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  1. Article: Exosomes as versatile nanoscaled biocompartments in cancer therapy and/or resistance.

    Rahbar Saadat, Yalda / Barar, Jaleh

    BioImpacts : BI

    2022  Volume 12, Issue 2, Page(s) 87–88

    Abstract: Cancer remains to be a major hurdle to global health. Exosomes as a versatile bio-derived platform, hold a bright prospect in nano-scaled delivery/targeting strategies. Shreds of evidence indicate that exosomes have a critical role in drug resistance in ... ...

    Abstract Cancer remains to be a major hurdle to global health. Exosomes as a versatile bio-derived platform, hold a bright prospect in nano-scaled delivery/targeting strategies. Shreds of evidence indicate that exosomes have a critical role in drug resistance in cancer cells through various mechanisms including shuttling of miRNAs, drug efflux transporters, and anti-apoptotic signaling. Exosomes' cargo, particularly miRNAs, may exert both resistance and in a few cases sensitivity to the anticancer agents in targeted cells. Therefore, the source and components of the exosomes should be carefully considered before any application. Our aim in this editorial is to further highlight the role of exosomes in the development of resistance to therapy in cancer cells. As a new chapter for drug delivery, the challenges should be elucidated before exosomes emerge as novel nanoplatforms for cancer therapy.
    Language English
    Publishing date 2022-01-29
    Publishing country Iran
    Document type Editorial
    ZDB-ID 2604624-6
    ISSN 2228-5660 ; 2228-5652
    ISSN (online) 2228-5660
    ISSN 2228-5652
    DOI 10.34172/bi.2022.24253
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Microbial exopolysaccharides-β-glucans-as promising postbiotic candidates in vaccine adjuvants.

    Abbasi, Amin / Rahbar Saadat, Tina / Rahbar Saadat, Yalda

    International journal of biological macromolecules

    2022  Volume 223, Issue Pt A, Page(s) 346–361

    Abstract: The urgent task of creating new, enhanced adjuvants is closely related to our comprehension of their mechanisms of action. A few adjuvants have shown sufficient efficacy and low toxicity to be allowed for use in human vaccines, despite the fact that they ...

    Abstract The urgent task of creating new, enhanced adjuvants is closely related to our comprehension of their mechanisms of action. A few adjuvants have shown sufficient efficacy and low toxicity to be allowed for use in human vaccines, despite the fact that they have a long history and an important function. Adjuvants have long been used without a clear understanding of how precisely they augment the immune response. The rational production of stronger and safer adjuvants has been impeded by this lack of information, which necessitates more mechanistic research to support the development of vaccines. Carbohydrate structures-polygalactans, fructans, β-D-glucans, α-D-glucans, D-galactose, and D-glucose-are desirable candidates for the creation of vaccine adjuvants and immunomodulators because they serve important functions in nature and are often biocompatible, safe, and well tolerated. In this review, we have discussed recent advances in microbial-derived carbohydrate-based adjuvants, their immunostimulatory activity, and the implications of this for vaccine development, along with the critical view on the microbial sources, chemical composition, and biosynthetic pathways.
    Language English
    Publishing date 2022-11-05
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2022.11.003
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    Zs.B 2374: Show issues Location:
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  3. Article ; Online: Identification of common genes and pathways underlying imatinib and nilotinib treatment in CML: a Bioinformatics Study.

    Hekmatshoar, Yalda / Rahbar Saadat, Yalda / Ozkan, Tulin / Bozkurt, Sureyya / Karadag Gurel, Aynur

    Nucleosides, nucleotides & nucleic acids

    2023  , Page(s) 1–21

    Abstract: Imatinib (IMA) and nilotinib are the first and second generations of BCR-ABL tyrosine kinase inhibitors, which widely applied in chronic myeloid leukemia (CML) treatment. Here we aimed to provide new targets for CML treatment by transcriptome analysis. ... ...

