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  1. Article ; Online: The sex-dependent and lasting effects of neonatal antibiotic exposure: a gut wrenching truth.

    Sadat-Afjeh, Niki / Zaheer, Wajeeha / Ragunayakam, Nandhitha

    The Journal of physiology

    2023  Volume 601, Issue 12, Page(s) 2249–2250

    MeSH term(s) Anti-Bacterial Agents/adverse effects ; Gastrointestinal Microbiome
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-05-09
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP284584
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.65: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Characterizing the effects of type I collagen alterations on respiratory function in mouse models with varying severity of osteogenesis imperfecta.

    Zaheer, Wajeeha / Sadat-Afjeh, Niki / Ragunayakam, Nandhitha

    The Journal of physiology

    2022  Volume 601, Issue 3, Page(s) 401–402

    MeSH term(s) Animals ; Mice ; Collagen Type I ; Osteogenesis Imperfecta/genetics ; Collagen ; Mutation ; Respiration
    Chemical Substances Collagen Type I ; Collagen (9007-34-5)
    Language English
    Publishing date 2022-12-30
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP284132
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.65: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Phase-Resolved Functional Lung (PREFUL) MRI to Quantify Ventilation: Feasibility and Physiological Relevance in Severe Asthma.

    Friedlander, Yonni / Munidasa, Samal / Thakar, Ashutosh / Ragunayakam, Nandhitha / Venegas, Carmen / Kjarsgaard, Melanie / Zanette, Brandon / Capaldi, Dante P I / Santyr, Giles / Nair, Parameswaran / Svenningsen, Sarah

    Academic radiology

    2024  

    Abstract: Rationale and objectives: Emergent evidence in several respiratory diseases supports translational potential for Phase-Resolved Functional Lung (PREFUL) MRI to spatially quantify ventilation but its feasibility and physiological relevance have not been ... ...

    Abstract Rationale and objectives: Emergent evidence in several respiratory diseases supports translational potential for Phase-Resolved Functional Lung (PREFUL) MRI to spatially quantify ventilation but its feasibility and physiological relevance have not been demonstrated in patients with asthma. This study compares PREFUL-derived ventilation defect percent (VDP) in severe asthma patients to healthy controls and measures its responsiveness to bronchodilator therapy and relation to established measures of airways disease.
    Materials and methods: Forty-one adults with severe asthma and seven healthy controls performed same-day free-breathing
    Results: PREFUL VDP measured pre-bronchodilator (19.1% [7.4-43.3], p = 0.0002) and post-bronchodilator (16.9% [6.1-38.4], p = 0.0007) were significantly greater than that of healthy controls (7.5% [3.7-15.5]) and was significantly decreased post-bronchodilator (from 21.9% [10.1-36.9] to 16.9% [6.1-38.4], p = 0.0053). PREFUL VDP was correlated with spirometry (FEV
    Conclusion: PREFUL-derived VDP is responsive to bronchodilator therapy in asthma and is associated with measures of airflow obstruction and small airway dysfunction. These findings validate PREFUL VDP as a physiologically relevant and accessible ventilation imaging outcome measure in asthma.
    Language English
    Publishing date 2024-02-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1355509-1
    ISSN 1878-4046 ; 1076-6332
    ISSN (online) 1878-4046
    ISSN 1076-6332
    DOI 10.1016/j.acra.2024.01.039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4594: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Effect of dupilumab on sputum eosinophils in patients with moderate-to-severe asthma.

    Svenningsen, Sarah / Kjarsgaard, Melanie / Zhang, Kayla / Serajeddini, Hana / Garrido, Carmen Venegas / Bhalla, Anurag / Radford, Katherine / Huang, Chynna / Ho, Terence / Ragunayakam, Nandhitha / Thakar, Ashutosh / Radadia, Nisarg / Mukherjee, Manali / Nair, Parameswaran

    Allergy

    2023  Volume 79, Issue 2, Page(s) 509–513

    MeSH term(s) Humans ; Eosinophils ; Sputum ; Asthma/diagnosis ; Asthma/drug therapy ; Antibodies, Monoclonal, Humanized/pharmacology ; Antibodies, Monoclonal, Humanized/therapeutic use
    Chemical Substances dupilumab (420K487FSG) ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2023-09-26
    Publishing country Denmark
    Document type Letter
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.15901
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.150: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 125: Show issues

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