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  1. Book: Manual of embryo selection in human assisted reproduction

    Racowsky, Catherine / Cohen, Jacques / Macklon, Nick S.

    (Cambridge medicine)

    2023  

    Title variant Embryo selection in human assisted reproduction
    Author's details edited by Catherine Racowsky, Jacques Cohen, Nicholas Macklon
    Series title Cambridge medicine
    Keywords Single Embryo Transfer / methods ; Embryo Disposition ; Embryo Implantation ; Sperm-Ovum Interactions / physiology ; Embryonic Development / physiology ; Fertilization in vitro, Human
    Subject code 618.1780599
    Language English
    Size ix, 183 Seiten, Illustrationen, 25 cm
    Publisher Cambridge University Press
    Publishing place Cambridge
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT021861346
    ISBN 978-1-009-01637-7 ; 9781009025218 ; 1-009-01637-7 ; 100902521X
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2023 A 542 available for loan (reading room) Lesesaal EG

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  2. Article ; Online: Training and recognition of clinical embryologists as professionals-now, but what does the future hold?

    Racowsky, Catherine

    F&S reports

    2023  Volume 4, Issue 3, Page(s) 254–255

    Language English
    Publishing date 2023-06-15
    Publishing country United States
    Document type Editorial
    ISSN 2666-3341
    ISSN (online) 2666-3341
    DOI 10.1016/j.xfre.2023.06.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: In-vitro fertilization

    Ginsburg, Elizabeth S. / Racowsky, Catherine

    a comprehensive guide

    2012  

    Title variant In vitro fertilization
    Author's details Elizabeth S. Ginsburg ; Catherine Racowsky, ed
    Keywords Fertilization in vitro, Human ; Extrakorporale Befruchtung ; Embryotransfer
    Subject Eitransplantation ; Embryonentransfer ; Embryo implantation ; Embryospende ; Eispende ; In-vitro-Befruchtung ; Retortenbaby ; In-vitro-Fertilisation ; Retortenbefruchtung ; IVF
    Subject code 618.1780599
    Language English
    Size XIII, 272 S. : Ill., graph. Darst., 24 cm
    Publisher Springer
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT017513367
    ISBN 978-1-4419-9847-7 ; 9781441998484 ; 1-4419-9847-0 ; 1441998489
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2012 A 4789 order for loan Magazin

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  4. Article ; Online: Is granulosa cell steroidogenesis defective in young poor responders?

    Pirtea, Paul / Ayoubi, Jean Marc / Racowsky, Catherine

    Fertility and sterility

    2022  Volume 117, Issue 5, Page(s) 1081–1082

    MeSH term(s) Cells, Cultured ; Estradiol ; Female ; Granulosa Cells ; Humans ; Progesterone
    Chemical Substances Progesterone (4G7DS2Q64Y) ; Estradiol (4TI98Z838E)
    Language English
    Publishing date 2022-05-05
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80133-1
    ISSN 1556-5653 ; 0015-0282
    ISSN (online) 1556-5653
    ISSN 0015-0282
    DOI 10.1016/j.fertnstert.2022.03.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 73: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Trophectoderm biopsy-perhaps not such a benign intervention.

    Gordon, Catherine E / Racowsky, Catherine

    Fertility and sterility

    2020  Volume 114, Issue 4, Page(s) 748–749

    MeSH term(s) Biopsy ; Chorionic Gonadotropin, beta Subunit, Human ; Female ; Humans ; Pregnancy ; Preimplantation Diagnosis
    Chemical Substances Chorionic Gonadotropin, beta Subunit, Human
    Language English
    Publishing date 2020-07-16
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80133-1
    ISSN 1556-5653 ; 0015-0282
    ISSN (online) 1556-5653
    ISSN 0015-0282
    DOI 10.1016/j.fertnstert.2020.06.027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 73: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Letter to editor.

    Magli, M Cristina / Racowsky, Catherine

    Journal of assisted reproduction and genetics

    2020  Volume 37, Issue 11, Page(s) 2653–2655

    Keywords covid19
    Language English
    Publishing date 2020-10-22
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 1112577-9
    ISSN 1573-7330 ; 1058-0468
    ISSN (online) 1573-7330
    ISSN 1058-0468
    DOI 10.1007/s10815-020-01968-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1985: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Day of trophectoderm biopsy and embryo quality are associated with outcomes following euploid embryo transfer.

    Gordon, Catherine E / Lanes, Andrea / Thomas, Ann / Racowsky, Catherine

    Journal of assisted reproduction and genetics

    2022  Volume 39, Issue 11, Page(s) 2539–2546

    Abstract: Purpose: To compare clinical outcomes following transfer of euploid blastocysts of varying quality biopsied on day 5 versus day 6.: Methods: Retrospective cohort study to evaluate embryo transfer outcomes for women undergoing autologous cryopreserved ...

