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  1. Article ; Online: Cytokines and their role as immunotherapeutics and vaccine Adjuvants: The emerging concepts.

    Rahman, Tanjilur / Das, Ayan / Abir, Mehedy Hasan / Nafiz, Iqbal Hossain / Mahmud, Aar Rafi / Sarker, Md Rifat / Emran, Talha Bin / Hassan, Mohammad Mahmudul

    Cytokine

    2023  Volume 169, Page(s) 156268

    Abstract: Cytokines are a protein family comprising interleukins, lymphokines, chemokines, monokines and interferons. They are significant constituents of the immune system, and they act in accordance with specific cytokine inhibiting compounds and receptors for ... ...

    Abstract Cytokines are a protein family comprising interleukins, lymphokines, chemokines, monokines and interferons. They are significant constituents of the immune system, and they act in accordance with specific cytokine inhibiting compounds and receptors for the regulation of immune responses. Cytokine studies have resulted in the establishment of newer therapies which are being utilized for the treatment of several malignant diseases. The advancement of these therapies has occurred from two distinct strategies. The first strategy involves administrating the recombinant and purified cytokines, and the second strategy involves administrating the therapeutics which inhibits harmful effects of endogenous and overexpressed cytokines. Colony stimulating factors and interferons are two exemplary therapeutics of cytokines. An important effect of cytokine receptor antagonist is that they can serve as anti-inflammatory agents by altering the treatments of inflammation disorder, therefore inhibiting the effects of tumour necrosis factor. In this article, we have highlighted the research behind the establishment of cytokines as therapeutics and vaccine adjuvants, their role of immunotolerance, and their limitations.
    MeSH term(s) Cytokines/metabolism ; Adjuvants, Vaccine ; Interferons/physiology ; Immunologic Factors ; Interleukins/physiology ; Immunotherapy
    Chemical Substances Cytokines ; Adjuvants, Vaccine ; Interferons (9008-11-1) ; Immunologic Factors ; Interleukins
    Language English
    Publishing date 2023-06-13
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1018055-2
    ISSN 1096-0023 ; 1043-4666
    ISSN (online) 1096-0023
    ISSN 1043-4666
    DOI 10.1016/j.cyto.2023.156268
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Pathogenicity and virulence of Marburg virus.

    Abir, Mehedy Hasan / Rahman, Tanjilur / Das, Ayan / Etu, Silvia Naznin / Nafiz, Iqbal Hossain / Rakib, Ahmed / Mitra, Saikat / Emran, Talha Bin / Dhama, Kuldeep / Islam, Ariful / Siyadatpanah, Abolghasem / Mahmud, Shafi / Kim, Bonlgee / Hassan, Mohammad Mahmudul

    Virulence

    2022  Volume 13, Issue 1, Page(s) 609–633

    Abstract: Marburg virus (MARV) has been a major concern since 1967, with two major outbreaks occurring in 1998 and 2004. Infection from MARV results in severe hemorrhagic fever, causing organ dysfunction and death. Exposure to fruit bats in caves and mines, and ... ...

    Abstract Marburg virus (MARV) has been a major concern since 1967, with two major outbreaks occurring in 1998 and 2004. Infection from MARV results in severe hemorrhagic fever, causing organ dysfunction and death. Exposure to fruit bats in caves and mines, and human-to-human transmission had major roles in the amplification of MARV outbreaks in African countries. The high fatality rate of up to 90% demands the broad study of MARV diseases (MVD) that correspond with MARV infection. Since large outbreaks are rare for MARV, clinical investigations are often inadequate for providing the substantial data necessary to determine the treatment of MARV disease. Therefore, an overall review may contribute to minimizing the limitations associated with future medical research and improve the clinical management of MVD. In this review, we sought to analyze and amalgamate significant information regarding MARV disease epidemics, pathophysiology, and management approaches to provide a better understanding of this deadly virus and the associated infection.
    MeSH term(s) Animals ; Chiroptera ; Disease Models, Animal ; Humans ; Marburg Virus Disease/epidemiology ; Marburgvirus/physiology ; Virulence
    Language English
    Publishing date 2022-04-01
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2657572-3
    ISSN 2150-5608 ; 2150-5594
    ISSN (online) 2150-5608
    ISSN 2150-5594
    DOI 10.1080/21505594.2022.2054760
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Multidrug Resistance in Cancer: Understanding Molecular Mechanisms, Immunoprevention and Therapeutic Approaches.

    Emran, Talha Bin / Shahriar, Asif / Mahmud, Aar Rafi / Rahman, Tanjilur / Abir, Mehedy Hasan / Siddiquee, Mohd Faijanur-Rob / Ahmed, Hossain / Rahman, Nova / Nainu, Firzan / Wahyudin, Elly / Mitra, Saikat / Dhama, Kuldeep / Habiballah, Mahmoud M / Haque, Shafiul / Islam, Ariful / Hassan, Mohammad Mahmudul

    Frontiers in oncology

    2022  Volume 12, Page(s) 891652

    Abstract: Cancer is one of the leading causes of death worldwide. Several treatments are available for cancer treatment, but many treatment methods are ineffective against multidrug-resistant cancer. Multidrug resistance (MDR) represents a major obstacle to ... ...

    Abstract Cancer is one of the leading causes of death worldwide. Several treatments are available for cancer treatment, but many treatment methods are ineffective against multidrug-resistant cancer. Multidrug resistance (MDR) represents a major obstacle to effective therapeutic interventions against cancer. This review describes the known MDR mechanisms in cancer cells and discusses ongoing laboratory approaches and novel therapeutic strategies that aim to inhibit, circumvent, or reverse MDR development in various cancer types. In this review, we discuss both intrinsic and acquired drug resistance, in addition to highlighting hypoxia- and autophagy-mediated drug resistance mechanisms. Several factors, including individual genetic differences, such as mutations, altered epigenetics, enhanced drug efflux, cell death inhibition, and various other molecular and cellular mechanisms, are responsible for the development of resistance against anticancer agents. Drug resistance can also depend on cellular autophagic and hypoxic status. The expression of drug-resistant genes and the regulatory mechanisms that determine drug resistance are also discussed. Methods to circumvent MDR, including immunoprevention, the use of microparticles and nanomedicine might result in better strategies for fighting cancer.
    Language English
    Publishing date 2022-06-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.891652
    Database MEDical Literature Analysis and Retrieval System OnLINE

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