LIVIVO - Search results -

Search results

Result 1 - 10 of total 46

Search options

Article ; Online: Multifunctional Liposomes Targeting Amyloid-β Oligomers for Early Diagnosis and Therapy of Alzheimer's Disease.

Senapati, Sudipta / Tripathi, Kuldeep / Awad, Khadeja / Rahimipour, Shai

Small (Weinheim an der Bergstrasse, Germany)

2024 , Page(s) e2311670

Abstract: Early detection and treatment are crucial for Alzheimer's disease (AD) management. Current diagnostic and therapeutic methods focus on late-stage amyloid fibrils and plaques, overlooking toxic soluble amyloid β oligomers (AβOs) accumulating early in AD. ... ...

Abstract	Early detection and treatment are crucial for Alzheimer's disease (AD) management. Current diagnostic and therapeutic methods focus on late-stage amyloid fibrils and plaques, overlooking toxic soluble amyloid β oligomers (AβOs) accumulating early in AD. A multifunctional liposome-based platform is designed for early diagnosis and therapy of AD, leveraging a novel self-assembled cyclic d,l-α-peptide (CP-2) that selectively targets AβOs. Biocompatible CP-2 conjugated liposomes (CP-2-LPs) effectively disrupt Aβ aggregation and mitigate Aβ-mediated toxicity in human neuroblastoma cells. In transgenic Caenorhabditis elegans AD models, CP-2-LPs significantly outperformed free CP-2 by improving cognitive and behavioral functions, extending lifespan, and reducing toxic AβO levels. Intravenous injection of fluorescently labeled CP-2-LPs reveals effective blood-brain barrier penetration, with significantly higher brain fluorescence in transgenic mice than WT, enabling precise diagnosis. These findings underscore CP-2-LPs as a valuable tool for early detection and targeted therapy in AD.
Language	English
Publishing date	2024-03-10
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2168935-0
ISSN	1613-6829 ; 1613-6810
ISSN (online)	1613-6829
ISSN	1613-6810
DOI	10.1002/smll.202311670
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- Full text online
- Order with fees

Article: Bifunctional Carbon Dots-Magnetic and Fluorescent Hybrid Nanoparticles for Diagnostic Applications.

Perelshtein, Ilana / Perkas, Nina / Rahimipour, Shai / Gedanken, Aharon

Nanomaterials (Basel, Switzerland)

2020 Volume 10, Issue 7

Abstract: There is a huge demand for materials capable of simple detection or separation after conjugation with specific biologic substances when applied as a diagnostic tools. Taking into account the photoluminescence properties of C-dots and the highly magnetic ... ...

Abstract	There is a huge demand for materials capable of simple detection or separation after conjugation with specific biologic substances when applied as a diagnostic tools. Taking into account the photoluminescence properties of C-dots and the highly magnetic properties of Fe(0), a new hybrid composite of these components was synthesized via ultrasound irradiation. The material was fully characterized by various physicochemical techniques. The main goal of the current study was to obtain a highly magnetic and intense fluorescent hybrid material. The goal was achieved. In addition, magnetic particles tended to agglomerate. The new hybrid can be suspended in ethanol, which is an additional feature of the current research. The dispersion of the hybrid nanoparticles in ethanol was achieved by utilizing the interaction of iron particles with C-dots which were decorated with functional groups on their surface. The newly formed hybrid material has potential applications in diagnostic by conjugating with specific antibodies or with any other biologic compounds. Such application may be useful in detection of various diseases such as: cancer, tuberculosis, etc.
Language	English
Publishing date	2020-07-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano10071384
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Aza-Residue Modulation of Cyclic d,l-α-Peptide Nanotube Assembly with Enhanced Anti-Amyloidogenic Activity.

Habashi, Maram / Chauhan, Pradeep S / Vutla, Suresh / Senapati, Sudipta / Diachkov, Mykhailo / El-Husseini, Ali / Guérin, Brigitte / Lubell, William D / Rahimipour, Shai

Journal of medicinal chemistry

2023 Volume 66, Issue 4, Page(s) 3058–3072

Abstract: Transient soluble oligomers of amyloid-β (Aβ) are considered among the most toxic species in Alzheimer's disease (AD). Soluble Aβ oligomers accumulate early prior to insoluble plaque formation and cognitive impairment. The cyclic d,l-α-peptide CP-2 ( ...