    Abstract Imatinib (IMA) and nilotinib are the first and second generations of BCR-ABL tyrosine kinase inhibitors, which widely applied in chronic myeloid leukemia (CML) treatment. Here we aimed to provide new targets for CML treatment by transcriptome analysis. Microarray data GSE19567 was downloaded and analyzed from Gene Expression Omnibus (GEO) to identify common genes, which are downregulated or upregulated in K562-imatinib and K562-nilotinib treated cells. The differentially expressed genes (DEGs) were assessed, and STRING and Cytoscape were used to create the protein-protein interaction (PPI) network. In imatinib and nilotinib treated groups' comparison, there were common 626 upregulated and 268 downregulated genes, which were differentially expressed. The GO analysis represented the enrichment of DEGs in iron ion binding, protein tyrosine kinase activity, transcription factor activity, ATP binding, sequence-specific DNA binding, cytokine activity, the mitochondrion, sequence-specific DNA binding, plasma membrane and cell-cell adherens junction. KEGG pathway analysis revealed that downregulated DEGs were associated with pathways including microRNAs in cancer and PI3K-Akt signaling pathway. Furthermore, upregulated DEGs were involved in hematopoietic cell lineage, lysosome and chemical carcinogenesis. Among the upregulated genes, MYH9, MYH14, MYL10, MYL7, MYL5, RXRA, CYP1A1, FECH, AKR1C3, ALAD, CAT, CITED2, CPT1A, CYP3A5, CYP3A7, FABP1, HBD, HMBS and PPOX genes were found as hub genes. Moreover, 20 downregulated genes, YARS, AARS, SARS, GARS, CARS, IARS, RRP79, CEBPB, RRP12, UTP14A, PNO1, CCND1, DDX10, MYC, WDR43, CEBPG, DDIT3, VEGFA, PIM1 and TRIB3 were identified as hub genes. These genes have the potential to become target genes for diagnosis and therapy of CML patients.
    Language English
    Publishing date 2023-12-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2008956-9
    ISSN 1532-2335 ; 1525-7770
    ISSN (online) 1532-2335
    ISSN 1525-7770
    DOI 10.1080/15257770.2023.2296021
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    Zs.A 3870: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article ; Online: Ischemic tubular injury: Oxygen-sensitive signals and metabolic reprogramming.

    Rahbar Saadat, Yalda / Hosseiniyan Khatibi, Seyed Mahdi / Sani, Anis / Zununi Vahed, Sepideh / Ardalan, Mohammadreza

    Inflammopharmacology

    2023  Volume 31, Issue 4, Page(s) 1657–1669

    Abstract: The kidneys are the most vulnerable organs to severe ischemic insult that results in cellular hypoxia under pathophysiological conditions. Large amounts of oxygen are consumed by the kidneys, mainly to produce energy for tubular reabsorption. Beyond high ...

    Abstract The kidneys are the most vulnerable organs to severe ischemic insult that results in cellular hypoxia under pathophysiological conditions. Large amounts of oxygen are consumed by the kidneys, mainly to produce energy for tubular reabsorption. Beyond high oxygen demand and the low oxygen supply, different other factors make kidneys vulnerable to ischemia which is deemed to be a major cause of acute kidney injury (AKI). On the other hand, kidneys are capable of sensing and responding to oxygen alternations to evade harms resulting from inadequate oxygen. The hypoxia-inducible factor (HIF) is the main conserved oxygen-sensing mechanism that maintains homeostasis under hypoxia through direct/indirect regulation of several genes that contribute to metabolic adaptation, angiogenesis, energy conservation, erythropoiesis, and so on. In response to oxygen availability, prolyl-hydroxylases (PHDs) control the HIF stability. This review focuses on the oxygen-sensing mechanisms in kidneys, particularly in proximal tubular cells (PTCs) and discusses the molecules involved in ischemic response and metabolic reprogramming. Moreover, the possible roles of non-coding RNAs (microRNAs and long non-coding RNAs) in the development of ischemic AKI are put forward.
    MeSH term(s) Humans ; Oxygen/metabolism ; Ischemia/metabolism ; Kidney/metabolism ; Hypoxia/genetics ; Hypoxia/metabolism ; Acute Kidney Injury/metabolism
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2023-05-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1080058-x
    ISSN 1568-5608 ; 0925-4692
    ISSN (online) 1568-5608
    ISSN 0925-4692
    DOI 10.1007/s10787-023-01232-x
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    Zs.A 3274: Show issues Location:
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  5. Article ; Online: Thrombotic microangiopathy during pregnancy.

    Zununi Vahed, Sepideh / Rahbar Saadat, Yalda / Ardalan, Mohammadreza

    Microvascular research

    2021  Volume 138, Page(s) 104226

    Abstract: Pregnancy is a high-risk time for the development of different kinds of thrombotic microangiopathy (TMA). Three major syndromes including TTP (thrombotic thrombocytopenic purpura), PE/HELLP (preeclampsia/hemolysis, elevated liver function tests, low ... ...

