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  1. AU="Rachidi, Saleh"
  2. AU="Baptista Serna, L" AU="Baptista Serna, L"
  3. AU=Fiandaca Massimo S
  4. AU="Belli, Sara"
  5. AU="Capogiri, Monica"
  6. AU="Al-Hattab, Eyad"
  7. AU="Hou, Tsung-Wei"
  8. AU="Meng, Ying Shirley"
  9. AU="Emanuele Rezoagli"
  10. AU="Verhagen, M A M T"
  11. AU="Haden, Kathleen"
  12. AU="Lee, Ju Yup"
  13. AU="Camilla Caimi"
  14. AU="Huynh, Nancy"
  15. AU="Sun, Weilin"
  16. AU="Whalon, Mark E."
  17. AU=Grishunin Kirill
  18. AU="Quaranta, Gianluigi"
  19. AU="Jitaroon, Kawinyarat"
  20. AU="Anderson, Eric C"
  21. AU="Thiyagarajan, Kamalraj"
  22. AU="Simnica, Donjetë"

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  1. Artikel ; Online: Platelet count correlates with stage and predicts survival in melanoma.

    Rachidi, Saleh / Kaur, Maneet / Lautenschlaeger, Tim / Li, Zihai

    Platelets

    2019  Band 30, Heft 8, Seite(n) 1042–1046

    Abstract: Cancer is a chronic inflammatory state which is often associated with increased platelet counts. Cancer cells induce thrombopoiesis and activate platelets, which in turn facilitate cancer invasion and metastasis. In this study, we investigate the ... ...

    Abstract Cancer is a chronic inflammatory state which is often associated with increased platelet counts. Cancer cells induce thrombopoiesis and activate platelets, which in turn facilitate cancer invasion and metastasis. In this study, we investigate the correlation between platelet counts with each of stage and overall survival in melanoma. This is a retrospective cohort study of 642 melanoma patients diagnosed or treated at a tertiary medical center between 2000 and 2016. Multivariable analysis adjusted for age, sex, stage, and treatment modality. Using multivariable analysis, patients with thrombocytosis around time of diagnosis were more likely to present with distant metastasis (Prevalence Ratio 3.5, 95% CI 2.35-5.22). In patients with metastatic disease and in all stages combined, thrombocytosis predicted decreased 5-year overall survival in univariate and multivariable analysis, and this was most pronounced during the first year after diagnosis. Finally, we show that mice with thrombocytopenia due to the lack of heat shock protein gp96 in their megakaryocytes are protected from melanoma dissemination to the lungs. These findings are concordant with preclinical studies showing a role for platelets in cancer metastasis and suppression of antitumor immunity, further supporting targeting platelets as an adjuvant to immunotherapy in melanoma.
    Mesh-Begriff(e) Female ; Humans ; Male ; Melanoma/blood ; Melanoma/mortality ; Middle Aged ; Neoplasm Staging ; Platelet Count/methods ; Prognosis ; Survival Rate
    Sprache Englisch
    Erscheinungsdatum 2019-02-13
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1034283-7
    ISSN 1369-1635 ; 0953-7104
    ISSN (online) 1369-1635
    ISSN 0953-7104
    DOI 10.1080/09537104.2019.1572879
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  2. Artikel ; Online: Shorter survival and later stage at diagnosis among unmarried patients with cutaneous melanoma: A US national and tertiary care center study.

    Rachidi, Saleh / Deng, Zhengyi / Sullivan, Danielle Y / Lipson, Evan J

    Journal of the American Academy of Dermatology

    2020  Band 83, Heft 4, Seite(n) 1012–1020

    Abstract: Background: Addressing risk factors of delayed melanoma detection minimizes disparities in outcome.: Objective: To elucidate the significance of marital status in melanoma outcomes across anatomic sites.: Methods: Retrospective cohort study of 73, ... ...

