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Article: Families with complex needs: an inside perspective from young people, their carers, and healthcare providers.

Radu, Mădălina / Moldovan, Ramona / Băban, Adriana

2022 Volume 13, Issue 3, Page(s) 293–302

Abstract: Complex health needs are demanding and often require additional medical, psychological and social support. All those involved (e.g., patients, carers, professionals) face a unique set of challenges and needs, especially in families where the patient is a ...

Abstract	Complex health needs are demanding and often require additional medical, psychological and social support. All those involved (e.g., patients, carers, professionals) face a unique set of challenges and needs, especially in families where the patient is a child or a young person with a lifelong condition. The aim of the study was to explore carers' and young people's needs when living with long term conditions, as well as the views of the healthcare professionals supporting them. Semi-structured interviews with 30 participants (11 professionals, 10 parents, and 9 young people) were conducted. Interviews focused on 3 main areas-(1) medical needs, (2) psychological needs, and (3) communication needs-and were analyzed using thematic analysis. Four main themes emerged: (1) Acceptance takes time refers to the often long and challenging process of adapting to the diagnosis and living with the condition; (2) Close guidance captures the importance of specialised and long term guidance in accessing and managing the complexities of the medical system; (3) Open communication shows the families' need to be collaboratively connected to healthcare providers and other families facing similar difficulties; and (4) Long-term support underlines the importance of long term formal and informal support strategies. The participants' experiences and views have provided us with insight and guidance for developing and implementing personalized and integrated services. This inside perspective is key for future research aimed at better understanding the impact of complex conditions and meaningful ways to support families throughout their journeys.
Language	English
Publishing date	2022-03-18
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2543127-4
ISSN	1868-6001 ; 1868-310X
ISSN (online)	1868-6001
ISSN	1868-310X
DOI	10.1007/s12687-022-00586-z
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Article: Adherence to Therapy in Glaucoma Treatment-A Review.

Zaharia, Alexandra-Cătălina / Dumitrescu, Otilia-Maria / Radu, Mădălina / Rogoz, Roxana-Elena

Journal of personalized medicine

2022 Volume 12, Issue 4

Abstract: Glaucoma is a chronic disease and the second leading cause of irreversible vision loss worldwide, whose initial treatment consists of self-administered topical ocular hypotensive eyedrops. Adherence with glaucoma medications is a fundamental problem in ... ...

Abstract	Glaucoma is a chronic disease and the second leading cause of irreversible vision loss worldwide, whose initial treatment consists of self-administered topical ocular hypotensive eyedrops. Adherence with glaucoma medications is a fundamental problem in the care of glaucoma patients as up to 50% of patients fail to receive the intended benefits of the treatment. The literature has identified many barriers to patients' compliance, from factors depending on the type of medication administered, communication between physician and patients, to factors dependent on patients' behaviour and lifestyle. Failure to take medication as prescribed increases the risk that patients will not receive the desired benefit, which often leads to a worsening of the disease. Our aim is to synthesize the methods used for measuring adherence of patients to glaucoma therapy and the interventions used for addressing adherence, laying emphasis on a patient-centred approach, taking time to educate patients about their chronic disease and to assess their views on treatment.
Language	English
Publishing date	2022-03-22
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm12040514
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Article: Ocular Complications of Radiotherapy in Uveal Melanoma.

Zemba, Mihail / Dumitrescu, Otilia-Maria / Gheorghe, Alina Gabriela / Radu, Madalina / Ionescu, Mihai Alexandru / Vatafu, Andrei / Dinu, Valentin

Cancers

2023 Volume 15, Issue 2

Abstract: Uveal melanoma is the most common primary malignant intraocular tumor in adults. Radiation therapy has replaced enucleation and is now the preferred treatment in most cases. Nonetheless, around 70% of patients develop radiation-related complications, ... ...

