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Article ; Online: The impact of mindfulness-based stress reduction on psychological health among patients with chronic diseases during COVID-19 outbreak lockdown.

Osama, Hasnaa / Rabea, Hoda M / Abdelrahman, Mona A

Beni-Suef University journal of basic and applied sciences

2023 Volume 12, Issue 1, Page(s) 50

Abstract: Background: The emergence of COVID-19 has spurred a wide range of psychological morbidities. However, its influence on a vulnerable population with chronic conditions is less addressed. Therefore, this study aimed to investigate the psychological health ...

Abstract	Background: The emergence of COVID-19 has spurred a wide range of psychological morbidities. However, its influence on a vulnerable population with chronic conditions is less addressed. Therefore, this study aimed to investigate the psychological health among patients with chronic diseases during the elevated psychiatric distress associated with the outbreak and examine the efficacy and feasibility of mindfulness-based stress reduction intervention (MBSR). The study involved 149 participants recruited from university hospital outpatient clinics. Patients were allocated into two groups: MBSR training program and control group. Standardized questionnaires were administered to assess depression, anxiety and stress prior to the MBSR program and at completion of the training after 8 weeks. Results: The results showed that MBSR intervention improved psychological distress and decreased the mean scores of depression, anxiety and stress. Conclusions: Mindfulness training program based on audio and smartphone was feasible and effective when it was applied to patients with chronic diseases and showed positive impact on negative psychological stress domains. These findings pave the way for the integration of psychological support for patients with chronic illnesses in clinical settings.
Language	English
Publishing date	2023-05-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2768279-1
ISSN	2314-8543 ; 2314-8535 ; 2314-8543
ISSN (online)	2314-8543
ISSN	2314-8535 ; 2314-8543
DOI	10.1186/s43088-023-00389-2
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Article: The preparedness and knowledge of pharmacists and general practitioners in managing human monkeypox: a highly spreading infectious disease.

Elsayed, Asmaa A / Rabea, Hoda M / Salman, Salman Ahmed / Wahsh, Engy A

Journal of pharmaceutical policy and practice

2023 Volume 16, Issue 1, Page(s) 125

Abstract: Background: After the era of the COVID-19 pandemic, the role of pharmacists was emphasized in the battle against highly spreading and infectious diseases like human Monkeypox (hMPV).: Aim: Assess the hMPV knowledge of the community, clinical ... ...

Abstract	Background: After the era of the COVID-19 pandemic, the role of pharmacists was emphasized in the battle against highly spreading and infectious diseases like human Monkeypox (hMPV). Aim: Assess the hMPV knowledge of the community, clinical pharmacists, and general practitioners (GPs) and raise their awareness about hMPV. Methods: A web-based questionnaire was distributed randomly to Egyptian community pharmacists, clinical pharmacists, and GPs from all governorates. The questionnaire was divided into two sections: one for demographic information and the other for hMPV knowledge (nature of the disease, incubation period, transmission, symptoms, Prophylaxis, Prevention, and management). The evidence-based answers were provided after completing the submission. Data were descriptively analyzed using IBM SPSS software. Results: From a total of 753 respondents, only 710 participants were included in the final data analysis. The % of respondents who presented good total knowledge scores about hMPV was comparable between study groups (P = 0.826). There were no differences between groups identifying different disease clinical characteristics (P = 0.689) and hMPV management (P = 0.324). Community pharmacists had better knowledge scores than GPs in the prevention and prophylaxis domain (P = 0.037). Conclusion: Pharmacists and GPs have good and similar knowledge levels of hMPV. However, a gap exists in recognizing the right hMPV incubation period, prophylaxis, and omitting antibiotics from hMPV management. Pharmacists and GPs are the frontline health care providers (HCPs), so they would require more knowledge enhancement about such contagious diseases to offer the best possible patient care.
Language	English
Publishing date	2023-10-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2734772-2
ISSN	2052-3211
ISSN	2052-3211
DOI	10.1186/s40545-023-00636-y
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Article ; Online: Target Blood Pressure and Combination Therapy: Focus on Angiotensin Receptor Blockers Combination with Either Calcium Channel Blockers or Beta Blockers.

Farag, Selvia M / Rabea, Hoda M / Abdelrahim, Mohamed Ea / Mahmoud, Hesham B

Current hypertension reviews

2022 Volume 18, Issue 2, Page(s) 138–144

Abstract: Background: The target blood pressure has changed many times in the guidelines in past years. However, there is always a question; is it good to lower blood pressure below 120/80 or not? Control of blood pressure in hypertension is very important in ... ...

