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Artikel ; Online: Clinical and echocardiographic predictors of the anterior mitral leaflet repair failure.

Stojanovic, Ivan / Okiljevic, Bogdan R / Radojicic, Zoran / Novakovic, Aleksandra / Kaitovic, Marko / Tomic, Slobodan

2022 Band 37, Heft 11, Seite(n) 3567–3574

Abstract: Background: Anterior mitral leaflet prolapse repair is a highly effective procedure, but despite excellent operative results still has an inferior long-term durability when compared to posterior leaflet repair.: Methods: We analysed mitral repair ... ...

Abstract	Background: Anterior mitral leaflet prolapse repair is a highly effective procedure, but despite excellent operative results still has an inferior long-term durability when compared to posterior leaflet repair. Methods: We analysed mitral repair durability in 74 consecutive patients operated for anterior leaflet prolapse between 2010 and 2021. Their pre- and postoperative clinical, echocardiographic data and repair durability as well, were compared with 74 randomly assigned posterior leaflet prolapse patients who underwent valve repair during the same period. Results: While groups were of similar age, patients with anterior leaflet prolapse had an inferior preoperative status in terms of functional reserve, atrial fibrillation, operative risk, ejection fraction and had more dilated left heart chambers as well. 1, 5, and 10-year freedom from repair failure was 87.1 ± 4.6%, 79.8 ± 6.5% and 50.7 ± 12.5% in the anterior, and 98.5 ± 1.5% respectively in the posterior leaflet group. Atrial fibrilation (hazard ratio [HR] 5.365; 95%; confidence interval [CI] 1.093-26.324 p = .038) and left ventricle end-systolic diameter (HR 1.160 95%; CI 1.037-1.299 p = .010) independently predicted anterior leaflet repair failure. Receiver Operating Curve analysis established left ventricle end-systolic diameter ≤42 mm as a cut-off value associated with improved anterior leaflet repair durability. Accordingly, 10-year repair durability in a subset of patients, with preserved left ventricle end-systolic diameter (≤42 mm) was 86.4 ± 7.8%. Conclusion: Better long-term repair durability in patients with anterior mitral leaflet prolapse and preserved sinus rhytm and left-ventricle diameters justifies early reconstructive approach.
Mesh-Begriff(e)	Echocardiography ; Humans ; Mitral Valve/diagnostic imaging ; Mitral Valve/surgery ; Mitral Valve Insufficiency/diagnostic imaging ; Mitral Valve Insufficiency/surgery ; Mitral Valve Prolapse/diagnostic imaging ; Mitral Valve Prolapse/surgery ; Prolapse ; Treatment Outcome
Sprache	Englisch
Erscheinungsdatum	2022-09-19
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Randomized Controlled Trial
ZDB-ID	639059-6
ISSN	1540-8191 ; 0886-0440
ISSN (online)	1540-8191
ISSN	0886-0440
DOI	10.1111/jocs.16945
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Buch ; Online: Emerging trends in the development and application of composite indicators

Dobrota, Marina / Jeremic, Veljko / Radojicic, Zoran

2017

Abstract: This book is an authoritative reference source for the latest scholarly research on the benefits and challenges presented by building composite indicators, and how these techniques promote optimized critical thinking"--Provided by publisher ... Measuring ... ...

