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  1. Article ; Online: VAGINAL CANDIDIASIS – GYNECOLOGICAL ASPECT OF THE PROBLEM

    Radomir Živadinović / Aleksandra Petrić / Dane Krtinić

    Acta Medica Medianae, Vol 53, Iss 4, Pp 46-

    2014  Volume 53

    Abstract: Vaginal candidiasis (VC) is one of the most common reasons for consultations with a gynecologist, with an increasing trend in occurrence in female patients. It is estimated that 75% of all women experience an episode of vulvovaginal candidiasis in their ... ...

    Abstract Vaginal candidiasis (VC) is one of the most common reasons for consultations with a gynecologist, with an increasing trend in occurrence in female patients. It is estimated that 75% of all women experience an episode of vulvovaginal candidiasis in their lifetime, 50% of them experience at least a second episode, and 5% have recurrent candidiasis. Cervical and vaginal secretions act as the last line of defense from ascendant infection pathway spreading. Factors that may disturb vaginal ecosystem are: endogenous factors, way of life, infectious factors and iatrogenic factors. The most common cause of VC in 85-90% of cases is C. albicans, but other Candida species tend to be more likely to cause VVC (Candida tropicalis , Candida glabrata , C particulary, C crusei and so on). These non-albicans species have been found to be fluconazole and antimycotics resistant in more than 70% of cases. This is especially true for C. glabrata. There are several predisposing factors that have been associated with VC recurrence and resistance, such as Candida genotypes, resistance and virulence, immunodeficiency, unregulated hyperglycemia, use of oral contraceptives, long-term use of antibiotics. Therapy approach should be individual, including local and oral antimycotics until the symptoms disappear. The maintenance dose can be continuous or intermittent. Due to hormone concentration increase, increase in local glycogen, alternations of vaginal flora, VC incidence in pregnancy is two times higher in comparison to other female population. The problem of vaginal candidiasis requires individual approach, taking into account all the risk factors and accompanying physiological conditions or diseases in female patients.
    Keywords vaginal candidiasis ; vaginal discharge ; recurrence ; resistance ; pregnancy ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2014-12-01T00:00:00Z
    Publisher University in Nis, Faculty of Medicine
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: In vitro fertilization outcome in women with endometriosis & previous ovarian surgery

    Sonja Pop-Trajkovic / Vesna Kopitovic / Jasmina Popovic / Vladimir Antic / Dragana Radovic / Radomir Zivadinovic

    Indian Journal of Medical Research, Vol 140, Iss 3, Pp 387-

    2014  Volume 391

    Abstract: Background & objectives: Women with endometriosis often need in vitro fertilization (IVF) to concieve. There are conflicting data on the results of IVF in patients with endometriosis. This study was undertaken to elucidate the influence of endometriosis ... ...

    Abstract Background & objectives: Women with endometriosis often need in vitro fertilization (IVF) to concieve. There are conflicting data on the results of IVF in patients with endometriosis. This study was undertaken to elucidate the influence of endometriosis on IVF outcome to give the best counselling for infertile patient with this problem. Methods: The outcome measures in 78 patients with surgically confirmed endometriosis were compared with 157 patients with tubal factor infertility, all of whom have undergone IVF. The groups were matched for age and follicle stimulating hormone (FSH) levels. Outcome measures included number of follicles, number of ocytes, peak oestradiol (E2) concentrations and mean number of ampoules of gonadotropins. Cumulative pregnancy, miscarriage and live birth rates were calculated in both the groups. Results: Higher cancelation rates, higher total gonadotropin requirements, lower peak E2 levels and lower oocyte yield were found in women with endometriosis and previous surgery compared with those with tubal factor infertility. However, no differences were found in fertilization, implantation, pregnancy, miscarriage, multiple births and delivery rates between the endometriosis and tubal factor infertility groups. Interpretation & conclusions: The present findings showed that women with endometriosis and previous surgery responded less well to gonadotropins during ovarian stimulation and hence the cost of treatment to achieve pregnancy was higher in this group compared with those with tubal factor infertility. However, the outcome of IVF treatment in patients with endometriosis was as good as in women with tubal factor infertility.
    Keywords Endometriosis - gonadotropins - infertility - in vitro fertlization - pregnancy ; Medicine ; R
    Subject code 616
    Language English
    Publishing date 2014-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: THE ROLE OF CARDIOTOCOGRAPHY IN ASSESSING THE CONDITION OF A FETUS IN PREECLAMPSIA