Abstract	Background: The target blood pressure has changed many times in the guidelines in past years. However, there is always a question; is it good to lower blood pressure below 120/80 or not? Control of blood pressure in hypertension is very important in reducing hypertension-modified organ damage. So, the guidelines recommend combining more than one antihypertensive drug to reach the target blood pressure goal. Results: Combination therapy is recommended by guidelines to reach the blood pressure goal. The guidelines recommend many combinations, such as the combination of angiotensin receptor blockers with either calcium channel blockers (CCB) or beta-blocker (BB). Angiotensin receptor blocker (ARB) combination with CCB has gained superiority over other antihypertension drug combinations because it reduces blood pressure and decreases the incidence of CV events and organ damage. BB combinations are recommended by guidelines in patients with ischemic events but not all hypertensive patients. Unfortunately, the new generation BB, for example, nebivolol, has a vasodilator effect, making it new hope for BB. Conclusion: Combination therapy is a must in treating the hypertensive patient. The new generation BBs may change the recommendations of guidelines because they have an effect that is similar to CCBs.
MeSH term(s)	Humans ; Angiotensin Receptor Antagonists/adverse effects ; Calcium Channel Blockers/adverse effects ; Blood Pressure ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Antihypertensive Agents/adverse effects ; Hypertension/diagnosis ; Hypertension/drug therapy ; Hypertension/epidemiology ; Adrenergic beta-Antagonists/adverse effects
Chemical Substances	Angiotensin Receptor Antagonists ; Calcium Channel Blockers ; Angiotensin-Converting Enzyme Inhibitors ; Antihypertensive Agents ; Adrenergic beta-Antagonists
Language	English
Publishing date	2022-12-12
Publishing country	United Arab Emirates
Document type	Journal Article
ISSN	1875-6506
ISSN (online)	1875-6506
DOI	10.2174/1573402118666220627120254
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Article ; Online: Effect of Amlodipine/Nebivolol combination therapy on central BP and PWV compared to Amlodipine/Valsartan combination therapy.

Sultan, El-Zahraa M / Rabea, Hoda / Elberry, Ahmed A / Mahmoud, Hesham B

The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology

2022 Volume 74, Issue 1, Page(s) 15

Abstract: Background: Pulse wave velocity (PWV) and central blood pressure (CBP) have been intoduced into managment of hypertensive patients. PWV is positively correlated with arterial wall stiffness while central aortic pressure becomes better predictor of ... ...

Abstract	Background: Pulse wave velocity (PWV) and central blood pressure (CBP) have been intoduced into managment of hypertensive patients. PWV is positively correlated with arterial wall stiffness while central aortic pressure becomes better predictor of cardiovascular outcome than peripheral pressure. Reduction in CBP provides protective properties against subclinical organ damage. This work aims to investigate the effect of a new combination therapy of Amlodipine/Nebivolol (A/N) on central BP, peripheral BP and PWV. The results of using this combination will be compared to the well-established fixed-dose combination of Amlodipine/Valsartan (A/V). The study conducted between October 2018 and August 2020. One hundred and two hypertensive patients were assigned for Amlodipine 10 mg/Valsartan 160 mg combination therapy (A/V, n = 52) or Amlodipine 10 mg/Nebivolol 5 mg combination therapy (A/N, n = 50) by simple 1:1 randomization. Office, central blood pressure and PWV were measured on first (0 week), second (4-8 weeks) and third visit (10-12). Difference in BP (in each arm and between arms) was calculated along all visits. Results: No statistical significant difference was found between A/V and A/N regarding age, gender, BMI and CV history. OBP, CBP and PWV were significantly reduced in each arm, but no differences were found when comparing both arm results to each other. Recorded side effects were insignificant. Conclusions: The new combination therapy Amlodipine/Nebivolol (A/N) affords a significant reduction in CBP, PBP and PWV with minor and tolerable side effects. It has provided comparable results to Amlodipine/Valsartan (A/V) combination therapy.
Language	English
Publishing date	2022-03-14
Publishing country	Germany
Document type	Journal Article
ISSN	2090-911X
ISSN (online)	2090-911X
DOI	10.1186/s43044-022-00254-0
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Article ; Online: Effect of Fixed-dose Combination Amlodipine/Valsartan in Comparison to Two Drug Combination Nebivolol/Valsartan on 24-Hour Ambulatory Blood Pressure.

Hanna, Selvia M / Rabea, Hoda M / Abdelrahim, Mohamed E A / Mahmoud, Hesham B

Current hypertension reviews

2023 Volume 19, Issue 2, Page(s) 123–129

Abstract: Background: Nebivolol has a dual mechanism of action, exerting a moderate b- blockade effect and reducing peripheral arterial resistance, as a result, the antihypertensive effect of nebivolol may be higher than that of a potent vasodilator CCB such as ... ...

Abstract	Background: Nebivolol has a dual mechanism of action, exerting a moderate b- blockade effect and reducing peripheral arterial resistance, as a result, the antihypertensive effect of nebivolol may be higher than that of a potent vasodilator CCB such as amlodipine. Aim: The study evaluated the effect of two nebivolol/valsartan on 24 hour ambulatory blood pressure versus amlodipine/valsartan in grade II or III hypertension patients or having uncontrolled BP despite treatment. Ambulatory blood pressure monitoring is a powerful method to monitor the changes in blood pressure over the 24 hour. Materials and methods: A total of 74 from 90 patients continued the study. Fourty patients received amlodipine 10 mg/valsartan 160 mg (group I), and thirty-four patients received nebivolol 5 mg/ valsartan 160 mg (group II). Peripheral blood pressure readings were measured at randomization at 6 and 12 weeks. Ambulatory blood pressure was measured at randomization and 12 weeks. Results: Both drug combinations showed high efficacy in reducing peripheral and 24 hour ambulatory BP. There was no statistically significant difference between the groups in lowering peripheral systolic and diastolic blood pressure at 6 and 12 weeks. Furthermore, both groups failed to show any significant difference in reducing 24 hour SBP and DBP. Regarding day SBP, the blood pressure dropped by -5.63 ± 14.87 in group I and -6.25 ± 11.59 in group II (p = 0.844). Also, group I reduced the day DBP average by -2.53 ± 9.83 and group II by -3.61 ± 9.78 (p = 0.640). In addition, both drug combinations had no statistically significant difference in lowering night SBP and DBP average. Conclusion: Both treatment groups reached the target ambulatory blood pressure, and there was no statistically significant difference between both groups as a regard reduction in all ambulatory blood pressure readings.
MeSH term(s)	Humans ; Amlodipine/pharmacology ; Antihypertensive Agents/pharmacology ; Blood Pressure ; Blood Pressure Monitoring, Ambulatory ; Drug Combinations ; Hypertension/diagnosis ; Hypertension/drug therapy ; Nebivolol/pharmacology ; Tetrazoles/pharmacology ; Treatment Outcome ; Valine/pharmacology ; Valine/therapeutic use ; Valsartan/pharmacology ; Valsartan/therapeutic use
Chemical Substances	Amlodipine (1J444QC288) ; Antihypertensive Agents ; Drug Combinations ; Nebivolol (030Y90569U) ; Tetrazoles ; Valine (HG18B9YRS7) ; Valsartan (80M03YXJ7I)
Language	English
Publishing date	2023-08-01
Publishing country	United Arab Emirates
Document type	Journal Article
ISSN	1875-6506
ISSN (online)	1875-6506
DOI	10.2174/1573402119666230330082128
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Article ; Online: Early Cost-Utility Analysis of Ataluren and Eteplirsen in the Treatment of Duchenne Muscular Dystrophy in Egypt.

Shehata, Zahraa / Metry, Andrew / Rabea, Hoda / El Sherif, Rasha / Abdelrahim, Mohamed / Dawoud, Dalia

Value in health regional issues

2023 Volume 38, Page(s) 109–117

Abstract: Objectives: Ataluren and eteplirsen are orphan drugs that delay progression of Duchenne muscular dystrophy in mutation-specific subgroups. They have yet to be approved in Egypt but are expected to reach the market soon. This study describes 2 cost- ... ...

Abstract	Objectives: Ataluren and eteplirsen are orphan drugs that delay progression of Duchenne muscular dystrophy in mutation-specific subgroups. They have yet to be approved in Egypt but are expected to reach the market soon. This study describes 2 cost-utility models comparing the drugs with the standard of care. Methods: We used a partition-survival model with 5 states based on the ambulatory status to model a cohort of ambulatory patients at the age of 5 years. Baseline curves were obtained from a published model; then the ambulation loss curve was updated using the Kaplan-Meier curve of the standard of care from a study by McDonald et al. Other curves were updated by calibration to this curve. Costs and utilities were from a local study. Deterministic and probabilistic sensitivity analyses were conducted. Prices were estimated based on other orphan drugs' prices. Results: In the base case, ataluren 1000 mg and eteplirsen 50 mg/mL resulted in an incremental cost-effectiveness ratio of EGP 51 745 605 and EGP 69 652 533/quality-adjusted life-year, respectively, at their hypothetical prices of EGP 308 600 for ataluren 30-sachet pack and EGP 62 800 for eteplirsen 10 mL vial. The incremental cost-effectiveness ratio was sensitive to health state utilities but not to state costs. At EGP 911 719/quality-adjusted life-year threshold, the value-based prices were EGP 4680 for ataluren 1000 mg and EGP 733 for eteplirsen 10 mL vial. Conclusions: Based on these models, there is a huge gap between the prices of orphan drugs and their value-based prices, which highlights the need for major policy reforms in the assessment and pricing of orphan drugs.
MeSH term(s)	Humans ; Child, Preschool ; Muscular Dystrophy, Duchenne/drug therapy ; Cost-Benefit Analysis ; Egypt
Chemical Substances	eteplirsen (AIW6036FAS) ; ataluren (K16AME9I3V)
Language	English
Publishing date	2023-10-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2679127-4
ISSN	2212-1102 ; 2212-1099
ISSN (online)	2212-1102
ISSN	2212-1099
DOI	10.1016/j.vhri.2023.08.004
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Article ; Online: Estimating Societal Cost of Illness and Patients' Quality of Life of Duchenne Muscular Dystrophy in Egypt.

