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Article: Buspirone for the Management of Functional Dyspepsia With Rapid Gastric Emptying.

Radetic, Mark / Gabbard, Scott

2019 Volume 6, Issue 11, Page(s) e00280

Abstract: Functional dyspepsia is characterized by a constellation of upper gastrointestinal symptoms consisting of epigastric pain and burning, early satiety, and postprandial fullness-all in the absence of any explanatory organic gastrointestinal pathology. ... ...

Abstract	Functional dyspepsia is characterized by a constellation of upper gastrointestinal symptoms consisting of epigastric pain and burning, early satiety, and postprandial fullness-all in the absence of any explanatory organic gastrointestinal pathology. Treatment options for the condition are limited, in part, because of the incomplete understanding of the pathophysiology of the disorder. A subset of patients diagnosed with functional dyspepsia are subsequently found to have rapid gastric emptying on gastric emptying scintigraphy. The significance of this finding is unknown but provides a potential therapeutic target. This case report describes functional dyspepsia with rapid gastric emptying responsive to treatment with buspirone.
Language	English
Publishing date	2019-11-26
Publishing country	United States
Document type	Case Reports
ZDB-ID	2814825-3
ISSN	2326-3253
ISSN	2326-3253
DOI	10.14309/crj.0000000000000280
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Management of Short Bowel Syndrome (SBS) and Intestinal Failure.

Radetic, Mark / Kamel, Amir / Lahey, Mark / Brown, Michelle / Sharma, Anil

Digestive diseases and sciences

2022 Volume 68, Issue 1, Page(s) 29–37

Abstract: Short bowel syndrome (SBS) is a chronic disease whose natural history requires a changing array of management strategies over time. Chief amongst these is the chronic use of parenteral nutrition (PN) to ensure adequate nutritional intake. With time and ... ...

Abstract	Short bowel syndrome (SBS) is a chronic disease whose natural history requires a changing array of management strategies over time. Chief amongst these is the chronic use of parenteral nutrition (PN) to ensure adequate nutritional intake. With time and appropriate management, approximately half of all SBS patients will successfully regain a functional, baseline level of intrinsic bowel function that will allow for them to achieve PN independence. However, the other half of SBS patients will progress into chronic intestinal failure which warrants a change in therapy to include more aggressive medical and potentially surgical measures. This review examines the evolving treatment strategies involved in the management of SBS as well as intestinal failure.
MeSH term(s)	Humans ; Short Bowel Syndrome/therapy ; Intestinal Failure ; Peptides/therapeutic use ; Gastrointestinal Agents/therapeutic use ; Intestinal Diseases/therapy ; Chronic Disease
Chemical Substances	Peptides ; Gastrointestinal Agents
Language	English
Publishing date	2022-11-25
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	304250-9
ISSN	1573-2568 ; 0163-2116
ISSN (online)	1573-2568
ISSN	0163-2116
DOI	10.1007/s10620-022-07760-w
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Article ; Online: When is contrast needed for abdominal and pelvic CT?

Radetic, Mark / DeVita, Robert / Haaga, John

Cleveland Clinic journal of medicine

2020 Volume 87, Issue 10, Page(s) 595–598

MeSH term(s)	Abdomen/diagnostic imaging ; Contraindications, Drug ; Contrast Media/therapeutic use ; Humans ; Pelvis/diagnostic imaging ; Risk Assessment ; Tomography, X-Ray Computed/methods
Chemical Substances	Contrast Media
Keywords	covid19
Language	English
Publishing date	2020-10-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	639116-3
ISSN	1939-2869 ; 0891-1150
ISSN (online)	1939-2869
ISSN	0891-1150
DOI	10.3949/ccjm.87a.19093
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Article ; Online: Case Report: Chagas Disease in a Traveler Who Developed Esophageal Involvement Decades after Acute Infection.

Beatty, Norman L / Alcala, Rodrigo F / Luque, Nelson A / Radetic, Mark / Joshi-Guske, Priti / Alakrad, Eyad / Forsyth, Colin J / Hamer, Davidson H

The American journal of tropical medicine and hygiene

2023 Volume 108, Issue 3, Page(s) 543–547

Abstract: Travelers to Chagas disease endemic regions of Latin America may be at risk for Trypanosoma cruzi infection. We report a 67-year-old woman who screened positive for T. cruzi infection while donating blood. The patient had a history of an unusual febrile ... ...

