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Article ; Online: The overall impact of COVID-19 on healthcare during the pandemic: A multidisciplinary point of view.

Sabetkish, Nastaran / Rahmani, Alireza

Health science reports

2021 Volume 4, Issue 4, Page(s) e386

Abstract: Background and aims: The Coronavirus disease 2019 (COVID-19) pandemic globally changed the priorities of medical and surgical procedures. It has caused many healthcare systems to stop performing their routine screenings. Altering medical clinics to ... ...

Abstract	Background and aims: The Coronavirus disease 2019 (COVID-19) pandemic globally changed the priorities of medical and surgical procedures. It has caused many healthcare systems to stop performing their routine screenings. Altering medical clinics to COVID-19 referral centers, lockdowns, and the public fear to refer to medical centers caused a significant reduction in the referral rate; especially in the elderly. This short review article highlights the transform in clinical practice during the post-COVID era and the need for future medical revolutions. Methods: A comprehensive literature search was separately performed by both authors. The articles published between 2019 and August 2021 were included in this study and selected according to a quality appraisal method. Results: We have summarized the possible corresponding changes in the diagnosis and treatment of all fields of medical care including internal medicine, surgical, and minor subcategories after the COVID-19 pandemic. We have also discussed the potential impacts of the pandemic on all these different categories and subcategories of medicine, including the outpatient setting and clinical work. We do believe that the lack of routine check-ups has led to an increase in the stage of disease in patients with a previously diagnosed problem. On the other hand, the dramatic change in the lifestyle of the population including restricted mobility and increased consumption of unhealthy food has caused metabolic syndrome and other new diseases that have not been diagnosed and properly managed. Conclusion: Our findings revealed the urgent need for public health awareness. It indicated the need to carry out both psychological and screening approaches in the post-COVID era to not miss patients with a chronic disease and new cases who were undiagnosed during the COVID pandemic.
Language	English
Publishing date	2021-10-01
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2398-8835
ISSN (online)	2398-8835
DOI	10.1002/hsr2.386
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Article ; Online: The effect of the combined system of hydrodynamic cavitation, ozone, and hydrogen peroxide on chlorophyll a and organic substances removal in the raw water.

Shokoohi, Reza / Rahmani, Alireza / Asgari, Ghorban / Ashrafi, Maysam / Ghahramani, Esmaeil

Scientific reports

2023 Volume 13, Issue 1, Page(s) 10102

Abstract: Increased levels of nutrients and algae can cause drinking water problems in communities. Harmful algal blooms affect humans, fish, marine mammals, birds, and other animals. In the present study, we investigated the use of a combined system [Hydrodynamic ...

Abstract	Increased levels of nutrients and algae can cause drinking water problems in communities. Harmful algal blooms affect humans, fish, marine mammals, birds, and other animals. In the present study, we investigated the use of a combined system [Hydrodynamic Cavitation, Ozone (O
MeSH term(s)	Humans ; Chlorophyll A ; Hydrogen Peroxide/chemistry ; Hydrodynamics ; Ozone/chemistry ; Water Purification/methods ; Drinking Water ; Water Pollutants, Chemical/chemistry ; Oxidation-Reduction
Chemical Substances	Chlorophyll A (YF5Q9EJC8Y) ; Hydrogen Peroxide (BBX060AN9V) ; Ozone (66H7ZZK23N) ; Drinking Water ; Water Pollutants, Chemical
Language	English
Publishing date	2023-06-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-37167-0
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Article ; Online: Arsenic level in drinking water, its correlation with water quality parameters, and associated health risks.

Rahmani, Alireza / Khamutian, Samira / Doosti-Irani, Amin / Saatchi, Omid / Shokoohizadeh, Mohammad Javad

Environmental monitoring and assessment

2023 Volume 195, Issue 7, Page(s) 899

Abstract: This study aimed to evaluate the occurrence and likelihood of health risks related to arsenic in drinking water of all counties of the Hamadan province in the northwest of Iran. In this work, 370 samples were collected from all of the water resources of ... ...

