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  1. Article ; Online: A validation of a questionnaire to assess consumer attitudes towards artificial sweeteners

    Christiansen, Paul / Roberts, Carl / Radu, Cristina / Hardman, Charlotte

    Food Quality and Preference. 2023 Jan., v. 103 p.104707-

    2023  

    Abstract: Bearth, Cousin, and Siegrist (2014) Perception of Artificial Sweetener Scale (PASS) has been widely used but has yet to be subject to thorough psychometric evaluation. The current study aimed to assess the factor structure and internal reliability of the ...

    Abstract Bearth, Cousin, and Siegrist (2014) Perception of Artificial Sweetener Scale (PASS) has been widely used but has yet to be subject to thorough psychometric evaluation. The current study aimed to assess the factor structure and internal reliability of the scale, as well as assess its predictive utility. In a pre-registered study, 489 participants (age range 18-86 y) completed the attitudes towards sweeteners scale and a survey assessing their sweetener consumption over the past month. Initial confirmatory factor analysis showed an acceptable to poor fit of the scale largely due to three reverse coded items. Upon their removal model fit was excellent and McDonald's Omega values showed good internal reliability for all subscales. Zero inflated (hurdle) negative binomial regression revealed that higher scores on the risk subscale, lower scores on the benefit subscale, and older age were associated with avoidance of sweeteners. Of those who did consume sweeteners, greater perceived benefit was associated with increased consumption. The current study recommends that a shorter version of the PASS (PASS-23) should be used in future research with this scale showing good psychometric properties. Furthermore, it suggests that if sweetener over sugar consumption is to be encouraged, perceived risk and benefits should be targeted in public health messaging.
    Keywords artificial sweeteners ; factor analysis ; food quality ; public health ; questionnaires ; risk ; sugars ; surveys ; Sweeteners ; Artificial ; Attitudes ; Benefit ; Psychometrics
    Language English
    Dates of publication 2023-01
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Use and reproduction
    ZDB-ID 1020221-3
    ISSN 0950-3293
    ISSN 0950-3293
    DOI 10.1016/j.foodqual.2022.104707
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: Awareness of ovarian cancer symptoms and risk factors in a young ethnically diverse British population.

    Radu, Cristina-Alexandra / Matos de Melo Fernandes, Nadia / Khalfe, Sumaira / Stordal, Britta

    Cancer medicine

    2023  Volume 12, Issue 8, Page(s) 9879–9892

    Abstract: Background: Ovarian cancer does not cause many symptoms in the early stages, which is why the majority of cases are of advanced disease. Increasing awareness of ovarian cancer symptoms may lead to earlier diagnosis and improved outcomes.: Methods: ... ...

    Abstract Background: Ovarian cancer does not cause many symptoms in the early stages, which is why the majority of cases are of advanced disease. Increasing awareness of ovarian cancer symptoms may lead to earlier diagnosis and improved outcomes.
    Methods: Participants in Britain completed the Ovarian Cancer Awareness Measure by online survey (n = 459).
    Results: Our participants were 75% female, 25% male and a young (27.89 ± 11.44 years) ethnically diverse population (40.3% White, 29.3% Asian and 18.0% Black). Individuals recalled 1.24 ± 1.30 symptoms, and recognised 5.96 ± 2.4 symptoms. We found higher levels of recall and recognition compared to previous research possibly due to using an online survey. Recognition was lowest for difficulty eating (39.4%) and persistently feeling full (38.7%). Males had slightly lower symptom recall and recognition than females. Participants incorrectly recalled an irregular menstrual cycle (22.4%) as an ovarian cancer symptom and 67% answered the age of incidence question incorrectly. Suggesting that participants incorrectly associate ovarian cancer as a disease of pre-menopausal women. Individuals recalled 1.47 ± 1.20 risk factors, and recognised 6.1 ± 2.4 risk factors. Family history of ovarian cancer was recalled by 59% of participants. Recognition was lowest for in vitro fertilisation treatment (23.0%) and talcum powder in the genital area (23.0%). The generic cancer risk factors of alcohol (9.3%) and poor diet (8.8%) were recalled as specific ovarian cancer risk factors. 57.9% of participants incorrectly answered that there is an ovarian cancer screening programme. Suggesting confusion between ovarian and cervical cancer as participants also recalled cervical cancer risk factors of sexually transmitted diseases (6.3%) and human papillomavirus (1.5%). 29.7% of female participants would seek help for an ovarian cancer symptom within 1-2 days. Help seeking was higher in the Black and Asian ethnicities (44.4% and 45.0%; p = 0.018).
    Conclusion: Awareness of ovarian cancer symptoms is low. Ovarian cancer awareness campaigns should include common misconceptions identified in this research.
    MeSH term(s) Female ; Humans ; Male ; Health Knowledge, Attitudes, Practice ; Ovarian Neoplasms/diagnosis ; Ovarian Neoplasms/epidemiology ; Risk Factors ; Uterine Cervical Neoplasms/epidemiology ; Adolescent ; Young Adult ; Adult
    Language English
    Publishing date 2023-02-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2659751-2
    ISSN 2045-7634 ; 2045-7634
    ISSN (online) 2045-7634
    ISSN 2045-7634
    DOI 10.1002/cam4.5670
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Real-Life Results of Palliative Chemotherapy in Metastatic Pancreatic Ductal Adenocarcinoma.