Abstract	Uveal melanoma is the most common primary malignant intraocular tumor in adults. Radiation therapy has replaced enucleation and is now the preferred treatment in most cases. Nonetheless, around 70% of patients develop radiation-related complications, some of which are vision-threatening. The objective of this review is to present the most important complications associated with radiotherapy in the treatment of uveal melanoma and their pathogenesis, incidence, risk factors, and available preventive and therapeutic measures. The most common complications are cataracts, with a reported incidence ranging from 4% to 69%, and radiation retinopathy, reported in 5-68% of cases. Radiation-related complications are responsible for approximately half of secondary enucleations, the leading cause being neovascular glaucoma. A poor visual outcome is mainly associated with the presence of radiation retinopathy and radiation optic neuropathy. Therapeutic options are available for the majority of complications with the notable exception of optic neuropathy. However, many studies report a final visual acuity of less than 20/200 in more than 60% of treated eyes. Reducing complication rates can be achieved by lowering the dose of radiation, with the use of eccentric, customized plaques and careful planning of the irradiation delivery in order to protect structures vital to vision and by associating radiation therapy with other methods with the aim of reducing tumor volume.
Language	English
Publishing date	2023-01-04
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15020333
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Article: Intrastromal Injections in the Management of Infectious Keratitis.

Zemba, Mihail / Radu, Madalina / Istrate, Sinziana / Dumitrescu, Otilia-Maria / Ionescu, Mihai Alexandru / Vatafu, Andrei / Barac, Ileana Ramona

Pharmaceutics

2023 Volume 15, Issue 4

Abstract: Infectious keratitis is a major global cause of vision loss and blindness. Prompt diagnosis and targeted antibiotic treatment are crucial for managing the condition. Topical antimicrobials are the most effective therapy for bacterial keratitis, but they ... ...

Abstract	Infectious keratitis is a major global cause of vision loss and blindness. Prompt diagnosis and targeted antibiotic treatment are crucial for managing the condition. Topical antimicrobials are the most effective therapy for bacterial keratitis, but they can lead to unsatisfactory results due to ocular perforation, scarring, and melting. Intrastromal injection is a newer technique for delivering antimicrobials directly to the site of infection and has been successful in treating severe, treatment-resistant infectious keratitis, especially when surgery is not recommended. In cases where deep stromal disease is resistant to topical treatment, intrastromal antimicrobial injections may be necessary to achieve higher drug concentration at the infection site. However, the use of intrastromal antibiotics is limited, as topical antibacterial agents have better penetration than antifungal agents. Bacterial and fungal keratitis have been extensively researched for intrastromal medication injections, while there is limited evidence for viral keratitis. This review emphasizes the potential of intrastromal antimicrobial injections as an alternative for managing severe refractory infectious keratitis. The technique offers direct targeting of the infection site and faster resolution in some cases compared to topical therapy. However, further research is needed to determine the safest antimicrobials options, minimal effective doses, and concentrations for various pathogens. Intrastromal injections may serve as a non-surgical treatment option in high-risk cases, with benefits including direct drug delivery and reduced epithelial toxicity. Despite promising findings, more studies are required to confirm the safety and efficacy of this approach.
Language	English
Publishing date	2023-03-29
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics15041091
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Article ; Online: Biomarkers of ocular allergy and dry eye disease.

Zemba, Mihail / Ionescu, Mihai-Alexandru / Pîrvulescu, Ruxandra Angela / Dumitrescu, Otilia-Maria / Daniel-Constantin, Brănişteanu / Radu, Mădălina / Stamate, Alina-Cristina / Istrate, Sînziana

Romanian journal of ophthalmology

2023 Volume 67, Issue 3, Page(s) 250–259

Abstract: The most common disorders of the ocular surface are dry eye disease (DED) and ocular allergy (OA). These conditions are frequently coexisting with or without a clinical overlap and can cause a severe impact on the patient's quality of life. Therefore, it ...

