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  1. Book ; Online: Beyond Antimicrobials: Non-Traditional Approaches to Combating Multidrug-Resistant Bacteria

    Kirienko, Natalia V. / Rahme, Laurence / Cho, You-Hee

    2019  

    Keywords Science: general issues ; Infectious & contagious diseases ; Drug discovery ; Infectious Disease ; Anti-Virulence ; Anti-Infectives ; Host-Microbe Interactions
    Size 1 electronic resource (281 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230836
    ISBN 9782889632565 ; 2889632563
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Interconnections of Pseudomonas aeruginosa Quorum-Sensing Systems in Intestinal Permeability and Inflammation.

    Singh, Vijay K / Almpani, Marianna / Wheeler, Kelsey M / Rahme, Laurence G

    mBio

    2023  Volume 14, Issue 2, Page(s) e0352422

    Abstract: Quorum sensing (QS) is a highly conserved microbial communication mechanism based on the production and sensing of secreted signaling molecules. The recalcitrant pathogen Pseudomonas aeruginosa is a problematic nosocomial pathogen with complex ... ...

    Abstract Quorum sensing (QS) is a highly conserved microbial communication mechanism based on the production and sensing of secreted signaling molecules. The recalcitrant pathogen Pseudomonas aeruginosa is a problematic nosocomial pathogen with complex interconnected QS systems controlling multiple virulence functions. The relevance of QS in P. aeruginosa pathogenesis is well established; however, the regulatory interrelationships of the three major QS systems, LasR/LasI, MvfR (PqsR)/PqsABCD, and RhlR/RhlI, have been studied primarily
    MeSH term(s) Humans ; Animals ; Mice ; Quorum Sensing ; Pseudomonas aeruginosa/metabolism ; Bacterial Proteins/metabolism ; Gene Expression Regulation, Bacterial ; Virulence Factors/genetics ; Inflammation ; Pseudomonas Infections/microbiology
    Chemical Substances Bacterial Proteins ; Virulence Factors
    Language English
    Publishing date 2023-02-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.03524-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Quorum-Sensing Signaling Molecule 2-Aminoacetophenone Mediates the Persistence of Pseudomonas aeruginosa in Macrophages by Interference with Autophagy through Epigenetic Regulation of Lipid Biosynthesis.

    Chakraborty, Arijit / Kabashi, Asel / Wilk, Samuel / Rahme, Laurence G

    mBio

    2023  Volume 14, Issue 2, Page(s) e0015923

    Abstract: Macrophages are crucial components of the host's defense against pathogens. Recent studies indicate that macrophage functions are influenced by lipid metabolism. However, knowledge of how bacterial pathogens exploit macrophage lipid metabolism for their ... ...

    Abstract Macrophages are crucial components of the host's defense against pathogens. Recent studies indicate that macrophage functions are influenced by lipid metabolism. However, knowledge of how bacterial pathogens exploit macrophage lipid metabolism for their benefit remains rudimentary. We have shown that the Pseudomonas aeruginosa MvfR-regulated quorum-sensing (QS) signaling molecule 2-aminoacetophenone (2-AA) mediates epigenetic and metabolic changes associated with this pathogen's persistence
    MeSH term(s) Pseudomonas aeruginosa/genetics ; Pseudomonas aeruginosa/metabolism ; Histone Deacetylase 1/metabolism ; Epigenesis, Genetic ; Beclin-1/metabolism ; Fatty Acids, Monounsaturated/metabolism ; Macrophages/metabolism ; Autophagy
    Chemical Substances 2-aminoacetophenone (551-93-9) ; Histone Deacetylase 1 (EC 3.5.1.98) ; Beclin-1 ; Fatty Acids, Monounsaturated
    Language English
    Publishing date 2023-04-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.00159-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: The Bacterial Quorum-Sensing Signal 2-Aminoacetophenone Rewires Immune Cell Bioenergetics through the PGC-1α/ERRα Axis to Mediate Tolerance to Infection.