    Abstract Purpose: To compare clinical outcomes following transfer of euploid blastocysts of varying quality biopsied on day 5 versus day 6.
    Methods: Retrospective cohort study to evaluate embryo transfer outcomes for women undergoing autologous cryopreserved next generation sequencing euploid single embryo transfer from 10/2015 to 2/2022 at an academic IVF program. The primary outcome was live birth rate (LBR). Secondary outcomes included ongoing pregnancy rate (OPR), implantation rate (IR), and miscarriage rate (SAB rate).
    Results: Five hundred and fifty-five transfers from 418 patients were analyzed. Euploid embryos biopsied on day 5 resulted in higher LBR compared to those biopsied on day 6 (62.3% vs. 49.6%; aRR 0.81 95% CI 0.65-0.996). When stratified by biopsy day and blastocyst quality, there was no difference in IR, OPR, and SAB rate for good, fair, and poor quality blastocysts biopsied on day 5 versus day 6. However, day 5 good quality embryos were associated with a higher LBR compared to day 6 good quality embryos (74.3% vs. 51.3%; aRR 0.69; 95% CI 0.48-0.999). There were no significant differences in LBR for fair and poor quality embryos biopsied on day 5 versus day 6.
    Conclusion: Overall LBR are higher for euploid embryos biopsied on day 5 versus day 6. When stratified by embryo quality and day of biopsy, LBR are significantly higher for good quality day 5 versus day 6 embryos. When choosing between multiple euploid embryos, day 5 biopsied good quality embryos should be preferentially selected for transfer over day 6 embryos of the same quality.
    MeSH term(s) Pregnancy ; Humans ; Female ; Retrospective Studies ; Aneuploidy ; Embryo Transfer/methods ; Pregnancy Rate ; Embryo Implantation ; Blastocyst/pathology ; Biopsy ; Preimplantation Diagnosis/methods
    Language English
    Publishing date 2022-09-12
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1112577-9
    ISSN 1573-7330 ; 1058-0468
    ISSN (online) 1573-7330
    ISSN 1058-0468
    DOI 10.1007/s10815-022-02613-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1985: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Inferring simple but precise quantitative models of human oocyte and early embryo development.

    Leahy, Brian D / Racowsky, Catherine / Needleman, Daniel

    Journal of the Royal Society, Interface

    2021  Volume 18, Issue 182, Page(s) 20210475

    Abstract: Macroscopic, phenomenological models are useful as concise framings of our understandings in fields from statistical physics to finance to biology. Constructing a phenomenological model for development would provide a framework for understanding the ... ...

    Abstract Macroscopic, phenomenological models are useful as concise framings of our understandings in fields from statistical physics to finance to biology. Constructing a phenomenological model for development would provide a framework for understanding the complicated, regulatory nature of oogenesis and embryogenesis. Here, we use a data-driven approach to infer quantitative, precise models of human oocyte maturation and pre-implantation embryo development, by analysing clinical
    MeSH term(s) Embryonic Development ; Female ; Fertilization in Vitro ; Humans ; Oocytes ; Oogenesis ; Ovarian Follicle
    Language English
    Publishing date 2021-09-08
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2156283-0
    ISSN 1742-5662 ; 1742-5689
    ISSN (online) 1742-5662
    ISSN 1742-5689
    DOI 10.1098/rsif.2021.0475
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A risk factor profile for placenta accreta spectrum in pregnancies conceived with assisted reproductive technology.

    Carusi, Daniela A / Gopal, Daksha / Cabral, Howard J / Racowsky, Catherine / Stern, Judy E

    F&S reports

    2023  Volume 4, Issue 3, Page(s) 279–285

    Abstract: Objective: To identify independent risk factors for placenta accreta spectrum among pregnancies conceived with assisted reproductive technology.: Design: Retrospective cohort study.: Setting: Tertiary hospital.: Patients: Individuals who ... ...

    Abstract Objective: To identify independent risk factors for placenta accreta spectrum among pregnancies conceived with assisted reproductive technology.
    Design: Retrospective cohort study.
    Setting: Tertiary hospital.
    Patients: Individuals who conceived with assisted reproductive technology and reached 20 weeks' gestation or later from 2011 to 2017.
    Interventions: Patient and cycle data was abstracted from hospital records and supplemented with state-level data. Poisson regression was used for multivariate analyses and reported as adjusted relative risks (aRR).
    Main outcome measures: Clinical or histologic placenta accreta spectrum.
    Results: Of 1,975 qualifying pregnancies, 44 (2.3%) met criteria for accreta spectrum at delivery. In the multivariate model, significant risk factors included low-lying placenta at delivery (aRR, 15.44; 95% CI 7.76-30.72), uterine factor infertility or prior uterine surgery (aRR, 4.68; 95% CI, 2.72-8.05), initial low-lying placentation that resolved (aRR, 3.83; 95% CI, 1.90-7.73), and use of frozen embryos (aRR, 3.02; 95% CI, 1.66-5.48). When the fresh vs frozen variable was replaced with controlled ovarian hyperstimulation, the final model did not change (aRR, 2.40 for unstimulated cycles, 95% CI, 1.32-4.38). With frozen transfers, the accreta rate was 16% when the endometrial thickness was < 6mm vs 3.8% with thicker endometrium (
    Conclusions: Among pregnancies conceived with assisted reproductive technology, accreta spectrum is associated with low placental implantation (even when resolved), uterine factor infertility and prior uterine surgery, and the use of frozen embryo transfer or unstimulated cycles.
    Language English
    Publishing date 2023-05-23
    Publishing country United States
    Document type Journal Article
    ISSN 2666-3341
    ISSN (online) 2666-3341
    DOI 10.1016/j.xfre.2023.05.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Cumulus cell co-culture in media drops does not improve rescue in vitro maturation of vitrified-warmed immature oocytes.