Abstract	The most common disorders of the ocular surface are dry eye disease (DED) and ocular allergy (OA). These conditions are frequently coexisting with or without a clinical overlap and can cause a severe impact on the patient's quality of life. Therefore, it can sometimes be hard to distinguish between DED and OA because similar changes and manifestations may be present. Atopic patients can also develop DED, which can aggravate their manifestations. Moreover, patients with DED can develop ocular allergies, so these two pathological entities of the ocular surface can be considered as mutual conditions that share the same background. Nowadays, by using different techniques to collect tissue from ocular surfaces, the changes in molecular homeostasis can be detected and this can lead to a precise diagnosis. The article provides an up-to-date review of the various ocular surface biomarkers that have been identified in DED, OA, or both conditions.
MeSH term(s)	Humans ; Cytokines/metabolism ; Calcitonin/metabolism ; Conjunctivitis, Allergic/diagnosis ; Ligands ; Calcitonin Gene-Related Peptide/metabolism ; Quality of Life ; Dry Eye Syndromes/diagnosis ; Dry Eye Syndromes/metabolism ; Chemokines/metabolism ; Tumor Necrosis Factor-alpha ; Biomarkers ; Annexins ; Proline
Chemical Substances	Cytokines ; Calcitonin (9007-12-9) ; Ligands ; Calcitonin Gene-Related Peptide (JHB2QIZ69Z) ; Chemokines ; Tumor Necrosis Factor-alpha ; Biomarkers ; Annexins ; Proline (9DLQ4CIU6V)
Language	English
Publishing date	2023-11-02
Publishing country	Romania
Document type	Journal Article
ZDB-ID	2842202-8
ISSN	2501-2533 ; 2457-4325
ISSN (online)	2501-2533
ISSN	2457-4325
DOI	10.22336/rjo.2023.42
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Article ; Online: Reply.

Radu, Mădălina / Băban, Adriana / Dumitrascu, Dan L

Journal of gastrointestinal and liver diseases : JGLD

2019 Volume 28, Issue 1, Page(s) 132–133

MeSH term(s)	Humans ; Irritable Bowel Syndrome
Language	English
Publishing date	2019-03-01
Publishing country	Romania
Document type	Letter ; Comment
ZDB-ID	2427021-0
ISSN	1842-1121 ; 1841-8724
ISSN (online)	1842-1121
ISSN	1841-8724
DOI	10.15403/jgld.2014.1121.281.pry
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Article: Ovarian Causes of Pseudomyxoma Peritonei (PMP)-A Literature Review.

Ionescu, Sinziana / Marincas, Marian / Madge, Octavia Luciana / Dicu-Andreescu, Irinel Gabriel / Chitoran, Elena / Rotaru, Vlad / Cirimbei, Ciprian / Gherghe, Mirela / Ene, Adina / Rosca, Robert / Radu, Madalina / Simion, Laurentiu

Cancers

2024 Volume 16, Issue 8

Abstract: Background: Pseudomyxoma peritonei (PMP) is a rare, progressive, slowly growing, inadequately understood neoplasm with a 5-year progression-free survival rate of as low as 48%. It is characterized by varying degrees of malignancy and the production of ... ...

Abstract	Background: Pseudomyxoma peritonei (PMP) is a rare, progressive, slowly growing, inadequately understood neoplasm with a 5-year progression-free survival rate of as low as 48%. It is characterized by varying degrees of malignancy and the production of mucinous and gelatinous structures. Typically, the development of pseudomyxoma peritonei is associated with the rupture of appendiceal mucinous tumors and other gastrointestinal or ovarian mucinous tumors. The goal of our literature review was to identify various aspects that characterize the ovarian causes of pseudomyxoma peritonei. Materials and methods: The authors performed an extensive literature search between 1 February 2024 and 2 March 2024 on the following databases: Pubmed, Scopus, Oxford Journals, and Reaxys, and the findings were summarized into seven main clinical and paraclinical situations. Results: According to our research, the main instances in which pseudomyxoma peritonei can be triggered by an ovarian cause are the following: (1) mucinous cystadenoma; (2) mucinous ovarian cancer; (3) colon cancer with ovarian metastasis; (4) malignant transformation of an ovarian primary mature cystic teratoma; (5) appendiceal mucocele with peritoneal dissemination mimicking an ovarian tumor with peritoneal carcinomatosis; (6) mucinous borderline tumor developing inside an ovarian teratoma; and (7) the association between a mucinous bilateral ovarian cancer and a colonic tumor. Conclusions: In our study, we aimed to provide a comprehensive overview of the ovarian causes of pseudomyxoma peritonei, including its epidemiology, imagery characteristics, symptoms, current treatment, and promising future therapies, in the hopes of finding feasible solutions, as a lack of understanding of this mucus-secreting malignant disease increases the risk of delayed diagnosis or uncontrolled deterioration.
Language	English
Publishing date	2024-04-09
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers16081446
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Article: Differential Diagnosis of Abdominal Tuberculosis in the Adult-Literature Review.