Abstract	This study aimed to evaluate the occurrence and likelihood of health risks related to arsenic in drinking water of all counties of the Hamadan province in the northwest of Iran. In this work, 370 samples were collected from all of the water resources of urban and rural regions, during 5 years (2017 to 2021). Oracle Crystal Ball software was used to perform the Monte Carlo simulation and investigate the potential health risks. According to the results, the average values of arsenic in the nine counties were in the order Kabudarahang (40.1 ppb), Malayer (13.1 ppb), Nahavand (6.1 ppb), Bahar (2.05 ppb), Famenin (0.41 ppb), Asadabad (0.36 ppb), Tuyserkan (0.28 ppb), Razan (0.14 ppb), and Hamadan (< 0.1 ppb). The highest concentration of arsenic occurred in Kabudarahang with a maximum value of 185 ppb. In the spring season, the average concentration of the cations, including calcium, magnesium, sodium, lead, cadmium, and chromium, obtained 109.51 mg/l, 44.67 mg/l, 20.50 mg/l, 88.76 ppb, 0.31 ppb, and 0.02 ppb, respectively. Based on the Delphi classification, the P 90% of oral lifetime cancer risk, in Hamadan province, were within level II (low risk) to VII (extremely high risk). The risk analysis revealed there was a possible carcinogenic risk to humans from oral exposure to As-contaminated groundwater, especially in Kabudarahang county. Therefore, there is an urgent need for management and precise measures in contaminated areas to reduce and prevent the adverse health effects of arsenic.
MeSH term(s)	Humans ; Drinking Water ; Arsenic ; Water Quality ; Environmental Monitoring ; Cadmium
Chemical Substances	Drinking Water ; Arsenic (N712M78A8G) ; Cadmium (00BH33GNGH)
Language	English
Publishing date	2023-06-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	782621-7
ISSN	1573-2959 ; 0167-6369
ISSN (online)	1573-2959
ISSN	0167-6369
DOI	10.1007/s10661-023-11486-1
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Article: The protective antioxidant activity of ginger extracts (Zingiber Officinale) in acute kidney injury: A systematic review and meta-analysis of animal studies

Rostamkhani, Helya / Faghfouri, Amir Hossein / Veisi, Parisa / Rahmani, Alireza / Noshadi, Nooshin / Ghoreishi, Zohreh

Journal of functional foods. 2022 July, v. 94

2022

Abstract: Zingiber officinale (Ginger) is considered an herbal medicinal plant with antioxidant features. This study attempted to perform a meta-analysis of the data obtained from previously conducted animal studies on the protective antioxidant effect of ginger ... ...

Abstract	Zingiber officinale (Ginger) is considered an herbal medicinal plant with antioxidant features. This study attempted to perform a meta-analysis of the data obtained from previously conducted animal studies on the protective antioxidant effect of ginger extracts on acute kidney injury. This literature search was conducted using some databases, including PubMed, Embase, and Scopus published up to August 2021, by searching relevant keywords. Thereafter, the pooled effect size was estimated using the random effect model. The SYRCLE’s risk of bias tool was then conducted to assess the quality of the obtained studies. The source of heterogeneity among these studies was detected using meta-regression and subgroup analyses. Finally, the meta-analysis on 17 eligible articles revealed that ginger extract supplementation significantly increased SOD (SMD = 5.451 U/mg protein; 95 % CI: 2.099, 8.804; P = 0.005), CAT (SMD = 2.912 U/mg protein; 95 % CI: 0.583, 5.241; P = 0.024), GSH (SMD = 3.400 µg/mg protein; 95 % CI: 1.941,4.859; P < 0.001), and TAC (SMD = 5.923 mmol/L; 95 % CI: 0.900,10.947; P = 0.005). In addition, Ginger extracts decreased MDA (SMD = −3.069 nmol/g tissue; 95 % CI: −5.971, −0.166; P = 0.005). However, no significant effect was noticed in terms of both GPx (SMD = 1.096 U/mg protein; 95 % CI: −0.699, 2.891; P = 0.177), and GST (SMD = 0.199 U/g protein; 95 % CI: −6.558, 6.957; P = 0.911). Therefore, the results of the meta-analysis support the convincing evidence regarding the protective antioxidant activity of ginger extracts in animals with acute kidney injury.
Keywords	Zingiber officinale ; acute kidney injury ; animals ; antioxidant activity ; antioxidants ; ginger ; medicinal plants ; meta-analysis ; risk ; statistical models ; systematic review
Language	English
Dates of publication	2022-07
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	2511964-3
ISSN	1756-4646
ISSN	1756-4646
DOI	10.1016/j.jff.2022.105111
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Article ; Online: Effect of Nigella sativa supplementation on kidney function, glycemic control, oxidative stress, inflammation, quality of life, and depression in diabetic hemodialysis patients: study protocol for a double-blind, randomized controlled trial.

