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Article ; Online: A unique case of intracranial collision tumor composed of ganglioglioma WHO gr I and supratentorial ependymoma WHO gr III: case-based literature review.

Nedeljkovic, Aleksandra / Ilic, Rosanda / Nedeljkovic, Zarko / Milicevic, Mihailo / Raicevic, Savo / Grujicic, Danica

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

2023 Volume 39, Issue 9, Page(s) 2407–2411

Abstract: Purpose: Intracranial collision tumor is a rare entity that represents the coexistence of two histopathological different tumor types in the same area without histological admixture or an intermediate cell population zone. So far, several cases of ... ...

Abstract	Purpose: Intracranial collision tumor is a rare entity that represents the coexistence of two histopathological different tumor types in the same area without histological admixture or an intermediate cell population zone. So far, several cases of collision tumors with ganglioglioma as its component have been reported in the literature, while supratentorial ependymoma has never been reported as a collision tumor component. We are presenting a unique case of collision tumor in patient without previous history of head trauma, neurological surgery, radiotherapy, or phakomatosis. Methods and results: A 17-year-old male with no previous history of head trauma, neurological surgery, radiotherapy, or phakomatosis was presented to our clinic with grand mal seizure. Brain magnetic resonance imaging with gadolinium contrast was done revealing a contrast-enhancing lesion of right frontal lobe closely related to dura, surrounded by perifocal edema. The patient underwent a gross total tumor resection. Histological examination revealed collision tumor with two distinct components: ganglioglioma and supratentorial ependymoma. Conclusion: To our best knowledge, no previous reports of collision tumor composed of ganglioglioma and supratentorial ependymoma in a single patient have been reported. We believe that this report could significantly contribute to further surgical practice as well as to treatment decision for these types of collision tumors.
MeSH term(s)	Male ; Humans ; Adolescent ; Ganglioglioma/diagnostic imaging ; Ganglioglioma/surgery ; Neurocutaneous Syndromes/complications ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/surgery ; Magnetic Resonance Imaging ; Craniocerebral Trauma/complications ; Ependymoma/diagnostic imaging ; Ependymoma/surgery ; World Health Organization ; Supratentorial Neoplasms/diagnostic imaging ; Supratentorial Neoplasms/surgery
Language	English
Publishing date	2023-06-17
Publishing country	Germany
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	605988-0
ISSN	1433-0350 ; 0302-2803 ; 0256-7040
ISSN (online)	1433-0350
ISSN	0302-2803 ; 0256-7040
DOI	10.1007/s00381-023-06028-6
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Article: A potential role of mechano-gated potassium channels in meningioma-related seizures.

Bogdanović, Ivan / Opačić, Miloš / Baščarević, Vladimir / Raičević, Savo / Ilić, Rosanda / Grujičić, Danica / Spasojević, Ivan / Ristić, Aleksandar J

Heliyon

2023 Volume 9, Issue 10, Page(s) e20761

Abstract: Every third patient with intracranial meningioma develops seizures of poorly understood etiology. Tumor and peritumoral edema may exert mechanical pressure on the cortex that may affect mechano-gated potassium channels - KCNK2 and KCNK4. These channels ... ...

Abstract	Every third patient with intracranial meningioma develops seizures of poorly understood etiology. Tumor and peritumoral edema may exert mechanical pressure on the cortex that may affect mechano-gated potassium channels - KCNK2 and KCNK4. These channels regulate neuron excitability and have been related to seizures in some other conditions. The objective of the present study was to explore a potential relation between the levels of these proteins in tumor tissue and adjacent cortex and seizures development. The study included 19 meningioma patients that presented one or more preoperative seizures and 24 patients with no seizures. Tissue samples were collected in the course of surgical removal of the meningioma. Postoperative seizure freedom was achieved in 11 out of 19 patients. The relative level of KCNK2 in the cortical tissue was lower in patients with preoperative seizures. On the other hand, cortical tissue level of KCNK4 was higher in patients that became seizure-free after the surgery. In addition, relative levels of KCNK4 in the cortical and tumor tissue appear to be lowered by the treatment with anti-seizure medication levetiracetam. These results imply that KCNK2 and KCNK4 may be involved in the development of meningioma-related seizures and may represent promising therapeutic targets.
Language	English
Publishing date	2023-10-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e20761
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Article ; Online: Oncogene-induced senescence in meningiomas-an immunohistochemical study.