Abstract	Transient soluble oligomers of amyloid-β (Aβ) are considered among the most toxic species in Alzheimer's disease (AD). Soluble Aβ oligomers accumulate early prior to insoluble plaque formation and cognitive impairment. The cyclic d,l-α-peptide CP-2 (
MeSH term(s)	Humans ; Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Amyloid beta-Peptides/antagonists & inhibitors ; Amyloid beta-Peptides/chemistry ; Nanotubes, Peptide ; Peptide Fragments/chemistry ; Protein Structure, Secondary ; Caenorhabditis elegans ; Disease Models, Animal
Chemical Substances	Amyloid beta-Peptides ; Nanotubes, Peptide ; Peptide Fragments
Language	English
Publishing date	2023-02-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/acs.jmedchem.2c02049
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 151: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MB 1: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Noninvasive Treatment of Alzheimer's Disease with Scintillating Nanotubes.

Senapati, Sudipta / Secchi, Valeria / Cova, Francesca / Richman, Michal / Villa, Irene / Yehuda, Ronen / Shenberger, Yulia / Campione, Marcello / Rahimipour, Shai / Monguzzi, Angelo

Advanced healthcare materials

2023 Volume 12, Issue 32, Page(s) e2301527

Abstract: Effective and accessible treatments for Alzheimer's disease (AD) are urgently needed. Soluble Aβ oligomers are identified as neurotoxic species in AD and targeted in antibody-based drug development to mitigate cognitive decline. However, controversy ... ...

Abstract	Effective and accessible treatments for Alzheimer's disease (AD) are urgently needed. Soluble Aβ oligomers are identified as neurotoxic species in AD and targeted in antibody-based drug development to mitigate cognitive decline. However, controversy exists concerning their efficacy and safety. In this study, an alternative strategy is proposed to inhibit the formation of Aβ oligomers by selectively oxidizing specific amino acids in the Aβ sequence, thereby preventing its aggregation. Targeted oxidation is achieved using biocompatible and blood-brain barrier-permeable multicomponent nanoscintillators that generate singlet oxygen upon X-ray interaction. Surface-modified scintillators interact selectively with Aβ and, upon X-ray irradiation, inhibit the formation of neurotoxic aggregates both in vitro and in vivo. Feeding transgenic Caenorhabditis elegans expressing human Aβ with the nanoscintillators and subsequent irradiation with soft X-ray reduces Aβ oligomer levels, extends lifespan, and restores memory and behavioral deficits. These findings support the potential of X-ray-based therapy for AD and warrant further development.
MeSH term(s)	Humans ; Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Amyloid beta-Peptides/chemistry ; Blood-Brain Barrier/metabolism ; Antibodies/metabolism
Chemical Substances	Amyloid beta-Peptides ; Antibodies
Language	English
Publishing date	2023-11-03
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2649576-4
ISSN	2192-2659 ; 2192-2640
ISSN (online)	2192-2659
ISSN	2192-2640
DOI	10.1002/adhm.202301527
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 6966: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Sonochemically-Produced Metal-Containing Polydopamine Nanoparticles and Their Antibacterial and Antibiofilm Activity

Yeroslavsky, Gil / Lavi Ronit / Alishaev Abraham / Rahimipour Shai

Langmuir. 2016 May 24, v. 32, no. 20

2016

Abstract: A facile one-pot sonochemical synthesis of Cu-, Ag-, and hybrid Cu/Ag-based polydopamine nanoparticles (Cu-, Ag-, and Cu/Ag-PDA-NPs) and the mechanisms by which they exert antibacterial and antibiofilm activities are reported. We showed that the ... ...

Abstract	A facile one-pot sonochemical synthesis of Cu-, Ag-, and hybrid Cu/Ag-based polydopamine nanoparticles (Cu-, Ag-, and Cu/Ag-PDA-NPs) and the mechanisms by which they exert antibacterial and antibiofilm activities are reported. We showed that the nanoparticles are spherical with a coreâshell structure. Whereas Cu is chelated to the shell of Cu-PDA-NPs in oxidation states of +1/+2, the core of Ag-PDA-NPs is filled with elemental AgÂ°. Sonochemical irradiation of dopamine in the presence of both CuÂ²âº and Agâº generates hybrid Cu/Ag-PDA-NPs, whose shells are composed of Cu-chelated PDA with AgÂ° in the core. The redox potential of the metals was found to be the main determinant of the location and oxidation state of the metals. Leaching studies under physiological conditions reveal a relatively fast release of Cu ions from the shell, whereas Ag leaches very slowly from the core. The metal-containing PDA-NPs are highly microbicidal and exhibit potent antibiofilm activity. The combination of both metals in Cu/Ag-PDA-NPs is especially effective against bacteria and robust biofilms, owing to the dual bactericidal mechanisms of the metals. Most importantly, both Ag- and Cu/Ag-PDA-NPs proved to be significantly more antibacterial than commercial Ag-NPs while exhibiting lower toxicity toward NIH 3T3 mouse embryonic fibroblasts. Mechanistically, the metal-containing PDA-NPs generate stable PDA-semiquinone and reactive oxygen species under physiological conditions, which contribute at least partly to the antimicrobial activity. We also demonstrated that simple treatment of surfaces with Ag-PDA-NPs converts them to antibacterial, the activity of which was preserved even after prolonged storage under ambient conditions.
Keywords	antimicrobial properties ; bacteria ; biofilm ; copper ; dopamine ; fibroblasts ; ions ; irradiation ; mice ; nanoparticles ; nanosilver ; oxidation ; reactive oxygen species ; redox potential ; silver ; storage time ; toxicity
Language	English
Dates of publication	2016-0524
Size	p. 5201-5212.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	2005937-1
ISSN	1520-5827 ; 0743-7463
ISSN (online)	1520-5827
ISSN	0743-7463
DOI	10.1021%2Facs.langmuir.6b00576
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article ; Online: Sonochemically-Produced Metal-Containing Polydopamine Nanoparticles and Their Antibacterial and Antibiofilm Activity.

