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Article: Allergic reactions after vaccination: translating guidelines into clinical practice.

Radice, A / Carli, G / Macchia, D / Farsi, A

European annals of allergy and clinical immunology

2019 Volume 51, Issue 2, Page(s) 51–61

Abstract: Summary: Vaccination represents one of the most powerful medical interventions on global health. Despite being safe, sustainable, and effective against infectious and in some cases also non-infectious diseases, it's nowadays facing general opinion's ... ...

Abstract	Summary: Vaccination represents one of the most powerful medical interventions on global health. Despite being safe, sustainable, and effective against infectious and in some cases also non-infectious diseases, it's nowadays facing general opinion's hesitancy because of a false perceived risk of adverse events. Adverse reactions to vaccines are relatively rare, instead, and those recognizing a hypersensitivity mechanism are even rarer. The purpose of this review is to offer a practical approach to adverse events after vaccination, focusing on immune-mediated reactions with particular regard to their recognition, diagnosis and management. According to clinical features, we propose an algorythm for allergologic work-up, which helps in confirming hypersensitivity to vaccine, nonetheless ensuring access to vaccination. Finally, a screening questionnaire is included, providing criteria for immunisation in specialized care settings.
MeSH term(s)	Anaphylaxis/diagnosis ; Anaphylaxis/immunology ; Anaphylaxis/therapy ; Cold Temperature ; Drug Hypersensitivity/diagnosis ; Drug Hypersensitivity/immunology ; Drug Hypersensitivity/therapy ; Histamine Antagonists/therapeutic use ; Humans ; Practice Guidelines as Topic ; Vaccination/adverse effects ; Vaccines/adverse effects ; Vaccines/immunology
Chemical Substances	Histamine Antagonists ; Vaccines
Language	English
Publishing date	2019-01-31
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	2105540-3
ISSN	1764-1489 ; 0397-9148
ISSN	1764-1489 ; 0397-9148
DOI	10.23822/EurAnnACI.1764-1489.86
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Article: Potential culprits for immediate hypersensitivity reactions to BNT162b2 mRNA COVID-19 vaccine: not just PEG.

Radice, A / Fassio, F / Meucci, E / Iorno, M C L / Macchia, D

European annals of allergy and clinical immunology

2021 Volume 53, Issue 5, Page(s) 240–242

MeSH term(s)	Acetamides/adverse effects ; Amino Alcohols/adverse effects ; COVID-19 Vaccines/adverse effects ; COVID-19 Vaccines/chemistry ; Decanoates/adverse effects ; Drug Compounding ; Drug Hypersensitivity/etiology ; Drug Hypersensitivity/immunology ; Fatty Alcohols/adverse effects ; Humans ; Hypersensitivity, Immediate/chemically induced ; Hypersensitivity, Immediate/immunology ; Nanoparticles ; Polyethylene Glycols/adverse effects ; Risk Assessment ; Risk Factors
Chemical Substances	Acetamides ; Amino Alcohols ; COVID-19 Vaccines ; Decanoates ; Fatty Alcohols ; Polyethylene Glycols (3WJQ0SDW1A) ; (4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis(2-hexyldecanoate) (AVX8DX713V) ; BNT162 vaccine (N38TVC63NU) ; 2-((polyethylene glycol)-2000)-N,N-ditetradecylacetamide (PJH39UMU6H)
Language	English
Publishing date	2021-04-29
Publishing country	Italy
Document type	Letter
ZDB-ID	2105540-3
ISSN	1764-1489 ; 0397-9148
ISSN	1764-1489 ; 0397-9148
DOI	10.23822/EurAnnACI.1764-1489.214
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Article: Diagnostic approach to hypersensitivity reactions to iodinated contrast media: a single-center experience on 98 patients.

Meucci, E / Radice, A / Fassio, F / Sibilio, M / Iorno, M L C / Testi, S / Severino, M / Macchia, D

European annals of allergy and clinical immunology

2020 Volume 52, Issue 5, Page(s) 220–229

Abstract: Summary: Adverse reactions to iodinated contrast media (ICM) are reported in 1%-3% of diagnostic procedures. They represent a relevant problem involving patients' safety as well as relevant costs for healthcare systems. Premedication with antihistamines ...

Abstract	Summary: Adverse reactions to iodinated contrast media (ICM) are reported in 1%-3% of diagnostic procedures. They represent a relevant problem involving patients' safety as well as relevant costs for healthcare systems. Premedication with antihistamines and corticosteroids is still widely used, but evidence of its efficacy is lacking and there is a risk for under-estimation of possible severe adverse reactions to ICM in those who undergo premedication. Data from 98 patients with a previous reaction to ICM that consecutively referred to our unit between 2015 and 2018 were retrospectively analyzed. They underwent an allergologic workup comprehending skin tests and drug provocation tests (DPT) with ICM. The skin test showed a very high negative predictive value (NPV) compared to DPT in patients with a previous immediate adverse reaction, while the NPV in patients with a previous delayed adverse reaction was lower. After completion of the allergologic workup, 94 patients (95.9%) could tolerate a DPT with the culprit or alternative ICM. Subsequently, 90 patients were reached by phone to assess if they had been re-exposed to ICM for radiologic procedure. Thirty-nine patients had been re-exposed, without any premedication in 13 cases: 12 of them had tolerated the ICM, while one reacted again despite a negative DPT with the same ICM. Overall, the NPV of this protocol was elevated (92.3%) for patients undergoing DPT and subsequent exposure to the same ICM in a real-life setting. Collaboration between the prescribing physician, the radiologist and the allergist, and an accurate allergologic workup are essential to ensure maximum safety for the patient.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Allergens/adverse effects ; Allergens/immunology ; Contrast Media/adverse effects ; Drug Hypersensitivity/diagnosis ; Drug-Related Side Effects and Adverse Reactions/diagnosis ; Female ; Humans ; Immunization ; Iodine Compounds/adverse effects ; Iodine Compounds/immunology ; Male ; Middle Aged ; Predictive Value of Tests ; Retrospective Studies ; Skin Tests ; Young Adult
Chemical Substances	Allergens ; Contrast Media ; Iodine Compounds
Language	English
Publishing date	2020-09-07
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2105540-3
ISSN	1764-1489 ; 0397-9148
ISSN	1764-1489 ; 0397-9148
DOI	10.23822/EurAnnACI.1764-1489.129
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Article ; Online: Microarray evaluation of allergen-specific IgE in eosinophilic granulomatosis with polyangiitis.

Bello, Federica / Maritati, Federica / Radice, Antonella / Sinico, Renato Alberto / Emmi, Giacomo / Vaglio, Augusto

Annals of the rheumatic diseases

2021 Volume 80, Issue 9, Page(s) 1247–1248

Language	English
Publishing date	2021-04-21
Publishing country	England
Document type	Letter
ZDB-ID	7090-7
ISSN	1468-2060 ; 0003-4967
ISSN (online)	1468-2060
ISSN	0003-4967
DOI	10.1136/annrheumdis-2021-220111
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Article: Omalizumab for prevention of anaphylactic episodes in a patient with severe mosquito allergy.

Meucci, Elisa / Radice, Anna / Fassio, Filippo / Iorno, Maria Loredana Chiara / Macchia, Donatella

Clinical case reports

2021 Volume 9, Issue 10, Page(s) e04935

Abstract: Anaphylaxis after mosquito bite is rare, but life threatening. No approved preventive therapy is available to date, but omalizumab could be a promising therapeutic option for reducing risk and improving quality of life in these patients. ...

Abstract	Anaphylaxis after mosquito bite is rare, but life threatening. No approved preventive therapy is available to date, but omalizumab could be a promising therapeutic option for reducing risk and improving quality of life in these patients.
Language	English
Publishing date	2021-10-21
Publishing country	England
Document type	Case Reports
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.4935
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Article: Image-based lagrangian particle tracking in bed-load experiments

Radice, Alessio / Sarkar, Sankar / Ballio, Francesco

Journal of visualized experiments. 2017 July 20, , no. 125

2017

Abstract: Image analysis has been increasingly used for the measurement of river flows due to its capabilities to furnish detailed quantitative depictions at a relatively low cost. This manuscript describes an application of particle tracking velocimetry (PTV) to ... ...

Abstract	Image analysis has been increasingly used for the measurement of river flows due to its capabilities to furnish detailed quantitative depictions at a relatively low cost. This manuscript describes an application of particle tracking velocimetry (PTV) to a bed-load experiment with lightweight sediment. The key characteristics of the investigated sediment transport conditions were the presence of a covered flow and of a fixed rough bed above which particles were released in limited number at the flume inlet. Under the applied flow conditions, the motion of the individual bed-load particles was intermittent, with alternating movement and stillness terms. The flow pattern was preliminarily characterized by acoustic measurements of vertical profiles of the stream-wise velocity. During process visualization, a large field of view was obtained using two action-cameras placed at different locations along the flume. The experimental protocol is described in terms of channel calibration, experiment realization, image pre-processing, automatic particle tracking, and post-processing of particle track data from the two cameras. The presented proof-of-concept results include probability distributions of the particle hop length and duration. The achievements of this work are compared to those of existing literature to demonstrate the validity of the protocol.
Keywords	acoustics ; bedload ; cameras ; hydraulic flumes ; image analysis ; probability distribution ; sediment transport ; sediments ; velocimetry
Language	English
Dates of publication	2017-0720
Size	p. e55874.
Publishing place	Journal of Visualized Experiments
Document type	Article
ZDB-ID	2259946-0
ISSN	1940-087X
ISSN	1940-087X
DOI	10.3791/55874
Database	NAL-Catalogue (AGRICOLA)

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Article: Antineutrophil cytoplasmic antibodies (ANCA) testing: detection methods and clinical application.

Sinico, Renato Alberto / Radice, Antonella

Clinical and experimental rheumatology

2014 Volume 32, Issue 3 Suppl 82, Page(s) S112–7

Abstract: Antineutrophil cytoplasmic antibodies (ANCA) are considered the diagnostic biomarker of some necrotising vasculitis such as granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and, to a lesser extent, eosinophilic granulomatosis with ... ...

Abstract	Antineutrophil cytoplasmic antibodies (ANCA) are considered the diagnostic biomarker of some necrotising vasculitis such as granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and, to a lesser extent, eosinophilic granulomatosis with polyangiitis (EGPA). According to the current recommendations, combining indirect immunofluorescence and proteinase 3 (PR3) and myeloperoxidase (MPO) antigen specific immunometric assays, in the proper clinical setting, assures the best diagnostic specificity. When such conditions are satisfied, ANCA are detected in up to 90% of patients with active generalised GPA and MPA and in about 40% of patients with EGPA. Cytoplasmic ANCA (C-ANCA) with specificity for PR3 are usually found in patients with GPA whereas perinuclear ANCA (P-ANCA) in patients with MPA and EGPA. However, ANCA antigen specificity is more closely associated with disease phenotype and prognosis than clinical diagnosis. The clinical value of serial ANCA testing in monitoring disease activity is still debated. Recently, new promising developments in methodology and techniques (computer-based image analysis of immunofluorescence patterns, novel generation of PR3-/MPO-ANCA immunometric assays and multiplex technology) have been proposed but studies comparing the performances of the different assays are scarce.
MeSH term(s)	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/diagnosis ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/immunology ; Antibodies, Antineutrophil Cytoplasmic/analysis ; Antibodies, Antineutrophil Cytoplasmic/immunology ; Biomarkers/analysis ; Biomarkers/blood ; Comparative Effectiveness Research ; Humans ; Image Interpretation, Computer-Assisted ; Immunoassay/classification ; Immunoassay/methods ; Immunoassay/trends ; Inventions ; Monitoring, Physiologic/methods ; Predictive Value of Tests ; Prognosis ; Secondary Prevention
Chemical Substances	Antibodies, Antineutrophil Cytoplasmic ; Biomarkers
Language	English
Publishing date	2014-05
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	605886-3
ISSN	1593-098X ; 0392-856X
ISSN (online)	1593-098X
ISSN	0392-856X
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Article ; Online: Image-based Lagrangian Particle Tracking in Bed-load Experiments.

Radice, Alessio / Sarkar, Sankar / Ballio, Francesco

Journal of visualized experiments : JoVE

2017 , Issue 125

Abstract	Image analysis has been increasingly used for the measurement of river flows due to its capabilities to furnish detailed quantitative depictions at a relatively low cost. This manuscript describes an application of particle tracking velocimetry (PTV) to a bed-load experiment with lightweight sediment. The key characteristics of the investigated sediment transport conditions were the presence of a covered flow and of a fixed rough bed above which particles were released in limited number at the flume inlet. Under the applied flow conditions, the motion of the individual bed-load particles was intermittent, with alternating movement and stillness terms. The flow pattern was preliminarily characterized by acoustic measurements of vertical profiles of the stream-wise velocity. During process visualization, a large field of view was obtained using two action-cameras placed at different locations along the flume. The experimental protocol is described in terms of channel calibration, experiment realization, image pre-processing, automatic particle tracking, and post-processing of particle track data from the two cameras. The presented proof-of-concept results include probability distributions of the particle hop length and duration. The achievements of this work are compared to those of existing literature to demonstrate the validity of the protocol.
Language	English
Publishing date	2017-07-20
Publishing country	United States
Document type	Journal Article
ISSN	1940-087X
ISSN (online)	1940-087X
DOI	10.3791/55874
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Article ; Online: Towards the Definition of the Molecular Hallmarks of Idiopathic Membranous Nephropathy in Serum Proteome: A DIA-PASEF Approach.

Previtali, Paolo / Pagani, Lisa / Risca, Giulia / Capitoli, Giulia / Bossi, Eleonora / Oliveira, Glenda / Piga, Isabella / Radice, Antonella / Trezzi, Barbara / Sinico, Renato Alberto / Magni, Fulvio / Chinello, Clizia

International journal of molecular sciences

2023 Volume 24, Issue 14

Abstract: Idiopathic membranous nephropathy (IMN) is a pathologically defined disorder of the glomerulus, primarily responsible for nephrotic syndromes (NS) in nondiabetic adults. The underlying molecular mechanisms are still not completely clarified. To explore ... ...

Abstract	Idiopathic membranous nephropathy (IMN) is a pathologically defined disorder of the glomerulus, primarily responsible for nephrotic syndromes (NS) in nondiabetic adults. The underlying molecular mechanisms are still not completely clarified. To explore possible molecular and functional signatures, an optimised mass spectrometry (MS) method based on next-generation data-independent acquisition combined with ion-mobility was applied to serum of patients affected by IMN (n = 15) or by other glomerulopathies (PN) (n = 15). The statistical comparison highlighted a panel of 57 de-regulated proteins with a significant increase in lipoprotein-related proteins (APOC1, APOB, APOA1, APOL1 and LCAT) and a substantial quantitative alteration of key serpins (including A4, D1, A7, A6, F2, F1 and 1) possibly associated with IMN or NS and podocyte stress. A critical dysregulation in metabolisms of lipids (e.g., VLDL assembly and clearance) likely to be related to known hyperlipidemia in IMN, along with involvement of non-classical complement pathways and a putative enrolment of ficolin-2 in sustaining the activation of the lectin-mediated complement system have been pinpointed. Moreover, mannose receptor CD206 (MRC1-down in IMN) and biotinidase (BTD-up in IMN) are able alone to accurately distinguish IMN vs. PN. To conclude, our work provides key proteomic insights into the IMN complexity, opening the way to an efficient stratification of MN patients.
MeSH term(s)	Adult ; Humans ; Glomerulonephritis, Membranous ; Proteome ; Proteomics ; Kidney Glomerulus/metabolism ; Nephrotic Syndrome ; Apolipoprotein L1
Chemical Substances	Proteome ; APOL1 protein, human ; Apolipoprotein L1
Language	English
Publishing date	2023-07-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241411756
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Article ; Online: Prevalence and clinical significance of ANCA positivity in lupus nephritis: a case series of 116 patients and literature review.

Lacetera, Rosanna / Calatroni, Marta / Roggero, Letizia / Radice, Antonella / Pozzi, Maria Rosa / Reggiani, Francesco / Sciascia, Savino / Trezzi, Barbara / Roccatello, Dario / Minetti, Enrico / Moroni, Gabriella / Sinico, Renato Alberto

Journal of nephrology

2023 Volume 36, Issue 4, Page(s) 1059–1070

Abstract: The prevalence and clinical significance of anti-neutrophil cytoplasmic antibodies [ANCAs] in patients with lupus nephritis [LN] is not fully elucidated. Our aim was to determine whether LN patients with ANCA positivity had different clinicopathological ... ...

Abstract	The prevalence and clinical significance of anti-neutrophil cytoplasmic antibodies [ANCAs] in patients with lupus nephritis [LN] is not fully elucidated. Our aim was to determine whether LN patients with ANCA positivity had different clinicopathological features and outcomes compared to ANCA-negative patients. Methods: Among our LN patients we retrospectively selected those who underwent ANCA testing the day of the kidney biopsy and before the start of induction treatment. Clinical/histopathological features at kidney biopsy and renal outcome of ANCA-positive patients were compared with those of ANCA-negative subjects. Results: We included 116 Caucasian LN patients in the study; 16 patients [13.8%] were ANCA-positive. At kidney biopsy, ANCA-positive patients presented more frequently with an acute nephritic syndrome than ANCA-negative ones; the difference however does not reach statistical significance [44 vs. 25%, p = 0.13]. At histological evaluation, proliferative classes [100% vs 73%; p = 0.02], class IV [68.8% vs 33%; p < 0.01] and necrotizing tuft lesions [27 vs 7%, p = 0.04] were more frequent, and the activity index was higher [10 vs 7; p = 0.03] in ANCA-positive than in ANCA-negative patients. Despite worse histological features, after a 10-year observation period, there were no significant differences in the number of patients with chronic kidney function impairment (defined as eGFR < 60 mL/min per 1.73 m Conclusions: ANCA-positive LN patients frequently have histological markers of severe activity (proliferative classes and high activity index) that require timely diagnosis and aggressive therapy to limit the development of irreversible chronic kidney damage.
MeSH term(s)	Humans ; Lupus Nephritis/diagnosis ; Lupus Nephritis/drug therapy ; Lupus Nephritis/epidemiology ; Antibodies, Antineutrophil Cytoplasmic ; Retrospective Studies ; Clinical Relevance ; Prevalence
Chemical Substances	Antibodies, Antineutrophil Cytoplasmic
Language	English
Publishing date	2023-03-20
Publishing country	Italy
Document type	Review ; Journal Article
ZDB-ID	1093991-x
ISSN	1724-6059 ; 1120-3625 ; 1121-8428
ISSN (online)	1724-6059
ISSN	1120-3625 ; 1121-8428
DOI	10.1007/s40620-023-01574-3
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