    Gordon, Catherine E / Combelles, Catherine Mh / Lanes, Andrea / Patel, Jay / Racowsky, Catherine

    F&S science

    2023  Volume 4, Issue 3, Page(s) 185–192

    Abstract: Objective: To assess whether co-culture with vitrified-warmed cumulus cells (CCs) in media drops improves rescue in vitro maturation (IVM) of previously vitrified immature oocytes. Previous studies have shown improved rescue IVM of fresh immature ... ...

    Abstract Objective: To assess whether co-culture with vitrified-warmed cumulus cells (CCs) in media drops improves rescue in vitro maturation (IVM) of previously vitrified immature oocytes. Previous studies have shown improved rescue IVM of fresh immature oocytes when cocultured with CCs in a three-dimensional matrix. However, the scheduling and workload of embryologists would benefit from a simpler IVM approach, particularly in the setting of time-sensitive oncofertility oocyte cryopreservation (OC) cases. Although the yield of developmentally competent mature metaphase II (MII) oocytes is increased when rescue IVM is performed before cryopreservation, it is unknown whether maturation of previously vitrified immature oocytes is improved after coculture with CCs in a simple system not involving a three-dimensional matrix.
    Design: Randomized controlled trial.
    Setting: Academic hospital.
    Patients: A total of 320 (160 germinal vesicles [GVs] and 160 metaphase I [MI]) immature oocytes and autologous CC clumps were vitrified from patients who were undergoing planned OC or intracytoplasmic sperm injection from July 2020 until September 2021.
    Interventions: On warming, the oocytes were randomized to culture in IVM media with CCs (+CC) or without CCs (-CC). Germinal vesicles and MI oocytes were cultured in 25 μL (SAGE IVM medium) for 32 hours and 20-22 hours, respectively.
    Main outcome measures: Oocytes with a polar body (MII) were randomized to confocal microscopy for analysis of spindle integrity and chromosomal alignment to assess nuclear maturity or to parthenogenetic activation to assess cytoplasmic maturity. Wilcoxon rank sum tests for continuous variables and the chi square or Fisher's exact test for categorical variables assessed statistical significance. Relative risks (RRs) and 95% confidence intervals (CIs) were calculated.
    Results: Patient demographic characteristics were similar for both the GV and MI groups after randomization to +CC vs. -CC. No statistically significant differences were observed between +CC vs. -CC groups regarding the percentage of MII from either GV (42.5% [34/80] vs. 52.5% [42/80]; RR 0.81; 95% CI: 0.57-1.15]) or MI (76.3% [61/80]; vs. 72.5% [58/80]; RR 1.05; 95% CI: 0.88-1.26]) oocytes. An increased percentage of GV-matured MIIs underwent parthenogenetic activation in the +CC group (92.3% [12/13] vs. 70.8% [17/24]), but the difference was not statistically significant (RR 1.30; 95% CI: 0.97-1.75), whereas the activation rate was identical for MI-matured oocytes (74.3% [26/35] vs. 75.0% [18/24], CC+ vs. CC-; RR 0.99; 95% CI: 0.74-1.32). No significant differences were observed between +CC vs. -CC groups for cleavage of parthenotes from GV-matured oocytes (91.7% [11/12] vs. 82.4% [14/17]) or blastulation (0 for both) or for MI-matured oocytes (cleavage: 80.8% [21/26] vs. 94.4% [17/18]; blastulation: 0 [0/26] vs. 16.7% [3/18]). Further, no significant differences were observed between +CC vs. -CC for GV-matured oocytes regarding incidence of bipolar spindles (38.9% [7/18] vs. 33.3% [5/15]) or aligned chromosomes (22.2% [4/18] vs. 0.0 [0/15]); or for MI-matured oocytes (bipolar spindle: 38.9% [7/18] vs. 42.9% [2/28]); aligned chromosomes (35.3% [6/17] vs. 24.1% [7/29]).
    Conclusions: Cumulus cell co-culture in this simple two-dimensional system does not improve rescue IVM of vitrified, warmed immature oocytes, at least by the markers assessed here. Further work is required to assess the efficacy of this system given its potential to provide flexibility in a busy, in vitro fertilization clinic.
    MeSH term(s) Female ; Male ; Animals ; Coculture Techniques ; Cumulus Cells ; Vitrification ; Semen ; Oocytes
    Language English
    Publishing date 2023-05-16
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2666-335X
    ISSN (online) 2666-335X
    DOI 10.1016/j.xfss.2023.05.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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