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Article: Long-Term Safety and Antihypertensive Effects of Renal Denervation: Current Insights.

Reyes, Klevin Roger L / Rader, Florian

2023 Volume 16, Page(s) 59–70

Abstract: Hypertension is the most potent modifiable risk factor for the development of cardiovascular morbidity and mortality worldwide. Nevertheless, blood pressure (BP) control on a broad scale appears to be insurmountable and has even worsened in the US. ... ...

Abstract	Hypertension is the most potent modifiable risk factor for the development of cardiovascular morbidity and mortality worldwide. Nevertheless, blood pressure (BP) control on a broad scale appears to be insurmountable and has even worsened in the US. Barriers to sustained hypertension control are multifactorial and although lack of patient awareness and socioeconomic barriers to healthcare access may play a role, medication non-compliance and therapeutic inertia are major causes. Renal denervation (RDN) is a minimally invasive procedure that has been the subject of interest in clinical trials for more than a decade and although the first sham-controlled trial could not detect group difference between treated and untreated hypertensives, subsequent, better designed sham-controlled trials clearly demonstrated the BP lowering effect of RDN, as well as its safety. While to-date, RDN is not available for routine clinical practice, one major requirement for broad implementation is that the BP lowering effect is durable. Therefore, this review will summarize the available long-term data of the different RDN modalities with respect to both effectiveness and safety.
Language	English
Publishing date	2023-09-07
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2520711-8
ISSN	1178-7104
ISSN	1178-7104
DOI	10.2147/IBPC.S392410
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Article ; Online: Mavacamten: A First-in-class Oral Modulator of Cardiac Myosin for the Treatment of Symptomatic Hypertrophic Obstructive Cardiomyopathy.

Reyes, Klevin Roger L / Bilgili, Gizem / Rader, Florian

Heart international

2022 Volume 16, Issue 2, Page(s) 91–98

Abstract: Hypertrophic cardiomyopathy is the most common monogenic cardiovascular disease that is caused by sarcomeric protein gene mutations. A hallmark of the most common form of the disease is outflow obstruction secondary to systolic narrowing of the left ... ...

Abstract	Hypertrophic cardiomyopathy is the most common monogenic cardiovascular disease that is caused by sarcomeric protein gene mutations. A hallmark of the most common form of the disease is outflow obstruction secondary to systolic narrowing of the left ventricular outflow tract from septal hypertrophy, mitral valve abnormalities and, most importantly, hyperdynamic contractility. Recent mechanistic studies have identified excessive myosin adenosine triphosphatase activation and actin-myosin cross-bridging as major underlying causes. These studies have led to the development of mavacamten, a first-in-class myosin adenosine triphosphatase inhibitor and the first specific therapy for hypertrophic obstructive cardiomyopathy. Preclinical and subsequent pivotal clinical studies have demonstrated the efficacy and safety of mavacamten. A remarkable improvement among treated patients in peak oxygen consumption, functional capacity, symptom relief and post-exercise left ventricular outflow tract gradient, along with dramatic reductions in heart failure biomarkers, suggests that this new medication will be transformative for the symptom management of hypertrophic obstructive cardiomyopathy. There is also hope and early evidence that mavacamten may delay or obviate the need for invasive septal reduction therapies. In this article, we review the current evidence for the efficacy and safety of mavacamten and highlight important considerations for its clinical use.
Language	English
Publishing date	2022-10-05
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2514156-9
ISSN	2036-2579 ; 2036-2579
ISSN (online)	2036-2579
ISSN	2036-2579
DOI	10.17925/HI.2022.16.2.91
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Article ; Online: Response to letter to the editors: Predictors of left atrial appendage thrombus despite NOAC use in nonvalvular atrial fibrillation and flutter.

Shah, Maulin / Rader, Florian

International journal of cardiology

2020 Volume 319, Page(s) 96

MeSH term(s)	Anticoagulants ; Atrial Appendage/diagnostic imaging ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/epidemiology ; Heart Diseases ; Humans ; Thrombosis/diagnostic imaging ; Thrombosis/epidemiology
Chemical Substances	Anticoagulants
Language	English
Publishing date	2020-07-04
Publishing country	Netherlands
Document type	Letter ; Comment
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2020.06.057
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Zs.A 1673: Show issues

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Article ; Online: Sustainability of blood pressure reduction in black barbershops.

Blyler, Ciantel A / Rader, Florian

Current opinion in cardiology

2019 Volume 34, Issue 6, Page(s) 693–699

Abstract: Purpose of review: The prevalence of hypertension (HTN) among non-Hispanic blacks increased from 41 to 55% with the release of the new 2017 ACC/AHA guidelines - the highest among any racial group. Non-Hispanic black men have less physician interaction ... ...