    Abstract Background: Addressing risk factors of delayed melanoma detection minimizes disparities in outcome.
    Objective: To elucidate the significance of marital status in melanoma outcomes across anatomic sites.
    Methods: Retrospective cohort study of 73,558 patients from the Surveillance, Epidemiology, and End Results (SEER) program and 2992 patients at Johns Hopkins University. Patients were stratified by marital status, anatomic site, age, and sex. Endpoints were prevalence of advanced melanoma (stages III or IV) and survival.
    Results: In the SEER cohort, single patients were more likely than married patients to present in stages III or IV among both men (prevalence ratio [PR], 1.45; 95% confidence interval [CI], 1.37-1.53) and women (PR, 1.28; 95% confidence interval, 1.18-1.39). This trend was consistent across all anatomic sites and in all age groups, particularly in those 18 to 68 years old. Overall and cancer-specific survival times were shorter in unmarried patients. Similarly, at Johns Hopkins, single patients had increased prevalence of advanced melanoma (PR, 1.54; 95% CI, 1.21-1.94) and experienced shorter overall survival (hazard ratio, 1.51; 95% CI, 1.15-1.99).
    Limitations: The anatomic sites were not very specific, and this was a retrospective study.
    Conclusions: Unmarried patients, especially men and those younger than 68 years, are diagnosed at more advanced stages, even in readily visible sites such as the face. They also experience worse survival independent of stage.
    Mesh-Begriff(e) Adult ; Age Factors ; Aged ; Aged, 80 and over ; Delayed Diagnosis ; Female ; Humans ; Male ; Marital Status/statistics & numerical data ; Melanoma/diagnosis ; Melanoma/epidemiology ; Melanoma/pathology ; Middle Aged ; Neoplasm Staging ; Prevalence ; Retrospective Studies ; SEER Program ; Sex Factors ; Skin Neoplasms/diagnosis ; Skin Neoplasms/epidemiology ; Skin Neoplasms/pathology ; Survival Rate ; Tertiary Care Centers ; United States ; Young Adult
    Sprache Englisch
    Erscheinungsdatum 2020-05-21
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/j.jaad.2020.05.088
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Demographic factors associated with missed follow-up among solid tumor patients treated at a large multi-site academic institution.

    Freije, Samantha L / Holmes, Jordan A / Rachidi, Saleh / Ellsworth, Susannah G / Zellars, Richard C / Lautenschlaeger, Tim

    Future oncology (London, England)

    2020  Band 16, Heft 32, Seite(n) 2635–2643

    Abstract: Aim: ...

    Abstract Aim:
    Mesh-Begriff(e) Continental Population Groups/statistics & numerical data ; Demography ; Female ; Health Care Surveys ; Healthcare Disparities ; Humans ; Male ; Medicaid ; Neoplasms/diagnosis ; Neoplasms/epidemiology ; Neoplasms/therapy ; United States
    Sprache Englisch
    Erscheinungsdatum 2020-09-25
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2274956-1
    ISSN 1744-8301 ; 1479-6694
    ISSN (online) 1744-8301
    ISSN 1479-6694
    DOI 10.2217/fon-2020-0425
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  4. Artikel ; Online: Postdiagnosis aspirin use and overall survival in patients with melanoma.

    Rachidi, Saleh / Wallace, Kristin / Li, Hong / Lautenschlaeger, Tim / Li, Zihai

    Journal of the American Academy of Dermatology

    2018  Band 78, Heft 5, Seite(n) 949–956.e1

    Abstract: Background: Mouse studies show that tumor-derived prostaglandins and platelets promote melanoma progression and immune evasion.: Objective: Determine whether aspirin confers longer survival in patients with melanoma.: Methods: A retrospective ... ...

