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  1. Article: Idiopathic recurrent serositis-Off the beaten track.

    Roy, Melanie Trishna Hui Min / Loh, Chee Hong / Sriranganathan, Melonie / Takano Pena, Angela Maria / Raghuram, Jagadesan

    Respirology case reports

    2021  Volume 9, Issue 11, Page(s) e0859

    Abstract: A 63-year-old female presented with chest pain and fever, and was found to have recurrent pleuropericardial effusions. Extensive investigations including infection screen and serologies, autoimmune screen and pleural and pericardial biopsy revealed no ... ...

    Abstract A 63-year-old female presented with chest pain and fever, and was found to have recurrent pleuropericardial effusions. Extensive investigations including infection screen and serologies, autoimmune screen and pleural and pericardial biopsy revealed no secondary aetiologies. She was diagnosed with idiopathic recurrent serositis (IRS). Our patient developed rash to naproxen, so she was started on colchicine monotherapy and responded well clinically. A review of the literature demonstrated that pleuropericardial effusions are rare occurrences, with patients occasionally being perceived as a medical enigma. This case study recommends an approach to guide physicians in their diagnosis and management of patients with pleuropericardial syndrome. Our case had an inflammatory phenotype, either autoimmune or seronegative serositis of unclear aetiology, which was recurrent and required pharmacological treatment. While the treatment for IRS lies in combined therapy with Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) and colchicine, monotherapy with colchicine was effective in the treatment and preventing recurrence in our unique case.
    Language English
    Publishing date 2021-10-12
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2750180-2
    ISSN 2051-3380
    ISSN 2051-3380
    DOI 10.1002/rcr2.859
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Massive hemoptysis, not your usual tuberculosis.

    Koh, Jansen / Law, John / Raghuram, Jagadesan

    American journal of respiratory and critical care medicine

    2012  Volume 185, Issue 4, Page(s) 455

    MeSH term(s) Adult ; Aneurysm, False/diagnosis ; Aneurysm, False/etiology ; Aorta, Thoracic ; Aortic Diseases/diagnosis ; Aortic Diseases/etiology ; Hemoptysis/etiology ; Humans ; Male ; Tuberculosis, Pulmonary/complications ; Tuberculosis, Pulmonary/diagnosis
    Language English
    Publishing date 2012-02-15
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.201105-0919IM
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: COVID-19 and the Risk to Health Care Workers: A Case Report.

    Ng, Kangqi / Poon, Beng Hoong / Kiat Puar, Troy Hai / Shan Quah, Jessica Li / Loh, Wann Jia / Wong, Yu Jun / Tan, Thean Yen / Raghuram, Jagadesan

    Annals of internal medicine

    2020  Volume 172, Issue 11, Page(s) 766–767

    MeSH term(s) Aerosols ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Health Personnel ; Humans ; Male ; Middle Aged ; Occupational Exposure ; Pandemics ; Pneumonia, Viral/epidemiology ; Quarantine ; Risk Factors ; SARS-CoV-2
    Chemical Substances Aerosols
    Keywords covid19
    Language English
    Publishing date 2020-03-16
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/L20-0175
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  4. Article ; Online: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Setting-specific Transmission Rates: A Systematic Review and Meta-analysis.

    Thompson, Hayley A / Mousa, Andria / Dighe, Amy / Fu, Han / Arnedo-Pena, Alberto / Barrett, Peter / Bellido-Blasco, Juan / Bi, Qifang / Caputi, Antonio / Chaw, Liling / De Maria, Luigi / Hoffmann, Matthias / Mahapure, Kiran / Ng, Kangqi / Raghuram, Jagadesan / Singh, Gurpreet / Soman, Biju / Soriano, Vicente / Valent, Francesca /
    Vimercati, Luigi / Wee, Liang En / Wong, Justin / Ghani, Azra C / Ferguson, Neil M

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2021  Volume 73, Issue 3, Page(s) e754–e764

    Abstract: Background: Understanding the drivers of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission is crucial for control policies, but evidence of transmission rates in different settings remains limited.: Methods: We conducted a ... ...