    Abstract Pregnancy is a high-risk time for the development of different kinds of thrombotic microangiopathy (TMA). Three major syndromes including TTP (thrombotic thrombocytopenic purpura), PE/HELLP (preeclampsia/hemolysis, elevated liver function tests, low platelets), and aHUS (atypical hemolytic- uremic syndrome) should be sought in pregnancy-TMA. These severe disorders share multiple clinical features and overlaps and even the coexistence of more than one pathologic mechanism. Each of these disorders finally ends in endothelial damage and fibrin thrombi formation within the microcirculation that fragments RBCs (schystocytes), aggregates platelets, and creates ischemic injury in the targeted organs i.e.; kidney and brain. Although the mechanisms of these severe disorders have been revealed, pregnancy-related TMA still interfaces with diagnostic and therapeutic challenges. Here, we highlight the current knowledge of diagnosis and management of these complications during pregnancy.
    MeSH term(s) Animals ; Atypical Hemolytic Uremic Syndrome/blood ; Atypical Hemolytic Uremic Syndrome/diagnosis ; Atypical Hemolytic Uremic Syndrome/physiopathology ; Atypical Hemolytic Uremic Syndrome/therapy ; Diagnosis, Differential ; Female ; HELLP Syndrome/blood ; HELLP Syndrome/diagnosis ; HELLP Syndrome/physiopathology ; HELLP Syndrome/therapy ; Humans ; Pre-Eclampsia/blood ; Pre-Eclampsia/diagnosis ; Pre-Eclampsia/physiopathology ; Pre-Eclampsia/therapy ; Predictive Value of Tests ; Pregnancy ; Prognosis ; Purpura, Thrombotic Thrombocytopenic/blood ; Purpura, Thrombotic Thrombocytopenic/diagnosis ; Purpura, Thrombotic Thrombocytopenic/physiopathology ; Purpura, Thrombotic Thrombocytopenic/therapy
    Language English
    Publishing date 2021-07-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80307-8
    ISSN 1095-9319 ; 0026-2862
    ISSN (online) 1095-9319
    ISSN 0026-2862
    DOI 10.1016/j.mvr.2021.104226
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    Zs.A 746: Show issues Location:
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  6. Article ; Online: Yeast exopolysaccharides and their physiological functions.

    Rahbar Saadat, Yalda / Yari Khosroushahi, Ahmad / Pourghassem Gargari, Bahram

    Folia microbiologica

    2021  Volume 66, Issue 2, Page(s) 171–182

    Abstract: Mounting evidence indicated the capability of various microorganisms in biosynthesis of exopolysaccharides (EPSs). A wide range of evidence extensively investigated the ability of bacterial species for EPS synthesis and their favorable effects, so little ...

    Abstract Mounting evidence indicated the capability of various microorganisms in biosynthesis of exopolysaccharides (EPSs). A wide range of evidence extensively investigated the ability of bacterial species for EPS synthesis and their favorable effects, so little is known regarding yeast species. Many factors like composition of growth media and fermentation conditions are related to the structural and physical properties of EPSs. The EPS protects the producer yeast strain against extreme environment. Researchers proposed that yeast EPSs have priority over bacterial EPSs because of high yields of EPS biosynthesis and easy separation methods from growth media. Besides, they have drawn increasing attention due to their interesting biological activities, food, pharmaceutical, and cosmetics applications. Although a limited number of studies exist, this review aims to highlight the EPS structure and various applications of known yeast species in detail.
    MeSH term(s) Bacteria/metabolism ; Culture Media ; Fermentation ; Polysaccharides, Bacterial/metabolism ; Yeasts/genetics ; Yeasts/metabolism
    Chemical Substances Culture Media ; Polysaccharides, Bacterial
    Language English
    Publishing date 2021-02-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 240503-9
    ISSN 1874-9356 ; 0015-5632
    ISSN (online) 1874-9356
    ISSN 0015-5632
    DOI 10.1007/s12223-021-00856-2
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    Zs.A 845: Show issues Location:
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  7. Article ; Online: Phenotypic and functional characterization of subpopulation of Imatinib resistant chronic myeloid leukemia cell line.

    Hekmatshoar, Yalda / Karadag Gurel, Aynur / Ozkan, Tulin / Rahbar Saadat, Yalda / Koc, Asli / Karabay, Arzu Zeynep / Bozkurt, Sureyya / Sunguroglu, Asuman

    Advances in medical sciences

    2023  Volume 68, Issue 2, Page(s) 238–248

    Abstract: Purpose: Chronic myeloid leukemia (CML) is a hematological malignancy characterized by the presence of BCR-ABL protein. Imatinib (IMA) is considered as the first line therapy in management of CML which particularly targets the BCR-ABL tyrosine kinase ... ...