Rahmani, Alireza / Maleki, Vahid / Niknafs, Bahram / Tavakoli-Rouzbehani, Omid Mohammad / Tarighat-Esfanjani, Ali

Trials

2022 Volume 23, Issue 1, Page(s) 111

Abstract: Background and objectives: The kidney is probably the most crucial target of microvascular damage in diabetes, which can ultimately eventuate end-stage renal disease (ESRD). Hemodialysis is the most usual way of renal replacement therapy in ESRD. ... ...

Abstract	Background and objectives: The kidney is probably the most crucial target of microvascular damage in diabetes, which can ultimately eventuate end-stage renal disease (ESRD). Hemodialysis is the most usual way of renal replacement therapy in ESRD. Patients receiving hemodialysis are susceptible to many complications like hyperglycemia, inflammation, depression, anxiety, and poor quality of life. So, they are constrained to consume many drugs. Medicinal herbs are used in different cultures as a reliable source of natural remedies. This study aims to determine the efficacy of Nigella sativa (NS) oil supplementation on blood glucose, kidney function tests, inflammation, oxidative stress, quality of life, and depression in hemodialysis patients. Methods and analysis: This double-blind, randomized controlled trial will enroll 46 patients with diabetes mellitus who give hemodialysis thrice a week. Patients who have an inflammatory or infectious disease and who are receiving nonsteroidal anti-inflammatory drugs will be excluded. Patients will be randomized to the treatment and control group, which will be recommended using two soft gels of NS and paraffin oil, respectively. Laboratory tests will be assessed at baseline and end of the study, including fasting blood sugar, glycated albumin, insulin, creatinine, blood urea nitrogen, urea, uric acid, superoxide dismutase, malondialdehyde, total antioxidant capacity, high sensitive C reactive protein, and 24-h urine volume. Also, the kidney disease and quality of life and hospital anxiety and depression scale questionnaires will be evaluated. Discussion: Previous studies have reported a positive effect of Nigella sativa supplementation in chronic kidney disease, but there is no evidence that this plant is safe in hemodialysis patients. The results of this study can be helpful in better control of blood sugar and kidney function and reduce complications in diabetic hemodialysis patients. Trial registration: Iranian Registry of Clinical Trials . Registered on 31 May 2020.
MeSH term(s)	Depression ; Diabetes Mellitus ; Dietary Supplements ; Double-Blind Method ; Glycemic Control ; Humans ; Inflammation/diagnosis ; Inflammation/drug therapy ; Iran ; Kidney ; Nigella sativa ; Oxidative Stress ; Quality of Life ; Randomized Controlled Trials as Topic ; Renal Dialysis/adverse effects
Language	English
Publishing date	2022-02-04
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	2040523-6
ISSN	1745-6215 ; 1468-6694 ; 1745-6215
ISSN (online)	1745-6215
ISSN	1468-6694 ; 1745-6215
DOI	10.1186/s13063-021-05917-y
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Article: Effect of Nigella Sativa Oil on Oxidative Stress, Inflammatory, and Glycemic Control Indices in Diabetic Hemodialysis Patients: A Randomized Double-Blind, Controlled Trial.

Rahmani, Alireza / Niknafs, Bahram / Naseri, Mohsen / Nouri, Maryam / Tarighat-Esfanjani, Ali

Evidence-based complementary and alternative medicine : eCAM

2022 Volume 2022, Page(s) 2753294

Abstract: Background and aims: Diabetes is a leading cause of renal failure. High levels of oxidative stress and inflammation in patients with renal diabetes lead to various disorders and mortality. This study was performed to determine the effect of Nigella ... ...

Abstract	Background and aims: Diabetes is a leading cause of renal failure. High levels of oxidative stress and inflammation in patients with renal diabetes lead to various disorders and mortality. This study was performed to determine the effect of Nigella sativa (NS) supplementation on superoxide dismutase (SOD), malondialdehyde (MDA), total antioxidant capacity (TAC), high-sensitivity C-reactive protein (hs-CRP), glycosylated hemoglobin (HbA1c), fasting blood sugar (FBS), and insulin (INS) in patients with diabetes mellitus undergoing hemodialysis (HD). Methods: In this randomized, double-blind, placebo-controlled clinical trial, a total of 46 diabetic HD patients were randomly divided into NS ( Results: Compared to baseline values, SOD, TAC, and INS levels increased, whereas MDA, hs-CRP, HbA1c, and FBS significantly decreased. After adjusting for covariates using the ANCOVA test, changes in the concentrations of SOD ( Conclusions: This study found that NS supplementation significantly enhanced the levels of SOD, MDA, TAC, hs-CRP, HbA1c, and FBS in diabetic HD patients.
Language	English
Publishing date	2022-04-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2022/2753294
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Article ; Online: The association of arsenic exposure with mortality due to cancer, diabetes, Alzheimer's and congenital anomalies using Poisson regression.