Shehata, Zahraa Hassan / Rabea, Hoda / El Sherif, Rasha / Abdelrahim, Mohamed E / Dawoud, Dalia M

Value in health regional issues

2022 Volume 33, Page(s) 10–16

Abstract: Objectives: Duchenne muscular dystrophy (DMD) is a rare neuromuscular disease that causes substantial economic burden. This study aims to measure the DMD cost from societal perspective and the quality of life (QOL) of the Egyptian patients.: Methods: ...

Abstract	Objectives: Duchenne muscular dystrophy (DMD) is a rare neuromuscular disease that causes substantial economic burden. This study aims to measure the DMD cost from societal perspective and the quality of life (QOL) of the Egyptian patients. Methods: We conducted interviews with caregivers of patients with DMD. The questionnaire included demographics, healthcare resource use, and nonmedical and indirect costs. Total disease burden was estimated with a bottom-up approach. QOL was measured with a disease-specific tool. Costs and utilities were stratified by the disease stage. Results: Caregivers of 97 patients with DMD were interviewed. The mean annual per-patient cost of $17 485 (SD ± 9240) was estimated resulting in a total burden of $138 217 043 in Egypt. Nonmedical costs made up the largest category representing 54% followed by medical then indirect costs. Informal care made the greatest contribution of nonmedical costs whereas physiotherapy was the largest medical subcategory. Nonmedical costs were highest in stage 3 and lowest at early stages whereas medical costs were almost steady among all stages with differences in individual subcategories. Of all medical costs, 95% were out of pocket. The mean utility score was 0.43 (± 0.31), which decreases with disease progression. Conclusion: Our study quantified the huge economic burden of DMD on the society and how it differs in different stages. Almost the whole burden is paid by households resulting in catastrophic expenditures, which leads to reduced compliance and quality of care. QOL is also severely compromised. Our findings can inform future healthcare policies and economic evaluation of new DMD therapies.
Language	English
Publishing date	2022-09-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2679127-4
ISSN	2212-1102 ; 2212-1099
ISSN (online)	2212-1102
ISSN	2212-1099
DOI	10.1016/j.vhri.2022.08.006
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Article ; Online: Application of different counseling strategies for better adult asthma control.

Mohamed, Basma M E / Laz, Nabila / Saeed, Haitham / Alghamdi, Saleh / AbdElrahman, Mohamed / Abdelrahim, Mohamed E A / Rabea, Hoda

The Journal of asthma : official journal of the Association for the Care of Asthma

2023 , Page(s) 1–8

Abstract: Objective: We aimed to compare the effectiveness of three distinct counseling methods to determine the most effective approach.: Methods: In this prospective cohort study with a two-month follow-up, A group of non-smoking adults, aged 19-60 years, ... ...

Abstract	Objective: We aimed to compare the effectiveness of three distinct counseling methods to determine the most effective approach. Methods: In this prospective cohort study with a two-month follow-up, A group of non-smoking adults, aged 19-60 years, were randomly collected at outpatients clinic with prior asthma diagnosis, based on the forced expiratory volume in one seconds to forced vital capacity ratio (FEV1/FVC) and the guidelines outlined by the Global Initiative for Asthma (GINA), At the baseline assessment, all patients, underwent FEV1/FVC measurements, asthma symptom evaluations using Asthma Control Test (ACT), Asthma Control Questionnaire (ACQ), and GINA symptoms control assessment questionnaire, and assessment of pressurized metered-dose inhaler (pMDI) usage. The patients were divided into three groups, each assigned a distinct counseling strategy: traditional verbal counseling, advanced counseling utilizing the Asthma smartphone-application, and a combination of advanced-verbal counseling. We conducted a two-month monitoring period for all three groups. Results: Significant differences ( Conclusion: The study findings indicate that the combining advanced-verbal counseling by incorporating the Asthma smartphone-application alongside traditional verbal counseling is a more effective approach for improving asthma control in adults.
Language	English
Publishing date	2023-12-28
Publishing country	England
Document type	Journal Article
ZDB-ID	603816-5
ISSN	1532-4303 ; 0277-0903
ISSN (online)	1532-4303
ISSN	0277-0903
DOI	10.1080/02770903.2023.2300709
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Article ; Online: First-time handling of different inhalers by chronic obstructive lung disease patients.