Abstract	Purpose of review: The prevalence of hypertension (HTN) among non-Hispanic blacks increased from 41 to 55% with the release of the new 2017 ACC/AHA guidelines - the highest among any racial group. Non-Hispanic black men have less physician interaction and lower blood pressure (BP) treatment and control rates when compared with their female counterparts, necessitating community outreach. Here, we review the Los Angeles Barbershop Blood Pressure Study (LABBPS) which demonstrated a community-based approach involving pharmacists, physicians, and barbers could improve BP control rates among black men. Recent findings: LABBPS was a cluster-randomized trial that evaluated both the efficacy and sustainability of a pharmacist-led HTN management program in which barbers promoted follow-up with pharmacists who prescribed antihypertensive therapy under collaborative practice agreements with intervention participant's primary care providers. After 6 months researchers observed a 21 mmHg greater fall in SBP among intervention group participants when compared with the control group participants who received 'usual care.' The 6-month extension phase of the study showed that the impressive BP reduction achieved was sustained with less pharmacist contact. Summary: Multidisciplinary, community-based approaches to HTN management can be effective and are necessary to tackle the current disparity seen in BP control rates. The model developed in LABBPS represents one such approach.
MeSH term(s)	Adult ; African Americans ; Aged ; Antihypertensive Agents/administration & dosage ; Antihypertensive Agents/therapeutic use ; Barbering ; Blood Pressure Monitoring, Ambulatory/methods ; Community-Institutional Relations ; Humans ; Hypertension/drug therapy ; Hypertension/therapy ; Los Angeles ; Male ; Middle Aged ; Professional-Patient Relations ; Randomized Controlled Trials as Topic
Chemical Substances	Antihypertensive Agents
Language	English
Publishing date	2019-08-19
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	645186-x
ISSN	1531-7080 ; 0268-4705
ISSN (online)	1531-7080
ISSN	0268-4705
DOI	10.1097/HCO.0000000000000674
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Zs.A 2556: Show issues

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Article ; Online: Finding Hay in the Haystack.

Rader, Florian / Blyler, C Adair

Journal of the American College of Cardiology

2019 Volume 74, Issue 15, Page(s) 1907–1909

MeSH term(s)	Cell Phone ; Community Health Workers ; Humans ; Hypertension ; Kenya
Language	English
Publishing date	2019-11-01
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	605507-2
ISSN	1558-3597 ; 0735-1097
ISSN (online)	1558-3597
ISSN	0735-1097
DOI	10.1016/j.jacc.2019.08.1001
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Zs.A 1846: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 196: Show issues

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Article ; Online: Implication of Right Atrial Pressure Estimated by Echocardiography in Patients with Severe Tricuspid Regurgitation.

Omori, Taku / Kuwajima, Ken / Rader, Florian / Siegel, Robert J / Shiota, Takahiro

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography

2023 Volume 36, Issue 11, Page(s) 1170–1177

Abstract: Background: Little is known about how tightly right atrial pressure (RAP) is associated with prognosis in patients with severe tricuspid regurgitation (TR). The aim of this study was to investigate the association of RAP estimated by echocardiography ( ... ...

Abstract	Background: Little is known about how tightly right atrial pressure (RAP) is associated with prognosis in patients with severe tricuspid regurgitation (TR). The aim of this study was to investigate the association of RAP estimated by echocardiography (RAP-echo) with cardiovascular events in patients with severe TR. Methods: Two hundred forty outpatients (median age, 75 years; 130 women) who underwent two-dimensional transthoracic echocardiography and were diagnosed with severe TR were retrospectively studied. According to RAP-echo using the diameter of the inferior vena cava and its response to a sniff, patients were classified into two groups: low or middle and high RAP-echo. Cardiovascular events were defined as cardiovascular death and admission for heart failure. Results: During follow-up (median, 428 days; range, 87-1,229 days), 64 patients experienced cardiovascular events. By multivariate analysis, high RAP-echo was independently associated with cardiovascular events (hazard ratio, 2.46; 95% CI, 1.17-5.18). Also, jugular venous distention and leg edema were not independently associated with cardiovascular events. Conclusions: The significant and stronger association of RAP-echo with clinical outcome compared with estimates of RAP on physical examination suggests that recognition of high RAP-echo can be a valuable surrogate for the clinical management of severe TR patients.
MeSH term(s)	Humans ; Female ; Aged ; Tricuspid Valve Insufficiency/diagnostic imaging ; Atrial Pressure ; Retrospective Studies ; Echocardiography/methods ; Heart Failure
Language	English
Publishing date	2023-06-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	1035622-8
ISSN	1097-6795 ; 0894-7317
ISSN (online)	1097-6795
ISSN	0894-7317
DOI	10.1016/j.echo.2023.06.009
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Zs.A 2638: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Effects of pericardiocentesis on renal function and cardiac hemodynamics.