Rahmani, Alireza / Khamutian, Samira / Doosti-Irani, Amin / Shokoohizadeh, Mohammad Javad / Shirmohammadi-Khorram, Nasrin / Sahraeei, Fatemeh / Khodabakhshi, Mahdi / Ahangaran, Nastaran

Scientific reports

2023 Volume 13, Issue 1, Page(s) 15456

Abstract: The present study aims to determine the relationship between the concentration of arsenic in the groundwater of Hamadan province and the mortality rate due to various types of malignancies, congenital anomalies, diabetes mellitus and Alzheimer's. ... ...

Abstract	The present study aims to determine the relationship between the concentration of arsenic in the groundwater of Hamadan province and the mortality rate due to various types of malignancies, congenital anomalies, diabetes mellitus and Alzheimer's. Mortality data due to various causes of death in Hamadan province were collected for five years (2016-2020). Sampling of drinking water was determined in the reference laboratory using polarography method. Poisson regression was used to investigate the relationship between arsenic level and the death rate due to various types of disease, at a significant level (p value < 0.05). According to the results of Poisson regression, among the various causes of death (N = 8042), Alzheimer's 5.94 (3.67-9.61), diabetes mellitus 4.05 (3.5-5.37), congenital malformations 2.98 (1.88-4.72), breast cancer 2.72 (1.56-4.71), leukemia 1.90 (1.24-2.92), stomach cancer 1.64 (1.28-2.10), Liver cancer 1.58 (1.58-2.30), other digestive organs 5.86 (3.38-10.16), meninges and brain cancer 1.57 (1.02-2.41) showed the highest relationship with arsenic contamination. The results of this study could be evidence for a positive and significant relationship between arsenic concentrations and mortality rates due to cancers, diabetes mellitus, Alzheimer disease, and congenital malformations. Therefore, it's necessary to use appropriate water treatment methods to remove arsenic at the source in contaminated areas.
MeSH term(s)	Humans ; Arsenic ; Alzheimer Disease/epidemiology ; Brain Neoplasms ; Diabetes Mellitus ; Leukemia
Chemical Substances	Arsenic (N712M78A8G)
Language	English
Publishing date	2023-09-19
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-42744-4
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Article: Application of a fluidized three-dimensional electrochemical reactor with Ti/SnO2–Sb/β-PbO2 anode and granular activated carbon particles for degradation and mineralization of 2,4-dichlorophenol: Process optimization and degradation pathway

Samarghandi, Mohammad Reza / Dargahi, Abdollah / Rahmani, Alireza / Shabanloo, Amir / Ansari, Amin / Nematollahi, Davood

Chemosphere. 2021 Sept., v. 279

2021

Abstract: A three-dimensional electrochemical reactor with Ti/SnO₂–Sb/β-PbO₂ anode and granular activated carbon (3DER-GAC) particle electrodes were used for degradation of 2,4-dichlorophenol (2,4-DCP). Process modeling and optimization were performed using an ... ...

Abstract	A three-dimensional electrochemical reactor with Ti/SnO₂–Sb/β-PbO₂ anode and granular activated carbon (3DER-GAC) particle electrodes were used for degradation of 2,4-dichlorophenol (2,4-DCP). Process modeling and optimization were performed using an orthogonal central composite design (OCCD) and genetic algorithm (GA), respectively. Ti/SnO₂–Sb/β-PbO₂ anode was prepared by electrochemical deposition method and then its properties were studied by FESEM, EDX, XRD, Linear sweep voltammetry and accelerated lifetime test techniques. The results showed that lead oxide was precipitated as highly compact pyramidal clusters in the form of β-PbO₂ on the electrode surface. In addition, the prepared anode had high stability (170 h) and oxygen evolution potential (2.32 V). A robust quadratic model (p-value < 0.0001 and R² > 0.99) was developed to predict the 2,4-DCP removal efficiency in the 3DER-GAC system. Under optimal conditions (pH = 4.98, Na₂SO₄ concentration = 0.07 M, current density = 35 mA cm⁻², GAC amount = 25 g and reaction time = 50 min), the removal efficiency of 2,4-DCP in the 3DER-GAC system and the separate electrochemical degradation process (without GAC particle electrode) were 99.8 and 71%, respectively. At a reaction time of 80 min, the TOC removal efficiencies in the 3DER-GAC and the separate electrochemical degradation system were 100 and 57.5%, respectively. Accordingly, the energy consumed in these two systems was calculated to be 0.81 and 1.57 kWh g⁻¹ TOC, respectively. Based on the results of LC-MS analysis, possible degradation pathways of 2,4-DCP were proposed. Trimerization and ring opening reactions were the two dominant mechanisms in 2,4-DCP degradation.
Keywords	2,4-dichlorophenol ; activated carbon ; algorithms ; anodes ; electrochemistry ; energy ; lead ; mineralization ; models ; oxygen production ; pH ; voltammetry
Language	English
Dates of publication	2021-09
Publishing place	Elsevier Ltd
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2021.130640
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Article ; Online: Investigation of the effects of different substrates on the promotion of the soil microbial consortium, encompassing bacteria and fungi, in the bioremediation of decabromodiphenyl ether (BDE-209).