    Chakraborty, Arijit / Bandyopadhaya, Arunava / Singh, Vijay K / Kovacic, Filip / Cha, Sujin / Oldham, William M / Tzika, A Aria / Rahme, Laurence G

    bioRxiv : the preprint server for biology

    2024  

    Abstract: How bacterial pathogens exploit host metabolism to promote immune tolerance and persist in infected hosts remains elusive. To achieve this, we show ... ...

    Abstract How bacterial pathogens exploit host metabolism to promote immune tolerance and persist in infected hosts remains elusive. To achieve this, we show that
    Language English
    Publishing date 2024-04-02
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.02.26.582124
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The Role of Common Solvents against Pseudomonas aeruginosa-Induced Pathogenicity in a Murine Burn Site Infection Model.

    Singh, Vijay K / Almpani, Marianna / Rahme, Laurence G

    Microbiology spectrum

    2021  Volume 9, Issue 1, Page(s) e0023321

    Abstract: Dimethyl sulfoxide (DMSO) and polyethylene glycols (PEGs) are frequently used as potent excipients in pharmaceutical formulations. However, these agents also have an interesting antimicrobial and anti-inflammatory profile that could interfere with the ... ...

    Abstract Dimethyl sulfoxide (DMSO) and polyethylene glycols (PEGs) are frequently used as potent excipients in pharmaceutical formulations. However, these agents also have an interesting antimicrobial and anti-inflammatory profile that could interfere with the efficacy testing of anti-infective compounds when the latter are solubilized in DMSO or PEGs. Here, we demonstrate the antimicrobial and anti-inflammatory effects of DMSO-PEG400 in a murine Pseudomonas aeruginosa infection model, aiming to draw attention to the appropriate selection of solvents for difficult-to-solubilize anti-infectives.
    MeSH term(s) Animals ; Anti-Bacterial Agents/pharmacology ; Burns/drug therapy ; Burns/microbiology ; Dimethyl Sulfoxide/pharmacology ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Microbial Sensitivity Tests ; Polyethylene Glycols/pharmacology ; Pseudomonas Infections/drug therapy ; Pseudomonas Infections/microbiology ; Pseudomonas aeruginosa/drug effects ; Pseudomonas aeruginosa/pathogenicity ; Pseudomonas aeruginosa/physiology ; Solvents ; Virulence/drug effects
    Chemical Substances Anti-Bacterial Agents ; Solvents ; Polyethylene Glycols (3WJQ0SDW1A) ; polyethylene glycol 400 (B697894SGQ) ; Dimethyl Sulfoxide (YOW8V9698H)
    Language English
    Publishing date 2021-08-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2165-0497
    ISSN (online) 2165-0497
    DOI 10.1128/Spectrum.00233-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Erratum for Bandyopadhaya et al., "Pseudomonas aeruginosa Quorum Sensing Molecule Alters Skeletal Muscle Protein Homeostasis by Perturbing the Antioxidant Defense System".

    Bandyopadhaya, Arunava / Tzika, A Aria / Rahme, Laurence G

    mBio

    2020  Volume 11, Issue 1

    Language English
    Publishing date 2020-02-04
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mBio.03316-19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Proteobacteria and Firmicutes Secreted Factors Exert Distinct Effects on

    Charalambous, Anna / Grivogiannis, Evangelos / Dieronitou, Irene / Michael, Christina / Rahme, Laurence / Apidianakis, Yiorgos

    Metabolites

    2022  Volume 12, Issue 5

    Abstract: Microbiota may alter a pathogen's virulence potential at polymicrobial infection sites. Here, we developed a multi- ... ...

    Abstract Microbiota may alter a pathogen's virulence potential at polymicrobial infection sites. Here, we developed a multi-modal
    Language English
    Publishing date 2022-05-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo12050449
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Pharmacological Inhibition of the Pseudomonas aeruginosa MvfR Quorum-Sensing System Interferes with Biofilm Formation and Potentiates Antibiotic-Mediated Biofilm Disruption.