Körperschaft	IGI Global
Verfasserangabe	Veljko Jeremic, Zoran Radojicic, and Marina Dobrota, editors
Abstract	"This book is an authoritative reference source for the latest scholarly research on the benefits and challenges presented by building composite indicators, and how these techniques promote optimized critical thinking"--Provided by publisher Measuring cross-border regional integration with composite indicators: the Oresund integration index / Teemu Makkonen -- Developing a sustainable urban mobility index: methodological steps / Yongjun Shen, Elke Hermans -- Composite indices in technology management: a critical approach / Milica Jovanovic [and 4 others] -- Composite indicators of a knowledge society: triangulation of experts interviews and factor analyses / Norsiah Abdul Hamid [and 3 others] -- Composite indicators construction by data envelopment analysis: methodological background / Gordana Savic, Milan Martic -- Methodological challenges in building composite indexes: linking theory to practice / Fabio Gaetano Santeramo -- Composite indicators of development: some recent contributions / Sandrina B. Moreira, Nuno Crespo -- Constructing a multidimensional socioeconomic index and the validation of it with early child developmental outcomes / Vijaya Krishnan -- The rule of law index: is it really impartial? A twofold multivariate i-distance approach / Milica Maricic, Milica Bulajic, Milica Vasilijevic -- Comparison of input and output indicators in measuring human capital: an analysis at provincial level for Turkey / Sibel Bali -- The Delphi method application in the analysis of postgraduate students' attitudes on the environmental performance index / Natasa Petrovic [and 4 others] -- How age-friendly are cities?: measuring age-friendliness with a composite index / Lucie Vidovicová -- Using data envelopment analysis to construct human development index / Paulo Nocera Alves Junior, Enzo Barberio Mariano, Daisy Aparecida do Nascimento Rebelatto -- Statistical approach for ranking OECD countries based on composite GICSES index and I-distance method / Maja Mitrovic, Maja Markovic, Stefan Zdravkovic
Schlagwörter	Economic indicators ; Political indicators ; Science indicators ; Social indicators ; Statistics
Sprache	Englisch
Umfang	1 Online-Ressource (PDFs (401 pages)), illustrations
Verlag	IGI Global
Erscheinungsort	Hershey, Pennsylvania (701 E. Chocolate Avenue, Hershey, PA 17033, USA)
Dokumenttyp	Buch ; Online
Anmerkung	Includes bibliographical references and index ; Restricted to subscribers or individual electronic text purchasers
ISBN	1522507140 ; 9781522507147 ; 9781522507154 ; 1522507159
Datenquelle	ECONomics Information System

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Artikel ; Online: The influence of bowel management on urodynamic findings in spina bifida children with detrusor overactivity and detrusor sphincter dyssynergia.

Milivojevic, Sasa / Milic, Natasa / Lazovic, Jelena Milin / Radojicic, Zoran

Journal of pediatric urology

2020 Band 16, Heft 5, Seite(n) 556.e1–556.e7

Abstract: Objective: To examine the effects of bowel management on urodynamic findings in spina bifida children with detrusor overactivity (DO) and detrusor sphincter dyssynergia (DSD).: Material and methods: Between 2014 and 2019 we prospectively evaluated 39 ...

