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  1. AU="Rachel T Eguia"
  2. AU="Kaneetah, Abdulrahman H"
  3. AU="Hrvoje Miletic"
  4. AU="Hardick, Justin"
  5. AU="Peiris, Alan N"
  6. AU="Lei Ke"
  7. AU="Mian-Hua Cai"
  8. AU=Lanzerath Dirk
  9. AU=Cakir Murat
  10. AU="Ng, Frank"
  11. AU="Miley, D"
  12. AU=Dikken Dirk Jan W.
  13. AU="Nasehi, Nahal"
  14. AU="Arun Seth"
  15. AU="Woitok, Mira"
  16. AU="Amparo MoraguesauthorDpto. Ingeniera Civil: Construccin, E.T.S.I. de Caminos, Canales y Puertos, Universidad Politcnica de Madrid, C/ Profesor Aranguren 3, 28040 Madrid, Spain"
  17. AU="Guidry, Jessie"
  18. AU=Mitry Maria A.
  19. AU="Rhodes, Rosamond"
  20. AU="Gromova, Alexandra S"
  21. AU=Ockene Ira
  22. AU=Hirsch Daniela
  23. AU=Navaratnam Annalan MD
  24. AU="Johnson, Matthew Thomas"
  25. AU=Wagstaff Peter GK
  26. AU="Almahboub, Sarah A"
  27. AU="Tuana Aksu"
  28. AU="Bozin, Tonci"
  29. AU="Rachel Marie Towle"
  30. AU="Soriano-Ursúa, Marvin A"
  31. AU="Cagnin, A"
  32. AU="Ivens, Al C"
  33. AU="Juan Mucci"
  34. AU="Alejandro Hlavnika"
  35. AU="Makarenko V."

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  1. Artikel ; Online: A SARS-CoV-2 variant elicits an antibody response with a shifted immunodominance hierarchy.

    Allison J Greaney / Tyler N Starr / Rachel T Eguia / Andrea N Loes / Khadija Khan / Farina Karim / Sandile Cele / John E Bowen / Jennifer K Logue / Davide Corti / David Veesler / Helen Y Chu / Alex Sigal / Jesse D Bloom

    PLoS Pathogens, Vol 18, Iss 2, p e

    2022  Band 1010248

    Abstract: Many SARS-CoV-2 variants have mutations at key sites targeted by antibodies. However, it is unknown if antibodies elicited by infection with these variants target the same or different regions of the viral spike as antibodies elicited by earlier viral ... ...

    Abstract Many SARS-CoV-2 variants have mutations at key sites targeted by antibodies. However, it is unknown if antibodies elicited by infection with these variants target the same or different regions of the viral spike as antibodies elicited by earlier viral isolates. Here we compare the specificities of polyclonal antibodies produced by humans infected with early 2020 isolates versus the B.1.351 variant of concern (also known as Beta or 20H/501Y.V2), which contains mutations in multiple key spike epitopes. The serum neutralizing activity of antibodies elicited by infection with both early 2020 viruses and B.1.351 is heavily focused on the spike receptor-binding domain (RBD). However, within the RBD, B.1.351-elicited antibodies are more focused on the "class 3" epitope spanning sites 443 to 452, and neutralization by these antibodies is notably less affected by mutations at residue 484. Our results show that SARS-CoV-2 variants can elicit polyclonal antibodies with different immunodominance hierarchies.
    Schlagwörter Immunologic diseases. Allergy ; RC581-607 ; Biology (General) ; QH301-705.5
    Sprache Englisch
    Erscheinungsdatum 2022-02-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: A human coronavirus evolves antigenically to escape antibody immunity.

    Rachel T Eguia / Katharine H D Crawford / Terry Stevens-Ayers / Laurel Kelnhofer-Millevolte / Alexander L Greninger / Janet A Englund / Michael J Boeckh / Jesse D Bloom

    PLoS Pathogens, Vol 17, Iss 4, p e

    2021  Band 1009453

    Abstract: There is intense interest in antibody immunity to coronaviruses. However, it is unknown if coronaviruses evolve to escape such immunity, and if so, how rapidly. Here we address this question by characterizing the historical evolution of human coronavirus ...

    Abstract There is intense interest in antibody immunity to coronaviruses. However, it is unknown if coronaviruses evolve to escape such immunity, and if so, how rapidly. Here we address this question by characterizing the historical evolution of human coronavirus 229E. We identify human sera from the 1980s and 1990s that have neutralizing titers against contemporaneous 229E that are comparable to the anti-SARS-CoV-2 titers induced by SARS-CoV-2 infection or vaccination. We test these sera against 229E strains isolated after sera collection, and find that neutralizing titers are lower against these "future" viruses. In some cases, sera that neutralize contemporaneous 229E viral strains with titers >1:100 do not detectably neutralize strains isolated 8-17 years later. The decreased neutralization of "future" viruses is due to antigenic evolution of the viral spike, especially in the receptor-binding domain. If these results extrapolate to other coronaviruses, then it may be advisable to periodically update SARS-CoV-2 vaccines.
    Schlagwörter Immunologic diseases. Allergy ; RC581-607 ; Biology (General) ; QH301-705.5
    Sprache Englisch
    Erscheinungsdatum 2021-04-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

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