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  1. Article: Experimental evaluation of inactivated and live attenuated vaccines against Mycoplasma mycoides subsp. mycoides

    Mwirigi, Martin / Andrew Potter / Emil Berberov / Hezron Wesonga / Horace Ochanda / Isabel Nkando / Jan Naessens / Jose Perez-Casal / Racheal Aye / Reuben Soi / Volker Gerdts

    Veterinary immunology and immunopathology. 2016 Jan., v. 169

    2016  

    Abstract: The current control method for contagious bovine pleuropneumonia (CBPP) in Africa is vaccination with a live, attenuated strain of Mycoplasma mycoides subsp. mycoides (Mmm). However, this method is not very efficient and often causes serious adverse ... ...

    Abstract The current control method for contagious bovine pleuropneumonia (CBPP) in Africa is vaccination with a live, attenuated strain of Mycoplasma mycoides subsp. mycoides (Mmm). However, this method is not very efficient and often causes serious adverse reactions. Several studies have attempted to induce protection using inactivated mycoplasma, but with widely contradictory results. Therefore, we compared the protective capacity of the live T1/44 vaccine with two inactivated preparations of Mmm strain Afadé, inoculated with an adjuvant. Protection was measured after a challenge with Afadé. The protection levels were 31%, 80.8% and 74.1% for the formalin-inactivated, heat-inactivated and live attenuated preparations, respectively. These findings indicate that low doses of heat-inactivated Mmm can offer protection to a level similar to the current live attenuated (T1/44) vaccine formulation.
    Keywords adjuvants ; adverse effects ; contagious bovine pleuropneumonia ; control methods ; live vaccines ; Mycoplasma ; Mycoplasma mycoides subsp. mycoides ; vaccination ; Africa
    Language English
    Dates of publication 2016-01
    Size p. 63-67.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 754160-0
    ISSN 1873-2534 ; 0165-2427
    ISSN (online) 1873-2534
    ISSN 0165-2427
    DOI 10.1016/j.vetimm.2015.12.006
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: Atypical B cells are part of an alternative lineage of B cells that participates in responses to vaccination and infection in humans

    Henry J. Sutton / Racheal Aye / Azza H. Idris / Rachel Vistein / Eunice Nduati / Oscar Kai / Jedida Mwacharo / Xi Li / Xin Gao / T. Daniel Andrews / Marios Koutsakos / Thi H.O. Nguyen / Maxim Nekrasov / Peter Milburn / Auda Eltahla / Andrea A. Berry / Natasha KC / Sumana Chakravarty / B. Kim Lee Sim /
    Adam K. Wheatley / Stephen J. Kent / Stephen L. Hoffman / Kirsten E. Lyke / Philip Bejon / Fabio Luciani / Katherine Kedzierska / Robert A. Seder / Francis M. Ndungu / Ian A. Cockburn

    Cell Reports, Vol 34, Iss 6, Pp 108684- (2021)

    2021  

    Abstract: Summary: The diversity of circulating human B cells is unknown. We use single-cell RNA sequencing (RNA-seq) to examine the diversity of both antigen-specific and total B cells in healthy subjects and malaria-exposed individuals. This reveals two B cell ... ...

    Abstract Summary: The diversity of circulating human B cells is unknown. We use single-cell RNA sequencing (RNA-seq) to examine the diversity of both antigen-specific and total B cells in healthy subjects and malaria-exposed individuals. This reveals two B cell lineages: a classical lineage of activated and resting memory B cells and an alternative lineage, which includes previously described atypical B cells. Although atypical B cells have previously been associated with disease states, the alternative lineage is common in healthy controls, as well as malaria-exposed individuals. We further track Plasmodium-specific B cells after malaria vaccination in naive volunteers. We find that alternative lineage cells are primed after the initial immunization and respond to booster doses. However, alternative lineage cells develop an atypical phenotype with repeated boosts. The data highlight that atypical cells are part of a wider alternative lineage of B cells that are a normal component of healthy immune responses.
    Keywords B cell memory ; atypical B cells ; alternative B cell lineage ; malaria ; sporozoite ; vaccination ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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