Harb, Hadeer S / Laz, Nabila Ibrahim / Rabea, Hoda / Abdelrahim, Mohamed E A

Experimental lung research

2020 Volume 46, Issue 7, Page(s) 258–269

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Administration, Inhalation ; Asthma/drug therapy ; Bronchodilator Agents/administration & dosage ; Cross-Over Studies ; Dry Powder Inhalers/instrumentation ; Female ; Humans ; Male ; Metered Dose Inhalers ; Middle Aged ; Pulmonary Disease, Chronic Obstructive/drug therapy
Chemical Substances	Bronchodilator Agents
Language	English
Publishing date	2020-07-02
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	603791-4
ISSN	1521-0499 ; 0190-2148
ISSN (online)	1521-0499
ISSN	0190-2148
DOI	10.1080/01902148.2020.1789903
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Article ; Online: Prevalence and predictors of suboptimal peak inspiratory flow rate in COPD patients.

Harb, Hadeer S / Laz, Nabila Ibrahim / Rabea, Hoda / Abdelrahim, Mohamed E A

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

2020 Volume 147, Page(s) 105298

Abstract: The aim of this study was to determine prevalence and possible clinical predictors of suboptimal peak inspiratory flow rate (PIFR) with different dry powder inhalers. PIFR was measured across all resistance ranges of In-Check Dial® in 180 chronic ... ...

Abstract	The aim of this study was to determine prevalence and possible clinical predictors of suboptimal peak inspiratory flow rate (PIFR) with different dry powder inhalers. PIFR was measured across all resistance ranges of In-Check Dial® in 180 chronic obstructive pulmonary disease (COPD) subjects before hospital discharge. COPD subjects were defined as suboptimal if measured PIFR was suboptimal with any resistance representative of specific inhalers (R1-R5). Demographics and clinical data were collected, including COPD Assessment Test (CAT) and modified Medical Research Council (mMRC) scores, Global Initiative for Obstructive Lung Disease (GOLD) stage spirometry by Spirodoc® and peak flow meter measurements with portable peak inspiratory and expiratory flow meters. All were correlated with In-Check Dial PIFRs. Suboptimal PIFR was 44.44% prevalent in COPD subjects. 55% of the suboptimal cohort was female which represent 57.14% of the total female population in the study. The distribution of suboptimal PIFR included 43.75% with R1, 67.5% with R2, 100% with R3, 13.75% with R4, and 21.25% with R5. In the suboptimal cohort, CAT score was significantly higher and spirometry demonstrated significantly lower lung function results compared to the optimal cohort (p < 0.05). The only parameter to show strong and moderate correlation with In-Check Dial PIFRs was PIFR measured by peak flow meter (p < 0.001). Suboptimal PIFR is common among COPD subjects at hospital discharge. Female gender and peak flow meter PIFR was the only predictor of suboptimal PIFR. Inhaler therapy for COPD patients must be personalized based on simple routine measurement of In-Check Dial PIFRs or peak flow meter PIFR to optimize clinical benefits .
MeSH term(s)	Administration, Inhalation ; Adult ; Aged ; Aged, 80 and over ; Airway Resistance ; Cohort Studies ; Cross-Sectional Studies ; Drug Delivery Systems/methods ; Dry Powder Inhalers/instrumentation ; Female ; Humans ; Inhalation ; Inspiratory Capacity/physiology ; Lung/drug effects ; Male ; Middle Aged ; Peak Expiratory Flow Rate ; Powders/administration & dosage ; Prevalence ; Prospective Studies ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Sex Factors ; Spirometry ; Vital Capacity/physiology
Chemical Substances	Powders
Language	English
Publishing date	2020-03-06
Publishing country	Netherlands
Document type	Journal Article ; Observational Study
ZDB-ID	1154366-8
ISSN	1879-0720 ; 0928-0987
ISSN (online)	1879-0720
ISSN	0928-0987
DOI	10.1016/j.ejps.2020.105298
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