Yeroslavsky, Gil / Lavi, Ronit / Alishaev, Abraham / Rahimipour, Shai

Langmuir : the ACS journal of surfaces and colloids

2016 Volume 32, Issue 20, Page(s) 5201–5212

Abstract	A facile one-pot sonochemical synthesis of Cu-, Ag-, and hybrid Cu/Ag-based polydopamine nanoparticles (Cu-, Ag-, and Cu/Ag-PDA-NPs) and the mechanisms by which they exert antibacterial and antibiofilm activities are reported. We showed that the nanoparticles are spherical with a core-shell structure. Whereas Cu is chelated to the shell of Cu-PDA-NPs in oxidation states of +1/+2, the core of Ag-PDA-NPs is filled with elemental Ag°. Sonochemical irradiation of dopamine in the presence of both Cu(2+) and Ag(+) generates hybrid Cu/Ag-PDA-NPs, whose shells are composed of Cu-chelated PDA with Ag° in the core. The redox potential of the metals was found to be the main determinant of the location and oxidation state of the metals. Leaching studies under physiological conditions reveal a relatively fast release of Cu ions from the shell, whereas Ag leaches very slowly from the core. The metal-containing PDA-NPs are highly microbicidal and exhibit potent antibiofilm activity. The combination of both metals in Cu/Ag-PDA-NPs is especially effective against bacteria and robust biofilms, owing to the dual bactericidal mechanisms of the metals. Most importantly, both Ag- and Cu/Ag-PDA-NPs proved to be significantly more antibacterial than commercial Ag-NPs while exhibiting lower toxicity toward NIH 3T3 mouse embryonic fibroblasts. Mechanistically, the metal-containing PDA-NPs generate stable PDA-semiquinone and reactive oxygen species under physiological conditions, which contribute at least partly to the antimicrobial activity. We also demonstrated that simple treatment of surfaces with Ag-PDA-NPs converts them to antibacterial, the activity of which was preserved even after prolonged storage under ambient conditions.
Language	English
Publishing date	2016-05-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2005937-1
ISSN	1520-5827 ; 0743-7463
ISSN (online)	1520-5827
ISSN	0743-7463
DOI	10.1021/acs.langmuir.6b00576
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Cu

Klose, Daniel / Vemulapalli, Sahithya Phani Babu / Richman, Michal / Rudnick, Safra / Aisha, Vered / Abayev, Meital / Chemerovski, Marina / Shviro, Meital / Zitoun, David / Majer, Katharina / Wili, Nino / Goobes, Gil / Griesinger, Christian / Jeschke, Gunnar / Rahimipour, Shai

Physical chemistry chemical physics : PCCP

2022 Volume 24, Issue 11, Page(s) 6699–6715

Abstract: In a wide spectrum of neurodegenerative diseases, self-assembly of pathogenic proteins to cytotoxic intermediates is accelerated by the presence of metal ions such as ... ...

Abstract	In a wide spectrum of neurodegenerative diseases, self-assembly of pathogenic proteins to cytotoxic intermediates is accelerated by the presence of metal ions such as Cu
MeSH term(s)	Amyloid/biosynthesis ; Amyloid/chemistry ; Amyloid beta-Peptides/chemistry ; Amyloid beta-Peptides/metabolism ; Amyloidogenic Proteins/chemistry ; Amyloidogenic Proteins/metabolism ; Humans ; Neurodegenerative Diseases/metabolism ; Peptides, Cyclic/chemistry ; Peptides, Cyclic/metabolism ; Protein Conformation, beta-Strand
Chemical Substances	Amyloid ; Amyloid beta-Peptides ; Amyloidogenic Proteins ; Peptides, Cyclic
Language	English
Publishing date	2022-03-16
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/d1cp05415e
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Glucose-Functionalized Liposomes for Reducing False Positives in Cancer Diagnosis.

