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  1. Article ; Online: How we do it-the use of peritoneal patches for reconstruction of vena cava inferior and portal vein in hepatopancreatobiliary surgery.

    Radulova-Mauersberger, O / Distler, M / Riediger, C / Weitz, J / Welsch, T / Kirchberg, J

    Langenbeck's archives of surgery

    2022  Volume 407, Issue 8, Page(s) 3819–3831

    Abstract: Purpose: Extended resections in hepatopancreatobiliary (HPB) surgery frequently require vascular resection to obtain tumor clearance. The use of alloplastic grafts may increase postoperative morbidity due to septic or thrombotic complications. The use ... ...

    Abstract Purpose: Extended resections in hepatopancreatobiliary (HPB) surgery frequently require vascular resection to obtain tumor clearance. The use of alloplastic grafts may increase postoperative morbidity due to septic or thrombotic complications. The use of suitable autologous venous interponates (internal jugular vein, great saphenous vein) is frequently associated with additional incisions. The aim of this study was to report on our experience with venous reconstruction using the introperative easily available parietal peritoneum, focusing on key technical aspects.
    Methods: All patients who underwent HPB resections with venous reconstruction using peritoneal patches at our department between January 2017 and November 2021 were included in this retrospective analysis with median follow-up of 2 months (IQR: 1-8 months). We focused on technical aspects of the procedure and evaluated vascular patency and perioperative morbidity.
    Results: Parietal peritoneum patches (PPPs) were applied for reconstruction of the inferior vena cava (IVC) (13 patients) and portal vein (PV) (4 patients) during major hepatic (n = 14) or pancreatic (n = 2) resections. There were no cases of postoperative bleeding due to anastomotic leakage. Following PV reconstruction, two patients showed postoperative vascular stenosis after severe pancreatitis with postoperative pancreatic fistula and bile leakage, respectively. In patients with reconstruction of the IVC, no relevant perioperative vascular complications occurred.
    Conclusions: The use of a peritoneal patch for reconstruction of the IVC in HPB surgery is a feasible, effective, and low-cost alternative to alloplastic, xenogenous, or venous grafts. The graft can be easily harvested and tailored to the required size. More evidence is still needed to confirm the safety of this procedure for the portal vein regarding long-term results.
    Language English
    Publishing date 2022-09-22
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1423681-3
    ISSN 1435-2451 ; 1435-2443
    ISSN (online) 1435-2451
    ISSN 1435-2443
    DOI 10.1007/s00423-022-02662-x
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  2. Article ; Online: Analysis of predictors for postoperative complications after pancreatectomy--what is new after establishing the definition of postpancreatectomy acute pancreatitis (PPAP)?

    Radulova-Mauersberger, O / Oehme, F / Missel, L / Kahlert, C / Welsch, T / Weitz, J / Distler, Marius

    Langenbeck's archives of surgery

    2023  Volume 408, Issue 1, Page(s) 79

    Abstract: Purpose: We aimed to analyze the predictive value of hyperamylasemia after pancreatectomy for morbidity and for the decision to perform rescue completion pancreatectomy (CP) in a retrospective cohort study.: Methods: Data were extracted from a ... ...