Mijajlović, Vladimir / Miler, Marko / Ilić, Rosanda / Rašić, Dejan / Dunđerović, Duško / Raičević, Savo / Soldatović, Ivan / De Luka, Silvio / Manojlović-Gačić, Emilija

Journal of neuro-oncology

2023 Volume 166, Issue 1, Page(s) 143–153

Abstract: Purpose: Meningiomas are tumours originating from meningothelial cells, the majority belonging to grade 1 according to the World Health Organization classification of the tumours of the Central Nervous System. Factors contributing to the progression to ... ...

Abstract	Purpose: Meningiomas are tumours originating from meningothelial cells, the majority belonging to grade 1 according to the World Health Organization classification of the tumours of the Central Nervous System. Factors contributing to the progression to the higher grades (grades 2 and 3) have not been elucidated yet. Senescence has been proposed as a potential mechanism constraining the malignant transformation of tumours. Senescence-associated beta-galactosidase (SA-β-GAL) and inhibitors of cyclin-dependent kinases p16 and p21 have been suggested as senescence markers. Methods: We analysed 318 meningiomas of total 343 (178 grade 1, 133 grade 2 and 7 grade 3). Tissue microarrays were constructed and stained immunohistochemically, using antibodies for SA-β-GAL, p16 and p21. Results: The positive correlation of the tumour grade with the expression of p16 (p = 0.016) and SA-β-GAL (p = 0.002) was observed. The expression of p16 and SA-β-GAL was significantly higher in meningiomas grade 2 compared to meningiomas grade 1 (p = 0.006 and p = 0.004, respectively). SA-β-GAL positivity positively correlated with p16 and p21 in the whole cohort. In grade 2 meningiomas, a positive correlation was only between SA-β-GAL and p16. Correlations of senescence markers in meningiomas grade 2 were not present. Conclusion: Our findings suggest the senescence activation in meningiomas grade 2 as a potential mechanism for the restraining of tumour growth and give hope for applying of promising senolytic therapy.
MeSH term(s)	Humans ; Meningioma ; Cellular Senescence/physiology ; Oncogenes ; beta-Galactosidase/metabolism ; Central Nervous System/chemistry ; Central Nervous System/metabolism ; Cyclin-Dependent Kinase Inhibitor p16/metabolism ; Meningeal Neoplasms
Chemical Substances	beta-Galactosidase (EC 3.2.1.23) ; Cyclin-Dependent Kinase Inhibitor p16
Language	English
Publishing date	2023-12-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	604875-4
ISSN	1573-7373 ; 0167-594X
ISSN (online)	1573-7373
ISSN	0167-594X
DOI	10.1007/s11060-023-04532-y
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Zs.A 1825: Show issues

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Article: Case Report: Atypical Solitary Brain Metastasis: The Role of MR Spectroscopy In Differential Diagnosis.

Kozic, Dusko / Lasica, Nebojsa / Grujicic, Danica / Raicevic, Savo / Prvulovic Bunovic, Natasa / Nosek, Igor / Boban, Jasmina

Frontiers in oncology

2022 Volume 12, Page(s) 866622

Abstract: Background: Metastatic brain tumors are typically located at the cerebral hemispheres or the cerebellum and most frequently originate from primary breast or lung tumors. Metastatic lesions are usually associated with blood-brain barrier disruption, ... ...

