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Article: Clostridium Histolyticum Collagenase Underdosed for Multicord Injection in Dupuytren's Disease: A Retrospective Cohort Study.

Boriani, Filippo / Raggini, Filippo / Evangelista, Andrea / Gustar, Adrian / Figus, Andrea

Plastic and reconstructive surgery. Global open

2022 Volume 10, Issue 11, Page(s) e4659

Abstract: An underdosing of collagenase clostridium histolyticum (0.32 mg) is proposed as a potentially effective option in patients with additional cords in the same hand, after the first cord has been treated with the regular dose of 0.58 mg. The aim of this ... ...

Abstract	An underdosing of collagenase clostridium histolyticum (0.32 mg) is proposed as a potentially effective option in patients with additional cords in the same hand, after the first cord has been treated with the regular dose of 0.58 mg. The aim of this study was to analyze whether this additional dose is tolerated and effective. Methods: Patients with Dupuytren's disease affecting MCP joints with at least two independent pathological cords, causing deformity of two digits, were considered, with their written informed consent, for a simultaneous injection of the two cords with a single vial of collagenase. Digits treated with the standard dose of 0.58 mg were compared with digits injected with the smaller dose of 0.32 mg. Passive extension deficit and range of motion were evaluated after injection. Complications were also compared. Results: A total of 26 patients (29 hands) were included in the study. Of these, nine patients had two independent cords within one hand, and 17 patients had a single cord (three of these with a cord in each hand). Thirty-five digits were injected, 23 with 0.58 mg and 12 with 0.32 mg. Apart from a smaller mean percentage variation in passive extension deficit within 24 hours in the 0.58-mg dose compared with 0.32 mg (29% versus 40%, Conclusion: Underdosing collagenase clostridium histolyticum is equally effective in the treatment of Dupuytren's disease.
Language	English
Publishing date	2022-11-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2851682-5
ISSN	2169-7574 ; 2169-7574
ISSN (online)	2169-7574
ISSN	2169-7574
DOI	10.1097/GOX.0000000000004659
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Article ; Online: Third generation Dual Mobility Cups: could be the future in total hip arthroplasty? A five-year experience with dualis.

Paderni, Stefania / Pari, Carlotta / Raggini, Filippo / Busatto, Carlo / Delmastro, Elena / Belluati, Alberto

Acta bio-medica : Atenei Parmensis

2022 Volume 92, Issue S3, Page(s) e2021553

Abstract: Background: The concept of dual mobility (DM) is currently approved as a valid option for reducing the risk of dislocation, with an incidence ranging from 0% to 4.6%. The principle is to achieve a high joint stability through a large diameter ... ...

Abstract	Background: The concept of dual mobility (DM) is currently approved as a valid option for reducing the risk of dislocation, with an incidence ranging from 0% to 4.6%. The principle is to achieve a high joint stability through a large diameter polyethylene (PE) liner, and to reduce cutting forces due to a "low-friction" head-liner coupling mechanism. Methods: From March 2015 to March 2020, 138 patients were treated with Dualis Cup (Gruppo Bioimpianti-Peschiera Borromeo, MI, Italy) for a total of 141 implants (three cases were bilateral). The average age at the time of the surgery was 77. Patients' clinical and X-ray follow-up was at 1, 3, 6, 12 months and then once a year. Results: Seven patients (4.9%) had complications which required a second surgery, but only one case (0.7%) of intraprosthetic dislocation (which required cup revision), was directly ascribable to the DM cup. Conclusions: Improvements in design and materials of the third generation DM cups allowed both to reduce the rate of dislocations in high-risk patients (i.e., patients with neuro-muscular diseases and cognitive disorders, patients needing revisions, osteosynthesis failures, femoral neck fractures) and to achieve a survival rate similar to standard cups, ensuring a range of motion (ROM) very close to the physiological one. In our brief experience, Dualis Cups showed results comparable to those reported in the literature for Dual Mobility. If this data is confirmed by long-term studies, the use of DM cups could be extended even for young patients with high functional demands. (www.actabiomedica.it).
MeSH term(s)	Arthroplasty, Replacement, Hip/adverse effects ; Follow-Up Studies ; Hip Prosthesis/adverse effects ; Humans ; Joint Dislocations/etiology ; Prosthesis Design ; Prosthesis Failure ; Reoperation/methods ; Retrospective Studies
Language	English
Publishing date	2022-03-10
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2114240-3
ISSN	2531-6745 ; 0392-4203
ISSN (online)	2531-6745
ISSN	0392-4203
DOI	10.23750/abm.v92iS3.12541
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Article ; Online: One-stage procedure for open tibial fractures: feasible without orthoplastic surgery?