    Varzaru, Bianca / Iacob, Razvan A / Croitoru, Adina E / Iacob, Speranta M / Radu, Cristina E / Dumitrescu, Stefania M / Gheorghe, Cristian

    Cancers

    2023  Volume 15, Issue 13

    Abstract: Purpose: To assess the efficacy of FOLFIRINOX(FFX), gemcitabine-based regimens (GB), and gemcitabine monotherapy (Gem) in patients with metastatic pancreatic ductal adenocarcinoma (mPDAC).: Methods: This is a retrospective study that included 83 ... ...

    Abstract Purpose: To assess the efficacy of FOLFIRINOX(FFX), gemcitabine-based regimens (GB), and gemcitabine monotherapy (Gem) in patients with metastatic pancreatic ductal adenocarcinoma (mPDAC).
    Methods: This is a retrospective study that included 83 patients with mPDAC treated with first-line chemotherapy (L1) with either FFX, GB or Gem between 2015 and 2017. Progression-free survival (PFS) for L1 and second-line chemotherapy (L2) (PFS-L1 and PFS-L2) and overall survival (OS) were estimated using the Kaplan-Meier method.
    Results: Median PFS-L1 for FFX, GB and Gem groups was 9 months (95% (Confidence Interval) CI 2.76-15.24), 5 months (95%CI 3.44-6.56), and 5 months (95%CI 3.76-6.24), respectively (
    Conclusions: The OS of patients who receive FFX or GB is comparable. The best PFS-L1 belongs to the FFX group. Male gender, ECOG-PS 0/1, the FFX regimen, and NLR > 4.15 were independent predictors of OS. PFS-L2 and OS-L2 were favorably impacted by L1 with FFX.
    Language English
    Publishing date 2023-07-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15133500
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Effects of non-nutritive sweetened beverages versus water after a 12-week weight-loss program: A randomized controlled trial.

    Harrold, Joanne A / Hill, Scott / Radu, Cristina / Thomas, Paul / Thorp, Paula / Hardman, Charlotte A / Christiansen, Paul / Halford, Jason C G

    Obesity (Silver Spring, Md.)

    2023  Volume 31, Issue 8, Page(s) 1996–2008

    Abstract: Objective: The aim of this study was to compare non-nutritive sweetened (NNS) beverages versus water for weight loss after a 12-week behavioral weight-management program.: Methods: This is an ongoing, 2-year, parallel-group, open-label, controlled ... ...

    Abstract Objective: The aim of this study was to compare non-nutritive sweetened (NNS) beverages versus water for weight loss after a 12-week behavioral weight-management program.
    Methods: This is an ongoing, 2-year, parallel-group, open-label, controlled equivalence trial; week-12 data are reported. Adults with BMI of 27 to 35 kg/m
    Results: Overall, 493 participants were randomized (water: n = 246; NNS beverages: n = 247); 24.1% were NNS beverage naïve. Weight change was equivalent with water versus NNS beverages (-5.6 vs. -5.8 kg; difference [90% CI]: -0.2 kg [-0.7 to 0.4]). There were no significant differences between groups for secondary end points except reductions in waist circumference (greater with NNS beverages vs. water), glycated hemoglobin, and consumption of any type of sweetener (both greater with water vs. NNS beverages).
    Conclusions: Weight loss was equivalent with NNS beverages and water following a 12-week behavioral weight-management program.
    MeSH term(s) Adult ; Humans ; Water ; Sugar-Sweetened Beverages ; Non-Nutritive Sweeteners ; Weight Loss ; Beverages ; Sweetening Agents
    Chemical Substances Water (059QF0KO0R) ; Non-Nutritive Sweeteners ; Sweetening Agents
    Language English
    Publishing date 2023-07-20
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2230457-5
    ISSN 1930-739X ; 1071-7323 ; 1930-7381
    ISSN (online) 1930-739X
    ISSN 1071-7323 ; 1930-7381
    DOI 10.1002/oby.23796
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Non-nutritive sweetened beverages versus water after a 52-week weight management programme: a randomised controlled trial.

