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  1. Article: Polyphenols as Possible Agents for Pancreatic Diseases

    Gašić, Uroš / Ćirić, Ivanka / Pejčić, Tomislav / Radenković, Dejan / Djordjević, Vladimir / Radulović, Siniša / Tešić, Živoslav

    Antioxidants. 2020 June 23, v. 9, no. 6

    2020  

    Abstract: Pancreatic cancer (PC) is very aggressive and it is estimated that it kills nearly 50% of patients within the first six months. The lack of symptoms specific to this disease prevents early diagnosis and treatment. Today, gemcitabine alone or in ... ...

    Abstract Pancreatic cancer (PC) is very aggressive and it is estimated that it kills nearly 50% of patients within the first six months. The lack of symptoms specific to this disease prevents early diagnosis and treatment. Today, gemcitabine alone or in combination with other cytostatic agents such as cisplatin (Cis), 5-fluorouracil (5-FU), irinotecan, capecitabine, or oxaliplatin (Oxa) is used in conventional therapy. Outgoing literature provides data on the use of polyphenols, biologically active compounds, in the treatment of pancreatic cancer and the prevention of acute pancreatitis. Therefore, the first part of this review gives a brief overview of the state of pancreatic disease as well as the procedures for its treatment. The second part provides a detailed overview of the research regarding the anticancer effects of both pure polyphenols and their plant extracts. The results regarding the antiproliferative, antimetastatic, as well as inhibitory effects of polyphenols against PC cell lines as well as the prevention of acute pancreatitis are presented in detail. Finally, particular emphasis is given to the polyphenolic profiles of apples, berries, cherries, sour cherries, and grapes, given the fact that these fruits are rich in polyphenols and anthocyanins. Polyphenolic profiles, the content of individual polyphenols, and their relationships are discussed. Based on this, significant data can be obtained regarding the amount of fruit that should be consumed daily to achieve a therapeutic effect.
    Keywords Prunus cerasus ; anthocyanins ; antineoplastic activity ; apples ; bioactive compounds ; cell lines ; cherries ; cisplatin ; early diagnosis ; fluorouracil ; fruits ; grapes ; pancreatic neoplasms ; pancreatitis ; patients ; plant extracts ; polyphenols ; small fruits ; therapeutics
    Language English
    Dates of publication 2020-0623
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox9060547
    Database NAL-Catalogue (AGRICOLA)

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  2. Article: Polyphenols as Possible Agents for Pancreatic Diseases.

    Gašić, Uroš / Ćirić, Ivanka / Pejčić, Tomislav / Radenković, Dejan / Djordjević, Vladimir / Radulović, Siniša / Tešić, Živoslav

    Antioxidants (Basel, Switzerland)

    2020  Volume 9, Issue 6

    Abstract: Pancreatic cancer (PC) is very aggressive and it is estimated that it kills nearly 50% of patients within the first six months. The lack of symptoms specific to this disease prevents early diagnosis and treatment. Today, gemcitabine alone or in ... ...

    Abstract Pancreatic cancer (PC) is very aggressive and it is estimated that it kills nearly 50% of patients within the first six months. The lack of symptoms specific to this disease prevents early diagnosis and treatment. Today, gemcitabine alone or in combination with other cytostatic agents such as cisplatin (Cis), 5-fluorouracil (5-FU), irinotecan, capecitabine, or oxaliplatin (Oxa) is used in conventional therapy. Outgoing literature provides data on the use of polyphenols, biologically active compounds, in the treatment of pancreatic cancer and the prevention of acute pancreatitis. Therefore, the first part of this review gives a brief overview of the state of pancreatic disease as well as the procedures for its treatment. The second part provides a detailed overview of the research regarding the anticancer effects of both pure polyphenols and their plant extracts. The results regarding the antiproliferative, antimetastatic, as well as inhibitory effects of polyphenols against PC cell lines as well as the prevention of acute pancreatitis are presented in detail. Finally, particular emphasis is given to the polyphenolic profiles of apples, berries, cherries, sour cherries, and grapes, given the fact that these fruits are rich in polyphenols and anthocyanins. Polyphenolic profiles, the content of individual polyphenols, and their relationships are discussed. Based on this, significant data can be obtained regarding the amount of fruit that should be consumed daily to achieve a therapeutic effect.
    Language English
    Publishing date 2020-06-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox9060547
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Meta-Analysis of Circulating Cell-Free DNA's Role in the Prognosis of Pancreatic Cancer.