Pari, Carlotta / Raggini, Filippo / Paderni, Stefania / Bettinelli, Giulia / Salini, Vincenzo / Vicenti, Giovanni / Belluati, Alberto

Acta bio-medica : Atenei Parmensis

2021 Volume 92, Issue S3, Page(s) e2021018

Abstract: Background: Open tibial fractures are mostly the result of high-energy traumas and often involve severe injuries with extensive bone and soft tissue loss, damage of muscles and neurovascular structures. Over recent- years, - the growth of Ortho-Plastic ... ...

Abstract	Background: Open tibial fractures are mostly the result of high-energy traumas and often involve severe injuries with extensive bone and soft tissue loss, damage of muscles and neurovascular structures. Over recent- years, - the growth of Ortho-Plastic teams, as a well-coordinated bone, joint and soft tissue treatment, contributed to change the approach to these fractures and to achieve higher successful results in lower limb salvage. Unfortunately, many hospitals cannot benefit of a combined team in emergency, and the orthopedic surgeon is forced to manage personally these kinds of traumas. Methods: We retrospectively reviewed all the open tibial fractures treated at our Orthopaedic Department over the last 10 years, in order to assess the treatments performed (one-stage fixation with Intramedullary Nailing or Open Reduction Internal Fixation - ORIF, versus two/multiple-stage fixation with temporary External Fixation followed by nailing or ORIF) and the differences in the outcome between the different methods. Purpose: Based on our experience and review of the literature, the purpose of this paper is to define what cases can be managed by a single-stage orthopaedic approach, and when the orthopaedist should lay down his arms in favor of other specialties.
MeSH term(s)	Fracture Fixation ; Fracture Fixation, Intramedullary ; Fractures, Open/surgery ; Humans ; Retrospective Studies ; Tibia ; Tibial Fractures/surgery ; Treatment Outcome
Language	English
Publishing date	2021-07-26
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2114240-3
ISSN	2531-6745 ; 0392-4203
ISSN (online)	2531-6745
ISSN	0392-4203
DOI	10.23750/abm.v92iS3.11736
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Article ; Online: An unusual two-stage infection following a scolopendra bite.

Puzzo, Agnese / Pari, Carlotta / Bettinelli, Giulia / Raggini, Filippo / Paderni, Stefania / Belluati, Alberto

Acta bio-medica : Atenei Parmensis

2020 Volume 91, Issue 14-S, Page(s) e2020009

Abstract: Background: Scolopendrae represent the best-known genus of centipedes. They are nocturnal general feeders with strong mandibles and venomous fangs which leave visible puncture marks at the bite site. The bite accidents occur during the warm rainy season ...

