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  1. Article ; Online: EZH2-interacting lncRNAs contribute to gastric tumorigenesis; a review on the mechanisms of action.

    Mohebbi, Hossein / Esbati, Romina / Hamid, Ran Abdalsalam / Akhavanfar, Roozbeh / Radi, Usama Kadem / Siri, Goli / Yazdani, Omid

    Molecular biology reports

    2024  Volume 51, Issue 1, Page(s) 334

    Abstract: Gastric cancer (GC) remains one of the deadliest malignancies worldwide, demanding new targets to improve its diagnosis and treatment. Long non-coding RNAs (lncRNAs) are dysregulated through gastric tumorigenesis and play a significant role in GC ... ...

    Abstract Gastric cancer (GC) remains one of the deadliest malignancies worldwide, demanding new targets to improve its diagnosis and treatment. Long non-coding RNAs (lncRNAs) are dysregulated through gastric tumorigenesis and play a significant role in GC progression and development. Recent studies have revealed that lncRNAs can interact with histone-modifying polycomb protein, enhance Zeste Homolog 2 (EZH2), and mediate its site-specific functioning. EZH2, which functions as an oncogene in GC, is the catalytic subunit of the PRC2 complex that induces H3K27 trimethylation and epigenetically represses gene expression. EZH2-interacting lncRNAs can recruit EZH2 to the promoter regions of various tumor suppressor genes and cause their transcriptional deactivation via histone methylation. The interactions between EZH2 and this lncRNA modulate different processes, such as cell cycle, cell proliferation and growth, migration, invasion, metastasis, and drug resistance, in vitro and in vivo GC models. Therefore, EZH2-interacting lncRNAs are exciting targets for developing novel targeted therapies for GC. Subsequently, this review aims to focus on the roles of these interactions in GC progression to understand the therapeutic value of EZH2-interacting lncRNAs further.
    MeSH term(s) Humans ; Carcinogenesis/genetics ; Cell Line, Tumor ; Cell Proliferation/genetics ; Cell Transformation, Neoplastic/genetics ; Enhancer of Zeste Homolog 2 Protein/genetics ; Enhancer of Zeste Homolog 2 Protein/metabolism ; Gene Expression Regulation, Neoplastic/genetics ; Histones/genetics ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Stomach Neoplasms/genetics ; Stomach Neoplasms/pathology
    Chemical Substances Enhancer of Zeste Homolog 2 Protein (EC 2.1.1.43) ; EZH2 protein, human (EC 2.1.1.43) ; Histones ; RNA, Long Noncoding
    Language English
    Publishing date 2024-02-23
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-024-09237-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Ultrasonic synthesis of green lipid nanocarriers loaded with Scutellaria barbata extract: a sustainable approach for enhanced anticancer and antibacterial therapy.

    Jetti, Raghu / Vaca Cárdenas, Maritza Lucia / Al-Saedi, Haider Falih Shamikh / Hussein, Shaymaa Abed / Abdulridui, Hussam Abdali / Al-Abdeen, Salah Hassan Zain / Radi, Usama Kadem / Abdulkadhim, Adnan Hashim / Hussein, Sahar Balkit / Alawadi, Ahmed / Alsalamy, Ali

    Bioprocess and biosystems engineering

    2024  

    Abstract: Ultrasonic manufacturing has emerged as a promising eco-friendly approach to synthesize lipid-based nanocarriers for targeted drug delivery. This study presents the novel ultrasonic preparation of lipid nanocarriers loaded with Scutellaria barbata ... ...

    Abstract Ultrasonic manufacturing has emerged as a promising eco-friendly approach to synthesize lipid-based nanocarriers for targeted drug delivery. This study presents the novel ultrasonic preparation of lipid nanocarriers loaded with Scutellaria barbata extract, repurposed for anticancer and antibacterial use. High-frequency ultrasonic waves enabled the precise self-assembly of DSPE-PEG, Span 40, and cholesterol to form nanocarriers encapsulating the therapeutic extract without the use of toxic solvents, exemplifying green nanotechnology. Leveraging the inherent anticancer and antibacterial properties of Scutellaria barbata, the study demonstrates that lipid encapsulation enhances the bioavailability and controlled release of the extract, which is vital for its therapeutic efficacy. Dynamic light scattering and transmission electron microscopy analyses confirmed the increase in size and successful encapsulation post-loading, along with an augmented negative zeta potential indicating enhanced stability. A high encapsulation efficiency of 91.93% was achieved, and in vitro assays revealed the loaded nanocarriers' optimized release kinetics and improved antimicrobial potency against Pseudomonas aeruginosa, compared to the free extract. The combination of ultrasonic synthesis and Scutellaria barbata in an eco-friendly manufacturing process not only advances green nanotechnology but also contributes to sustainable practices in pharmaceutical manufacturing. The data suggest that this innovative nanocarrier system could provide a robust platform for the development of nanotechnology-based therapeutics, enhancing drug delivery efficacy while aligning with environmental sustainability.
    Language English
    Publishing date 2024-04-22
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1476357-6
    ISSN 1615-7605 ; 1432-0797 ; 1615-7591
    ISSN (online) 1615-7605 ; 1432-0797
    ISSN 1615-7591
    DOI 10.1007/s00449-024-03021-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A chemometric approach based on response surface methodology for optimization of antibiotic and organic dyes removal from water samples.

    Hsu, Chou-Yi / Ali, Eyhab / Al-Saedi, Haider Falih Shamikh / Mohammed, Amjed Qasim / Mustafa, Nadia Khalid / Talib, Maysm Barzan / Radi, Usama Kadem / Ramadan, Montather F / Ami, Ahmed Ali / Al-Shuwaili, Saeb Jasim / Alawadi, Ahmed / Alsalamy, Ali / Baharinikoo, Leila

    BMC chemistry

    2024  Volume 18, Issue 1, Page(s) 5

    Abstract: In this study, the ... ...

    Abstract In this study, the Fe
    Language English
    Publishing date 2024-01-03
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2661-801X
    ISSN (online) 2661-801X
    DOI 10.1186/s13065-023-01107-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: MicroRNA-155 and cancer metastasis: Regulation of invasion, migration, and epithelial-to-mesenchymal transition.

    Moutabian, Hossein / Radi, Usama Kadem / Saleman, Abdulkarem Younis / Adil, Mohaned / Zabibah, Rahman S / Chaitanya, Mv N L / Saadh, Mohamed J / Jawad, Mahmood Jasem / Hazrati, Ebrahi / Bagheri, Hamed / Pal, Rashmi Saxena / Akhavan-Sigari, Reza

    Pathology, research and practice

    2023  Volume 250, Page(s) 154789

    Abstract: Among the leading causes of death globally has been cancer. Nearly 90% of all cancer-related fatalities are attributed to metastasis, which is the growing of additional malignant growths out of the original cancer origin. Therefore, a significant ... ...

    Abstract Among the leading causes of death globally has been cancer. Nearly 90% of all cancer-related fatalities are attributed to metastasis, which is the growing of additional malignant growths out of the original cancer origin. Therefore, a significant clinical need for a deeper comprehension of metastasis exists. Beginning investigations are being made on the function of microRNAs (miRNAs) in the metastatic process. Tiny non-coding RNAs called miRNAs have a crucial part in controlling the spread of cancer. Some miRNAs regulate migration, invasion, colonization, cancer stem cells' properties, the epithelial-mesenchymal transition (EMT), and the microenvironment, among other processes, to either promote or prevent metastasis. One of the most well-conserved and versatile miRNAs, miR-155 is primarily distinguished by overexpression in a variety of illnesses, including malignant tumors. It has been discovered that altered miR-155 expression is connected to a number of physiological and pathological processes, including metastasis. As a result, miR-155-mediated signaling pathways were identified as possible cancer molecular therapy targets. The current research on miR-155, which is important in controlling cancer cells' invasion, and metastasis as well as migration, will be summarized in the current work. The crucial significance of the lncRNA/circRNA-miR-155-mRNA network as a crucial regulator of carcinogenesis and a player in the regulation of signaling pathways or related genes implicated in cancer metastasis will be covered in the final section. These might provide light on the creation of fresh treatment plans for controlling cancer metastasis.
    Language English
    Publishing date 2023-09-12
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 391889-0
    ISSN 1618-0631 ; 0344-0338
    ISSN (online) 1618-0631
    ISSN 0344-0338
    DOI 10.1016/j.prp.2023.154789
    Database MEDical Literature Analysis and Retrieval System OnLINE

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