    Abstract Purpose: We aimed to analyze the predictive value of hyperamylasemia after pancreatectomy for morbidity and for the decision to perform rescue completion pancreatectomy (CP) in a retrospective cohort study.
    Methods: Data were extracted from a retrospective clinical database. Postoperative hyperamylasemia (POH) and postoperative hyperlipasemia (POHL) were defined by values greater than those accepted as the upper limit at our institution on postoperative day 1 (POD1). The endpoints of the study were the association of POH with postoperative morbidity and the possible predictors for postpancreatectomy acute pancreatitis (PPAP) and severe complications such as the necessity for rescue CP.
    Results: We analyzed 437 patients who underwent pancreaticoduodenectomy over a period of 7 years. Among them, 219 (52.3%) patients had POH and 200 (47.7%) had normal postoperative amylase (non-POH) levels. A soft pancreatic texture (odds ratio [OR] 3.86) and POH on POD1 (OR 8.2) were independent predictors of postoperative pancreatic fistula (POPF), and POH on POD1 (OR 6.38) was an independent predictor of rescue CP. The clinically relevant POPF (49.5% vs. 11.4%, p < 0.001), intraabdominal abscess (38.3% vs. 15.3%, p < 0.001), postoperative hemorrhage (22.8% vs. 5.1%, p < 0.001), major complications (Clavien-Dindo classification > 2) (52.5% vs. 25.6%, p < 0.001), and CP (13% vs. 1.8%, p < 0.001) occurred significantly more often in the POH group than in the non-POH group.
    Conclusion: Although POH on POD1 occurs frequently, in addition to other risk factors, it has a predictive value for the development of postoperative morbidity associated with PPAP and CP.
    MeSH term(s) Humans ; Pancreatectomy/adverse effects ; Pancreatitis/diagnosis ; Pancreatitis/etiology ; Retrospective Studies ; Hyperamylasemia/complications ; Acute Disease ; Postoperative Complications/diagnosis ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Pancreaticoduodenectomy/adverse effects ; Pancreatic Fistula/diagnosis ; Pancreatic Fistula/epidemiology ; Pancreatic Fistula/etiology ; Risk Factors
    Chemical Substances N-(3-phenyl-n-propyl)-1-phenyl-2-aminopropane (131903-56-5)
    Language English
    Publishing date 2023-02-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1423681-3
    ISSN 1435-2451 ; 1435-2443
    ISSN (online) 1435-2451
    ISSN 1435-2443
    DOI 10.1007/s00423-023-02814-7
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  3. Book ; Thesis: Endoskopische versus konventionelle Operationstechniken der Hernioplastik am KKH Freiberg

    Radulova-Mauersberger, Olga

    eine retrospektive Analyse über 9 Jahre

    2008  

    Author's details vorgelegt von Olga Radulova-Mauersberger, geb. Radulova
    Subject code 617.5
    Language German
    Size 90 S., Ill., graph. Darst., 30 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dresden, Techn. Univ., Diss., 2009
    HBZ-ID HT016474519
    Database Catalogue ZB MED Medicine, Health

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    2010 E 2746 order for loan Magazin

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  4. Article ; Online: Textbook outcome after pancreatoduodenectomy and distal pancreatectomy with postoperative hyperamylasemia-a propensity score matching analysis.

    Radulova-Mauersberger, Olga / Mibelli, Nicolas / von Bechtolsheim, Felix / Kroesen, Louisa / Hempel, Sebastian / Weitz, Jürgen / Distler, Marius / Oehme, Florian

    Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

    2024  Volume 28, Issue 4, Page(s) 451–457

    Abstract: Purpose: Postoperative serum hyperamylasemia (POH) is a part of the new, increasingly highlighted, definition for postpancreatectomy pancreatitis (PPAP). This study aimed to analyze whether the biochemical changes of PPAP are differently associated with ...

    Abstract Purpose: Postoperative serum hyperamylasemia (POH) is a part of the new, increasingly highlighted, definition for postpancreatectomy pancreatitis (PPAP). This study aimed to analyze whether the biochemical changes of PPAP are differently associated with postoperative complications after distal pancreatectomy (DP) compared with pancreatoduodenectomy (PD). The textbook outcome (TO) was used as a summary measure to capture real-world data.
    Methods: The data were retrospectively extracted from a prospective clinical database. Patients with POH, defined as levels above our institution's upper limit of normal on postoperative day 1, after DP and the corresponding propensity score-matched cohort after PD were evaluated on postoperative complications by using logistic regression analyses.
    Results: We analyzed 723 patients who underwent PD and DP over a period of 9 years. After propensity score matching, 384 patients (192 patients in each group) remained. POH was observed in 78 (41.1%) and 74 (39.4%) after PD and DP correspondingly. There was a significant increase of postoperative complications in the PD group: Clavien-Dindo classification system ≥3 (P < .01 vs P = .71), clinically relevant postoperative pancreatic fistula (P < .001 vs P = .2), postpancreatectomy hemorrhage (P < .001 vs P = .11), and length of hospital stay (P < .001 vs P = .69) if POH occurred compared with in the DP group. TO was significantly unlikely in cases with POH after PD compared with DP (P > .001 vs P = .41). Furthermore, POH was found to be an independent predictor for missing TO after PD (odds ratio [OR], 0.29; 95% CI, 0.14-0.60; P < .001), whereas this was not observed in patients after DP (OR, 0.53; 95% CI, 0.21-1.33; P = .18).
    Conclusion: As a part of the definition for PPAP, POH is a predictive indicator associated with postoperative complications after PD but not after DP.
    MeSH term(s) Humans ; Pancreatectomy/adverse effects ; Pancreaticoduodenectomy/adverse effects ; Hyperamylasemia/complications ; Propensity Score ; Retrospective Studies ; Prospective Studies ; Pancreatic Fistula/epidemiology ; Pancreatic Fistula/etiology ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Pancreatitis/complications ; Propylamines
    Chemical Substances N-(3-phenyl-n-propyl)-1-phenyl-2-aminopropane (131903-56-5) ; Propylamines
    Language English
    Publishing date 2024-02-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2012365-6
    ISSN 1873-4626 ; 1934-3213 ; 1091-255X
    ISSN (online) 1873-4626 ; 1934-3213
    ISSN 1091-255X
    DOI 10.1016/j.gassur.2024.02.012
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  5. Article ; Online: Vascular surgery in liver resection.

    Radulova-Mauersberger, Olga / Weitz, Jürgen / Riediger, Carina

    Langenbeck's archives of surgery

    2021  Volume 406, Issue 7, Page(s) 2217–2248

    Abstract: Vascular surgery in liver resection is a standard part of liver transplantation, but is also used in oncological liver surgery. Malignant liver tumors with vascular involvement have a poor prognosis without resection. Surgery is currently the only ... ...

    Abstract Vascular surgery in liver resection is a standard part of liver transplantation, but is also used in oncological liver surgery. Malignant liver tumors with vascular involvement have a poor prognosis without resection. Surgery is currently the only treatment to provide long-term survival in advanced hepatic malignancy. Even though extended liver resections are increasingly performed, vascular involvement with need of vascular reconstruction is still considered a contraindication for surgery in many institutions. However, vascular resection and reconstruction in liver surgery-despite being complex procedures-are safely performed in specialized centers. The improvements of the postoperative results with reduced postoperative morbidity and mortality are a result of rising surgical and anesthesiological experience and advancements in multimodal treatment concepts with preconditioning measures regarding liver function and systemic treatment options. This review focuses on vascular surgery in oncological liver resections. Even though many surgical techniques were developed and are also used during liver transplantation, this special procedure is not particularly covered within this review article. We provide a summary of vascular reconstruction techniques in oncological liver surgery according to the literature and present also our own experience. We aim to outline the current advances and standards in extended surgical procedures for liver tumors with vascular involvement established in specialized centers, since curative resection improves long-term survival and shifts palliative concepts to curative therapy.
    MeSH term(s) Carcinoma, Hepatocellular/surgery ; Hepatectomy ; Humans ; Liver Neoplasms/surgery ; Vascular Surgical Procedures
    Language English
    Publishing date 2021-09-14
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1423681-3
    ISSN 1435-2451 ; 1435-2443
    ISSN (online) 1435-2451
    ISSN 1435-2443
    DOI 10.1007/s00423-021-02310-w
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  6. Article ; Conference proceedings: Postoperative Hyperamylasämie – ist sie ein Prädiktor für Morbidität nach Pankreaslinksresektionen? – Textbook Outcome in einer Propensity-Score-Matching-Analyse

    Radulova-Mauersberger, O. / Oehme, F. / Freiherr von Bechtolsheim, F. / Mibelli, N. / Weitz, J. / Distler, M.

    Zeitschrift für Gastroenterologie

    2023  Volume 61, Issue 08

    Event/congress Viszeralmedizin 2023 77. Jahrestagung der DGVS mit Sektion Endoskopie Herbsttagung der Deutschen Gesellschaft für Allgemein- und Viszeralchirurgie mit den Arbeitsgemeinschaften der DGAV und Jahrestagung der CACP, Erst online. Dann Hamburg., 2023-09-11
    Language German
    Publishing date 2023-08-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 201387-3
    ISSN 1439-7803 ; 0044-2771 ; 0172-8504
    ISSN (online) 1439-7803
    ISSN 0044-2771 ; 0172-8504
    DOI 10.1055/s-0043-1772070
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  7. Article ; Online: Drainless robot-assisted minimally invasive oesophagectomy-randomized controlled trial (RESPECT).

    Müssle, B / Kirchberg, J / Buck, N / Radulova-Mauersberger, O / Stange, D / Richter, T / Müller-Stich, B / Klotz, R / Larmann, J / Korn, S / Klimova, A / Grählert, X / Trips, E / Weitz, J / Welsch, T

    Trials

    2023  Volume 24, Issue 1, Page(s) 303

    Abstract: Background: The purpose of this randomized trial is to evaluate the early removal of postoperative drains after robot-assisted minimally invasive oesophagectomy (RAMIE). Evidence is lacking about feasibility, associated pain, recovery, and morbidity.: ...

    Abstract Background: The purpose of this randomized trial is to evaluate the early removal of postoperative drains after robot-assisted minimally invasive oesophagectomy (RAMIE). Evidence is lacking about feasibility, associated pain, recovery, and morbidity.
    Methods/design: This is a randomized controlled multicentric trial involving 72 patients undergoing RAMIE. Patients will be allocated into two groups. The "intervention" group consists of 36 patients. In this group, abdominal and chest drains are removed 3 h after the end of surgery in the absence of contraindications. The control group consists of 36 patients with conventional chest drain management. These drains are removed during the further postoperative course according to a standard algorithm. The primary objective is to investigate whether postoperative pain measured by NRS on the second postoperative day can be significantly reduced in the intervention group. Secondary endpoints are the intensity of pain during the first week, analgesic use, number of postoperative chest X-ray and CT scans, interventions, postoperative mobilization (steps per day as measured with an activity tracker), postoperative morbidity and mortality.
    Discussion: Until now, there have been no trials investigating different intraoperative chest drain strategies in patients undergoing RAMIE for oesophageal cancer with regard to perioperative complications until discharge. Minimally invasive approaches combined with enhanced recovery after surgery (ERAS) protocols lower morbidity but still include the insertion of chest drains. Reduction and early removal have been proposed after pulmonary surgery but not after RAMIE. The study concept is based on our own experience and the promising current results of the RAMIE procedure. Therefore, the presented randomized controlled trial will provide statistical evidence of the effectiveness and feasibility of the "drainless" RAMIE.
    Trial registration: ClinicalTrials.gov NCT05553795. Registered on 23 September 2022.
    MeSH term(s) Humans ; Esophagectomy/methods ; Robotics ; Postoperative Complications/etiology ; Abdomen ; Esophageal Neoplasms/surgery ; Pain, Postoperative/surgery ; Treatment Outcome ; Minimally Invasive Surgical Procedures/methods
    Language English
    Publishing date 2023-05-02
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2040523-6
    ISSN 1745-6215 ; 1468-6694 ; 1745-6215
    ISSN (online) 1745-6215
    ISSN 1468-6694 ; 1745-6215
    DOI 10.1186/s13063-023-07233-z
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  8. Article ; Online: Rektale neuroendokrine Tumoren: chirurgische Therapie.

    Radulova-Mauersberger, O / Stelzner, S / Witzigmannn, H

    Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen

    2016  Volume 87, Issue 4, Page(s) 292–297

    Abstract: The incidence of rectal neuroendocrine tumors (NET) has increased in recent years. Most of these neoplasms are asymptomatic and are diagnosed by colonoscopy screening, which could be one of the reasons for the increasing occurrence. As less than 1 % of ... ...