    Milin-Lazovic, Jelena / Madzarevic, Petar / Rajovic, Nina / Djordjevic, Vladimir / Milic, Nikola / Pavlovic, Sonja / Veljkovic, Nevena / Milic, Natasa M / Radenkovic, Dejan

    Cancers

    2021  Volume 13, Issue 14

    Abstract: Introduction: The analysis of cell-free DNA (cfDNA) for genetic abnormalities is a promising new approach for the diagnosis and prognosis of pancreatic cancer patients. Insights into the molecular characteristics of pancreatic cancer may provide ... ...

    Abstract Introduction: The analysis of cell-free DNA (cfDNA) for genetic abnormalities is a promising new approach for the diagnosis and prognosis of pancreatic cancer patients. Insights into the molecular characteristics of pancreatic cancer may provide valuable information, leading to its earlier detection and the development of targeted therapies.
    Material and methods: We conducted a systematic review and a meta-analysis of studies that reported cfDNA in pancreatic ductal adenocarcinoma (PDAC). The studies were considered eligible if they included patients with PDAC, if they had blood tests for cfDNA/ctDNA, and if they analyzed the prognostic value of cfDNA/ctDNA for patients' survival. The studies published before 22 October 2020 were identified through the PubMED, EMBASE, Web of Science and Cochrane Library databases. The assessed outcomes were the overall (OS) and progression-free survival (PFS), expressed as the log hazard ratio (HR) and standard error (SE). The summary of the HR effect size was estimated by pooling the individual trial results using the Review Manager, version 5.3, Cochrane Collaboration. The heterogeneity was assessed using the Cochran Q test and I
    Results: In total, 48 studies were included in the qualitative review, while 44 were assessed in the quantitative synthesis, with the total number of patients included being 3524. Overall negative impacts of cfDNA and
    Conclusion: The assessment of
    Language English
    Publishing date 2021-07-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13143378
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Impact of the COVID-19 Pandemic on Surgical Oncology in Europe: Results of a European Survey.

    Stöss, Christian / Steffani, Marcella / Pergolini, Ilaria / Hartmann, Daniel / Radenkovic, Dejan / Novotny, Alexander / Friess, Helmut / Müller, Michael W

    Digestive surgery

    2021  Volume 38, Issue 4, Page(s) 259–265

    Abstract: Background: The first COVID-19 pandemic wave hit most of the health-care systems worldwide. The present survey aimed to provide a European overview on the COVID-19 impact on surgical oncology.: Methods: This anonymous online survey was accessible ... ...

    Abstract Background: The first COVID-19 pandemic wave hit most of the health-care systems worldwide. The present survey aimed to provide a European overview on the COVID-19 impact on surgical oncology.
    Methods: This anonymous online survey was accessible from April 24 to May 11, 2020, for surgeons (n = 298) who were contacted by the surgical society European Digestive Surgery. The survey was completed by 88 surgeons (29.2%) from 69 different departments. The responses per department were evaluated.
    Results: Of the departments, 88.4% (n = 61/69) reported a lower volume of patients in the outpatient clinic; 69.1% (n = 47/68) and 75.0% (n = 51/68) reported a reduction in hospital bed and the operating room capacity, respectively. As a result, the participants reported an average reduction of 29.3% for all types of oncological resections surveyed in this questionnaire. The strongest reduction was observed for oncological resections of hepato-pancreatico-biliary (HPB) cancers. Of the interviewed surgeons, 68.7% (n = 46/67) agreed that survival outcomes will be negatively impacted by the pandemic.
    Conclusion: The first COVID-19 pandemic wave had a significant impact on surgical oncology in Europe. The surveyed surgeons expect an increase in the number of unresectable cancers as well as poorer survival outcomes due to cancellations of follow-ups and postponements of surgeries.
    MeSH term(s) Adult ; Ambulatory Care/statistics & numerical data ; COVID-19/diagnosis ; COVID-19/epidemiology ; Chemotherapy, Adjuvant/statistics & numerical data ; Cross-Sectional Studies ; Europe/epidemiology ; Female ; Hospital Bed Capacity/statistics & numerical data ; Humans ; Male ; Middle Aged ; Neoplasms/diagnosis ; Neoplasms/drug therapy ; Neoplasms/surgery ; Oncology Service, Hospital/statistics & numerical data ; Operating Rooms/statistics & numerical data ; Surgical Oncology/statistics & numerical data ; Surveys and Questionnaires ; Survival Rate ; Time-to-Treatment/statistics & numerical data
    Language English
    Publishing date 2021-05-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 605888-7
    ISSN 1421-9883 ; 0253-4886
    ISSN (online) 1421-9883
    ISSN 0253-4886
    DOI 10.1159/000515186
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Quality of life following two different techniques of an open ventral hernia repair for large hernias: a prospective randomized study.