    Abstract Background: Mouse studies show that tumor-derived prostaglandins and platelets promote melanoma progression and immune evasion.
    Objective: Determine whether aspirin confers longer survival in patients with melanoma.
    Methods: A retrospective cohort study of 1522 patients at Indiana University Health who had melanoma diagnosed between 2000 and 2014 and were followed up through September 2016.
    Results: Aspirin use was associated with longer overall survival in univariate analysis and after controlling for age, sex, stage, and treatment modalities (hazard ratio [HR], 0.58; 95% confidence interval [CI], 0.45-0.75). Aspirin use was not associated with survival in patients with in situ and stage I melanoma but was associated with better survival in stages II (HR, 0.45; 95% CI, 0.24-0.82) and III (HR, 0.57; 95% CI; 0.34-0.96). No statistical significance was observed in stage IV patients (HR, 0.55; 95% CI, 0.27-1.13). In turn, melanoma in patients using aspirin before diagnosis was less likely to be diagnosed in stages III or IV.
    Limitations: Observational study.
    Conclusions: Aspirin could provide a survival advantage in melanoma. Clinical trials investigating the therapeutic potential of aspirin are warranted.
    Mesh-Begriff(e) Academic Medical Centers ; Adult ; Aged ; Analysis of Variance ; Aspirin/therapeutic use ; Cohort Studies ; Confidence Intervals ; Disease-Free Survival ; Female ; Humans ; Indiana ; Male ; Melanoma/diagnosis ; Melanoma/drug therapy ; Melanoma/mortality ; Middle Aged ; Neoplasm Invasiveness/pathology ; Neoplasm Staging ; Proportional Hazards Models ; Reference Values ; Retrospective Studies ; Skin Neoplasms/diagnosis ; Skin Neoplasms/drug therapy ; Skin Neoplasms/mortality ; Survival Analysis ; Treatment Outcome
    Chemische Substanzen Aspirin (R16CO5Y76E)
    Sprache Englisch
    Erscheinungsdatum 2018-01-06
    Erscheinungsland United States
    Dokumenttyp Comparative Study ; Journal Article ; Observational Study
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/j.jaad.2017.12.076
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Preoperative platelet counts and postoperative outcomes in cancer surgery: a multicenter, retrospective cohort study.

    Rachidi, Saleh / Li, Hong / Wallace, Kristin / Li, Zihai / Balch, Charles / Lautenschlaeger, Tim

    Platelets

    2019  Band 31, Heft 1, Seite(n) 79–87

    Abstract: Platelets play roles in malignancy, wound healing, and immunity. Nevertheless, their significance in postoperative outcomes is not established. This is a retrospective cohort study of 100,795 patients undergoing cancer surgery in 2010 and 2014 in >500 ... ...

    Abstract Platelets play roles in malignancy, wound healing, and immunity. Nevertheless, their significance in postoperative outcomes is not established. This is a retrospective cohort study of 100,795 patients undergoing cancer surgery in 2010 and 2014 in >500 hospitals. Patients were stratified into five groups based on preoperative platelet counts. Multivariable logistic regression was used to determine the risk of 30-day mortality, morbidities, readmission, and prolonged hospitalization using the mid-normal group as a reference. We adjusted for demographic variables, comorbidities, and operation complexity. In the 2014 cohort, multivariable analysis showed that mortality was higher in patients with thrombocytopenia (OR 1.49, 95% CI [1.23-1.81]), high-normal platelets (OR 1.29, [1.06-1.55]), and thrombocytosis (OR 1.78, [1.45-2.19]). Composite postoperative morbidity followed a similar trend with thrombocytopenia (OR 1.34, [1.25-1.43]), high-normal counts (OR 1.41, [1.33-1.49]), and thrombocytosis (OR 2.20, [2.05-2.36]). Concordantly, the risks of prolonged hospitalization and 30-day readmission followed the same pattern. These results were validated in a large colon cancer cohort from the 2010 database. In conclusion, platelet count is a prognostic indicator in cancer surgeries. This could be related to the role of platelets in wound healing and immunity on one hand, and propagating malignancy on the other.
    Mesh-Begriff(e) Adult ; Aged ; Aged, 80 and over ; Biomarkers ; Comorbidity ; Female ; Hospitalization ; Humans ; Male ; Middle Aged ; Morbidity ; Neoplasms/blood ; Neoplasms/mortality ; Neoplasms/surgery ; Perioperative Period ; Platelet Count ; Prognosis ; Retrospective Studies
    Chemische Substanzen Biomarkers
    Sprache Englisch
    Erscheinungsdatum 2019-02-11
    Erscheinungsland England
    Dokumenttyp Journal Article ; Multicenter Study
    ZDB-ID 1034283-7
    ISSN 1369-1635 ; 0953-7104
    ISSN (online) 1369-1635
    ISSN 0953-7104
    DOI 10.1080/09537104.2019.1573977
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Endoplasmic reticulum heat shock protein gp96/grp94 is a pro-oncogenic chaperone, not a tumor suppressor.