Abstract	Travelers to Chagas disease endemic regions of Latin America may be at risk for Trypanosoma cruzi infection. We report a 67-year-old woman who screened positive for T. cruzi infection while donating blood. The patient had a history of an unusual febrile illness and marked swelling of the face sustained at age 10 after camping in northern Mexico that led to a 3-week hospitalization without a diagnosis. More than 4 decades later, rapid diagnostic tests and commercial and confirmatory serology for Chagas disease were all positive for T. cruzi infection. On evaluation, the patient described a progressive chronic cough, gastroesophageal reflux, and dysphagia for > 10 years. There was no evidence of any cardiac complications. However, esophageal manometry demonstrated significant dysmotility, with 90% of swallows being ineffective with evidence of esophageal pressurization and retrograde peristalsis in several swallows, suggesting early autonomic disruption due to Chagas disease esophagopathy. In this report, we highlight the importance of travel-related Chagas disease among travelers to endemic regions and the need to further identify potential risks of transmission among this at-risk population.
MeSH term(s)	Female ; Humans ; Child ; Aged ; Trypanosoma cruzi ; Travel ; Travel-Related Illness ; Chagas Disease ; Mexico/epidemiology
Language	English
Publishing date	2023-01-16
Publishing country	United States
Document type	Case Reports ; Research Support, Non-U.S. Gov't
ZDB-ID	2942-7
ISSN	1476-1645 ; 0002-9637
ISSN (online)	1476-1645
ISSN	0002-9637
DOI	10.4269/ajtmh.22-0461
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Article ; Online: A tattoo granuloma with uveitis (TAGU) without sarcoidosis.

Radetic, Mark / Khan, Sami / Venkat, Arthi / Mendel, Thomas / Phelan, Michael

The American journal of emergency medicine

2020 Volume 38, Issue 11, Page(s) 2489.e3–2489.e5

Abstract: Tattooing is associated with a handful of potential complications. Short-term complications such as pain, pruritus, erythema, or swelling at the tattoo-site commonly occur from local skin trauma. Long-term complications tend to involve infections or ... ...

Abstract	Tattooing is associated with a handful of potential complications. Short-term complications such as pain, pruritus, erythema, or swelling at the tattoo-site commonly occur from local skin trauma. Long-term complications tend to involve infections or immune-mediated reactions such as sarcoidosis. The sudden development of a papulonodular skin eruption affecting a particular pigment in a tattoo is often the initial manifestation of undiagnosed sarcoidosis in these patients. However, in a small number of individuals, the granulomatous change in the tattoo and uveitis occur in the absence of any evidence of sarcoidosis. A case is presented of a tattoo granuloma with uveitis (TAGU) without sarcoidosis.
MeSH term(s)	Diagnosis, Differential ; Glucocorticoids/therapeutic use ; Granuloma/diagnosis ; Granuloma/drug therapy ; Granuloma/etiology ; Granuloma/pathology ; Humans ; Male ; Middle Aged ; Sarcoidosis/diagnosis ; Tattooing/adverse effects ; Uveitis/diagnosis ; Uveitis/drug therapy ; Uveitis/etiology
Chemical Substances	Glucocorticoids
Language	English
Publishing date	2020-06-02
Publishing country	United States
Document type	Case Reports
ZDB-ID	605890-5
ISSN	1532-8171 ; 0735-6757
ISSN (online)	1532-8171
ISSN	0735-6757
DOI	10.1016/j.ajem.2020.05.106
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Article: When is contrast needed for abdominal and pelvic CT?

Radetic, Mark / DeVita, Robert / Haaga, John

Cleve Clin J Med

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #33004318
Database	COVID19

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Article ; Online: Clinical Predictors of Rapid Gastric Emptying in Patients Presenting with Dyspeptic Symptoms.

Gomez Cifuentes, Juan / Radetic, Mark / Lopez, Rocio / Gabbard, Scott

Digestive diseases and sciences

2019 Volume 64, Issue 10, Page(s) 2899–2909

Abstract: Background: Rapid gastric emptying (RGE) is defined as less than 30% retention at 1 h of solid meal ingestion. It is unclear whether RGE represents a separated clinical entity or part of the functional dyspepsia spectrum.: Aims: To determine clinical ...