    Antic, Andrija / Kmezic, Stefan / Nikolic, Vladimir / Radenkovic, Dejan / Markovic, Velimir / Pejovic, Ilija / Aleksic, Lidija / Loncar, Zlatibor / Antic, Svetlana / Kovac, Jelena / Markovic-Denic, Ljiljana

    BMC surgery

    2022  Volume 22, Issue 1, Page(s) 99

    Abstract: Background: We compare the health-related quality of life (QoL) of patients with incision hernias before and after surgery with two different techniques.: Methods: In this prospective randomized study, the study population consisted of all patients ... ...

    Abstract Background: We compare the health-related quality of life (QoL) of patients with incision hernias before and after surgery with two different techniques.
    Methods: In this prospective randomized study, the study population consisted of all patients who underwent the first surgical incisional hernias repair during the 1-year study period. Patients who met the criteria for inclusion in the study were randomized into two groups: the first group consisted of patients operated by an open Rives sublay technique, and the second group included patients operated by a segregation component technique. The change in the quality of life before and 6 months after surgery was assessed using two general (Short form of SF-36 questionnaires and European Quality of Life Questionnaire-EQ-5D-3L), and three specific hernia questionnaires (Hernia Related Quality of Life Survey-HerQles, Eura HS Quality of Life Scale-EuraHS QoL, and Carolinas Comfort Scale-CCS).
    Results: A total of 93 patients were included in the study. Patients operated on by the Rives technique had a better role physical score before surgery, according to the SF-36 tool, although this was not found after surgery. The postoperative QoL measured with each scale of all questionnaires was significantly better after surgery. Comparing two groups of patients after surgery, only the pain domain of the EuraHS Qol questionnaire was worse in patients operated by a segregation component technique.
    Conclusion: Both techniques improve the quality of life after surgery. Generic QoL questionnaires showed no difference in the quality of life compared to repair technique but specific hernia-related questionnaires showed differences.
    MeSH term(s) Hernia, Ventral/surgery ; Herniorrhaphy/methods ; Humans ; Prospective Studies ; Quality of Life ; Surgical Mesh
    Language English
    Publishing date 2022-03-17
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 2050442-1
    ISSN 1471-2482 ; 1471-2482
    ISSN (online) 1471-2482
    ISSN 1471-2482
    DOI 10.1186/s12893-022-01551-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Five-Year Outcomes in Bariatric Surgery Patients.

    Nedeljkovic-Arsenovic, Olga / Banovic, Marko / Radenkovic, Dejan / Rancic, Nemanja / Polovina, Snezana / Micic, Dragan / Nedeljkovic, Ivana

    Medicina (Kaunas, Lithuania)

    2020  Volume 56, Issue 12

    Abstract: Background and objectives: ...