    Abstract Background: Understanding the drivers of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission is crucial for control policies, but evidence of transmission rates in different settings remains limited.
    Methods: We conducted a systematic review to estimate secondary attack rates (SARs) and observed reproduction numbers (Robs) in different settings exploring differences by age, symptom status, and duration of exposure. To account for additional study heterogeneity, we employed a beta-binomial model to pool SARs across studies and a negative-binomial model to estimate Robs.
    Results: Households showed the highest transmission rates, with a pooled SAR of 21.1% (95% confidence interval [CI]:17.4-24.8). SARs were significantly higher where the duration of household exposure exceeded 5 days compared with exposure of ≤5 days. SARs related to contacts at social events with family and friends were higher than those for low-risk casual contacts (5.9% vs 1.2%). Estimates of SARs and Robs for asymptomatic index cases were approximately one-seventh, and for presymptomatic two-thirds of those for symptomatic index cases. We found some evidence for reduced transmission potential both from and to individuals younger than 20 years of age in the household context, which is more limited when examining all settings.
    Conclusions: Our results suggest that exposure in settings with familiar contacts increases SARS-CoV-2 transmission potential. Additionally, the differences observed in transmissibility by index case symptom status and duration of exposure have important implications for control strategies, such as contact tracing, testing, and rapid isolation of cases. There were limited data to explore transmission patterns in workplaces, schools, and care homes, highlighting the need for further research in such settings.
    MeSH term(s) COVID-19 ; Contact Tracing ; Family Characteristics ; Humans ; Incidence ; SARS-CoV-2
    Language English
    Publishing date 2021-02-07
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Systematic Review
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciab100
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  5. Article: COVID-19 and the Risk to Health Care Workers: A Case Report

    Ng, Kangqi / Poon, Beng Hoong / Kiat Puar, Troy Hai / Shan Quah, Jessica Li / Loh, Wann Jia / Wong, Yu Jun / Tan, Thean Yen / Raghuram, Jagadesan

    Ann Intern Med

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #8707
    Database COVID19

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  6. Article ; Online: Dyspnea in a transplant recipient with pulmonary nodules.

    Chay, Wen Yee / Penafiel, Alvin / Raghuram, Jagadesan / Chuah, Khoon Leong / Loo, Chian Min / Lee, Pyng

    Chest

    2009  Volume 135, Issue 3, Page(s) 860–865

    MeSH term(s) Bronchial Diseases/etiology ; Bronchial Neoplasms/complications ; Bronchial Neoplasms/diagnosis ; Bronchial Neoplasms/virology ; Constriction, Pathologic ; Dyspnea/etiology ; Epstein-Barr Virus Infections/complications ; Epstein-Barr Virus Infections/immunology ; Female ; Humans ; Immunocompromised Host ; Kidney Transplantation ; Lung Neoplasms/complications ; Lung Neoplasms/diagnosis ; Lung Neoplasms/virology ; Middle Aged ; Multiple Pulmonary Nodules/diagnosis ; Smooth Muscle Tumor/diagnosis ; Smooth Muscle Tumor/virology
    Language English
    Publishing date 2009-03
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1378/chest.08-0857
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  7. Article ; Online: Achieving optimal clinical outcomes in ultrasound-guided central venous catheterizations of the internal jugular vein after a simulation-based training program for novice learners.

    Koh, Jansen / Xu, Ying / Yeo, LiFang / Tee, Augustine / Chuin, Siau / Law, John / Noor, Imran Bin Mohd / Poulose, Vijo / Raghuram, Jagadesan / Verma, Akash / Ng, Alvin

    Simulation in healthcare : journal of the Society for Simulation in Healthcare

    2014  Volume 9, Issue 3, Page(s) 161–166

    Abstract: Introduction: The aim of this study was to determine the number of ultrasound-guided (USG) central venous catheterization (CVC) of the internal jugular vein (IJV) residents had to perform, after a simulation-based training program, to achieve optimal ... ...

