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  1. AU="Rafael Ambar"
  2. AU="Concetta Aprea"
  3. AU="Cushing, D J"
  4. AU=Fernandez Hugo F
  5. AU="Martinez Rolón, Juliana"
  6. AU="Roeder, Elizabeth R"
  7. AU="van der Kevie-Kersemaekers, Anne-Marie M F"
  8. AU="Ghuman, Samarjit Singh"
  9. AU="Ahu Cerit Çakır"
  10. AU="Sun, Yin-Qiang"
  11. AU=Brown M.W.
  12. AU="Andrés Izaguirre"
  13. AU="Mahdieh Eftekhari"
  14. AU="Patrick Rairoux"
  15. AU=Lanna Alessio
  16. AU="Fusco, Augusto"
  17. AU="Mahboobe Hosseinikia"
  18. AU="Stone, G"
  19. AU="Seuthe, Leni Katharina"
  20. AU="Schuetz, Thomas J"
  21. AU="Thielen, Peter"
  22. AU="Anders Tveita"
  23. AU="Joseph O. Fadare"
  24. AU="Koech, O K"
  25. AU="Kapp, William"
  26. AU="Argañaraz, Gustavo A."
  27. AU="Winters, Adrienna"
  28. AU="Iman Mamdouh Talaat"
  29. AU="Benjamin Kingsley Harley"
  30. AU="Cirio, Maria Cecilia"
  31. AU="Rodriguez-Rodriguez, Alvaro Manuel"
  32. AU="Anna Maria Aloisi"
  33. AU="Na, Li"
  34. AU="Beatriz Aguiar Jordão Paranhos"
  35. AU="johnson, Michael"
  36. AU=Hunt S A
  37. AU="Gniazdowski, Victoria"
  38. AU="Griffin, Matthew E"
  39. AU="Bean, Paris"
  40. AU="Elomaa, Paula"
  41. AU="Robert Fowler"
  42. AU="Nielsen, Stine"
  43. AU="Chabartier, Cyrille"

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  1. Artikel ; Online: The Impact of Single- and Double-Strand DNA Breaks in Human Spermatozoa on Assisted Reproduction

    Ashok Agarwal / Cătălina Barbăroșie / Rafael Ambar / Renata Finelli

    International Journal of Molecular Sciences, Vol 21, Iss 3882, p

    2020  Band 3882

    Abstract: Several cellular insults can result in sperm DNA fragmentation either on one or both DNA strands. Oxidative damage, premature interruption of the apoptotic process and defects in DNA compaction during spermatogenesis are the main mechanisms that cause ... ...

    Abstract Several cellular insults can result in sperm DNA fragmentation either on one or both DNA strands. Oxidative damage, premature interruption of the apoptotic process and defects in DNA compaction during spermatogenesis are the main mechanisms that cause DNA breaks in sperm. The two-tailed Comet assay is the only technique that can differentiate single- (SSBs) from double- (DSBs) strand DNA breaks. Increased levels of the phosphorylated isoform of the H2AX histone are directly correlated with DSBs and proposed as a molecular biomarker of DSBs. We have carried out a narrative review on the etiologies associated with SSBs and DSBs in sperm DNA, their association with reproductive outcomes and the mechanisms involved in their repair. Evidence suggests a stronger negative impact of DSBs on reproductive outcomes (fertilization, implantation, miscarriage, pregnancy, and live birth rates) than SSBs, which can be partially overcome by using intracytoplasmic sperm injection (ICSI). In sperm, SSBs are irreversible, whereas DSBs can be repaired by homologous recombination, non-homologous end joining (NHEJ) and alternative NHEJ pathways. Although few studies have been published, further research is warranted to provide a better understanding of the differential effects of sperm SSBs and DSBs on reproductive outcomes as well as the prognostic relevance of DNA breaks discrimination in clinical practice.
    Schlagwörter DNA damage ; DNA breaks ; double-stranded DNA breaks ; single-stranded DNA breaks ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 612
    Sprache Englisch
    Erscheinungsdatum 2020-05-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Sperm DNA Fragmentation

