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  1. Book ; Online ; E-Book: Biomarkers in drug discovery and development

    Rahbari, Ramin / Van Niewaal, Jonathan / Bleavins, Michael R.

    a handbook of practice, application, and strategy

    2020  

    Abstract: This book continues the legacy of a well-established reference within the pharmaceutical industry -- providing perspective, covering recent developments in technologies that have enabled the expanded use of biomarkers, and discussing biomarker ... ...

    Author's details edited by Ramin Rahbari, Jonathan Van Niewaal, Michael R. Bleavins
    Abstract "This book continues the legacy of a well-established reference within the pharmaceutical industry -- providing perspective, covering recent developments in technologies that have enabled the expanded use of biomarkers, and discussing biomarker characterization and validation and applications throughout drug discovery and development. Several case studies of biomarkers that have helped and hindered decision making are presented, as well as an overview of the areas where proper use of biomarkers can substantively impact timelines and costs by streamlining development programs, enabling selection of better compounds and reducing late stage attrition, and facilitating personalized medicine. The new edition updates existing information with developments in pre-clinical and clinical testing and introduces substantial new materials on data mining, decision making, and personal genetic tools. With such significant expansion and revision, the 2nd edition ensures Biomarkers in Drug Development remains a key resource for biotechnology and major pharmaceutical companies, and their efforts to improve and expedite drug development"-- Provided by publisher.
    Keywords Biochemical markers ; Drugs/Design ; Drug development
    Subject code 615.19
    Language English
    Size 1 online resource (611 pages)
    Edition Second edition.
    Publisher Wiley
    Publishing place Hoboken, New Jersey
    Document type Book ; Online ; E-Book
    Note Preceded by Biomarkers in drug development : a handbook of practice, application, and strategy / edited by Michael R. Bleavins ... [et al.], 2010.
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 1-119-18752-4 ; 1-119-18751-6 ; 1-119-18754-0 ; 1-119-18750-8 ; 978-1-119-18752-3 ; 978-1-119-18751-6 ; 978-1-119-18754-7 ; 978-1-119-18750-9
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Agree that idiosyncratic hepatotoxicity in TRO-treated patients is uncertain, but concerned about the data.

    Kostrubsky, Vsevolod E / Rahbari, Ramin / Lodola, Alberto / Davies, Thomas

    Toxicological sciences : an official journal of the Society of Toxicology

    2003  Volume 71, Issue 2, Page(s) 282; author reply 282–4

    MeSH term(s) Apoptosis/drug effects ; Cell Survival/drug effects ; Chromans/toxicity ; Cyclosporine/pharmacology ; Dose-Response Relationship, Drug ; Drug Antagonism ; Hepatocytes/drug effects ; Hepatocytes/enzymology ; Hepatocytes/pathology ; Humans ; Hypoglycemic Agents/toxicity ; Mitochondria, Liver/drug effects ; Mitochondria, Liver/ultrastructure ; Thiazoles/toxicity ; Thiazolidinediones ; Troglitazone ; Tumor Cells, Cultured
    Chemical Substances Chromans ; Hypoglycemic Agents ; Thiazoles ; Thiazolidinediones ; Cyclosporine (83HN0GTJ6D) ; Troglitazone (I66ZZ0ZN0E)
    Language English
    Publishing date 2003-02
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1420885-4
    ISSN 1096-0929 ; 1096-6080
    ISSN (online) 1096-0929
    ISSN 1096-6080
    DOI 10.1093/toxsci/71.2.282
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1709: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Pregabalin induces hepatic hypoxia and increases endothelial cell proliferation in mice, a process inhibited by dietary vitamin E supplementation.

    Criswell, Kay A / Cook, Jon C / Morse, Dennis / Lawton, Michael / Somps, Christopher / Obert, Leslie / Roy, Marc / Sokolowski, Sharon / Koza-Taylor, Petra / Colangelo, Jennifer / Navetta, Kimberly / Brady, Joseph / Pegg, David / Wojcinski, Zbigniew / Rahbari, Ramin / Duddy, Steven / Anderson, Timothy

    Toxicological sciences : an official journal of the Society of Toxicology

    2012  Volume 128, Issue 1, Page(s) 42–56

    Abstract: The preceding article identified key components of pregabalin's mode of action on nongenotoxic hemangiosarcoma formation in mice, including increased serum bicarbonate leading to decreased respiratory rate, increased blood pH, increased venous oxygen ... ...

    Abstract The preceding article identified key components of pregabalin's mode of action on nongenotoxic hemangiosarcoma formation in mice, including increased serum bicarbonate leading to decreased respiratory rate, increased blood pH, increased venous oxygen saturation, increased vascular endothelial growth factor and basic fibroblast growth factor expression, increased hepatic vascular endothelial growth factor receptor 2 expression, and increased iron-laden macrophages. Increased platelet count and platelet activation were early, species-specific biomarkers in mice. Dysregulated erythropoiesis, macrophage activation, and elevations of tissue growth factors were consistent with the unified mode of action for nongenotoxic hemangiosarcoma recently proposed at an international hemangiosarcoma workshop (Cohen, S. M., Storer, R. D., Criswell, K. A., Doerrer, N. G., Dellarco, V. L., Pegg, D. G., Wojcinski, Z. W., Malarkey, D. E., Jacobs, A. C., Klaunig, J. E., et al. (2009). Hemangiosarcoma in rodents: Mode-of-action evaluation and human relevance. Toxicol. Sci. 111, 4-18). In this article, we present evidence that pregabalin induces hypoxia and increases endothelial cell (EC) proliferation in a species-specific manner. Dietary administration of pregabalin produced a significant 35% increase in an immunohistochemical stain for hypoxia (Hypoxyprobe) in livers from pregabalin-treated mice. Increased Hypoxyprobe staining was not observed in the liver, bone marrow, or spleen of rats, supporting the hypothesis that pregabalin produces local tissue hypoxia in a species-specific manner. Transcriptional analysis supports that rats, unlike mice, adapt to pregabalin-induced hypoxia. Using a dual-label method, increased EC proliferation was observed as early as 2 weeks in mouse liver and 12 weeks in bone marrow following pregabalin administration. These same assays showed decreased EC proliferation in hepatic ECs of rats, further supporting species specificity. Dietary supplementation with vitamin E, which is known to have antioxidant and antiangiogenic activity, inhibited pregabalin-induced increases in mouse hepatic EC proliferation, providing confirmatory evidence for the proposed mode of action and its species-specific response.
    MeSH term(s) Animals ; Cell Hypoxia ; Cell Proliferation/drug effects ; Chromatography, High Pressure Liquid ; Diet ; Endothelium, Vascular/cytology ; Endothelium, Vascular/drug effects ; Female ; Liver/cytology ; Liver/drug effects ; Mice ; Pregabalin ; Vitamin E/administration & dosage ; gamma-Aminobutyric Acid/analogs & derivatives ; gamma-Aminobutyric Acid/toxicity
    Chemical Substances Vitamin E (1406-18-4) ; Pregabalin (55JG375S6M) ; gamma-Aminobutyric Acid (56-12-2)
    Language English
    Publishing date 2012-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1420885-4
    ISSN 1096-0929 ; 1096-6080
    ISSN (online) 1096-0929
    ISSN 1096-6080
    DOI 10.1093/toxsci/kfs148
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1709: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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