    Harrold, Joanne A / Hill, Scott / Radu, Cristina / Thomas, Paul / Thorp, Paula / Hardman, Charlotte A / Christiansen, Paul / Halford, Jason C G

    International journal of obesity (2005)

    2023  Volume 48, Issue 1, Page(s) 83–93

    Abstract: Background/objective: Sugar-sweetened beverages are a substantial source of dietary sugar that can contribute to weight gain and the risk of type 2 diabetes. Dietary guidelines recommend non-nutritive sweetened (NNS) beverages to reduce sugar ... ...

    Abstract Background/objective: Sugar-sweetened beverages are a substantial source of dietary sugar that can contribute to weight gain and the risk of type 2 diabetes. Dietary guidelines recommend non-nutritive sweetened (NNS) beverages to reduce sugar consumption, however, there is a need for long-term randomised controlled trials on their use. We aimed to compare the effects of NNS beverages and water on body weight during weight loss and maintenance in a behavioural weight management programme.
    Methods: In this parallel-group, open-label, controlled equivalence trial, adults with a BMI of 27-35 kg/m
    Results: Of 493 participants randomised (water: n = 246; NNS beverages: n = 247), 24.1% were NNS-naïve. At week 52, water and NNS beverages were non-equivalent, with significantly greater weight loss in the NNS beverages group. Participants consuming water maintained a weight loss of 6.1 kg over 52 weeks versus 7.5 kg with NNS beverages (difference [90% CI]: 1.4 kg [-2.6, -0.2]; p < 0.05).
    Conclusions: During a 52-week behavioural weight management programme, water and NNS beverages were non-equivalent, with weight loss maintained to a statistically greater extent with NNS beverages compared with water. However, this difference was not clinically significant.
    Clinical trial registration: This trial is registered with ClinicalTrials.gov: NCT02591134.
    MeSH term(s) Adult ; Humans ; Beverages ; Diabetes Mellitus, Type 2 ; Non-Nutritive Sweeteners/adverse effects ; Randomized Controlled Trials as Topic ; Sugar-Sweetened Beverages ; Water ; Weight Loss ; Weight Reduction Programs
    Chemical Substances Non-Nutritive Sweeteners ; Water (059QF0KO0R)
    Language English
    Publishing date 2023-10-05
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 752409-2
    ISSN 1476-5497 ; 0307-0565
    ISSN (online) 1476-5497
    ISSN 0307-0565
    DOI 10.1038/s41366-023-01393-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Article ; Online: The impact of border changes and protectionism on real wages in early modern Scania

    Gary, Kathryn E. / Radu, Cristina Victoria

    2019  

    Abstract: In the aftermath of Brexit there has been increased speculation into what national borders mean for economic and individual wellbeing. Investigating similar events in history can help us understand some of these potential effects. Malmö, a city in modern- ...

    Abstract In the aftermath of Brexit there has been increased speculation into what national borders mean for economic and individual wellbeing. Investigating similar events in history can help us understand some of these potential effects. Malmö, a city in modern-day southern Sweden, was a part of Denmark until the middle of the seventeenth century, located just across the Sound from the capital of Copenhagen. Malmö and its surrounding regions were ceded to Sweden at the end of the Second Northern War in 1658 and Sweden immediately established barriers to trade and to human capital flow between its new territories and Denmark, going so far as to prohibit Swedish attendance to Copenhagen University and instead establishing its own university in Lund in 1666. Malmö and its surrounding region, Scania, quickly shifted from an important trade city located within sight of the capital to a distant periphery with limited trade capacity. This change in possession of Scania provides a historical experiment that can highlight the effect of the second nature geography changes as well as protectionism on well-being. We use a novel database of Danish and Swedish real wages to investigate the impact of these changes on Scanian living standards by employing a difference in difference approach to show that wages fell more in Scania than those in surrounding regions in relation to the border change and associated protectionism.
    Keywords ddc:330 ; J31 ; N33 ; N93 ; Border Changes ; Real Wages ; Second Nature Geography ; Welfare Ratios ; Standard of Living ; Denmark ; Sweden ; Malmo ; Scania ; Scandinavia ; Early Modern Period
    Subject code 950
    Language English
    Publisher s.l.: European Historical Economics Society (EHES)
    Publishing country de
    Document type Book ; Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Book ; Article ; Online: Standards of Living and Skill Premia in Eighteenth Century Denmark

    Jensen, Peter Sandholt / Radu, Cristina Victoria / Sharp, Paul

    What can we learn from a large microlevel wage database?

    2020  

    Abstract: Granular microdata is of growing interest within economics and economic history. Thus, we document, present, and make available to the scholarly community a uniquely detailed database of 20,152 observations of wages and 30,000 observations of prices in ... ...