    Ashok Agarwal / Ala’a Farkouh / Neel Parekh / Armand Zini / Mohamed Arafa / Hussein Kandil / Nick Tadros / Gian Maria Busetto / Rafael Ambar / Sijo Parekattil / Florence Boitrelle / Hassan Sallam / Sunil Jindal / Edmund Ko / Mara Simopoulou / Hyun Jun Park / Mohammad Ali Sadighi / Ramadan Saleh / Jonathan Ramsay /
    Marlon Martine / Haitham Elbardisi / Juan Alvarez / Giovanni Colpi / Jaime Gosalvez / Donald Evenson / Rupin Shah

    The World Journal of Men's Health, Vol 40, Iss 1, Pp 30-

    A Critical Assessment of Clinical Practice Guidelines

    2022  Band 37

    Abstract: Sperm DNA fragmentation (SDF) is implicated in male infertility and adverse reproductive outcomes. With the publication of many studies regarding the etiologies and contributors to SDF, as well as the effects of SDF, guidelines are necessary to aid ... ...

    Abstract Sperm DNA fragmentation (SDF) is implicated in male infertility and adverse reproductive outcomes. With the publication of many studies regarding the etiologies and contributors to SDF, as well as the effects of SDF, guidelines are necessary to aid clinicians in the application of SDF for male fertility evaluation. Two recent clinical practice guidelines were published by Agarwal et al and Esteves et al. In this article, we have evaluated and compared both guidelines. We have found fairly similar recommendations between the two guidelines and have also highlighted the differences between them. Finally, we have summarized and combined the best practice recommendations from both guidelines.
    Schlagwörter dna fragmentation ; male infertility ; oxidative stress ; practice guidelines as topic ; assisted reproductive techniques ; Medicine ; R ; Diseases of the genitourinary system. Urology ; RC870-923
    Sprache Englisch
    Erscheinungsdatum 2022-01-01T00:00:00Z
    Verlag Korean Society for Sexual Medicine and Andrology
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Sperm DNA Fragmentation

    Ashok Agarwal / Ahmad Majzoub / Saradha Baskaran / Manesh Kumar Panner Selvam / Chak Lam Cho / Ralf Henkel / Renata Finelli / Kristian Leisegang / Pallav Sengupta / Catalina Barbarosie / Neel Parekh / Marco G. Alves / Edmund Ko / Mohamed Arafa / Nicholas Tadros / Ranjith Ramasamy / Parviz Kavoussi / Rafael Ambar / Manish Kuchakulla /
    Kathy Amy Robert / Concetta Iovine / Damayanthi Durairajanayagam / Sunil Jindal / Rupin Shah

    The World Journal of Men's Health, Vol 38, Iss 4, Pp 412-

    A New Guideline for Clinicians

    2020  Band 471

    Abstract: Sperm DNA integrity is crucial for fertilization and development of healthy offspring. The spermatozoon undergoes extensive molecular remodeling of its nucleus during later phases of spermatogenesis, which imparts compaction and protects the genetic ... ...

    Abstract Sperm DNA integrity is crucial for fertilization and development of healthy offspring. The spermatozoon undergoes extensive molecular remodeling of its nucleus during later phases of spermatogenesis, which imparts compaction and protects the genetic content. Testicular (defective maturation and abortive apoptosis) and post-testicular (oxidative stress) mechanisms are implicated in the etiology of sperm DNA fragmentation (SDF), which affects both natural and assisted reproduction. Several clinical and environmental factors are known to negatively impact sperm DNA integrity. An increasing number of reports emphasizes the direct relationship between sperm DNA damage and male infertility. Currently, several assays are available to assess sperm DNA damage, however, routine assessment of SDF in clinical practice is not recommended by professional organizations. This article provides an overview of SDF types, origin and comparative analysis of various SDF assays while primarily focusing on the clinical indications of SDF testing. Importantly, we report four clinical cases where SDF testing had played a significant role in improving fertility outcome. In light of these clinical case reports and recent scientific evidence, this review provides expert recommendations on SDF testing and examines the advantages and drawbacks of the clinical utility of SDF testing using Strength-Weaknesses-Opportunities-Threats (SWOT) analysis.
    Schlagwörter assisted reproductive techniques outcome ; clinical guidelines ; infertility ; male ; oxidative stress ; sperm dna fragmentation ; Medicine ; R ; Diseases of the genitourinary system. Urology ; RC870-923
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2020-10-01T00:00:00Z
    Verlag Korean Society for Sexual Medicine and Andrology
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

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