Abstract	Background: Metastatic brain tumors are typically located at the cerebral hemispheres or the cerebellum and most frequently originate from primary breast or lung tumors. Metastatic lesions are usually associated with blood-brain barrier disruption, solid or ring-like contrast enhancement, and perilesional vasogenic edema on brain imaging. Even in cases where metastases are predominantly cystic, enhancement of the minor solid component can be detected. In contrast, non-enhancing secondary brain tumors were only reported in a patient after antiangiogenic treatment with bevacizumab. Case report: We report a case of a 54-year-old male who presented with left-sided weakness and multiple seizures. Brain magnetic resonance imaging revealed a T2-weighted heterogeneous solid tumor in the right frontoparietal parasagittal region, with no apparent enhancement on T1-weighted post-contrast images and no evident perilesional edema. Further MRS analysis revealed markedly increased choline and lipid peaks. The patient underwent craniotomy for tumor removal. Histopathology revealed findings consistent with metastatic non-microcellular neuroendocrine lung cancer. positron emission tomography/computed tomography (PET/CT) revealed a stellate lesion within the right upper lung lobe, compatible with primary lung cancer. Conclusion: Non-enhancing brain metastatic tumors are rarely reported in the literature, usually following antiangiogenic treatment. Here, we report the first ever case of a non-enhancing metastatic brain tumor with no prior history of antiangiogenic treatment, with particular emphasis on the importance of MRS analysis in atypical brain lesions.
Language	English
Publishing date	2022-07-22
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2022.866622
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Article: Case report: Nocardial brain abscess in a persistently SARS-CoV-2 PCR positive patient with systemic lupus erythematosus.

Veličković, Jelena / Vukičević, Tatjana Adžić / Spurnić, Aleksandra Radovanović / Lazić, Igor / Popović, Bojana / Bogdanović, Ivan / Raičević, Savo / Marić, Dragana / Berisavac, Ivana

Frontiers in medicine

2022 Volume 9, Page(s) 973817

Abstract: Coronavirus disease (COVID-19) in immunocompromised patients represents a major challenge for diagnostics, surveillance, and treatment. Some individuals remain SARS-CoV-2 PCR-positive for a prolonged period. The clinical and epidemiological significance ... ...

Abstract	Coronavirus disease (COVID-19) in immunocompromised patients represents a major challenge for diagnostics, surveillance, and treatment. Some individuals remain SARS-CoV-2 PCR-positive for a prolonged period. The clinical and epidemiological significance of this phenomenon is not well understood. We report a case of a patient with a history of systemic lupus erythematosus (SLE) who has been persistently SARS-CoV-2 PCR positive for 9 months, with multiple thromboembolic complications, and development of nocardial brain abscess successfully treated with surgery and antibiotics.
Language	English
Publishing date	2022-08-18
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2022.973817
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Article ; Online: Proapoptotic and proautophagy effect of H1-receptor antagonist desloratadine in human glioblastoma cell lines.

Vidicevic-Novakovic, Sasenka / Stanojevic, Zeljka / Tomonjic, Nina / Karapandza, Katarina / Zekovic, Janko / Martinovic, Tamara / Grujicic, Danica / Ilic, Rosanda / Raicevic, Savo / Tasic, Jelena / Isakovic, Aleksandra

Medical oncology (Northwood, London, England)

2023 Volume 40, Issue 8, Page(s) 241

Abstract: Glioblastomas are aggressive and usually incurable high-grade gliomas without adequate treatment. In this study, we aimed to investigate the potential of desloratadine to induce apoptosis/autophagy as genetically regulated processes that can seal cancer ... ...