    Abstract Purpose: Chronic myeloid leukemia (CML) is a hematological malignancy characterized by the presence of BCR-ABL protein. Imatinib (IMA) is considered as the first line therapy in management of CML which particularly targets the BCR-ABL tyrosine kinase protein. However, emergence of resistance to IMA hinders its clinical efficiency. Hence, identifying novel targets for therapeutic approaches in CML treatment is of great importance. Here, we characterize a new subpopulation of highly adherent IMA-resistant CML cells that express stemness and adhesion markers compared to naive counterparts.
    Materials and methods: We performed several experimental assays including FISH, flow cytometry, and gene expression assays. Additionally, bioinformatics analysis was performed by normalized web-available microarray data (GSE120932) to revalidate and introduce probable biomarkers. Protein-protein interactions (PPI) network was analyzed by the STRING database employing Cytoscape v3.8.2.
    Results: Our findings demonstrated that constant exposure to 5 ​μM IMA led to development of the adherent phenotype (K562R-adh). FISH and BCR-ABL expression analysis indicated that K562R-adh cells were derived from the original cells (K562R). In order to determine the role of various genes involved in epithelial-mesenchymal transition (EMT) and stem cell characterization, up/down-regulation of various genes including cancer stem cell (CSC), adhesion and cell surface markers and integrins were observed which was similar to the findings of the GSE120932 dataset.
    Conclusion: Treating CML patients with tyrosine kinase inhibitors (TKIs) as well as targeting adhesion molecules deemed to be effective approaches in prevention of IMA resistance emergence which in turn may provide promising effects in the clinical management of CML patients.
    MeSH term(s) Humans ; Imatinib Mesylate/pharmacology ; Imatinib Mesylate/therapeutic use ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Drug Resistance, Neoplasm/genetics ; K562 Cells ; Apoptosis ; Fusion Proteins, bcr-abl/genetics ; Fusion Proteins, bcr-abl/metabolism ; Fusion Proteins, bcr-abl/pharmacology ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/pathology ; Phenotype
    Chemical Substances Imatinib Mesylate (8A1O1M485B) ; Protein Kinase Inhibitors ; Fusion Proteins, bcr-abl (EC 2.7.10.2)
    Language English
    Publishing date 2023-07-06
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2273668-2
    ISSN 1898-4002 ; 1896-1126
    ISSN (online) 1898-4002
    ISSN 1896-1126
    DOI 10.1016/j.advms.2023.06.002
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    Zs.B 953: Show issues Location:
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  8. Article ; Online: Decoding the Possible Molecular Mechanisms in Pediatric Wilms Tumor and Rhabdoid Tumor of the Kidney through Machine Learning Approaches.

    Hosseiniyan Khatibi, Seyed Mahdi / Rahbar Saadat, Yalda / Hejazian, Seyyedeh Mina / Sharifi, Simin / Ardalan, Mohammadreza / Teshnehlab, Mohammad / Zununi Vahed, Sepideh / Pirmoradi, Saeed

    Fetal and pediatric pathology

    2023  Volume 42, Issue 6, Page(s) 825–844

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Child ; Humans ; Rhabdoid Tumor/diagnosis ; Rhabdoid Tumor/genetics ; Rhabdoid Tumor/pathology ; Wilms Tumor/diagnosis ; Wilms Tumor/genetics ; Kidney Neoplasms/diagnosis ; Kidney Neoplasms/genetics ; Kidney Neoplasms/pathology ; MicroRNAs/genetics ; Prognosis
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2023-08-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2165508-X
    ISSN 1551-3823 ; 1551-3815 ; 1522-7952
    ISSN (online) 1551-3823
    ISSN 1551-3815 ; 1522-7952
    DOI 10.1080/15513815.2023.2242979
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    Zs.A 2043: Show issues Location:
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  9. Article ; Online: Bitter apricot ethanolic extract induces apoptosis through increasing expression of Bax/Bcl-2 ratio and caspase-3 in PANC-1 pancreatic cancer cells.

    Aamazadeh, Fatemeh / Ostadrahimi, Alireza / Rahbar Saadat, Yalda / Barar, Jaleh

    Molecular biology reports

    2020  Volume 47, Issue 3, Page(s) 1895–1904

    Abstract: Pancreatic cancer is the fourth common cause of cancer death. Surgery and chemotherapy are the common treatment strategies for pancreatic cancer patients; however, the response rate is less than 20% at advanced stages. In recent years, growing interest ... ...