Shmueli, Hezzy / Shah, Maulin / Patel, Yatindra / Nguyen, Long-Co / Hardy, Hannah / Rader, Florian / Siegel, Robert J

Echocardiography (Mount Kisco, N.Y.)

2024 Volume 41, Issue 2, Page(s) e15764

Abstract: Background: Previous case studies have reported reversal of acute renal failure after pericardiocentesis in pericardial effusion. This study examines the effects of pericardiocentesis on preprocedural low cardiac output and acute renal dysfunction in ... ...

Abstract	Background: Previous case studies have reported reversal of acute renal failure after pericardiocentesis in pericardial effusion. This study examines the effects of pericardiocentesis on preprocedural low cardiac output and acute renal dysfunction in patients with pericardial effusion. Methods: This is a retrospective study of 95 patients undergoing pericardiocentesis between 2015 and 2020. Pre- and post-procedure transthoracic echocardiograms (TTE) were reviewed for evidence of cardiac tamponade, resolution of pericardial effusion, and for estimation of right atrial (RA) pressure and cardiac output. Laboratory values were compared at presentation and post-procedure. Patients on active renal replacement therapy were excluded. Results: Ninety-five patients were included for analysis (mean age 62.2 ± 17.8 years, 58% male). There was a significant increase in glomerular filtration rate pre- and post-procedure. Fifty-six patients (58.9%) had an improvement in glomerular filtration rate after pericardiocentesis (termed "responders"), and these patients had a lower pre-procedure glomerular filtration rate than "non-responders." There was a significant improvement in estimated cardiac output and right atrial pressure for patients in both groups. Patients who had an improvement in renal function had significantly lower pre-procedural diastolic blood pressure and mean arterial pressure. Conclusions: Pericardial drainage may improve effusion-mediated acute renal dysfunction by reducing right atrial pressure and thus systemic venous congestion, and by increasing forward stroke volume and perfusion pressure.
MeSH term(s)	Humans ; Male ; Adult ; Middle Aged ; Aged ; Aged, 80 and over ; Female ; Pericardiocentesis ; Pericardial Effusion/diagnostic imaging ; Pericardial Effusion/surgery ; Retrospective Studies ; Cardiac Tamponade/surgery ; Hemodynamics ; Kidney Diseases ; Kidney/diagnostic imaging
Language	English
Publishing date	2024-02-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	843645-9
ISSN	1540-8175 ; 0742-2822
ISSN (online)	1540-8175
ISSN	0742-2822
DOI	10.1111/echo.15764
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Zs.A 2170: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 359: Show issues

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Article ; Online: Safe to go with the flow? Large left atrial appendage thrombus despite robust appendage flow velocities.

Yuan, Neal / Rader, Florian / Siegel, Robert J

European heart journal. Cardiovascular Imaging

2020 Volume 22, Issue 6, Page(s) e76

MeSH term(s)	Atrial Appendage/diagnostic imaging ; Atrial Fibrillation/diagnostic imaging ; Atrial Function, Left ; Blood Flow Velocity ; Echocardiography, Transesophageal ; Heart Diseases ; Humans ; Thrombosis/diagnostic imaging
Language	English
Publishing date	2020-11-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2638345-7
ISSN	2047-2412 ; 2047-2404
ISSN (online)	2047-2412
ISSN	2047-2404
DOI	10.1093/ehjci/jeaa290
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Zs.A 5614: Show issues

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Article ; Online: Determining Which Hospitalized Coronavirus Disease 2019 Patients Require Urgent Echocardiography.

Yuan, Neal / Wu, Stephanie / Rader, Florian / Siegel, Robert J

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography

2021 Volume 34, Issue 8, Page(s) 831–838

Abstract: Background: Patients hospitalized with coronavirus disease 2019 (COVID-19) often have abnormal findings on transthoracic echocardiography (TTE). However, although not all abnormalities on TTE result in changes in clinical management, performing TTE in ... ...