    Abstract Granular microdata is of growing interest within economics and economic history. Thus, we document, present, and make available to the scholarly community a uniquely detailed database of 20,152 observations of wages and 30,000 observations of prices in rural Denmark for men, women and children, and for both skilled and unskilled workers over the eighteenth century. We the proceed to illustrate two potential applications. First, we construct nominal wages and deflate them using Allen's constant consumer baskets. Real wages exhibit a considerable fall with the introduction of serfdom, and other changes consistent with known historical events. Second, we consider skill premia, finding no secular trends between skill categories, but considerable variation both within and between categories over time, suggesting that estimates based on simple averages should be interpreted with caution.
    Keywords ddc:330 ; J31 ; N33 ; N93 ; Denmark ; microdata ; prices ; skill premia ; wages
    Subject code 331
    Language English
    Publisher s.l.: European Historical Economics Society (EHES)
    Publishing country de
    Document type Book ; Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Book ; Article ; Online: Days Worked and Seasonality Patterns of Work in Eighteenth Century Denmark

    Jensen, Peter Sandholt / Radu, Cristina Victoria / Sharp, Paul

    2019  

    Abstract: The calculation of the number of days worked per year is crucial for understanding pre-industrial living standards, and yet has presented considerable obstacles due to data scarcity. We present evidence on days worked and seasonality patterns of work ... ...

    Abstract The calculation of the number of days worked per year is crucial for understanding pre-industrial living standards, and yet has presented considerable obstacles due to data scarcity. We present evidence on days worked and seasonality patterns of work using evidence from a large database of micro-level labor market data for eighteenth century rural Denmark. We estimate that workers worked approximately 5.6 days per week when under full employment. Seasonality of work meant, however, that they were unlikely to find employment during the winter, bringing the estimated number of working days per year to 184. This is lower than often assumed in the literature on real wage calculations, but in line with recent evidence for Malmö and London. We find that days worked increased over the eighteenth century, consistent with the idea of an "industrious revolution". We suggest however that this was probably mostly due to economic necessity rather than a consumer revolution, since unskilled and low skilled workers needed to work over 300 days per year to afford a subsistence basket.
    Keywords ddc:330 ; J22 ; N33 ; working year ; seasonality patterns ; real wages ; annual workers ; casual workers ; Denmark ; eighteenth century
    Subject code 331
    Language English
    Publisher s.l.: European Historical Economics Society (EHES)
    Publishing country de
    Document type Book ; Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Lipoprotein(a) Levels in Thyroid Disorders

    Pop-Radu Cristina Corina / Gliga Mirela

    Acta Medica Marisiensis, Vol 59, Iss 2, Pp 81-

    2013  Volume 84

    Abstract: Objective: The aim of this study was to assess the serum levels of Lipoprotein(a) [Lp(a)] in subjects with thyroid disorders, as well as to investigate their relationship with lipid profile and the markers of thyroid function and autoimmunity, admitting ... ...

    Abstract Objective: The aim of this study was to assess the serum levels of Lipoprotein(a) [Lp(a)] in subjects with thyroid disorders, as well as to investigate their relationship with lipid profile and the markers of thyroid function and autoimmunity, admitting that elevated Lp(a) levels and dyslipidemia caused by thyroid disorders synergistically increased the atherogenic process.
    Keywords hypothyroidism ; hyperthyroidism ; lipoprotein(a) ; Medicine ; R
    Language English
    Publishing date 2013-04-01T00:00:00Z
    Publisher Sciendo
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: The Influence of GPX1 Pro198Leu, CAT C262T and MnSOD Ala16Val Gene Polymorphisms on Susceptibility for Non-Hodgkin Lymphoma and Overall Survival Rate at Five Years from Diagnosis

    Cosma Adriana-Stela / Radu Cristina / Moldovan Alexandra / Bogliș Alina / Crauciuc George Andrei / Horváth Emőke / Cândea Marcela / Tripon Florin

    Acta Medica Marisiensis, Vol 65, Iss 1, Pp 25-

    2019  Volume 30

    Abstract: Objective: The aim of the current study was to investigate possible associations between catalase C262T (CAT C262T), glutathione peroxidase 1 Pro198Leu (GPX1 Pro198Leu), manganese superoxide dismutase Ala16Val (MnSOD Ala16Val) gene polymorphisms and non- ... ...

    Abstract Objective: The aim of the current study was to investigate possible associations between catalase C262T (CAT C262T), glutathione peroxidase 1 Pro198Leu (GPX1 Pro198Leu), manganese superoxide dismutase Ala16Val (MnSOD Ala16Val) gene polymorphisms and non-Hodgkin Lymphoma risk (NHL) in a Romanian population and the five-year overall survival rate of the NHL patients.
    Keywords nhl ; gpx1 ; cat ; mnsod polymorphism ; Medicine ; R
    Language English
    Publishing date 2019-03-01T00:00:00Z
    Publisher Sciendo
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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