Abstract	Objective: To examine the effects of bowel management on urodynamic findings in spina bifida children with detrusor overactivity (DO) and detrusor sphincter dyssynergia (DSD). Material and methods: Between 2014 and 2019 we prospectively evaluated 39 consecutive spina bifida children with DO and DSD (18 (46.2%) boys and 21 (53.8%) girls, aged 4-16 years; mean age 9.5 ± 3.7 years) who received bowel management and we treated their bowel dysfunction with an aim of alleviating the symptoms of constipation, preventing constant overdistension of the rectosigmoid, providing regular emptying of the colon and faecal continence. Bowel management included daily enema, laxative application and a special diet who was performed during 12 months. All children had undergone urodynamic studies before and after starting bowel management, with no changes in their urological treatment. Results: Bowel management caused an increase in maximum bladder capacity from 183.0 (112.0-234.0) to 237.0 (165.0-298.0) (p < 0.001). When maximal bladder capacity adjusted for age there was also significant increment (adjusted before 0.54 (0.47-0.64), adjusted after 0.75 (0.70-0.82), p < 0.001). In addition, we observed a decrease in maximal detrusor pressure from 64.3 (49.0-77.0) to 46.4 (32.0-59.0) cm H2O (p < 0.001) and an increase in bladder compliance from 3.0 (2.0-3.3) to 5.6 (3.9-6.6) ml/cm H2O (p < 0.001). There was also significant reductions in leak point pressure from 62.0 (48.0-69.0) to 39.0 (30.0-43.0) cm H2O (p = 0.001), and significant reductions in post-void residual volume (PVR) from 165.0 (128.0-187.0) to 98.0 (68.0-136.0) ml in our 13 patients who could achieve spontaneous voiding (p = 0.001). Conclusion: Administering bowel management may be useful for bladder function and urodynamic findings in spina bifida children with DO and DSD. Therefore, bowel management should form an integral part of the treatment in spina bifida children with DO and DSD.
Mesh-Begriff(e)	Adolescent ; Ataxia ; Child ; Child, Preschool ; Female ; Humans ; Laxatives ; Male ; Spinal Dysraphism/complications ; Urinary Bladder, Neurogenic/etiology ; Urinary Bladder, Neurogenic/therapy ; Urodynamics
Chemische Substanzen	Laxatives
Sprache	Englisch
Erscheinungsdatum	2020-04-21
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	2237683-5
ISSN	1873-4898 ; 1477-5131
ISSN (online)	1873-4898
ISSN	1477-5131
DOI	10.1016/j.jpurol.2020.04.013
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Hyperhomocysteinemia and inflammatory biomarkers are associated with higher clinical SYNTAX score in patients with stable coronary artery disease

Đurić Predrag / Mladenović Zorica / Spasić Marijan / Jović Zoran / Marić-Kocijančić Jelena / Prokić Đorđe / Subota Vesna / Radojičić Zoran / Đurić Dragan

Vojnosanitetski Pregled, Vol 78, Iss 7, Pp 736-

2021 Band 744

Abstract: Background/Aim. Previous studies have confirmed a positive correlation between homocysteine levels and a greater risk for acute coronary syndrome and stroke, but there are no available data to support an association between homo-cysteine and inflammatory ...

Abstract	Background/Aim. Previous studies have confirmed a positive correlation between homocysteine levels and a greater risk for acute coronary syndrome and stroke, but there are no available data to support an association between homo-cysteine and inflammatory markers and the severity of coronary artery disease according to the clinical SYNTAX score in patients with stable angina. The aim was to determine the association between homocysteine and inflammatory biomarker levels: interleukin (IL)-6, high sensitive C-reactive protein (hs-CRP), fibrinogen, erythrocyte sedimentation rate (ESR) and the severity of coronary artery disease according to clinical SYNTAX score. Methods. Eighty-two patients with stable angina pectoris (average age 65 ± 8 years, 28.9% females) underwent coronary angiography and were divided into three groups according to the clinical SYNTAX score: the group I < 22 (39 patients), the group II 23–32 (16 patients), the group III > 33 (27 patients). The severity and complexity of coronary artery disease were calculated by clinical SYNTAX score, multiplying the SYN-TAX score with the modified ACEF score, based on the patients’ left ventricular ejection fraction, age and creatinine clearance (derived with Cockcroft–Gault equation). Results. Homocysteine levels were significantly higher in patients with high clinical SYNTAX score [the group I: median (interquartile range – IQR): 10.20 (3.97), the group II: 10.45 (5.77), the group III: 14.70 (7.50), p = 0.005]. Patients in the group III had significantly higher homocysteine levels compared to the group I (p = 0.001). We also found a posi-tive association between inflammatory biomarkers (IL-6, hsCRP, fibrinogen, ESR) and the severity of coronary artery disease according to the clinical SYNTAX score (p = 0.017, 0.001, 0.032, 0.049 respectively). We detected significantly lower plasma levels of vitamin B12 in the group III and group II in comparison with the group I (the group I: median (IQR): 238 (160), the group II: 171 (160), the group III: 172 (102), ...
Schlagwörter	coronary disease ; inflammation mediators ; homocysteine ; angina ; stable ; Medicine (General) ; R5-920
Thema/Rubrik (Code)	610
Sprache	Englisch
Erscheinungsdatum	2021-01-01T00:00:00Z
Verlag	Military Health Department, Ministry of Defance, Serbia
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel: The correlation between the transverse rectal diameter and urodynamic findings in children with neurogenic bowel and bladder dysfunction.

Milivojevic, Sasa / Zelenovic, Aleksandra / Milin-Lazovic, Jelena / Radojicic, Ognjen / Laketic, Darko / Dasic, Ivana / Milic, Natasa / Radojicic, Zoran

Frontiers in pediatrics

2022 Band 10, Seite(n) 957123

Abstract: Background: The aim of this study was to examine the correlation between the transverse rectal diameter and urodynamic findings in children with neurogenic bowel and bladder dysfunction.: Methods: Between 2014 and 2022, we prospectively evaluated 81 ... ...

Abstract	Background: The aim of this study was to examine the correlation between the transverse rectal diameter and urodynamic findings in children with neurogenic bowel and bladder dysfunction. Methods: Between 2014 and 2022, we prospectively evaluated 81 consecutive spina bifida children with neurogenic bowel and bladder dysfunction (35 boys and 46 girls, mean age 9.5 ± 3.4 years). All patients underwent echosonographic measurement of transverse rectal diameter and urodynamic studies. Results: We found a strong negative correlation between transverse rectal diameter and maximum bladder capacity ( Conclusion: There is a correlation between the transverse rectal diameter and urodynamic findings in children with neurogenic bowel and bladder dysfunction. Ultrasonographically assessed transverse rectal diameter of ≥40 mm may be used as a risk factor for upper urinary tract deterioration (unfavorable urodynamic findings). We suggest the transverse rectal diameter echosonographic measurement use as an integral part of the diagnostic approach in children with neurogenic bowel and bladder dysfunction, as it can help decision-making while waiting for urodynamic testing.
Sprache	Englisch
Erscheinungsdatum	2022-09-29
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2022.957123
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Reduction of transverse rectal diameter and its effect on bladder dynamics in children with spinal dysraphism.

Radojicic, Zoran / Milivojevic, Sasa / Lazovic, Jelena Milin / Radojicic, Ognjen / Laketic, Darko / Zelenovic, Aleksandra / Dasic, Ivana / Milic, Natasa

BMC urology

2022 Band 22, Heft 1, Seite(n) 155

Abstract: Introduction: To examine the reduction of transverse rectal diameter and its effect on bladder dynamics in children with spinal dysraphism.: Methods: We prospectively evaluated 61 consecutive children with spinal dysraphism, 25 (41%) boys and 36 (59%) ...