    Rachidi, Saleh / Sun, Shaoli / Li, Zihai

    Hepatology (Baltimore, Md.)

    2015  Band 61, Heft 5, Seite(n) 1766–1767

    Mesh-Begriff(e) Animals ; Carcinogenesis/genetics ; Humans ; Liver Neoplasms, Experimental/genetics ; Liver Neoplasms, Experimental/pathology ; Membrane Glycoproteins/genetics ; Neoplastic Stem Cells/physiology
    Chemische Substanzen Membrane Glycoproteins
    Sprache Englisch
    Erscheinungsdatum 2015-03-23
    Erscheinungsland United States
    Dokumenttyp Letter ; Comment
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1002/hep.27400
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  7. Artikel: Intramuscular myxoma of the paraspinal muscles: A case report and systematic review of the literature.

    Rachidi, Saleh / Sood, Amit J / Rumboldt, Tihana / Day, Terry A

    Oncology letters

    2015  Band 11, Heft 1, Seite(n) 466–470

    Abstract: Intramuscular myxoma (IM) is a rare mesenchymal tumor of the head and neck region. The current study reports a case of a 45-year-old man who presented with a painless neck mass. Imaging showed involvement of the levator scapulae and scalene muscles. Core ...

    Abstract Intramuscular myxoma (IM) is a rare mesenchymal tumor of the head and neck region. The current study reports a case of a 45-year-old man who presented with a painless neck mass. Imaging showed involvement of the levator scapulae and scalene muscles. Core needle biopsy was consistent with intramuscular myxoma. Surgical excision was performed and follow-up for 30 months showed no recurrence. The present study includes a systematic review of head and neck IMs, with a summary of the clinical and demographic parameters of all reported cases in the head and neck region. Surgery was curative in 28 of the 29 published cases, as well as in the current case (96.7%), with the lone recurrent tumor cured following re-resection. Females constituted 57% of the cases and the mean age was 49.7±20.4 years. Although uncommon, IM should be considered in the differential diagnosis of deep neck masses, and surgical excision is the treatment of choice with a low risk of recurrence.
    Sprache Englisch
    Erscheinungsdatum 2015-11-05
    Erscheinungsland Greece
    Dokumenttyp Journal Article
    ZDB-ID 2573196-8
    ISSN 1792-1082 ; 1792-1074
    ISSN (online) 1792-1082
    ISSN 1792-1074
    DOI 10.3892/ol.2015.3864
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Topical timolol 0.5% gel-forming solution for erythema in rosacea: A quantitative, split-face, randomized, and rater-masked pilot clinical trial.

    Tsai, Jerry / Chien, Anna L / Kim, Noori / Rachidi, Saleh / Connolly, Brian M / Lim, Hester / Alessi César, Sabrina Sisto / Kang, Sewon / Garza, Luis A

    Journal of the American Academy of Dermatology

    2021  Band 85, Heft 4, Seite(n) 1044–1046

    Mesh-Begriff(e) Double-Blind Method ; Erythema/drug therapy ; Gels ; Humans ; Research Design ; Rosacea/drug therapy ; Timolol ; Treatment Outcome
    Chemische Substanzen Gels ; Timolol (817W3C6175)
    Sprache Englisch
    Erscheinungsdatum 2021-02-03
    Erscheinungsland United States
    Dokumenttyp Letter ; Randomized Controlled Trial
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/j.jaad.2021.01.098
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  9. Artikel ; Online: Neutrophil-to-lymphocyte ratio and overall survival in all sites of head and neck squamous cell carcinoma.

    Rachidi, Saleh / Wallace, Kristin / Wrangle, John M / Day, Terry A / Alberg, Anthony J / Li, Zihai

    Head & neck

    2016  Band 38 Suppl 1, Seite(n) E1068–74

    Abstract: Background: Current prognostic criteria are insufficient in predicting outcomes in head and neck cancer, necessitating new, readily available biomarkers.: Methods: Pretreatment neutrophil and lymphocyte counts and their ratio (NLR) were ... ...