Abstract	Glioblastomas are aggressive and usually incurable high-grade gliomas without adequate treatment. In this study, we aimed to investigate the potential of desloratadine to induce apoptosis/autophagy as genetically regulated processes that can seal cancer cell fates. All experiments were performed on U251 human glioblastoma cell line and primary human glioblastoma cell culture. Cytotoxic effect of desloratadine was investigated using MTT and CV assays, while oxidative stress, apoptosis, and autophagy were detected by flow cytometry and immunoblot. Desloratadine treatment decreased cell viability of U251 human glioblastoma cell line and primary human glioblastoma cell culture (IC50 value 50 µM) by an increase of intracellular reactive oxygen species and caspase activity. Also, desloratadine decreased the expression of main autophagy repressor mTOR and its upstream activator Akt and increased the expression of AMPK. Desloratadine exerted dual cytotoxic effect inducing both apoptosis- and mTOR/AMPK-dependent cytotoxic autophagy in glioblastoma cells and primary glioblastoma cell culture.
MeSH term(s)	Humans ; Glioblastoma/drug therapy ; Glioblastoma/metabolism ; Cell Line, Tumor ; AMP-Activated Protein Kinases ; TOR Serine-Threonine Kinases/metabolism ; Antineoplastic Agents/therapeutic use ; Apoptosis ; Autophagy ; Cell Proliferation
Chemical Substances	desloratadine (FVF865388R) ; AMP-Activated Protein Kinases (EC 2.7.11.31) ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; Antineoplastic Agents
Language	English
Publishing date	2023-07-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	1201189-7
ISSN	1559-131X ; 0736-0118 ; 1357-0560
ISSN (online)	1559-131X
ISSN	0736-0118 ; 1357-0560
DOI	10.1007/s12032-023-02117-3
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Article ; Online: Tanycytic Ependymoma of the Filum Terminale Region; a Case Report

Petrovic Marko / Miletic-Kovacevic Marina / Jovanovic Nemanja / Nikolic Radivoje / Raicevic Savo / Kovacevic Vojin

Serbian Journal of Experimental and Clinical Research, Vol 19, Iss 3, Pp 277-

2018 Volume 280

Abstract: Tanycytic ependymoma is a very rare spindle-cell variant of ependymoma derived from tanycytes, which are part of the primitive nervous system. This paper is presenting 48-year old woman who presented with low back and right-sided leg pain of moderate ... ...

Abstract	Tanycytic ependymoma is a very rare spindle-cell variant of ependymoma derived from tanycytes, which are part of the primitive nervous system. This paper is presenting 48-year old woman who presented with low back and right-sided leg pain of moderate intensity. MRI showed spinal intradural tumor at the level of the L1 vertebral body. Right-sided L1 hemilaminectomy and en bloc tumor resection were performed. Neuroradiological and intraoperative diagnosis of schwannoma was revised to tanycytic ependymoma after careful immunohistochemical analysis. Six months post-operativly, MRI did not show tumor recurrence. Tanycytic ependymoma at the region of filum terminale is extremely uncommon and only three cases have been described in the literature. The low incidence of this tumor and atypical histological image, which is distinct from the typical features of commonly encountered ependymomas, can present a challenge in terms of making an accurate diagnosis. Awareness of this transitional form of ependymoma among neurosurgeons and pathologists may avoid incorrect surgical approaches and postoperative treatment course.
Keywords	tanycytes ; ependymoma ; filum terminale ; Medicine ; R
Subject code	610
Language	English
Publishing date	2018-09-01T00:00:00Z
Publisher	Sciendo
Document type	Article ; Online
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Article ; Online: Multinodular and vacuolating neuronal tumour of the cerebrum: a rare neuroimaging incidentaloma or a potentially treatable cause of focal epilepsy?

Baščarević, Vladimir / Pejović, Aleksa T / Ristić, Aleksandar J / Vojvodić, Nikola / Raičević, Savo / Đukić, Tijana / Brajković, Leposava / Sokić, Dragoslav

Epileptic disorders : international epilepsy journal with videotape

2019 Volume 21, Issue 2, Page(s) 209–214

Abstract: Multinodular and vacuolating neuronal tumour (MVNT) of the cerebrum is a relatively new, well defined histopathological and neuroradiological entity, in many cases associated with an early adult-onset epilepsy. These lesions have an indolent course and ... ...