Abstract	Introduction: To examine the reduction of transverse rectal diameter and its effect on bladder dynamics in children with spinal dysraphism. Methods: We prospectively evaluated 61 consecutive children with spinal dysraphism, 25 (41%) boys and 36 (59%) girls, aged 4 to 16 years; mean age 9.3 ± 3.8 years, who received bowel management. All children underwent echosonographic measurement of transverse rectal diameter before and after starting bowel management. Also, all the patients had undergone urodynamic studies before and after starting bowel management, with no changes in their urological treatment. Results: Bowel management caused an decrease in transverse rectal diameter by 56 ± 7.2% (p < 0.001). In addition, a decrease was observed for maximal detrusor pressure by 27.8 ± 7.8% (p < 0.001), leak point pressure by 37.2 ± 4.4% (p < 0.001), and PVR by 36.7 ± 8.0 (p < 0.001). Maximum bladder capacity was significantly increased after bowel management in both non-adjusted (36.4 ± 14.8%; p < 0.001) and adjusted analysis for age (39.4 ± 14.3%, p < 0.001). Detrusor compliance was also increased by 89.2 ± 24.8% (p < 0.001). Female gender and % change of maximal detrusor pressure were significant predictors of transversal rectal diameter change in univariate as well as in multivariate analysis (OR = 10.548, 95% CI 2.309-48.180; p = 0.002 and OR = 1.121, 95% CI 1.009-1.245; p = 0.034). Conclusions: Decrease in transverse rectal diameter may be useful for bladder function and urodynamic findings in children with spinal dysraphism. Therefore, decrease in transverse rectal diameter should be a supplement to standard urotherapy.
Mesh-Begriff(e)	Adolescent ; Child ; Child, Preschool ; Female ; Humans ; Male ; Spinal Dysraphism/complications ; Spinal Dysraphism/diagnostic imaging ; Urinary Bladder/diagnostic imaging ; Urinary Bladder/physiology ; Urinary Bladder, Neurogenic/etiology ; Urinary Bladder, Neurogenic/therapy ; Urodynamics ; Rectum/diagnostic imaging ; Rectum/physiopathology ; Defecation
Sprache	Englisch
Erscheinungsdatum	2022-09-21
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	2059857-9
ISSN	1471-2490 ; 1471-2490
ISSN (online)	1471-2490
ISSN	1471-2490
DOI	10.1186/s12894-022-01105-5
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Therapeutic effects of desmopressin in primary monosymptomatic noctural enuresis treatment depending on Patients'Age.

Radojicic, Zoran / Milivojevic, Sasa / Milin Lazovic, Jelena / Toplicic, Djordje / Milic, Natasa

Journal of pediatric urology

2020 Band 16, Heft 5, Seite(n) 646.e1–646.e7

Abstract: Purpose: To test the therapeutic effects of Desmopressin (dDAVP) in primary monosymptomatic nocturnal enuresis (PMNE) treatment depending on patients'age.: Material and methods: The prospective research was carried out in the 2014-2018 period, during ...

Abstract	Purpose: To test the therapeutic effects of Desmopressin (dDAVP) in primary monosymptomatic nocturnal enuresis (PMNE) treatment depending on patients'age. Material and methods: The prospective research was carried out in the 2014-2018 period, during which 89 patients were observed who were treated with dDAVP due to the previously diagnosed PMNE. The patients were divided into two age groups. The first group (Group 1) consisted of 43 patients age 5 to 6, with the average age of 5.6 ± 0.5, out of whom 35 (81.4%) were boys, and 8 (18.6%) girls. The second group (Group 2) consisted of 46 patients age over 7 to 12, with the average age of 9.7 ± 1.6, out of whom 30 (65.2%) were boys, and 16 (34.8%) were girls. There was no statistically relevant difference according to sex (p = 0.086). After the 3-month treatment, all the patients in both groups were tested for the effects of dDAVP in PMNE treatment. Results: The average enuresis frequency in the first group (Group 1) before therapy was 26.0 ± 6.2 per month, whereas the average enuresis frequency after therapy was 11.0 ± 8.0 per month (p = 0.040). The average enuresis frequency in the second group (Group 2) before therapy was 23.1 ± 6.2 per month, whereas the average enuresis frequency after therapy was 3.8 ± 3.6 per month (p = 0.036). ANOVA data analysis of repeated measurements has indicated that there is a statistically relevant interaction between the groups (p = 0.006), i.e. enuresis frequency decreases considerably more in the second group (Group 2). Conclusion: PMNE with dDAVP is noticeably more effective with patients over 7 years of age.
Mesh-Begriff(e)	Child ; Child, Preschool ; Deamino Arginine Vasopressin ; Enuresis ; Female ; Humans ; Male ; Nocturnal Enuresis/drug therapy ; Prospective Studies ; Urinary Incontinence
Chemische Substanzen	Deamino Arginine Vasopressin (ENR1LLB0FP)
Sprache	Englisch
Erscheinungsdatum	2020-08-10
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	2237683-5
ISSN	1873-4898 ; 1477-5131
ISSN (online)	1873-4898
ISSN	1477-5131
DOI	10.1016/j.jpurol.2020.08.003
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Morphometric and volumetric analysis of lacrimal glands in patients with thyroid eye disease.