Abstract	Background: Scolopendrae represent the best-known genus of centipedes. They are nocturnal general feeders with strong mandibles and venomous fangs which leave visible puncture marks at the bite site. The bite accidents occur during the warm rainy season and mostly take place on the extremities. Following the bite, the most common symptoms are mild: limited localized erythema, pain, swelling, local itching and burning sensation. However, more severe local and systemic sequelae can not be excluded. Method: we report the case of a 63-year-old man with fever and a widespread edema of the right hand and forearm, happened as a consequence of a Scolopendra Subspinipes bite. During the weeks following the bite, he developed a severe unusual superinfection via hematogenous dissemination, which required a double surgical debridement and a targeted intravenous antibiotic therapy. Results: the complete clinical recovery took over two month. Conclusions: Many victims of Scolopendra envenomation do not seek medical attention since most symptoms will resolve spontaneously. The case presented falls within the spectrum of those rare cases which escalate due to bacterial superinfection.
MeSH term(s)	Animals ; Bites and Stings/complications ; Chilopoda ; Communicable Diseases ; Edema/etiology ; Humans ; Male ; Middle Aged ; Pain
Language	English
Publishing date	2020-12-30
Publishing country	Italy
Document type	Case Reports ; Journal Article
ZDB-ID	2114240-3
ISSN	2531-6745 ; 0392-4203
ISSN (online)	2531-6745
ISSN	0392-4203
DOI	10.23750/abm.v91i14-S.10783
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Article ; Online: Retrospective analysis of outcomes and complications after Korus hemiarthroplasty in elderly patients with neck femur fractures.

Maniscalco, Pietro / Puma Pagliarello, Calogero / Ciatti, Corrado / Gattoni, Serena / Burgio, Valeria / Cauteruccio, Michele / Di Stefano, Giovanni / Quattrini, Fabrizio / Guerra, Giovanni / Polidoro, Federico / Raggini, Filippo / Belluati, Alberto / Giolitti, Andrea / Rivera, Fabrizio

Acta bio-medica : Atenei Parmensis

2022 Volume 93, Issue 1, Page(s) e2022008

Abstract: Background: Femoral neck fractures (FNF) is one of the most common traumatic events in elderly patients: the choice of an appropriate treatment is necessary to decrease the related mortality and to achieve the best possible outcomes. Nowadays, it is ... ...

Abstract	Background: Femoral neck fractures (FNF) is one of the most common traumatic events in elderly patients: the choice of an appropriate treatment is necessary to decrease the related mortality and to achieve the best possible outcomes. Nowadays, it is still debated whether or not to cement the stem in hemiarthroplasty and above all, which stem to use to best respect the integrity of the elderly bone. Methods: From January 2017 to December 2019, a bi-centric study utilizing prospectively collected databases of elderly patients with FNF treated with uncemented Korus stem hemiarthroplasty was performed. Patients were preoperatively classified according to ASA score. Patients' clinical and X-ray follow-up was at 1, 3, 6, 12 months. Harris Hip Score (HHS) was used for analysed clinical improvement. On the X-rays, we analysed iatrogenic fractures, osteolysis area and radiolucent lines in the stem region during follow up. Results: 233 patients were identified. Median follow-up was 12 months. Over time, 51 patients died (21.88%). Mean age was 89,56 ± 6,25. 75 patients had ASA score of 2 (32.3%), 102 patients a score of 3 (43.7%), 56 an ASA score of 4 (24,0%). The main Harris hip score was 68,66 ± 8.53 at 1 month of follow-up, 71,74 ± 9.65 after 3 months, 72,50 ± 10.66 at 6 months and 75,61 ± 9.63 at 12 months control. Conclusions: Hydroxyapatite coated stem with an accurate design guarantee early fixation, good clinical and radiographic results, low rate of re-intervention and mortality rate and a satisfying return to pre-injury activities.
MeSH term(s)	Aged ; Arthroplasty, Replacement, Hip/adverse effects ; Arthroplasty, Replacement, Hip/methods ; Femoral Fractures/surgery ; Femoral Neck Fractures/surgery ; Femur/surgery ; Hemiarthroplasty/adverse effects ; Hemiarthroplasty/methods ; Humans ; Retrospective Studies ; Spinal Fractures ; Treatment Outcome
Language	English
Publishing date	2022-03-14
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2114240-3
ISSN	2531-6745 ; 0392-4203
ISSN (online)	2531-6745
ISSN	0392-4203
DOI	10.23750/abm.v93i1.11249
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Article ; Online: International trauma care: initial European approaches during the COVID 19 pandemic.