Abstract	Background: Patients hospitalized with coronavirus disease 2019 (COVID-19) often have abnormal findings on transthoracic echocardiography (TTE). However, although not all abnormalities on TTE result in changes in clinical management, performing TTE in recently infected patients increases disease transmission risks. It remains unknown whether common biomarker tests, such as troponin and B-type natriuretic peptide (BNP), can help distinguish in which patients with COVID-19 TTE may be safely delayed until infection risks subside. Methods: Using electronic health records data and chart review, the authors retrospectively studied all patients hospitalized with COVID-19 in a multisite health care system from March 1, 2020, to January 15, 2021, who underwent TTE within 14 days of their first positive COVID-19 result and had BNP and troponin measured before or within 7 days of TTE. The primary outcome was the presence of one or more urgent echocardiographic findings, defined as left ventricular ejection fraction ≤ 35%, wall motion score index ≥ 1.5, moderate or greater right ventricular dysfunction, moderate or greater pericardial effusion, intracardiac thrombus, pulmonary artery systolic pressure > 50 mm Hg, or at least moderate to severe valvular disease. Stepwise logistic regression was conducted to determine biomarkers and comorbidities associated with the outcome. The performance of a rule for classifying TTE using troponin and BNP was evaluated. Results: Four hundred thirty-four hospitalized and 151 intensive care unit patients with COVID-19 were included. Urgent findings on TTE were present in 105 patients (24.2%). Troponin and BNP were abnormal in 311 (71.7%). Heart failure (odds ratio, 5.41; 95% CI, 2.61-11.68), troponin > 0.04 ng/mL (odds ratio, 4.40; 95% CI, 2.05-10.05), and BNP > 100 pg/mL (odds ratio, 5.85; 95% CI, 2.35-16.09) remained significant predictors of urgent findings on TTE after stepwise selection. No urgent findings on TTE were seen in 95.1% of all patients and in 91.3% of intensive care unit patients with normal troponin and BNP. Conclusions: Troponin and BNP were highly associated with urgent echocardiographic findings and may be used in triaging algorithms for determining in which patients TTE can be safely delayed until after their peak infectious window has passed.
MeSH term(s)	Aged ; COVID-19/epidemiology ; Comorbidity ; Critical Care/methods ; Echocardiography/methods ; Emergencies ; Female ; Heart Diseases/diagnosis ; Heart Diseases/epidemiology ; Heart Diseases/physiopathology ; Humans ; Inpatients ; Male ; Middle Aged ; Retrospective Studies ; SARS-CoV-2 ; Stroke Volume/physiology ; Ventricular Function, Left/physiology
Language	English
Publishing date	2021-04-01
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Observational Study ; Research Support, N.I.H., Extramural
ZDB-ID	1035622-8
ISSN	1097-6795 ; 0894-7317
ISSN (online)	1097-6795
ISSN	0894-7317
DOI	10.1016/j.echo.2021.03.010
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Zs.A 2638: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 55: Show issues

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Article ; Online: Oral Anticoagulant Use in Morbid Obesity and Post Bariatric Surgery: A Review.

Nasser, Mohamed Farhan / Jabri, Ahmad / Gandhi, Sanjay / Rader, Florian

The American journal of medicine

2021 Volume 134, Issue 12, Page(s) 1465–1475

Abstract: Bariatric surgery has emerged as a therapy for obesity and the associated comorbidities. Obesity has been shown to be a risk factor for atrial fibrillation as well as venous thromboembolism, both of which are conditions that warrant anticoagulation. ... ...

Abstract	Bariatric surgery has emerged as a therapy for obesity and the associated comorbidities. Obesity has been shown to be a risk factor for atrial fibrillation as well as venous thromboembolism, both of which are conditions that warrant anticoagulation. There is significant underrepresentation of the morbidly obese population in prospective trials that evaluated direct oral anticoagulants and vitamin K antagonists in atrial fibrillation and venous thromboembolism. We aim to review all the available data that assessed these oral anticoagulants in the morbidly obese population (body mass index >40 kg/m
MeSH term(s)	Anticoagulants/therapeutic use ; Atrial Fibrillation/complications ; Atrial Fibrillation/drug therapy ; Bariatric Surgery ; Factor Xa Inhibitors/therapeutic use ; Humans ; Obesity, Morbid/complications ; Obesity, Morbid/surgery ; Stroke/etiology ; Stroke/prevention & control ; Venous Thromboembolism/complications ; Venous Thromboembolism/drug therapy ; Warfarin/therapeutic use
Chemical Substances	Anticoagulants ; Factor Xa Inhibitors ; Warfarin (5Q7ZVV76EI)
Language	English
Publishing date	2021-08-15
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	80015-6
ISSN	1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
ISSN (online)	1555-7162 ; 1873-2178
ISSN	0002-9343 ; 1548-2766
DOI	10.1016/j.amjmed.2021.07.017
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