Zabihollahi, Solmaz / Rahmani, Alireza / Aghadadashi, Vahid / Khazaei, Mohammad / Samadi, Mohammad Taghi / Leili, Mostafa / Afshar, Saeid / Safari Sinegani, Ali Akbar / Karami, Pezhman / Zafari, Dostmorad

Environmental science and pollution research international

2024 Volume 31, Issue 11, Page(s) 16359–16374

Abstract: Decabromodiphenyl ether (BDE-209) is recognized as an emerging and hazardous pollutant in numerous ecosystems. Despite this, only a few studies have concurrently investigated the biodegradation of BDE-209 by a microbial consortium comprising both ... ...

Abstract	Decabromodiphenyl ether (BDE-209) is recognized as an emerging and hazardous pollutant in numerous ecosystems. Despite this, only a few studies have concurrently investigated the biodegradation of BDE-209 by a microbial consortium comprising both bacteria and fungi. Consequently, the interactions between bacterial and fungal populations and their mutual effects on BDE-209 degradation remain unclear. Our main objective was to concurrently assess the changes and activity of bacterial and fungal communities during the biodegradation of BDE-209 in a real soil matrix. In the present study, various organic substrates were employed to promote soil biomass for the biodegradation of BDE-209. Soil respiration and molecular analysis were utilized to monitor biological activity and biomass community structure, respectively. The findings revealed that the use of wheat straw in the soil matrix resulted in the highest soil respiration and microbial activity among the treatments. This approach obviously provided suitable habitats for the soil microflora, which led to a significant increase in the biodegradability of BDE-209 (49%). Biomass survival efforts and the metabolic pathway of lignin degradation through co-metabolism contributed to the biodegradation of BDE-209. Microbial community analysis identified Proteobacteria (Alphaproteobacteria-Betaproteobacteria), Firmicutes, Bacteroides (bacterial phyla), as well as Ascomycota and Basidiomycota (fungal phyla) as the key microorganisms in the biological community involved in the biodegradation of BDE-209. This study demonstrated that applying wheat straw can improve both the biological activity and the biodegradation of BDE-209 in the soil of polluted sites.
MeSH term(s)	Biodegradation, Environmental ; Ecosystem ; Microbial Consortia ; Soil ; Basidiomycota ; Bacteria/metabolism ; Soil Microbiology ; Fungi ; Halogenated Diphenyl Ethers
Chemical Substances	decabromobiphenyl ether (N80BQ29A0H) ; Soil ; Halogenated Diphenyl Ethers
Language	English
Publishing date	2024-02-05
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-024-32152-0
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Article ; Online: Application of a fluidized three-dimensional electrochemical reactor with Ti/SnO

Samarghandi, Mohammad Reza / Dargahi, Abdollah / Rahmani, Alireza / Shabanloo, Amir / Ansari, Amin / Nematollahi, Davood

Chemosphere

2021 Volume 279, Page(s) 130640

Abstract: A three-dimensional electrochemical reactor with Ti/ ... ...

Abstract	A three-dimensional electrochemical reactor with Ti/SnO
MeSH term(s)	Charcoal ; Chlorophenols ; Electrodes ; Oxidation-Reduction ; Oxides ; Titanium ; Water Pollutants, Chemical/analysis
Chemical Substances	Chlorophenols ; Oxides ; Water Pollutants, Chemical ; Charcoal (16291-96-6) ; Titanium (D1JT611TNE) ; 2,4-dichlorophenol (R669TG1950)
Language	English
Publishing date	2021-04-22
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2021.130640
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