Chesser, Tim J S / Handley, Robert / Kloos, Johannes / De Wachter, Gerrit / Putzeys, Guy / Gómez-Vallejo, Jesús / Sánchez-Pérez, Coral / Chana-Rodríguez, Francisco / Raggini, Filippo / Pari, Carlotta / Paderni, Stefania / Contini, Achille / Belluati Md, Alberto / Daskalakis, Ioannis / Sperelakis, Ioannis / Kostakos, Athanasios / Tosounidis, Theodoros H / Halvachizadeh Md, Sascha / Pape Md, Hans-Christoph /

Bouillon, Bertil / de Bruin, Berend-Jan / Ponsen, Keesjan J

OTA international : the open access journal of orthopaedic trauma

2021 Volume 4, Issue 1 Suppl, Page(s) e112

Abstract: The world was not prepared for the global of pandemic in early 2020 with the arrival of COVID 19. Europe has some of the most developed health care systems in the world and this article explains the initial response to the pandemic from an orthopaedic ... ...

Abstract	The world was not prepared for the global of pandemic in early 2020 with the arrival of COVID 19. Europe has some of the most developed health care systems in the world and this article explains the initial response to the pandemic from an orthopaedic and trauma viewpoint from 8 nations. Italy reported the first cluster in February, which then rapidly spread around the continent, requiring a rapid reorganization of services. The reports highlight how elective surgery was universally stopped, surgical services were reconfigured, and new practices, such as the widespread use of telemedicine, may well become permanent. It also emphasizes how the pandemic has re-educated us on the importance of a consistent and central approach to deal with a global health crisis, and how medical services need to remain flexible and responsive to new ways of working.
Language	English
Publishing date	2021-03-15
Publishing country	United States
Document type	Journal Article
ISSN	2574-2167
ISSN (online)	2574-2167
DOI	10.1097/OI9.0000000000000112
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Article ; Online: The orthopaedic and traumatology scenario during Covid-19 outbreak in Italy: chronicles of a silent war.

Benazzo, Francesco / Rossi, Stefano Marco Paolo / Maniscalco, Pietro / Moretti, Biagio / Vaienti, Enrico / Ruggieri, Pietro / Massè, Alessandro / Medici, Antonio / Formica, Alessandro / Di Maggio, Bruno / Caiaffa, Vincenzo / Mosconi, Mario / Murena, Luigi / D'Angelo, Fabio / Belluati, Alberto / Mazza, Emilio Luigi / Rivera, Fabrizio / Castelli, Alberto / Ghiara, Matteo /

Rosolani, Marco / Cioffi, Raffaele / Pezzella, Raffaele / Scaravilli, Gabriele / Bove, Giovanni / Stissi, Placido / Mazzacane, Michael / Quattrini, Fabrizio / Ciatti, Corrado / Trovarelli, Giulia / Pala, Elisa / Angelini, Andrea / Sanna, Francesco / Nonne, Daniela / Colombelli, Andrea / Raggini, Filippo / Puzzo, Agnese / Canton, Gianluca / Maritan, Guido / Iuliano, Angela / Randelli, Pietro / Solarino, Giuseppe / Moretti, Lorenzo / Vicenti, Giovanni / Garofalo, Nunzia / Nappi, Vittorio / Ripanti, Simone / Chinni, Carmela / Pogliacomi, Francesco / Visigalli, Alberto / Bini, Nathalie / Aprato, Alessandro / Perticarini, Loris

International orthopaedics

2020 Volume 44, Issue 8, Page(s) 1453–1459

Abstract: Background: From February 21, the day of hospitalisation in ICU of the first diagnosed case of Covid-19, the social situation and the hospitals' organisation throughout Italy dramatically changed.: Methods: The CIO (Club Italiano dell'Osteosintesi) ... ...

