021-09-22
Publishing country	England
Document type	Journal Article
ISSN	2666-7568
ISSN (online)	2666-7568
DOI	10.1016/S2666-7568(21)00230-0
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Article: Perceptions, Representations, and Experiences of Patients Presenting Nonspecific Symptoms in the Context of Suspected Lyme Borreliosis

Raffetin, Alice / Barquin, Aude / Nguala, Steve / Paoletti, Giulia / Rabaud, Christian / Chassany, Olivier / Caraux-Paz, Pauline / Covasso, Sarah / Partouche, Henri

Microorganisms. 2021 July 15, v. 9, no. 7

2021

Abstract	Background: Some subjective symptoms may be reported at all stages of Lyme borreliosis (LB) and may persist for several months after treatment. Nonspecific symptoms without any objective manifestation of LB are sometimes attributed by patients to a possible tick bite. The aim of our study was to explore the perceptions, representations, and experiences that these patients had of their disease and care paths. Methods: We performed a qualitative study through individual interviews (October 2017–May 2018), based on grounded theory, following the COREQ checklist. A balanced sample of patients with diverse profiles was recruited at consultations with general practitioners and infectious disease physicians. Results: Twelve patients were interviewed. Data saturation was reached at the twelfth interview. For codes, 293 were identified, and classified into 5 themes: (1) the experience of disabling nonspecific symptoms, especially pain, causing confusion and fear, (2) long and difficult care paths for the majority of the patients, experienced as an obstacle course, (3) a break with the previous state of health, causing a negative impact on every sphere of the patient’s life, (4) empowerment of the patients and the self-management of their disease, and (5) the strong expression of a desire for change, with better listening, greater recognition of the symptoms, and simpler care paths. Conclusions: This study allows for the understanding of a patient’s behaviours and the obstacles encountered, the way they are perceived, and the necessary solutions. The patients’ expectations identified here could help physicians better understand the doctor–patient relationship in these complex management situations, which would reduce the burden of the disease. The current development of specialised reference centres could help meet the patients’ demands and those of family physicians.
Keywords	Lyme disease ; fearfulness ; pain ; patients ; qualitative analysis ; ticks
Language	English
Dates of publication	2021-0715
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms9071515
Database	NAL-Catalogue (AGRICOLA)

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Article: Comment mieux prescrire les antibiotiques?

Pulcini, Céline / Rabaud, Christian

La Revue du praticien

2012 Volume 62, Issue 7, Page(s) 976–7, 979–80

Abstract: France remains one of the European countries with the highest antibiotic use. It is a matter of emergency to use less antibiotics and in a more wisely manner, given the current worldwide bacterial resistance crisis. The following points are key in order ... ...

Title translation	How could antibiotics be better prescribed?.
Abstract	France remains one of the European countries with the highest antibiotic use. It is a matter of emergency to use less antibiotics and in a more wisely manner, given the current worldwide bacterial resistance crisis. The following points are key in order to better prescribe antibiotics: use of a structured approach when prescribing an antibiotic, use of diagnostic tests when needed, compliance to recommendations, request for specialist advice in complicated cases, education of patients and continuous medical education/assessment of practice for the physicians.
MeSH term(s)	Anti-Bacterial Agents/administration & dosage ; Drug Resistance, Bacterial ; Humans ; Patient Education as Topic
Chemical Substances	Anti-Bacterial Agents
Language	French
Publishing date	2012-09
Publishing country	France
Document type	English Abstract ; Journal Article
ZDB-ID	205365-2
ISSN	2101-017X ; 0035-2640
ISSN (online)	2101-017X
ISSN	0035-2640
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Article ; Online: Opportunistic Infections in Patients with Inflammatory Bowel Disease Treated with Advanced Therapies: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Olivera, Pablo A / Lasa, Juan S / Zubiaurre, Ignacio / Jairath, Vipul / Abreu, Maria T / Rubin, David T / Reinisch, Walter / Magro, Fernando / Rahier, Jean-François / Danese, Silvio / Rabaud, Christian / Peyrin-Biroulet, Laurent

Journal of Crohn's & colitis

2022 Volume 17, Issue 2, Page(s) 199–210

Abstract: Background and aims: Advanced therapies for inflammatory bowel disease [IBD] could potentially lead to a state of immunosuppression with an increased risk of opportunistic infections [OIs]. We aimed to provide an update on the incidence of OIs among ... ...