    Abstract Background: Current prognostic criteria are insufficient in predicting outcomes in head and neck cancer, necessitating new, readily available biomarkers.
    Methods: Pretreatment neutrophil and lymphocyte counts and their ratio (NLR) were retrospectively investigated for correlation with overall survival while controlling for demographic and clinical confounders.
    Results: Patients in the highest tertile of neutrophil counts and those in the lowest tertile of lymphocytes experienced shorter survival than the rest of the population. Patients in the highest tertile of the NLR were at a higher risk compared with those in the lowest tertile after multivariate analysis (hazard ratio [HR] = 2.39; p = .0001). Additionally, NLR was lower in patients with human papillomavirus (HPV)-positive tumors compared to HPV-negative tumors and predicted survival in both tumor types.
    Conclusion: Neutrophil and lymphocyte counts are strong biomarkers with opposing prognostic significance and the NLR is a robust predictor of overall survival in oral, pharyngeal, and laryngeal squamous cell carcinomas. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1068-E1074, 2016.
    Sprache Englisch
    Erscheinungsdatum 2016-04
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 645165-2
    ISSN 1097-0347 ; 0148-6403 ; 1043-3074
    ISSN (online) 1097-0347
    ISSN 0148-6403 ; 1043-3074
    DOI 10.1002/hed.24159
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  10. Artikel ; Online: Platelet and hemoglobin count at diagnosis are associated with survival in African American and Caucasian patients with colorectal cancer.

    Wallace, Kristin / Li, Hong / Brazeal, J Grant / Lewin, David N / Sun, Shaoli / Ba, Aissatou / Paulos, Chrystal M / Rachidi, Saleh / Li, Zihai / Alekseyenko, Alexander V

    Cancer epidemiology

    2020  Band 67, Seite(n) 101746

    Abstract: Background: African Americans (AAs) compared to Caucasian Americans (CAs) with colorectal cancer (CRC) have lower stage-specific survival. CRC patients often present with several hematopathologies (such as thrombocytosis, thrombocytopenia, anemia) at ... ...

    Abstract Background: African Americans (AAs) compared to Caucasian Americans (CAs) with colorectal cancer (CRC) have lower stage-specific survival. CRC patients often present with several hematopathologies (such as thrombocytosis, thrombocytopenia, anemia) at diagnosis, which is associated with poorer survival. However, whether these measures impact the racial disparity in survival is not known.
    Methods: The study population was composed of 581 histologically confirmed CRCs at the Medical University of South Carolina (393 CA, 188 AA) diagnosed between 01/01/2000 and 06/30/2013. We used Cox proportional hazards regression to estimate the association between thrombocytosis, thrombocytopenia, or anemia at diagnosis and risk of death by race. This analysis was adjusted for age, sex, stage and first-line treatment.
    Results: In all patients combined, thrombocytosis, thrombocytopenia, and anemia (vs. the normal ranges) were associated with significantly higher risks of death. In the race-specific analyses, AAs (HR 2.51 [95 % CI: 1.52-4.15]) vs. CAs (HR 1.15 [95 % CI: 0.75-1.75]) with thrombocytosis compared to normal had a higher risk of death (p for difference = 0.03).
    Conclusions: Abnormal thrombocyte and hemoglobin levels at diagnosis were associated with poorer survival. AAs compared to CAs with elevated platelets at diagnosis had a higher risk of death. Our study is the first to examine the role of race, hematologic measures at diagnosis, and risk of death in colorectal cancer patients. These results suggest that the racial differences in the immune response may contribute to the racial disparity in survival.
    Mesh-Begriff(e) African Americans/statistics & numerical data ; Blood Platelets/pathology ; Colorectal Neoplasms/blood ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/mortality ; Colorectal Neoplasms/therapy ; Female ; Hemoglobins/analysis ; Humans ; Male ; Middle Aged ; Prognosis ; Survival Rate ; Whites/statistics & numerical data
    Chemische Substanzen Hemoglobins
    Sprache Englisch
    Erscheinungsdatum 2020-06-07
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2508729-0
    ISSN 1877-783X ; 1877-7821
    ISSN (online) 1877-783X
    ISSN 1877-7821
    DOI 10.1016/j.canep.2020.101746
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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