Abstract	Background: From February 21, the day of hospitalisation in ICU of the first diagnosed case of Covid-19, the social situation and the hospitals' organisation throughout Italy dramatically changed. Methods: The CIO (Club Italiano dell'Osteosintesi) is an Italian society devoted to the study of traumatology that counts members spread in public and private hospitals throughout the country. Fifteen members of the CIO, Chairmen of 15 Orthopaedic and Trauma Units of level 1 or 2 trauma centres in Italy, have been involved in the study. They were asked to record data about surgical, outpatients clinics and ER activity from the 23rd of February to the 4th of April 2020. The data collected were compared with the data of the same timeframe of the previous year (2019). Results: Comparing with last year, overall outpatient activity reduced up to 75%, overall Emergency Room (ER) trauma consultations up to 71%, elective surgical activity reduced up to 100% within two weeks and trauma surgery excluding femoral neck fractures up to 50%. The surgical treatment of femoral neck fractures showed a stable reduction from 15 to 20% without a significant variation during the timeframe. Conclusions: Covid-19 outbreak showed a tremendous impact on all orthopaedic trauma activities throughout the country except for the surgical treatment of femoral neck fractures, which, although reduced, did not change in percentage within the analysed timeframe.
MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Disease Outbreaks ; Elective Surgical Procedures/statistics & numerical data ; Emergency Service, Hospital ; Humans ; Italy/epidemiology ; Orthopedic Procedures/statistics & numerical data ; Orthopedics ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; Trauma Centers ; Traumatology
Keywords	covid19
Language	English
Publishing date	2020-06-26
Publishing country	Germany
Document type	Journal Article
ZDB-ID	80384-4
ISSN	1432-5195 ; 0341-2695
ISSN (online)	1432-5195
ISSN	0341-2695
DOI	10.1007/s00264-020-04637-3
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Article: The orthopaedic and traumatology scenario during Covid-19 outbreak in Italy: chronicles of a silent war

Benazzo, Francesco / Rossi, Stefano Marco Paolo / Maniscalco, Pietro / Moretti, Biagio / Vaienti, Enrico / Ruggieri, Pietro / Massè, Alessandro / Medici, Antonio / Formica, Alessandro / Di Maggio, Bruno / Caiaffa, Vincenzo / Mosconi, Mario / Murena, Luigi / D039, / Angelo, Fabio / Belluati, Alberto / Mazza, Emilio Luigi / Rivera, Fabrizio / Castelli, Alberto /

Ghiara, Matteo / Rosolani, Marco / Cioffi, Raffaele / Pezzella, Raffaele / Scaravilli, Gabriele / Bove, Giovanni / Stissi, Placido / Mazzacane, Michael / Quattrini, Fabrizio / Ciatti, Corrado / Trovarelli, Giulia / Pala, Elisa / Angelini, Andrea / Sanna, Francesco / Nonne, Daniela / Colombelli, Andrea / Raggini, Filippo / Puzzo, Agnese / Canton, Gianluca / Maritan, Guido / Iuliano, Angela / Randelli, Pietro / Solarino, Giuseppe / Moretti, Lorenzo / Vicenti, Giovanni / Garofalo, Nunzia / Nappi, Vittorio / Ripanti, Simone / Chinni, Carmela / Pogliacomi, Francesco / Visigalli, Alberto / Bini, Nathalie

Int Orthop

Abstract: BACKGROUND: From February 21, the day of hospitalisation in ICU of the first diagnosed case of Covid-19, the social situation and the hospitals' organisation throughout Italy dramatically changed. METHODS: The CIO (Club Italiano dell'Osteosintesi) is an ... ...

Abstract	BACKGROUND: From February 21, the day of hospitalisation in ICU of the first diagnosed case of Covid-19, the social situation and the hospitals' organisation throughout Italy dramatically changed. METHODS: The CIO (Club Italiano dell'Osteosintesi) is an Italian society devoted to the study of traumatology that counts members spread in public and private hospitals throughout the country. Fifteen members of the CIO, Chairmen of 15 Orthopaedic and Trauma Units of level 1 or 2 trauma centres in Italy, have been involved in the study. They were asked to record data about surgical, outpatients clinics and ER activity from the 23rd of February to the 4th of April 2020. The data collected were compared with the data of the same timeframe of the previous year (2019). RESULTS: Comparing with last year, overall outpatient activity reduced up to 75%, overall Emergency Room (ER) trauma consultations up to 71%, elective surgical activity reduced up to 100% within two weeks and trauma surgery excluding femoral neck fractures up to 50%. The surgical treatment of femoral neck fractures showed a stable reduction from 15 to 20% without a significant variation during the timeframe. CONCLUSIONS: Covid-19 outbreak showed a tremendous impact on all orthopaedic trauma activities throughout the country except for the surgical treatment of femoral neck fractures, which, although reduced, did not change in percentage within the analysed timeframe.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #615878
Database	COVID19