    Title translation Rectal neuroendocrine tumors: surgical therapy.
    Abstract The incidence of rectal neuroendocrine tumors (NET) has increased in recent years. Most of these neoplasms are asymptomatic and are diagnosed by colonoscopy screening, which could be one of the reasons for the increasing occurrence. As less than 1 % of rectal NET produce serotonin they are practically never discovered due to a carcinoid syndrome. The current guidelines of the European (ENETS) and North American (NANETS) Neuroendocrine Tumor Societies support clinicians with useful diagnostic and treatment algorithms. The most important criteria for therapy are tumor size and histopathological risk factors for metastases. For well-differentiated rectal neuroendocrine neoplasms < 1 cm, local endoscopic or surgical excision is recommended. Due to the lack of evidence tumors sized 1-2 cm represent a grey area for prognosis and treatment. All NET > 1.5 cm must be excised by radical surgery as low anterior rectal resection or abdominoperineal extirpation with total mesorectal excision (TME). Resectable liver and lung metastases of well-differentiated NETs should be surgically treated with curative intent.
    MeSH term(s) Algorithms ; Colonoscopy ; Early Detection of Cancer ; Early Diagnosis ; Guideline Adherence ; Humans ; Liver Neoplasms/pathology ; Liver Neoplasms/secondary ; Liver Neoplasms/surgery ; Lung Neoplasms/pathology ; Lung Neoplasms/secondary ; Lung Neoplasms/surgery ; Neuroendocrine Tumors/pathology ; Neuroendocrine Tumors/surgery ; Prognosis ; Rectal Neoplasms/pathology ; Rectal Neoplasms/surgery ; Tumor Burden
    Language German
    Publishing date 2016-04
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1521-0
    ISSN 1433-0385 ; 0009-4722
    ISSN (online) 1433-0385
    ISSN 0009-4722
    DOI 10.1007/s00104-016-0153-x
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  9. Article ; Conference proceedings: Preoperative Anemia in Distal Pancreatectomy – an evident, prevalent and underestimated burden

    Oehme, F / von Bechtolsheim, F / Radulova-Mauersberger, O / Teske, C / Hempel, S / Frohneberg, L / Kahlert, C / Weitz, J / Distler, M

    Zeitschrift für Gastroenterologie

    2022  Volume 60, Issue 08

    Event/congress Viszeralmedizin 2022 76. Jahrestagung der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten mit Sektion Endoskopie 13. Herbsttagung der Deutschen Gesellschaft für Allgemein- und Viszeralchirurgie gemeinsam mit den Arbeitsgemeinschaften der DGAV, Erst online. Dann Hamburg., 2022-09-12
    Language German
    Publishing date 2022-08-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 201387-3
    ISSN 1439-7803 ; 0044-2771 ; 0172-8504
    ISSN (online) 1439-7803
    ISSN 0044-2771 ; 0172-8504
    DOI 10.1055/s-0042-1754665
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  10. Article ; Conference proceedings: The importance of hyperamylasemia as predictor of postoperative pancreatitis (PPAP) and severe morbidity after pancreatoduodenectomy

    Radulova-Mauersberger, O / Oehme, F / Teske, C / von Bechtolsheim, F / Missel, L / Weitz, J / Distler, M

    Zeitschrift für Gastroenterologie

    2022  Volume 60, Issue 08

    Event/congress Viszeralmedizin 2022 76. Jahrestagung der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten mit Sektion Endoskopie 13. Herbsttagung der Deutschen Gesellschaft für Allgemein- und Viszeralchirurgie gemeinsam mit den Arbeitsgemeinschaften der DGAV, Erst online. Dann Hamburg., 2022-09-12
    Language German
    Publishing date 2022-08-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 201387-3
    ISSN 1439-7803 ; 0044-2771 ; 0172-8504
    ISSN (online) 1439-7803
    ISSN 0044-2771 ; 0172-8504
    DOI 10.1055/s-0042-1754672
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