    Jelena Milošević-Stevanović / Marija Tasić / Radomir Živadinović / Predrag Vukomanović / Aleksandra Andrić / Sonja Pop-Trajković-Dinić

    Acta Medica Medianae, Vol 54, Iss 2, Pp 41-

    2015  Volume 47

    Abstract: The role of cardiotocography (CTG) in preeclampsia is still vaguely defined. The aim of this study was to investigate the possible role of CTG in assessing the condition of the fetus in preeclampsia with and without intrauterine growth retardation (IUGR) ...

    Abstract The role of cardiotocography (CTG) in preeclampsia is still vaguely defined. The aim of this study was to investigate the possible role of CTG in assessing the condition of the fetus in preeclampsia with and without intrauterine growth retardation (IUGR) and to compare the CTG findings with Doppler parameters and perinatal outcome. The prospective study included 30 singleton pregnancies with preeclampsia completed by caesarean section. The study group was divided into subgroups based on the presence of IUGR in relation to the severity of preeclampsia. The control group consisted of 20 healthy women delivered by elective caesarean section. In 53.3% of preeclamptic cases, cardiotocographic findings differed from normal (p<0.001) and they were either warning or pathological. There were no significant differences in the presence of a pattern deviating from normal based on the severity of preeclampsia, and it was significantly more prevalent in preeclampsia with IUGR (p<0.01) than the one without it. The prevalence of CTG pattern types in the study group was significantly altered by presence of olygoamnion (p<0.05) as well as the parameters of the flow through the uterine arteries, umbilical artery and middle cerebral artery (p<0.05). Apgar score significantly depends on the CTG findings and decreases with the unfavourable CTG pattern. CTG and Doppler ultrasonography complement each other in order to improve perinatal outcome in preeclampsia. CTG is irreplaceable as a first measure of rapid assessment of the fetal condition in newly diagnosed cases of preeclampsia, aiming also to and in order to detect complications from umbilical cord during its follow-up.
    Keywords cardiotocography ; IUGR ; preeclampsia ; Medicine ; R
    Language English
    Publishing date 2015-06-01T00:00:00Z
    Publisher University in Nis, Faculty of Medicine
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: The value of Pap test in women with endometrial cancer

    Aleksandra Petrić / Vekoslav Lilić / Radomir Živadinović / Predrag Vukomanović / Olivera Dunjić / Radmila Ignjatović / Goran Lilić

    Journal of Health Sciences, Vol 1, Iss

    2011  Volume 3

    Abstract: Introduction: Endometrial cancer is the second most common gynecological tumor. There is still no recommended screening method for endometrial cancer. The application of transvaginal sonography, hysteroscopy and Pap test may prove useful in screening for ...

    Abstract Introduction: Endometrial cancer is the second most common gynecological tumor. There is still no recommended screening method for endometrial cancer. The application of transvaginal sonography, hysteroscopy and Pap test may prove useful in screening for this disease. Atypical glandular cells represent an important finding in Pap tests and they are related to histopathological verification of the endometrium. The aim of the study was to determine the usefulness of the Pap test in assessing the cervical infiltration, as well as to determine the significance of hormonal status and histopathological type of tumor in a pathological Pap test in patients with endometrial cancer. Methods: The study was retrospective. The analysis included the data obtained from 62 operated patients diagnosed with enometrial cancer, medical history (menopausal status), histopathological findings after surgery (type and stage of the disease) and a preoperative Pap smear. The chi squared and Fisher’s test were used. Results: The difference in the prevalence of pathological Pap test in premenopausal and postmenopausal group of patients was not statistically significant. The difference in the prevalence of pathological Pap test in the group of endometrioid and non-endometrioid tumours of the uterine corpus had statistical significance. The difference in the prevalence of pathological Pap test compared to the present stage (I and II) was not statistically significant. Conclusion: Pap smear does not correlate with menopausal status in women with endometrial carcinoma. Abnormal Pap test is more commonly found in cases of non-endometroid tumours. Pap smears cannot be used to assess cervical involvement.
    Keywords Pap smear ; endometrial cancer ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2011-12-01T00:00:00Z
    Publisher University of Sarajevo
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: COMPLICATIONS AT THE OPERATIVE TREATMENT OF THE INVASIVE CERVIX UTERI CARCINOMA