Abstract	Multinodular and vacuolating neuronal tumour (MVNT) of the cerebrum is a relatively new, well defined histopathological and neuroradiological entity, in many cases associated with an early adult-onset epilepsy. These lesions have an indolent course and resemble both malformative and neoplastic processes, combining a focal developmental anomaly and a low-grade tumour. Herein, we report a case of a 48-year-old female patient with left temporal lobe epilepsy associated with MVNT. In addition, a comprehensive review of all the previously published cases is provided with a focus on seizure-related cases, surgical treatment, and postoperative outcome.
MeSH term(s)	Brain Neoplasms/complications ; Brain Neoplasms/diagnosis ; Brain Neoplasms/pathology ; Brain Neoplasms/surgery ; Electroencephalography ; Epilepsy, Temporal Lobe/diagnosis ; Epilepsy, Temporal Lobe/etiology ; Epilepsy, Temporal Lobe/surgery ; Female ; Humans ; Magnetic Resonance Imaging ; Middle Aged
Language	English
Publishing date	2019-04-20
Publishing country	France
Document type	Case Reports ; Journal Article
ZDB-ID	2086797-9
ISSN	1950-6945 ; 1294-9361
ISSN (online)	1950-6945
ISSN	1294-9361
DOI	10.1684/epd.2019.1045
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Zs.A 5740: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Clinical profile, treatment and outcome of pediatric brain tumors in Serbia in a 10-year period: A national referral institution experience.

Stanić, Dragana / Grujičić, Danica / Pekmezović, Tatjana / Bokun, Jelena / Popović-Vuković, Marija / Janić, Dragana / Paripović, Lejla / Ilić, Vesna / Pudrlja Slović, Marija / Ilić, Rosanda / Raičević, Savo / Sarić, Milan / Mišković, Ivana / Nidžović, Borko / Nikitović, Marina

PloS one

2021 Volume 16, Issue 10, Page(s) e0259095

Abstract: Objective: This study aimed to evaluate the characteristics of children with primary brain tumors, the effectiveness of treatment modalities, and to detect factors related to the outcome.: Methods: A detailed analysis was performed on a series of 173 ...

Abstract	Objective: This study aimed to evaluate the characteristics of children with primary brain tumors, the effectiveness of treatment modalities, and to detect factors related to the outcome. Methods: A detailed analysis was performed on a series of 173 pediatric patients treated in a Serbian referral oncology institution between 2007 and 2016, based on their clinical, histological, treatment, and follow-up data. Results: Mean survival time of all children was 94.5months. 2-, 5- and 10-year overall survival probabilities were 68.8%, 59.4%, and 52.8%, respectively. Patients with supratentorial tumors had longer survival than patients with infratentorial tumors and patients with tumors in both compartments (p = 0.011). Children with the unknown histopathology (brainstem glioma) and high-grade glioma had a shorter life than embryonal tumors, ependymoma, and low-grade glioma (p<0.001). Survival of the children who underwent gross total resection was longer than the children in whom lesser degrees of resection were achieved (p = 0.015). The extent of the disease is a very important parameter found to be associated with survival. Patients with no evidence of disease after surgery had a mean survival of 123 months, compared with 82 months in patients with local residual disease and 55 months in patients with disseminated disease (p<0.001). By the univariate analysis, factors predicting poor outcome in our series were the presentation of disease with hormonal abnormalities, tumor location, and the extent of the disease, while the factors predicting a better outcome were age at the time of diagnosis, presentation of the disease with neurological deficit, and type of resection. By the multivariate analysis, the extent of the disease remained as the only strong adverse risk factor for survival (HR 2.06; 95% CI = 1.38-3.07; p<0.001). Conclusions: With an organized and dedicated multidisciplinary team, the adequate outcomes can be achieved in a middle-income country setting. The presence of local residual disease after surgery and disseminated disease has a strong negative effect on survival.
MeSH term(s)	Adolescent ; Antineoplastic Agents/therapeutic use ; Brain Neoplasms/mortality ; Brain Neoplasms/pathology ; Brain Neoplasms/therapy ; Child ; Child, Preschool ; Female ; Glioma/mortality ; Glioma/pathology ; Glioma/therapy ; Humans ; Infant ; Infant, Newborn ; Male ; Neurosurgical Procedures ; Prognosis ; Radiotherapy ; Serbia ; Survival Rate ; Treatment Outcome
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	2021-10-26
Publishing country	United States
Document type	Journal Article
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0259095
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Article ; Online: Expression of kisspeptin and KISS1 receptor in pituitary neuroendocrine tumours - an immunohistochemical study.