Starčević, Ana / Radojičić, Zoran / Djurić Stefanović, Aleksandra / Trivić, Aleksandar / Milić, Ivan / Milić, Marina / Matić, Dragan / Andrejic, Jovana / Djulejic, Vuk / Djoric, Igor

Scientific reports

2023 Band 13, Heft 1, Seite(n) 16345

Abstract: Assessment of morphometric and volumetric changes in lacrimal glands in thyroid eye disease, its clinical manifestations in relation of disease progression. Retrospective volumetric analysis included both genders and was performed on total of 183 ... ...

Abstract	Assessment of morphometric and volumetric changes in lacrimal glands in thyroid eye disease, its clinical manifestations in relation of disease progression. Retrospective volumetric analysis included both genders and was performed on total of 183 patients - 91 patients with diagnosed Grave's disease and thyroid eye disease and 92 patients without Grave's disease and thyroid eye disease who underwent multidetector computed tomography (MDCT) examination in routine daily work according to other medical indications. In the group of females, there was statistical significance between patients with thyroid eye disease and controls who were smoking and had body weight gain. We found statistical significance in volumetric enlargements for both orbits in both genders for the patients group when compared to controls. There was also statistical significance in morphometric characteristics for the lacrimal gland diameters measured. Determination planimetric morphometric parameters of importance were coronary height of lacrimal gland of the right eye, coronary height of lacrimal gland of the left eye and coronary width of lacrimal gland of the left eye for the group of males. In a group of females the established determination parameters of importance were the coronary height of lacrimal gland of the left eye, the axial width of lacrimal gland of the left eye, volume of lacrimal gland of the right eye and the volume of lacrimal gland of the left eye. When we compared the displaced lacrimal gland coming forward (proptosis) in time progressing disease between group of patients and controls, we also found statistical significant connection. Evaluation of lacrimal gland volumetric and morphometric data may increase validity of defining this anatomical substrate and its morphology disruption as liable tool for thyroid eye disease progression follow up and treatment planning and outcome.
Mesh-Begriff(e)	Humans ; Male ; Female ; Lacrimal Apparatus/diagnostic imaging ; Graves Ophthalmopathy/diagnostic imaging ; Retrospective Studies ; Multidetector Computed Tomography ; Disease Progression
Sprache	Englisch
Erscheinungsdatum	2023-09-28
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-43083-0
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Measurement properties of New Mobility Score to evaluate functional recovery in the elderly following total hip arthroplasty

Mitrović Dragica / Erceg Predrag / Milić Ljiljana / Ćuk Vladica / Juloski Jovan / Radulović Radosav / Konstantinović Ljubica / Radojičić Zoran / Jovanović Vesna R. / Dugonjić Sanja

Srpski Arhiv za Celokupno Lekarstvo, Vol 150, Iss 1-2, Pp 64-

2022 Band 70

Abstract: Introduction/Objective. The aim of this study is to identify and evaluate the use of New Mobility Score (NMS) in estimating functional recovery three months after total hip arthroplasty (THA). Methods. In total, 70 patients, aged > 60 years, underwent ... ...