    Radomir Živadinović / Vekoslav Lilić / Milan Vukelić

    Acta Medica Medianae, Vol 41, Iss 5, Pp 133-

    2002  Volume 139

    Abstract: In the period from 1997 to 2001 at the Clinic for Gynecology and Obstetrics of the Clinic Center, Nis, there were 140 treated patients suffering from the cervix uteri carcinoma in I-B and II-A stadiums according to the FIGO classification. In 16 (11,42%) ...

    Abstract In the period from 1997 to 2001 at the Clinic for Gynecology and Obstetrics of the Clinic Center, Nis, there were 140 treated patients suffering from the cervix uteri carcinoma in I-B and II-A stadiums according to the FIGO classification. In 16 (11,42%) patients there was modified radical hysterectomy (class 11) done while in 124 (88,57%) the Wertheim-Meigs hysterectomy (class III) done. Inter operative complications (lesions) were recorded in 8 (5,69%) patients, namely, urinary tract lesions in 4 (2,85%) while blood vessel ones in 3 (2,13%) patients. The obturator nerve is cut in 1 (0,71%) patient. Immediate postoperative complications were recorded in 56 (39,96%) patients. Most often they are infection-induced. Urinary infections were noticed in 25 (17,85%) patients, febrility in 22 (15,71%) and infections of the operative wound in 3 (2,14%) patients. Later complications of the operative cervix treatment were noticed in 37 (26,42%) patients. Their emergence depends on the fact whether the patient was radiated before or before and after the operation. Most often later complications emerge in the patients that undenvent, after the operation, brachytherapy and transcutaneous radiotherapy (27 or 19,28%); the least frequent were in only 3 (2,14%) of the operated patients. The most frequent later complications are those of the urinary tract (fistulas, cystitis) in 11 (7,83%) patients as well as changes upon the last part of the gastrointestinal tract, namely, hemorrhage colitis in 9 (9,28%), late ileus in 3 (2,14%) and rectovaginal fistula in 3 (2,14%) patients. Hydronephrosis was recorded in 7 (5,00%) patients. There were no lethal cases. All the patients are still living.
    Keywords Carcinoma ; cervix uteri ; operation ; complications ; Medicine ; R
    Subject code 616 ; 610
    Language English
    Publishing date 2002-09-01T00:00:00Z
    Publisher University in Nis, Faculty of Medicine
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: OVARIAN ARRHENOBLASTOMA - CASE REPORT

    Tomislav Jocić / Vuka Katić / Miljan Krstić / Ivana Stojanović / Miodrag Radović / Radomir Živadinović

    Acta Medica Medianae, Vol 44, Iss 3, Pp 59-

    2005  Volume 61

    Abstract: Sertoli-Leydig cell tumors belong to the group of sex-cord stromal tumors of the ovary. They account for less than 0,5% of all ovarian neoplasms. The majority of these tumors are benign and almost all are localized unilaterally. Herewith, we describe an ... ...

    Abstract Sertoli-Leydig cell tumors belong to the group of sex-cord stromal tumors of the ovary. They account for less than 0,5% of all ovarian neoplasms. The majority of these tumors are benign and almost all are localized unilaterally. Herewith, we describe an ovarian Sertoli- Leydig cell tumor (arrhenoblastoma) with virilization, in an 63-year-old woman. A left salpingo-oohorectomy (and hysterectomy) was performed. Macroscopically, the tumor was 10 x 8 x 6cm, incapsulated, yellow-white in color, both solid and pseudocystic. Microscopically, the tumor was well differentiated, composed from Sertoli-Leydig cells, mixed with theca cells, fibrocytes and collagen fibers. During the 4-year follow-up, there was neither clinical nor sonographical evidence of recurrence. The treatment of this pathological entity has to be individualized according to the patient’s age, stage the of tumor and degree of differentiation.
    Keywords ovarian arrhenoblastoma ; clinical characteristics ; morphological characteristics ; Medicine ; R
    Subject code 616
    Language English
    Publishing date 2005-07-01T00:00:00Z
    Publisher University in Nis, Faculty of Medicine
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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