    Abstract Introduction: The aim of this study was to determine the number of ultrasound-guided (USG) central venous catheterization (CVC) of the internal jugular vein (IJV) residents had to perform, after a simulation-based training program, to achieve optimal clinical outcomes.
    Methods: We conducted a single-center, prospective, observational study in the medical intensive care unit of a university-affiliated teaching hospital. Residents participated in a formal training program, consisting of a simulation-based workshop and 5 supervised USG CVC insertions on patients. Subsequent USG CVC of the IJV performed by residents during their rotation were assessed. Data on the overall success (OS), first pass success (FP) and mechanical complication (MC) rates were serially collected over 2 years, spanning 4 cohorts of residents.
    Results: Thirty-two residents performed a total of 337 USG CVC of the IJV. Residents had previously performed an average of 9 CVC via the landmark technique. None had performed USG CVC before. Results showed that residents improved in their OS, FP, and MC rates as they performed more USG CVC. Residents needed to perform 7 USG CVCs to achieve optimal clinical outcomes of high OS and FP as well as low MC rates. There was a significant improvement in OS, FP, and MC rates for the eighth and subsequent USG CVCs compared with the first 7 USG CVCs (82% vs. 99% [P < 0.001], 70% vs. 92% [P < 0.001] and 11% vs. 0%, respectively).
    Conclusions: After a formal training program consisting of a simulation-based workshop and 5 supervised USG CVCs on critically ill adults, residents were able to achieve optimal clinical outcomes after performing 7 procedures.
    MeSH term(s) Adolescent ; Aged ; Aged, 80 and over ; Catheterization, Central Venous/methods ; Clinical Competence ; Computer Simulation ; Female ; Hospitals, Teaching ; Humans ; Intensive Care Units ; Internship and Residency/methods ; Jugular Veins ; Learning ; Male ; Middle Aged ; Models, Anatomic ; Prospective Studies ; Ultrasonography, Interventional/methods ; Young Adult
    Language English
    Publishing date 2014-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2223429-9
    ISSN 1559-713X ; 1559-2332
    ISSN (online) 1559-713X
    ISSN 1559-2332
    DOI 10.1097/SIH.0000000000000010
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  8. Article: Clinical characteristics and outcome of severe melioidosis requiring intensive care.

    Chan, Kenneth P W / Low, Jenny G H / Raghuram, Jagadesan / Fook-Chong, Stephanie M C / Kurup, Asok

    Chest

    2005  Volume 128, Issue 5, Page(s) 3674–3678

    Abstract: Study objective: To describe the clinical characteristics and outcome of patients with severe melioidosis requiring intensive care.: Design: Retrospective chart review.: Setting: Two ICUs from a tertiary-care teaching hospital.: Patients: ... ...

    Abstract Study objective: To describe the clinical characteristics and outcome of patients with severe melioidosis requiring intensive care.
    Design: Retrospective chart review.
    Setting: Two ICUs from a tertiary-care teaching hospital.
    Patients: Twenty-seven adult ICU patients with microbiologically documented melioidosis.
    Interventions: None.
    Measurements and results: The median age was 59 years with a male preponderance (26:1). Twenty patients (74%) had medical comorbidities, with diabetes mellitus being the most common (59.3%). Almost all patients (96.3%) were bacteremic. Twenty patients (74.1%) presented with pneumonia. Twenty patients (74.1%) were in septic shock, and 16 patients (59.3%) had ARDS. Twelve patients (44.4%) required hemodialysis. The patients had a median of three organ dysfunctions, and the median APACHE (acute physiology and chronic health evaluation) II score was 27. The overall mortality was 48.1%. Mortality among patients with septic shock was 60%. The median ICU length of stay for survivors and nonsurvivors was 11 days and 2 days, respectively. Multivariate analysis revealed that the number of organ dysfunctions is an independent predictor of mortality (odds ratio, 8.2; 95% confidence interval, 1.3 to 51.4).
    Conclusions: The outcome of severe melioidosis requiring intensive care is poor, with death being predicted by the number of organ dysfunctions.
    MeSH term(s) APACHE ; Adult ; Aged ; Comorbidity ; Critical Care ; Female ; Humans ; Length of Stay ; Male ; Melioidosis/diagnosis ; Melioidosis/epidemiology ; Melioidosis/therapy ; Middle Aged ; Multivariate Analysis ; Retrospective Studies ; Risk Factors ; Shock, Septic/mortality ; Survival Analysis
    Language English
    Publishing date 2005-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1378/chest.128.5.3674
    Database MEDical Literature Analysis and Retrieval System OnLINE

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