    Abstract Pancreatic cancer is the fourth common cause of cancer death. Surgery and chemotherapy are the common treatment strategies for pancreatic cancer patients; however, the response rate is less than 20% at advanced stages. In recent years, growing interest has been dedicated to natural products. Bitter apricot seeds possess a number of pharmacological properties including antitumor activity and amygdalin from bitter apricot seeds can induce apoptosis. In this study, we investigated the cyto/genotoxic effects of bitter apricot ethanolic extract (BAEE) and amygdalin on human pancreatic cancer PANC-1 and normal epithelial 293/KDR cells. BAEE was assessed using high-performance liquid chromatography for the confirmation of the structure. The biological impacts of BAEE and amygdalin on PANC-1 and 293/KDR cells were evaluated by MTT assay, DAPI staining, AnnexinV/PI and Real-time qPCR analysis. BAEE and amygdalin inhibited cancer cell growth in a dose- and time-dependent manner. DAPI staining and flow cytometric analysis revealed fragmented nuclei and elevated numbers of early and late apoptotic cells, respectively. Also, increased Bax/Bcl-2 ratio and upregulation of caspase-3 further confirmed the occurrence of apoptosis in PANC-1 cells, but not in non-cancerous 293/KDR cells. These results indicate that BAEE could mediate apoptosis induction in cancer cells through a mitochondria dependent pathway. These findings suggest that BAEE functions as a potent pro-apoptotic factor for human pancreatic cancer cells without a significant effect on 293/KDR cells. Though, the potent anti-cancer components of BAEE should be further identified. Moreover, in vivo investigations are required to confirm bitter apricot ethanolic extract's clinical value as an anti-tumor drug.
    MeSH term(s) Amygdalin/chemistry ; Amygdalin/pharmacology ; Antineoplastic Agents, Phytogenic/chemistry ; Antineoplastic Agents, Phytogenic/pharmacology ; Caspase 3/genetics ; Caspase 3/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Ethanol/chemistry ; Ethanol/pharmacology ; Gene Expression Regulation, Neoplastic/drug effects ; HEK293 Cells ; Humans ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/metabolism ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Proto-Oncogene Proteins c-bcl-2/genetics ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Prunus armeniaca/chemistry ; Time Factors ; Up-Regulation ; bcl-2-Associated X Protein/genetics ; bcl-2-Associated X Protein/metabolism
    Chemical Substances Antineoplastic Agents, Phytogenic ; BAX protein, human ; BCL2 protein, human ; Plant Extracts ; Proto-Oncogene Proteins c-bcl-2 ; bcl-2-Associated X Protein ; Amygdalin (214UUQ9N0H) ; Ethanol (3K9958V90M) ; CASP3 protein, human (EC 3.4.22.-) ; Caspase 3 (EC 3.4.22.-)
    Language English
    Publishing date 2020-02-05
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-020-05286-w
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  10. Article: Host Serine Proteases: A Potential Targeted Therapy for COVID-19 and Influenza.

    Rahbar Saadat, Yalda / Hosseiniyan Khatibi, Seyed Mahdi / Zununi Vahed, Sepideh / Ardalan, Mohammadreza

    Frontiers in molecular biosciences

    2021  Volume 8, Page(s) 725528

    Abstract: The ongoing pandemic illustrates limited therapeutic options for controlling SARS-CoV-2 infections, calling a need for additional therapeutic targets. The viral spike S glycoprotein binds to the human receptor angiotensin-converting enzyme 2 (ACE2) and ... ...

    Abstract The ongoing pandemic illustrates limited therapeutic options for controlling SARS-CoV-2 infections, calling a need for additional therapeutic targets. The viral spike S glycoprotein binds to the human receptor angiotensin-converting enzyme 2 (ACE2) and then is activated by the host proteases. Based on the accessibility of the cellular proteases needed for SARS-S activation, SARS-CoV-2 entrance and activation can be mediated by endosomal (such as cathepsin L) and non-endosomal pathways. Evidence indicates that in the non-endosomal pathway, the viral S protein is cleaved by the furin enzyme in infected host cells. To help the virus enter efficiently, the S protein is further activated by the serine protease 2 (TMPRSS2), provided that the S has been cleaved by furin previously. In this review, important roles for host proteases within host cells will be outlined in SARS-CoV-2 infection and antiviral therapeutic strategies will be highlighted. Although there are at least five highly effective vaccines at this time, the appearance of the new viral mutations demands the development of therapeutic agents. Targeted inhibition of host proteases can be used as a therapeutic approach for viral infection.
    Language English
    Publishing date 2021-08-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2021.725528
    Database MEDical Literature Analysis and Retrieval System OnLINE

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