Article: Postmortem Neocortical
Frontiers in aging neuroscience
2021 Volume 13, Page(s) 728739
Abstract: Individuals with Down syndrome (DS) have a genetic predisposition for amyloid-β (Aβ) overproduction and earlier onset of Aβ deposits compared to patients with sporadic late-onset Alzheimer's disease (AD). Positron emission tomography (PET) with ... ...
| Abstract | Individuals with Down syndrome (DS) have a genetic predisposition for amyloid-β (Aβ) overproduction and earlier onset of Aβ deposits compared to patients with sporadic late-onset Alzheimer's disease (AD). Positron emission tomography (PET) with Pittsburgh Compound-B (PiB) detects fibrillar Aβ pathology in living people with DS and AD, but its relationship with heterogeneous Aβ forms aggregated within amyloid deposits is not well understood. We performed quantitative |
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| Language | English |
| Publishing date | 2021-08-13 |
| Publishing country | Switzerland |
| Document type | Journal Article |
| ZDB-ID | 2558898-9 |
| ISSN | 1663-4365 |
| ISSN | 1663-4365 |
| DOI | 10.3389/fnagi.2021.728739 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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