Tzror-Azankot, Chen / Betzer, Oshra / Sadan, Tamar / Motiei, Menachem / Rahimipour, Shai / Atkins, Ayelet / Popovtzer, Aron / Popovtzer, Rachela

ACS nano

2020 Volume 15, Issue 1, Page(s) 1301–1309

Abstract: Fluorodeoxyglucose-positron emission tomography ( ...

Abstract	Fluorodeoxyglucose-positron emission tomography (
MeSH term(s)	Animals ; Fluorodeoxyglucose F18 ; Glucose ; Liposomes ; Mice ; Neoplasms/diagnostic imaging ; Positron-Emission Tomography ; Radiopharmaceuticals ; Sensitivity and Specificity
Chemical Substances	Liposomes ; Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2020-12-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.0c08530
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Effective Targeting of AÎ² to Macrophages by Sonochemically Prepared Surface-Modified Protein Microspheres

Richman, Michal / Perelman Alex / Gertler Asaf / Rahimipour Shai

Biomacromolecules. 2013 Jan. 14, v. 14, no. 1

2013

Abstract: Imbalanced homeostasis and oligomerization of the amyloid-Î² (AÎ²) peptide in the brain are hallmarks of Alzheimerâs disease (AD). Microglia and macrophages play a critical role in the etiology of AD either by clearing AÎ² from the brain or inducing ... ...

Abstract	Imbalanced homeostasis and oligomerization of the amyloid-Î² (AÎ²) peptide in the brain are hallmarks of Alzheimerâs disease (AD). Microglia and macrophages play a critical role in the etiology of AD either by clearing AÎ² from the brain or inducing inflammation. Recent evidence suggests that clearance of AÎ² by microglia/macrophages via the phagocytic pathway is defective in AD, which can contribute to the accumulation of AÎ² in the brain. We have recently demonstrated that protein microspheres modified at their surface with multiple copies of an AÎ²-recognition motif can strongly bind AÎ², inhibit its aggregation, and directly reduce its toxicity by sequestering it from the medium. Here, we describe how microsphere-bound AÎ² can stimulate microglial cells and be phagocytosed through a mechanism that is distinct from that of AÎ² removal and, thus, contribute to the clearance of AÎ², even by defective microglial cells. The phagocytosis was most effective, with microspheres having a diameter of <1 Î¼m. The introduction of polyethylene glycol to the surface of the microspheres changed the kinetics of the phagocytosis. Moreover, while aggregated AÎ² induced a significant inflammatory response that was manifested by the release of TNF-Î±, the microsphere-bound AÎ² dramatically reduced the amount of cytokine released from microglial cells.
Keywords	Alzheimer disease ; brain ; etiology ; homeostasis ; inflammation ; macrophages ; neuroglia ; oligomerization ; phagocytosis ; polyethylene glycol ; toxicity ; tumor necrosis factor-alpha
Language	English
Dates of publication	2013-0114
Size	p. 110-116.
Publishing place	American Chemical Society
Document type	Article
ISSN	1526-4602
DOI	10.1021%2Fbm301401b
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Early diagnosis and treatment of Alzheimer's disease by targeting toxic soluble Aβ oligomers.

Habashi, Maram / Vutla, Suresh / Tripathi, Kuldeep / Senapati, Sudipta / Chauhan, Pradeep S / Haviv-Chesner, Anat / Richman, Michal / Mohand, Samia-Ait / Dumulon-Perreault, Véronique / Mulamreddy, Ramakotaiah / Okun, Eitan / Chill, Jordan H / Guérin, Brigitte / Lubell, William D / Rahimipour, Shai

Proceedings of the National Academy of Sciences of the United States of America

2022 Volume 119, Issue 49, Page(s) e2210766119

Abstract: Transient soluble oligomers of amyloid-β (Aβ) are toxic and accumulate early prior to insoluble plaque formation and cognitive impairment in Alzheimer's disease (AD). Synthetic cyclic D,L-α-peptides (e.g., ...

Abstract	Transient soluble oligomers of amyloid-β (Aβ) are toxic and accumulate early prior to insoluble plaque formation and cognitive impairment in Alzheimer's disease (AD). Synthetic cyclic D,L-α-peptides (e.g.,
MeSH term(s)	Animals ; Mice ; Alzheimer Disease/diagnostic imaging ; Alzheimer Disease/drug therapy ; Early Diagnosis ; Amyloid beta-Peptides ; Plaque, Amyloid ; Amyloidogenic Proteins ; Amyloidosis
Chemical Substances	Amyloid beta-Peptides ; Amyloidogenic Proteins
Language	English
Publishing date	2022-11-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2210766119
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1148: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

Your last searches

Full text online

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito