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  1. AU="Rackova, Sylva"
  2. AU="Jordan Denizeau"
  3. AU="Alexandra J. Corbett"
  4. AU="Felderman, Howard E"
  5. AU="Chen, Fuxing"
  6. AU="Soekadar, Surjo R"
  7. AU="Pagotto, Sara"
  8. AU="Dominguez, Georgina Cutillas"
  9. AU=Barabutis Nektarios
  10. AU="Rumalla, Kavelin"
  11. AU=Meares Gordon P.
  12. AU="Gawron, Lori M"
  13. AU=Guettari Moez
  14. AU=Ma Xingcong
  15. AU="Greene, Kerrie" AU="Greene, Kerrie"
  16. AU="Adebayo, Abe"
  17. AU=Amoako Yaw Ampem
  18. AU="Khanna, Sakshum"

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  1. Artikel ; Online: A Real-World Study on the Use of the Alcohol Use Disorders Identification Test (AUDIT) in Men Admitted to a Psychiatric Hospital.

    Anders, Martin / Kitzlerová, Eva / Racková, Sylva / Ćapek, Václav

    Medical science monitor : international medical journal of experimental and clinical research

    2021  Band 27, Seite(n) e929667

    Abstract: BACKGROUND This real-world study aimed to investigate the use of the Alcohol Use Disorders Identification Test (AUDIT) in men admitted to a psychiatric hospital. MATERIAL AND METHODS The AUDIT questionnaire (10 items) was consecutively administered for a ...

    Abstract BACKGROUND This real-world study aimed to investigate the use of the Alcohol Use Disorders Identification Test (AUDIT) in men admitted to a psychiatric hospital. MATERIAL AND METHODS The AUDIT questionnaire (10 items) was consecutively administered for a period of 3 years to male patients admitted to a psychiatric hospital (n=636). Laboratory blood tests of biochemical parameters were measured as biomarkers of alcohol consumption. Data were evaluated using linear models with mixed effects in the case of continuous dependent variables and logistic regression models with mixed effects in the case of categorical dependent variables. RESULTS We found that 45.3% of the patients had a high risk of alcohol consumption or alcohol dependence and 54.7% had a low risk of alcohol consumption. The ICD-10 diagnoses of alcohol-related disorders (F1x), psychotic disorders (F2x), affective disorders (F3x), neurotic and psychosomatic disorders (F4x) were statistically significantly associated with total AUDIT score (P<0.001). There was a statistically significant association between the total AUDIT score and length of hospitalization (P=0.004) and the incidence of suicidal thoughts (P=0.003). Plasma concentrations of alanine aminotransferase (P=0.005), aspartate aminotransferase (P<0.001), gamma glutamyltransferase (P=0.001), total cholesterol (P=0.027) and mean corpuscular value of erythrocytes (P<0.001) were statistically significantly increased with a higher AUDIT score. CONCLUSIONS This real-world study showed that the AUDIT questionnaire evaluated the severity of disorders caused by alcohol and their impact on comorbid mental disorders. These results may be helpful in improving targeted interventions in this group of patients.
    Mesh-Begriff(e) Adult ; Alcohol Drinking/epidemiology ; Alcoholism/diagnosis ; Alcoholism/epidemiology ; Biometry ; Czech Republic/epidemiology ; Hospitalization ; Hospitals, Psychiatric ; Humans ; Male ; Mass Screening ; Middle Aged ; Surveys and Questionnaires
    Sprache Englisch
    Erscheinungsdatum 2021-03-29
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1439041-3
    ISSN 1643-3750 ; 1234-1010
    ISSN (online) 1643-3750
    ISSN 1234-1010
    DOI 10.12659/MSM.929667
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Borna disease virus (BDV) circulating immunocomplex positivity in addicted patients in the Czech Republic

    Rackova Sylva / Janu Lubos / Kabickova Hana

    BMC Psychiatry, Vol 10, Iss 1, p

    a prospective cohort analysis

    2010  Band 70

    Abstract: Abstract Background Borna disease virus (BDV) is an RNA virus belonging to the family Bornaviridae. Borna disease virus is a neurotropic virus that causes changes in mood, behaviour and cognition. BDV causes persistent infection of the central nervous ... ...

    Abstract Abstract Background Borna disease virus (BDV) is an RNA virus belonging to the family Bornaviridae. Borna disease virus is a neurotropic virus that causes changes in mood, behaviour and cognition. BDV causes persistent infection of the central nervous system. Immune changes lead to activation of infection. Alcohol and drug dependence are associated with immune impairment. Methods We examined the seropositivity of BDV circulating immunocomplexes (CIC) in patients with alcohol and drug dependence and healthy individuals (blood donors). We examined 41 addicted patients for the presence of BDV CIC in the serum by ELISA at the beginning of detoxification, and after eight weeks of abstinence. This is the first such study performed in patients with alcohol and drug dependence. Results BDV CIC positivity was detected in 36.59% of addicted patients on day 0 and in 42.86% on day 56. The control group was 37.3% positive. However, we did not detect higher BDV CIC positivity in addicted patients in comparison with blood donors (p = 0.179). The significantly higher level of BDV CIC was associated with lower levels of GGT (gamma glutamyl transferase) (p = 0.027) and approached statistical significance with the lower age of addicted patients (p = 0.064). We did not find any association between BDV CIC positivity and other anamnestic and demographic characteristics. Conclusions In our study addicted patients did not have significantly higher levels of BDV CIC than the control group. The highest levels of BDV CIC were detected in patients with lower levels of GGT and a lower age. Trial registration This study was approved by the ethical committee of the University Hospital Medical Faculty of Charles University in Pilsen, Czech Republic (registration number 303/2001).
    Schlagwörter Psychiatry ; RC435-571 ; Neurology. Diseases of the nervous system ; RC346-429 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Psychiatry ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Thema/Rubrik (Code) 610 ; 616
    Sprache Englisch
    Erscheinungsdatum 2010-09-01T00:00:00Z
    Verlag BioMed Central
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel: Regional cerebellar metabolism (18FDG PET) predicts the clinical outcome of the short-term inpatient treatment of alcohol addiction.

    Janu, Lubos / Rackova, Sylva / Horacek, Jiri

    Neuro endocrinology letters

    2012  Band 33, Heft 4, Seite(n) 419–424

    Abstract: Objectives: The acute and maintenance treatment of alcohol addiction represents the clinical challenge. The aims of our study were to evaluate the influence of alcohol consumption on regional brain metabolism and the predictive value of PET by means of ... ...

    Abstract Objectives: The acute and maintenance treatment of alcohol addiction represents the clinical challenge. The aims of our study were to evaluate the influence of alcohol consumption on regional brain metabolism and the predictive value of PET by means of the duration and quality of remission which followed the sub-acute treatment.
    Methods: PET investigation with 18 fluoro-deoxyglucose (18FDG) were performed in detoxified patients with alcohol dependence at the end of short-term treatment. Abstinence was evaluated in patients during the one year follow-up period.
    Results: We detected the positive correlation between 18FDG uptake in the cerebellar vermis (FWE, p<0.05) and duration of abstinence within one year.
    Discussion: Our findings support the assumption that the cerebellum would be involved in the maintenance of abstinence in alcohol dependent subjects. Cerebellar connections with cortical areas critical for addiction such as frontal, parietal, temporal regions would mediate the influence of the cerebellum on emotional systems related to addiction.
    Conclusions: Our study is the first to document that the cerebellum and particularly the vermis is involved in the clinical outcome in terms of abstinence during one year. Our findings support the role of the cerebellum in addiction and the possibility to predict therapeutic outcome.
    Mesh-Begriff(e) Adult ; Alcohol Drinking/metabolism ; Alcoholism/metabolism ; Alcoholism/therapy ; Cerebellum/diagnostic imaging ; Cerebellum/metabolism ; Female ; Fluorodeoxyglucose F18/metabolism ; Humans ; Male ; Middle Aged ; Positron-Emission Tomography/methods ; Radiopharmaceuticals/metabolism ; Time Factors ; Treatment Failure ; Young Adult
    Chemische Substanzen Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Sprache Englisch
    Erscheinungsdatum 2012
    Erscheinungsland Sweden
    Dokumenttyp Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 135951-4
    ISSN 0172-780X
    ISSN 0172-780X
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Borna disease virus (BDV) circulating immunocomplex positivity in addicted patients in the Czech Republic: a prospective cohort analysis.

    Rackova, Sylva / Janu, Lubos / Kabickova, Hana

    BMC psychiatry

    2010  Band 10, Seite(n) 70

    Abstract: Background: Borna disease virus (BDV) is an RNA virus belonging to the family Bornaviridae. Borna disease virus is a neurotropic virus that causes changes in mood, behaviour and cognition. BDV causes persistent infection of the central nervous system. ... ...

    Abstract Background: Borna disease virus (BDV) is an RNA virus belonging to the family Bornaviridae. Borna disease virus is a neurotropic virus that causes changes in mood, behaviour and cognition. BDV causes persistent infection of the central nervous system. Immune changes lead to activation of infection. Alcohol and drug dependence are associated with immune impairment.
    Methods: We examined the seropositivity of BDV circulating immunocomplexes (CIC) in patients with alcohol and drug dependence and healthy individuals (blood donors). We examined 41 addicted patients for the presence of BDV CIC in the serum by ELISA at the beginning of detoxification, and after eight weeks of abstinence. This is the first such study performed in patients with alcohol and drug dependence.
    Results: BDV CIC positivity was detected in 36.59% of addicted patients on day 0 and in 42.86% on day 56. The control group was 37.3% positive. However, we did not detect higher BDV CIC positivity in addicted patients in comparison with blood donors (p = 0.179). The significantly higher level of BDV CIC was associated with lower levels of GGT (gamma glutamyl transferase) (p = 0.027) and approached statistical significance with the lower age of addicted patients (p = 0.064). We did not find any association between BDV CIC positivity and other anamnestic and demographic characteristics.
    Conclusions: In our study addicted patients did not have significantly higher levels of BDV CIC than the control group. The highest levels of BDV CIC were detected in patients with lower levels of GGT and a lower age.
    Trial registration: This study was approved by the ethical committee of the University Hospital Medical Faculty of Charles University in Pilsen, Czech Republic (registration number 303/2001).
    Mesh-Begriff(e) Adult ; Age Factors ; Aged ; Alcoholism/blood ; Alcoholism/immunology ; Antibodies, Viral/blood ; Antibodies, Viral/immunology ; Antigen-Antibody Complex/blood ; Antigen-Antibody Complex/immunology ; Antigens, Viral/blood ; Antigens, Viral/immunology ; Behavior, Addictive/blood ; Behavior, Addictive/immunology ; Blood Donors/statistics & numerical data ; Borna Disease/immunology ; Borna Disease/virology ; Borna disease virus/immunology ; Cohort Studies ; Czech Republic ; Female ; Humans ; Male ; Middle Aged ; Prospective Studies ; Substance-Related Disorders/blood ; Substance-Related Disorders/immunology
    Chemische Substanzen Antibodies, Viral ; Antigen-Antibody Complex ; Antigens, Viral
    Sprache Englisch
    Erscheinungsdatum 2010-09-08
    Erscheinungsland England
    Dokumenttyp Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1471-244X
    ISSN (online) 1471-244X
    DOI 10.1186/1471-244X-10-70
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Borna disease virus circulating immunocomplex positivity and psychopathology in psychiatric patients in the Czech Republic.

    Rackova, Sylva / Janu, Lubos / Kabickova, Hana

    Neuro endocrinology letters

    2009  Band 30, Heft 3, Seite(n) 414–420

    Abstract: Objectives: Borna disease virus (BDV) is an RNA virus belonging to the family Bornaviridae. BDV is a neurotropic virus that causes changes in mood, behaviour and cognition. Patients with psychiatric disorders have a higher incidence of BDV positivity ... ...

    Abstract Objectives: Borna disease virus (BDV) is an RNA virus belonging to the family Bornaviridae. BDV is a neurotropic virus that causes changes in mood, behaviour and cognition. Patients with psychiatric disorders have a higher incidence of BDV positivity than healthy individuals.
    Methods: We examined the seropositivity of BDV circulating immunocomplexes (CIC) in psychiatric patients and healthy individuals (blood donors). We examined 39 psychiatric inpatients for the presence of BDV CIC in the serum by ELISA on day 0, 28 and 56. During the same period psychopathology was measured using psychiatric scales (CGI, CGI-I, MADRS, SDS, PANSS). This is the first such study performed in the Czech Republic.
    Results: BDV CIC positivity was detected in 66.7% of psychiatric patients (26/39) on day 0, in 53.9% (14/26) on day 28 and in 52.9% on day 56 (9/17). The control group was 22.2% (28/126) positive. The incidence of BDV CIC was significantly higher in psychiatric patients than in healthy individuals (p=0.001). The significantly higher level of BDV CIC was associated with the higher severity of psychopathology in comparison with patients with mild or moderate psychopathology (p=0.03). We did not find any association between BDV CIC positivity and other characteristics (age, diagnosis, family, personal history, the history of infectious diseases, contact with animals).
    Conclusion: In our study psychiatric patients had significantly higher levels of BDV CIC than the control group. The highest levels of BDV CIC were detected in patients with more severe psychopathology.
    Mesh-Begriff(e) Adult ; Antibodies, Viral/blood ; Blood Donors ; Borna Disease/complications ; Borna Disease/virology ; Borna disease virus/metabolism ; Czech Republic ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Male ; Middle Aged ; Mood Disorders/complications ; Mood Disorders/psychology ; Mood Disorders/virology ; Psychiatric Status Rating Scales ; Psychotic Disorders/complications ; Psychotic Disorders/psychology ; Psychotic Disorders/virology ; RNA, Viral/analysis ; Schizophrenia/complications ; Schizophrenia/virology ; Schizophrenic Psychology ; Time Factors
    Chemische Substanzen Antibodies, Viral ; RNA, Viral
    Sprache Englisch
    Erscheinungsdatum 2009
    Erscheinungsland Sweden
    Dokumenttyp Journal Article
    ZDB-ID 135951-4
    ISSN 0172-780X
    ISSN 0172-780X
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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