    Maura, Damien / Rahme, Laurence G

    Antimicrobial agents and chemotherapy

    2017  Volume 61, Issue 12

    Abstract: Pseudomonas ... ...

    Abstract Pseudomonas aeruginosa
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Bacterial Proteins/antagonists & inhibitors ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Benzamides/chemical synthesis ; Benzamides/pharmacology ; Benzimidazoles/chemical synthesis ; Benzimidazoles/pharmacology ; Biofilms/drug effects ; Biofilms/growth & development ; Colony Count, Microbial ; Culture Media/chemistry ; Drug Synergism ; Drug Tolerance/genetics ; Gene Expression Regulation, Bacterial ; Pseudomonas aeruginosa/drug effects ; Pseudomonas aeruginosa/genetics ; Pseudomonas aeruginosa/growth & development ; Quorum Sensing/drug effects ; Thienamycins/pharmacology ; Tobramycin/pharmacology ; Transcription, Genetic
    Chemical Substances Anti-Bacterial Agents ; Bacterial Proteins ; Benzamides ; Benzimidazoles ; Culture Media ; Thienamycins ; meropenem (FV9J3JU8B1) ; Tobramycin (VZ8RRZ51VK)
    Language English
    Publishing date 2017-11-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/AAC.01362-17
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 809: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Einzelsignatur: Show issues

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  9. Article ; Online: Editorial: Beyond Antimicrobials: Non-traditional Approaches to Combating Multidrug-Resistant Bacteria.

    Kirienko, Natalia V / Rahme, Laurence / Cho, You-Hee

    Frontiers in cellular and infection microbiology

    2019  Volume 9, Page(s) 343

    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Anti-Infective Agents/pharmacology ; Anti-Infective Agents/therapeutic use ; Bacterial Infections/microbiology ; Bacterial Infections/therapy ; Biological Therapy/methods ; Combined Modality Therapy ; Disease Management ; Drug Repositioning ; Drug Resistance, Multiple, Bacterial/drug effects ; Humans ; Quorum Sensing/drug effects ; Virulence/drug effects ; Virulence/genetics
    Chemical Substances Anti-Bacterial Agents ; Anti-Infective Agents
    Language English
    Publishing date 2019-10-11
    Publishing country Switzerland
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2019.00343
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Pseudomonas aeruginosa Quorum Sensing Molecule Alters Skeletal Muscle Protein Homeostasis by Perturbing the Antioxidant Defense System.

    Bandyopadhaya, Arunava / Tzika, A Aria / Rahme, Laurence G

    mBio

    2019  Volume 10, Issue 5

    Abstract: Skeletal muscle function is compromised in many illnesses, including chronic infections. ... ...

    Abstract Skeletal muscle function is compromised in many illnesses, including chronic infections. The
    MeSH term(s) Acetylcysteine/metabolism ; Animals ; Antioxidants ; Cells, Cultured ; Male ; Mice ; Muscle Fibers, Skeletal/metabolism ; Muscle Proteins/metabolism ; Muscle, Skeletal/enzymology ; Muscle, Skeletal/metabolism ; NADP/metabolism ; Pseudomonas Infections/metabolism ; Pseudomonas Infections/microbiology ; Pseudomonas aeruginosa/physiology ; Quorum Sensing ; Reactive Oxygen Species/metabolism ; Transcription Factors/metabolism ; Uncoupling Protein 3/metabolism ; Xanthine Oxidase/metabolism
    Chemical Substances Antioxidants ; Muscle Proteins ; Reactive Oxygen Species ; Transcription Factors ; Ucp3 protein, mouse ; Uncoupling Protein 3 ; peroxisome-proliferator-activated receptor-gamma coactivator-1 ; NADP (53-59-8) ; Xanthine Oxidase (EC 1.17.3.2) ; Acetylcysteine (WYQ7N0BPYC)
    Language English
    Publishing date 2019-10-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mBio.02211-19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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