Abstract	Background: Rapid gastric emptying (RGE) is defined as less than 30% retention at 1 h of solid meal ingestion. It is unclear whether RGE represents a separated clinical entity or part of the functional dyspepsia spectrum. Aims: To determine clinical predictors of RGE in patients presenting with dyspeptic symptoms. Methods: Retrospective study of patients who underwent solid Gastric Emptying Scintigraphy to evaluate dyspeptic symptoms from January 2011 to September 2012. Patients with delayed gastric emptying (> 10% gastric retention at 4 h) or prior gastric surgery were excluded. Patients with RGE were compared to those with normal gastric emptying (NGE) in a patient ratio of 1:3. Demographic data, symptoms, comorbidities, surgeries, endoscopy findings, medications, HbA1c, and TSH were analyzed. Univariate and multivariate logistic regression analyses were performed. Results: A total of 808 patients were included, 202 patients with RGE and 606 patients with NGE. Mean gastric retention at 1 h was 18% [12.0, 24.0] and 65% [52.0, 76.0], respectively. Patient with RGE were more likely to present with nausea/vomiting (OR 2.4, p < 0.001), weight loss (OR 1.7, p = 0.008), and autonomic symptoms (OR 2.8, p = 0.022). Identified clinical predictors of RGE were older age (OR 1.08 [1.01, 1.1], p = 0.018), male gender (OR 2.0 [1.4, 2.9], p ≤ <0.001), higher BMI (OR 1.03 [1.00, 1.05], p = 0.018), diabetes (OR 1.8 [1.2, 2.7], p = 0.05), and fundoplication (OR 4.3 [2.4, 7.7], p ≤ 0.001). Conclusion: RGE represents a distinct population among patients presenting with dyspepsia in whom fundoplication, diabetes, and male gender were the strongest clinical predictors. RGE was significantly associated with nausea/vomiting, weight loss, and autonomic symptoms.
MeSH term(s)	Diabetes Mellitus/epidemiology ; Dyspepsia/diagnosis ; Dyspepsia/epidemiology ; Dyspepsia/physiopathology ; Female ; Fundoplication/adverse effects ; Gastric Emptying/physiology ; Gastrointestinal Diseases/diagnosis ; Gastroparesis/diagnostic imaging ; Gastroparesis/physiopathology ; Humans ; Male ; Middle Aged ; Nausea/diagnosis ; Nausea/etiology ; Radionuclide Imaging/methods ; Retrospective Studies ; Risk Factors ; Sex Factors ; Stomach/diagnostic imaging ; Symptom Assessment/methods ; Symptom Assessment/statistics & numerical data ; United States/epidemiology
Language	English
Publishing date	2019-04-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	304250-9
ISSN	1573-2568 ; 0163-2116
ISSN (online)	1573-2568
ISSN	0163-2116
DOI	10.1007/s10620-019-05620-8
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Article ; Online: Severe gastroparesis is associated with an increased incidence of slow-transit constipation as measured by wireless motility capsule.

Radetic, Mark / Kamal, Afrin / Rouphael, Carol / Kou, Lei / Lyu, Ruishen / Cline, Michael

Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society

2020 Volume 33, Issue 5, Page(s) e14045

Abstract: Background: Dysmotility in one region of the gastrointestinal tract has been found to predispose patients to developing motility disorders in other gastrointestinal segments. However, few studies have evaluated the relationship between gastroparesis and ...

Abstract	Background: Dysmotility in one region of the gastrointestinal tract has been found to predispose patients to developing motility disorders in other gastrointestinal segments. However, few studies have evaluated the relationship between gastroparesis and constipation. Methods: Retrospective review of 224 patients who completed 4-hour, solid-phase gastric emptying scintigraphy (GES), and wireless motility capsule (WMC) testing to evaluate for gastroparesis and slow-transit constipation, respectively. When available, anorectal manometry data were reviewed to evaluate for dyssynergic defecation. Patients were divided into two groups based on the results of the GES: 101 patients with normal gastric emptying and 123 patients with gastroparesis (stratified by severity). Differences in constipation rates were compared between the groups. Key results: Slow-transit constipation was more common in the gastroparesis group, but statistical significance was not reached (42.3% vs 34.7%, p = 0.304). Univariate logistical regression analysis found no association between slow-transit constipation and gastroparesis (OR 1.38, 95% CI 0.80-2.38, p = 0.245) nor dyssynergic defecation and gastroparesis (OR 0.88, 95% CI 0.29-2.70, p = 0.822). However, when stratifying gastroparesis based on severity, slow-transit constipation was found to be associated with severe gastroparesis (OR 2.45, 95% CI 1.20-5.00, p = 0.014). This association was strengthened with the exclusion of patients with diabetes mellitus (OR 3.5, 95% CI 1.39-8.83, p = 0.008) - a potential confounder. Conclusions & inferences: Patients with severe gastroparesis (>35% gastric retention at the 4-hour mark on solid-phase GES) have an increased likelihood of having underlying slow-transit constipation. Dyssynergic defecation does not appear to be associated with gastroparesis (of any severity).
MeSH term(s)	Adult ; Case-Control Studies ; Constipation/epidemiology ; Constipation/physiopathology ; Female ; Gastric Emptying ; Gastrointestinal Transit/physiology ; Gastroparesis/epidemiology ; Humans ; Incidence ; Male ; Middle Aged ; Severity of Illness Index ; Wireless Technology
Language	English
Publishing date	2020-11-24
Publishing country	England
Document type	Journal Article
ZDB-ID	1186328-6
ISSN	1365-2982 ; 1350-1925
ISSN (online)	1365-2982
ISSN	1350-1925
DOI	10.1111/nmo.14045
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Article ; Online: Novel through-the-scope suture closure of colonic EMR defects (with video).