Mihajlovic, Milena / Pekic, Sandra / Doknic, Mirjana / Stojanovic, Marko / Miljic, Dragana / Soldatovic, Ivan / Vukotic, Tatjana / Janev, Tijana / Cirovic, Sanja / Terzic, Tatjana / Raicevic, Savo / Skender-Gazibara, Milica / Popovic, Vera / Manojlovic-Gacic, Emilija

Endokrynologia Polska

2021 Volume 72, Issue 2, Page(s) 91–96

Abstract: Introduction: Pituitary neuroendocrine tumours (PitNETs), traditionally designated as pituitary adenomas, show elatively frequent invasive growth with exceptional metastatic potential, the causes of which are not entirely elucidated. Kisspeptins, which ... ...

Abstract	Introduction: Pituitary neuroendocrine tumours (PitNETs), traditionally designated as pituitary adenomas, show elatively frequent invasive growth with exceptional metastatic potential, the causes of which are not entirely elucidated. Kisspeptins, which perform their activity through KISS1 receptor (KISS1R), are recognised as metastatic suppressors in many malignant tumours. This study aimed to investigate the immunohistochemical expression of kisspeptin and KISS1R in different types of PitNETs and to compare it with the expression in the normal anterior pituitary, using tissue microarray. Material and methods: The experimental group consisted of 101 patients with PitNETs, with 45 (37.3%) being of gonadotroph, 40 (33.9%) somatotroph, 4 (3.4%) corticotroph, 4 (3.4%) thyrotroph, 3 (2.5%) lactotroph, and 6 (5.1%) null-cell type. The control group consisted of anterior pituitary tissue accidentally removed during the surgery for PitNETs in 17 patients. Results: Kisspeptin expression was observed in both experimental and control groups, without statistically significant differences in the staining intensity. Negative kisspeptin staining was detected in 10 (9.9%), weak in 79 (78.2%), and moderate in 12 tumours (11.9%); none of the tumours had strong staining intensity. The weak staining intensity was predominant in all PitNET types except thyrotroph tumours. Significant statistical difference in terms of kisspeptin expression between types of PitNET and the control group was not observed. Immunohistochemical expression of KISS1R was not observed in the control group or in the experimental group. Conclusions: We conclude that immunohistochemistry, as a method, cannot confirm the involvement of kisspeptin in tumourigenesis and aggressiveness of PitNETs, but potentially supports its antimetastatic role. The absence of KISS1R immunohistochemical expression in all anterior pituitaries and PitNETs in our cohort needs verification through the use of different procedures designed for the detection of the presence and localisation of proteins in the cell.
MeSH term(s)	Humans ; Kisspeptins ; Neuroendocrine Tumors ; Pituitary Gland ; Pituitary Neoplasms ; Receptors, Kisspeptin-1
Chemical Substances	KISS1 protein, human ; Kisspeptins ; Receptors, Kisspeptin-1
Language	English
Publishing date	2021-02-23
Publishing country	Poland
Document type	Journal Article
ZDB-ID	419270-9
ISSN	2299-8306 ; 0423-104X
ISSN (online)	2299-8306
ISSN	0423-104X
DOI	10.5603/EP.a2021.0009
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