Abstract	Introduction/Objective. The aim of this study is to identify and evaluate the use of New Mobility Score (NMS) in estimating functional recovery three months after total hip arthroplasty (THA). Methods. In total, 70 patients, aged > 60 years, underwent THA. Treatment group was subjected to the comprehensive rehabilitation program and control group to the standard one. Primary outcome was assessed with Harris Hip Score (HHS) and NMS, and secondary one by Medical Outcomes Health Survey (Short-Form Health Survey – SF-36). Questionnaires were collected before and three months after hip surgery. Results. Treatment group showed significant improvement three months postoperatively. The correlation in both groups between HHS and NMS was very strong (r > 0.700). Treatment group following surgery showed strong correlation between Recovery through Personal Care Services (PCS) and HHS and NMS (r > 0.700), moderate to strong between pain categories and HHS (r = 0.380; r = 0.583) and NMS (r = 0.424). Control group showed strong correlation between PCS and HHS (r = 0.704), and NMS (r = 0.568) and moderate to pain categories and HHS (r = 0.546; r = 0.466). The area under the curve (AUC) described the inherent validity of all measurement used AUCNMS = 0.724, p = 0.001, AUCHHS = 0.788, p = 0.000 and AUCPCS = 0.747, p = 0.001. Conclusion. The NMS could be successfully used in routine clinical assessment of elderly patients following THA. The trial is registered in ISRCTN Register with https://doi.org/10.1186/ISRCTN73197506.
Schlagwörter	harris hip score ; new mobility score ; sf-36 ; outcome assessment ; hip arthroplasty ; rehabilitation ; roc curve ; Medicine ; R
Thema/Rubrik (Code)	616
Sprache	Englisch
Erscheinungsdatum	2022-01-01T00:00:00Z
Verlag	Serbian Medical Society
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel ; Online: Low compliance contribute to insufficient Desmopressin response of primary monosymptomatic nocturnal enuresis and the role of voiding school.

Radojicic, Zoran / Milivojevic, Sasa / Koricanac, Irena / Lazovic, Jelena Milin / Laketic, Darko / Radojicic, Ognjen / Milic, Natasa

BMC pediatrics

2021 Band 21, Heft 1, Seite(n) 244

Abstract: Aims: To evaluate the impact of compliance on the therapeutic effects of Desmopressin, as well as the importance of establishing the voiding school for low-compliance children in primary monosymptomatic enuresis treatment.: Methods: Eighty-nine ... ...

Abstract	Aims: To evaluate the impact of compliance on the therapeutic effects of Desmopressin, as well as the importance of establishing the voiding school for low-compliance children in primary monosymptomatic enuresis treatment. Methods: Eighty-nine patients with primary monosymptomatic enuresis treated with Desmopressin were observed during the 2017-2020 at University Children's Hospital Belgrade, Serbia. The average patients age was 7.7 ± 2.4 years; 65 (73%) were boys and 24 (27%) % were girls. After the 3 months of Desmopressin treatment, the effect of therapy was evaluated according to the compliance. After the treatment, low-compliance patients and their parents were suggested to visit a voiding school. Results: A significant decrease in the median enuresis frequency was noticed during the Desmopressin treatment (25.0 (20.0-26.0) vs 10.0 (2.0-17.0) per month, before vs after treatment, respectively) (p < 0.001). Patients with low compliance had a poorer response to Desmopressin (p < 0.001). An median enuresis reduction in the good compliance group was 92.3% (86.7 -95%), while in the low compliance group was 28.6% (16.7-43.3%). After attending voiding school, there was a significant increase in compliance (p < 0.001), associated with an median percent decrease in enuresis of 84.0% (75.0-95.5%) (p < 0.001). Conclusion: Compliance considerably influences the beneficial effects of Desmopressin. Patients with poor therapeutic effects should be evaluated for compliance and introduced to voiding school.
Mesh-Begriff(e)	Child ; Child, Preschool ; Deamino Arginine Vasopressin/therapeutic use ; Female ; Humans ; Male ; Nocturnal Enuresis/drug therapy ; Schools ; Urination
Chemische Substanzen	Deamino Arginine Vasopressin (ENR1LLB0FP)
Sprache	Englisch
Erscheinungsdatum	2021-05-20
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	2041342-7
ISSN	1471-2431 ; 1471-2431
ISSN (online)	1471-2431
ISSN	1471-2431
DOI	10.1186/s12887-021-02714-z
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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