    Abstract Background and objectives:
    MeSH term(s) Adult ; Bariatric Surgery ; Body Mass Index ; Cross-Sectional Studies ; Female ; Gastric Bypass ; Humans ; Laparoscopy ; Middle Aged ; Obesity, Morbid/surgery ; Quality of Life ; Retrospective Studies ; Treatment Outcome ; Young Adult
    Language English
    Publishing date 2020-12-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina56120669
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Pancreatic Hydatid Cyst Misdiagnosed as Mucinous Cystadenoma: CT and MRI Findings.

    Mitrovic, Milica / Tadic, Boris / Kovac, Jelena / Grubor, Nikola / Milosavljevic, Vladimir / Jankovic, Aleksandra / Khatkov, Igor / Radenkovic, Dejan / Matic, Slavko

    Medicina (Kaunas, Lithuania)

    2020  Volume 56, Issue 3

    Abstract: Isolated hydatid cysts of the pancreas are rare lesions, even in endemic regions. In this report, we present the case of a 76-year-old patient who was admitted to our clinic with a diagnosis of a cystic lesion in the tail of the pancreas. On preoperative ...

    Abstract Isolated hydatid cysts of the pancreas are rare lesions, even in endemic regions. In this report, we present the case of a 76-year-old patient who was admitted to our clinic with a diagnosis of a cystic lesion in the tail of the pancreas. On preoperative computed tomography (CT) and magnetic resonance (MR) examination, the cyst was characterized as a mucinous cystadenoma. A laparoscopic distal pancreatectomy followed. A histopathological examination revealed a large hydatid cyst in the tail of the pancreas.
    MeSH term(s) Aged ; Animals ; Cattle/parasitology ; Cystadenoma, Mucinous/diagnosis ; Cystadenoma, Mucinous/diagnostic imaging ; Cystadenoma, Mucinous/physiopathology ; Diagnostic Errors ; Echinococcosis/complications ; Echinococcosis/diagnosis ; Echinococcosis/physiopathology ; Echinococcus granulosus/parasitology ; Female ; Humans ; Pancreas/abnormalities ; Pancreas/pathology ; Pancreas/surgery ; Tomography, X-Ray Computed/methods
    Language English
    Publishing date 2020-03-13
    Publishing country Switzerland
    Document type Case Reports ; Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina56030124
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book: Poremećaji hemostaze u akutnom pankreatitisu

    Radenković, Dejan

    (Biblioteka Dissertatio, ; 229)

    2006  

    Author's details Dejan Radenković
    Series title Biblioteka Dissertatio, ; 229
    MeSH term(s) Pancreatitis/blood ; Hemostasis
    Language Serbian
    Size 95 p. :, ill.
    Publisher Zadužbina Andrejević
    Publishing place Beograd
    Document type Book
    ISBN 9788672445879 ; 8672445872
    Database Catalogue of the US National Library of Medicine (NLM)

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  9. Article: Evolving Techniques in Pancreatic Surgery.

    Radenkovic, Dejan / Farnell, Michael B / Bassi, Claudio / Besselink, Marc

    Gastroenterology research and practice

    2016  Volume 2016, Page(s) 4289724

    Language English
    Publishing date 2016-03-28
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2435460-0
    ISSN 1687-630X ; 1687-6121
    ISSN (online) 1687-630X
    ISSN 1687-6121
    DOI 10.1155/2016/4289724
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Fasciola hepatica as an uncommon cause of cholangitis.

    Popa, Daniel / Jovanovic, Ivan / Radenkovic, Dejan

    Endoscopy

    2014  Volume 46 Suppl 1 UCTN, Page(s) E600

    MeSH term(s) Anthelmintics/therapeutic use ; Benzimidazoles/therapeutic use ; Cholangiopancreatography, Endoscopic Retrograde ; Cholangitis/etiology ; Cholangitis/parasitology ; Common Bile Duct/parasitology ; Common Bile Duct/pathology ; Dilatation, Pathologic ; Fascioliasis/complications ; Fascioliasis/diagnosis ; Fascioliasis/drug therapy ; Humans ; Male ; Middle Aged
    Chemical Substances Anthelmintics ; Benzimidazoles ; triclabendazole (4784C8E03O)
    Language English
    Publishing date 2014
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/s-0034-1390719
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 162: Show issues

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