Abstract	Background and aims: Advanced therapies for inflammatory bowel disease [IBD] could potentially lead to a state of immunosuppression with an increased risk of opportunistic infections [OIs]. We aimed to provide an update on the incidence of OIs among adult IBD patients in randomized controlled trials [RCTs] of approved biologics and small-molecule drugs [SMDs]. Also, we aimed to describe OI definitions utilized in RCTs, to ultimately propose a standardized definition. Methods: Electronic databases were searched from January 1, 1990, until April 16, 2022. Our primary outcome was incidence rate of overall OIs among IBD patients exposed and unexposed to biologics or SMDs. We also describe specific OIs reported in included trials, as well as definitions of OIs within studies when provided. Results: Ninety studies were included. The incidence rates of reported OIs were 0.42 and 0.21 per 100 person-years in patients exposed to advanced therapies and placebo, respectively. This was highest for anti-tumour necrosis factors [0.83 per 100 person-years] and Janus kinase inhibitors [0.55 per 100 person-years] and lowest for anti-integrins and ozanimod. On meta-analysis, no increased risk of OIs was observed. None of the studies provided a detailed definition of OIs, or a comprehensive list of infections considered as OIs. Conclusion: Different mechanisms of action may have specific OI profiles. In the absence of a uniform definition of OIs, these estimates are less reliable. We propose a definition to be used in future studies to help provide standardized reporting. When using this definition, we saw significant differences in incidence rates of OIs across mechanisms of action.
MeSH term(s)	Adult ; Humans ; Randomized Controlled Trials as Topic ; Opportunistic Infections/epidemiology ; Opportunistic Infections/etiology ; Inflammatory Bowel Diseases/complications ; Inflammatory Bowel Diseases/drug therapy ; Incidence
Language	English
Publishing date	2022-09-08
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	2390120-2
ISSN	1876-4479 ; 1873-9946
ISSN (online)	1876-4479
ISSN	1873-9946
DOI	10.1093/ecco-jcc/jjac133
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Zs.A 6634: Show issues

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Article ; Online: Herpes Zoster and Vaccination Strategies in Inflammatory Bowel Diseases: A Practical Guide.

Guillo, Lucas / Rabaud, Christian / Choy, Ernest H / D'Amico, Ferdinando / Danese, Silvio / Ng, Siew C / Peyrin-Biroulet, Laurent

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

2020 Volume 20, Issue 3, Page(s) 481–490

Abstract: Herpes zoster is a painful dermatomal cutaneous eruption resulting from reactivation of the latent varicella-zoster virus. Patients with inflammatory bowel diseases have an increased risk of shingles compared with the general population and this risk can ...

Abstract	Herpes zoster is a painful dermatomal cutaneous eruption resulting from reactivation of the latent varicella-zoster virus. Patients with inflammatory bowel diseases have an increased risk of shingles compared with the general population and this risk can be increased with the use of immunosuppressive therapy. Live zoster vaccine and recombinant zoster vaccine have shown efficacy for the prevention of herpes zoster. The recombinant zoster vaccine seems to offer greater efficacy and long-term protection profile compared with the life zoster vaccine. However, their use in clinical practice still is unclear and updated vaccination recommendations are lacking. This review discusses the risk for shingles in patients with inflammatory bowel diseases, available vaccines, and their efficacy and safety profiles. We also provide guidance on who, when, and how to vaccinate for herpes zoster in routine clinical practice among patients with inflammatory bowel diseases.
MeSH term(s)	Herpes Zoster/epidemiology ; Herpes Zoster/prevention & control ; Herpes Zoster Vaccine/adverse effects ; Herpesvirus 3, Human ; Humans ; Inflammatory Bowel Diseases/chemically induced ; Inflammatory Bowel Diseases/complications ; Inflammatory Bowel Diseases/drug therapy ; Vaccination/adverse effects
Chemical Substances	Herpes Zoster Vaccine
Language	English
Publishing date	2020-10-17
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2119789-1
ISSN	1542-7714 ; 1542-3565
ISSN (online)	1542-7714
ISSN	1542-3565
DOI	10.1016/j.cgh.2020.10.027
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