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Article ; Online: The orthopaedic and traumatology scenario during Covid-19 outbreak in Italy

chronicles of a silent war

2020

Abstract: Background From February 21, the day of hospitalisation in ICU of the first diagnosed case of Covid-19, the social situation and the hospitals’ organisation throughout Italy dramatically changed. Methods The CIO (Club Italiano dell’Osteosintesi) is an ... ...

Abstract	Background From February 21, the day of hospitalisation in ICU of the first diagnosed case of Covid-19, the social situation and the hospitals’ organisation throughout Italy dramatically changed. Methods The CIO (Club Italiano dell’Osteosintesi) is an Italian society devoted to the study of traumatology that counts members spread in public and private hospitals throughout the country. Fifteen members of the CIO, Chairmen of 15 Orthopaedic and Trauma Units of level 1 or 2 trauma centres in Italy, have been involved in the study. They were asked to record data about surgical, outpatients clinics and ER activity from the 23rd of February to the 4th of April 2020. The data collected were compared with the data of the same timeframe of the previous year (2019). Results Comparing with last year, overall outpatient activity reduced up to 75%, overall Emergency Room (ER) trauma consultations up to 71%, elective surgical activity reduced up to 100%within two weeks and trauma surgery excluding femoral neck fractures up to 50%. The surgical treatment of femoral neck fractures showed a stable reduction from 15 to 20% without a significant variation during the timeframe. Conclusions Covid-19 outbreak showed a tremendous impact on all orthopaedic trauma activities throughout the country except for the surgical treatment of femoral neck fractures, which, although reduced, did not change in percentage within the analysed timeframe.
Keywords	Covid-19 ; Orthopaedics ; Outbreak ; Pandemic ; Traumatology ; covid19
Subject code	940
Language	English
Publishing country	it
Document type	Article ; Online
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Article ; Online: The orthopaedic and traumatology scenario during Covid-19 outbreak in Italy

chronicles of a silent war

2020

Abstract	Background From February 21, the day of hospitalisation in ICU of the first diagnosed case of Covid-19, the social situation and the hospitals’ organisation throughout Italy dramatically changed. Methods The CIO (Club Italiano dell’Osteosintesi) is an Italian society devoted to the study of traumatology that counts members spread in public and private hospitals throughout the country. Fifteen members of the CIO, Chairmen of 15 Orthopaedic and Trauma Units of level 1 or 2 trauma centres in Italy, have been involved in the study. They were asked to record data about surgical, outpatients clinics and ER activity from the 23rd of February to the 4th of April 2020. The data collected were compared with the data of the same timeframe of the previous year (2019). Results Comparing with last year, overall outpatient activity reduced up to 75%, overall Emergency Room (ER) trauma consultations up to 71%, elective surgical activity reduced up to 100%within two weeks and trauma surgery excluding femoral neck fractures up to 50%. The surgical treatment of femoral neck fractures showed a stable reduction from 15 to 20% without a significant variation during the timeframe. Conclusions Covid-19 outbreak showed a tremendous impact on all orthopaedic trauma activities throughout the country except for the surgical treatment of femoral neck fractures, which, although reduced, did not change in percentage within the analysed timeframe.
Keywords	Covid-19 ; Orthopaedics ; Outbreak ; Pandemic ; Traumatology ; covid19
Subject code	940
Language	English
Publishing country	it
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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