Ionescu, Sinziana / Nicolescu, Alin Codrut / Madge, Octavia Luciana / Marincas, Marian / Radu, Madalina / Simion, Laurentiu

Diagnostics (Basel, Switzerland)

2021 Volume 11, Issue 12

Abstract: Tuberculosis (TB) is a public health issue that affects mostly, but not exclusively, developing countries. Abdominal TB is difficult to detect at first, with the incidence ranging from 10% to 30% of individuals with lung TB. Symptoms are non-specific, ... ...

Abstract	Tuberculosis (TB) is a public health issue that affects mostly, but not exclusively, developing countries. Abdominal TB is difficult to detect at first, with the incidence ranging from 10% to 30% of individuals with lung TB. Symptoms are non-specific, examinations can be misleading, and biomarkers commonly linked with other diseases can also make appropriate diagnosis difficult. As a background for this literature review, the method used was to look into the main characteristics and features of abdominal tuberculosis that could help with differentiation on the PubMed, Science Direct, and Academic Oxford Journals databases. The results were grouped into three categories: A. general features (the five forms of abdominal tuberculosis: wet and dry peritonitis, lymphadenopathy, lesions at the level of the cavitary organs, lesions at the level of the solid organs), B. different intra-abdominal organs and patterns of involvement (oesophageal, gastro-duodenal, jejunal, ileal, colorectal, hepatosplenic, and pancreatic TB with calcified lymphadenopathy, also with description of extraperitoneal forms), and C. special challenges of the differential diagnosis in abdominal TB (such as diagnostic overlap, the disease in transplant candidates and transplant recipients, and zoonotic TB). The study concluded that, particularly in endemic countries, any disease manifesting with peritonitis, lymphadenopathy, or lesions at the level of the intestines or solid organs should have workups and protocols applied that can confirm/dismiss the suspicion of abdominal tuberculosis.
Language	English
Publishing date	2021-12-15
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics11122362
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Article ; Online: Research priorities in psychiatric genetic counselling: how to talk to children and adolescents about genetics and psychiatric disorders.

Mundy, Jessica / Davies, Helena L / Radu, Mădălina / Austin, Jehannine / Vassos, Evangelos / Eley, Thalia C / Breen, Gerome / Moldovan, Ramona

European journal of human genetics : EJHG

2022 Volume 31, Issue 3, Page(s) 262–264

MeSH term(s)	Humans ; Child ; Adolescent ; Genetic Counseling ; Mental Disorders/genetics ; Mental Disorders/therapy ; Mental Disorders/psychology ; Research
Language	English
Publishing date	2022-12-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1141470-4
ISSN	1476-5438 ; 1018-4813
ISSN (online)	1476-5438
ISSN	1018-4813
DOI	10.1038/s41431-022-01253-0
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Article ; Online: The impact of psychiatric disorders on caregivers: An integrative predictive model of burden, stigma, and well-being.

Radu, Mădălina / Ciucă, Andrada / Crișan, Cătălina-Angela / Pintea, Sebastian / Predescu, Elena / Șipos, Roxana / Moldovan, Ramona / Băban, Adriana

Perspectives in psychiatric care

2022 Volume 58, Issue 4, Page(s) 2372–2382

Abstract: Purpose: The study investigates the predictors of caregivers' experienced burden, stigma, and well-being, when looking after family members diagnosed with a psychiatric disorder.: Design and methods: This cross-sectional study included 168 caregivers; ...

Abstract	Purpose: The study investigates the predictors of caregivers' experienced burden, stigma, and well-being, when looking after family members diagnosed with a psychiatric disorder. Design and methods: This cross-sectional study included 168 caregivers; perceived burden, stigma, well-being, knowledge, illness perception, and medical variables were assessed. Findings: A number of correlates of burden, stigma, and well-being have been identified and are being discussed. The integrative predictive model showed that the caregiver's emotional representation of illness best predicts burden (β = 0.38, p < 0.001), stigma (β = 0.53, p < 0.001) and well-being (β = -0.36, p < 0.001). Practice implications: Our results can enable health professionals to tailor psychosocial interventions addressed to family members of individuals living with a psychiatric condition.
MeSH term(s)	Humans ; Caregivers/psychology ; Cross-Sectional Studies ; Social Stigma ; Mental Disorders ; Family/psychology
Language	English
Publishing date	2022-03-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	391097-0
ISSN	1744-6163 ; 0031-5990
ISSN (online)	1744-6163
ISSN	0031-5990
DOI	10.1111/ppc.13071
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