Bi, Danse / Zhang, Linda Y / Alqaisieh, Mohammad / Shrigiriwar, Apurva / Farha, Jad / Mahmoud, Tala / Akiki, Karl / Almario, Jose Antonio / Shah-Khan, Sardar M / Gordon, Stuart R / Adler, Jeffrey M / Radetic, Mark / Draganov, Peter V / David, Yakira N / Shinn, Brianna / Mohammed, Zahraa / Schlachterman, Alexander / Yuen, Sofia / Al-Taee, Ahmad /

Gastrointestinal endoscopy

2023 Volume 98, Issue 1, Page(s) 122–129

Abstract: Background and aims: Large colon polyps removed by EMR can be complicated by delayed bleeding. Prophylactic defect clip closure can reduce post-EMR bleeding. Larger defects can be challenging to close using through-the-scope clips (TTSCs), and proximal ... ...

Abstract	Background and aims: Large colon polyps removed by EMR can be complicated by delayed bleeding. Prophylactic defect clip closure can reduce post-EMR bleeding. Larger defects can be challenging to close using through-the-scope clips (TTSCs), and proximal defects are difficult to reach using over-the-scope techniques. A novel, through-the-scope suturing (TTSS) device allows direct closure of mucosal defects without scope withdrawal. The goal of this study was to evaluate the rate of delayed bleeding after the closure of large colon polyp EMR sites with TTSS. Methods: A multicenter retrospective cohort study was performed involving 13 centers. All defect closure by TTSS after EMR of colon polyps ≥2 cm from January 2021 to February 2022 were included. The primary outcome was rate of delayed bleeding. Results: A total of 94 patients (52% female; mean age, 65 years) underwent EMR of predominantly right-sided (n = 62 [66%]) colon polyps (median size, 35 mm; interquartile range, 30-40 mm) followed by defect closure with TTSS during the study period. All defects were successfully closed with TTSS alone (n = 62 [66%]) or with TTSS and TTSCs (n = 32 [34%]), using a median of 1 (interquartile range, 1-1) TTSS system. Delayed bleeding occurred in 3 patients (3.2%), with 2 requiring repeated endoscopic evaluation/treatment (moderate). Conclusion: TTSS alone or with TTSCs was effective in achieving complete closure of all post-EMR defects, despite a large lesion size. After TTSS closure with or without adjunctive devices, delayed bleeding was seen in 3.2% of cases. Further prospective studies are needed to validate these findings before wider adoption of TTSS for large polypectomy closure.
MeSH term(s)	Aged ; Female ; Humans ; Male ; Colon/surgery ; Colon/pathology ; Colonic Polyps/pathology ; Colonoscopy/methods ; Endoscopic Mucosal Resection/adverse effects ; Postoperative Hemorrhage/epidemiology ; Postoperative Hemorrhage/etiology ; Retrospective Studies ; Surgical Instruments
Language	English
Publishing date	2023-03-06
Publishing country	United States
Document type	Video-Audio Media ; Multicenter Study ; Journal Article
ZDB-ID	391583-9
ISSN	1097-6779 ; 0016-5107
ISSN (online)	1097-6779
ISSN	0016-5107
DOI	10.1016/j.gie.2023.02.031
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