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  1. Article: Clinical and Epidemiological Characteristics of Hospitalized COVID-19 Patients in an Isolation Centre in South-West Nigeria.

    Dada, Samuel A / Dele-Ojo, Bolade F / Raimi, Taiwo H / Ojo, Peter / Adeoti, Adekunle O / Fadare, Joseph O / Rafiu, Mojeed O / Dada, Oluwamayowa E / Olabanji, Jimoh K

    Cureus

    2023  Volume 15, Issue 10, Page(s) e46992

    Abstract: Introduction: The clinical presentation of coronavirus disease 2019 (COVID-19) can vary widely, and while the primary infection involves the respiratory system, other organs can also be affected. This study presents the clinical and epidemiological ... ...

    Abstract Introduction: The clinical presentation of coronavirus disease 2019 (COVID-19) can vary widely, and while the primary infection involves the respiratory system, other organs can also be affected. This study presents the clinical and epidemiological characteristics of hospitalized COVID-19 patients in a tertiary hospital in Ado Ekiti, South-West Nigeria.
    Materials and methods: This is a retrospective study involving COVID-19 patients admitted to the isolation ward between August 2020 and January 2021. The data used for this study was obtained from the patient's medical record, which includes demographic characteristics, clinical presentation, baseline co-morbidities, and laboratory investigations.
    Results: The average age of the patients was 60.3 years, and more than two-thirds were male. The most common symptoms were fever, shortness of breath, cough, and tiredness. Comorbidities identified among the patients included diabetes mellitus, heart disease, obesity, and chronic kidney disease. The most common radiological findings were bilateral homogeneous patchy opacities and peripheral fluffy infiltrates. The overall mortality rate was 21.9%, with 13 deaths in patients with severe disease. Age and duration of admission were found to be significant predictors of death.
    Conclusion: The results of this study provide valuable insights into the clinical presentation of COVID-19 in Nigeria and may guide future management strategies for similar infections.
    Language English
    Publishing date 2023-10-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.46992
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Triglyceride-Glucose Index and Related Parameters Predicted Metabolic Syndrome in Nigerians.

    Raimi, Taiwo H / Dele-Ojo, Bolade F / Dada, Samuel A / Fadare, Joseph O / Ajayi, David D / Ajayi, Ebenezer A / Ajayi, Oladimeji A

    Metabolic syndrome and related disorders

    2020  Volume 19, Issue 2, Page(s) 76–82

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Adult ; Biomarkers/analysis ; Biomarkers/blood ; Blood Glucose/analysis ; Blood Glucose/metabolism ; Cross-Sectional Studies ; Female ; Health Status Indicators ; Hospitals, Teaching ; Humans ; Male ; Metabolic Syndrome/blood ; Metabolic Syndrome/diagnosis ; Metabolic Syndrome/epidemiology ; Middle Aged ; Nigeria/epidemiology ; Risk Factors ; Triglycerides/blood ; Young Adult
    Chemical Substances Biomarkers ; Blood Glucose ; Triglycerides
    Language English
    Publishing date 2020-11-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2151220-6
    ISSN 1557-8518 ; 1540-4196
    ISSN (online) 1557-8518
    ISSN 1540-4196
    DOI 10.1089/met.2020.0092
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5950: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Uncovering the Burden of Diabetes in Ekiti State, Nigeria: Insights From a Statewide, Household-Based, Cross-Sectional Study.

    Oluwadiya, Kehinde S / Raimi, Taiwo H / Dada, Samuel A / Dele-Ojo, Bolade F / Adeoti, Adekunle O / Solomon, Oluremi O / Amu, Eyitope / Awoleke, Jacob O / Atiba, Samuel A / Babatola, Adefunke O / Dada, Mobolaji U / Ariyo, Olumuyiwa E / Omotayo, Adetunji J / Adelekan, Ademola O / Ezeani, Esu S / Ogundipe, Laofe / Akinwunmi, Adebowale F / Aina, Felix O / Agboola, Segun M

    Cureus

    2023  Volume 15, Issue 12, Page(s) e50686

    Abstract: Introduction: Diabetes mellitus (DM) is an important global public health challenge, and the burden of the disease is huge, particularly in low- and middle-income countries (LMICs), where the majority of people with this condition reside. Undiagnosed DM ...

    Abstract Introduction: Diabetes mellitus (DM) is an important global public health challenge, and the burden of the disease is huge, particularly in low- and middle-income countries (LMICs), where the majority of people with this condition reside. Undiagnosed DM is more prevalent in LMICs. The aim of this study is to determine the prevalence and associated factors for DM in Ekiti State.
    Materials and methods: A cross-sectional, household-based survey using a four-stage multistage sampling design and the World Health Organization (WHO)-STEPS survey manual was conducted from July to September 2020 as a part of the Ekiti State coronavirus disease 2019 (COVID-19) survey. Of the 5,145 sampled households, 4,726 individuals gave consent to participate in the survey. Out of these, 3043 had fasting plasma glucose results available and were included in the analysis.
    Results: There were 2257 (74.2%) women and 786 (25.8%) men. The prevalence of DM was 6.5% (6.5% in males and 6.6% in females, P = 0.946). Diabetes was found to be more prevalent among those with a secondary school education or higher (10.9%); employed in the formal sector (13.4%); separated, divorced, or widowed (8.5%); with raised blood pressure (9.3%); and who were aged 30-59 years (all P < 0.05). Multivariable logistic regression showed that age, education, occupation, and hypertension were all positively and significantly associated with an increased risk of DM.
    Conclusion: The prevalence of DM in Ekiti State is high, and its predictors include advancing age, hypertension, education, and occupation. This calls for scaling up public health interventions for controlling DM, targeting the identified risk factors among the people of Ekiti.
    Language English
    Publishing date 2023-12-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.50686
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Diabetic neuropathy is associated with increased pain perception, low serum beta-endorphin and increase insulin resistance among Nigerian cohorts in Ekiti State.

    Akintoye, Olabode O / Owoyele, Bamidele V / Fabunmi, Oyesanmi A / Raimi, Taiwo H / Oniyide, Adesola A / Akintoye, Abimbola O / Ajibare, Ayodeji J / Ajayi, David D / Adeleye, Gbenga S

    Heliyon

    2020  Volume 6, Issue 7, Page(s) e04377

    Abstract: Introduction: There has been an increase in the global prevalence of diabetic polyneuropathy and research evidence suggests that insulin resistance plays an important role in its development and prognosis. However, there seem to be a dearth of ... ...

    Abstract Introduction: There has been an increase in the global prevalence of diabetic polyneuropathy and research evidence suggests that insulin resistance plays an important role in its development and prognosis. However, there seem to be a dearth of information in understanding the likely interplay between beta endorphin, insulin resistance and pain perception especially in the setting of painful diabetic neuropathy.
    Method: This study recruited 120 volunteers divided into four groups (30 per group): group 1 healthy volunteer (control); group 2 DM type 2 without neuropathy (DM group); group 3 DM type 2 with painful neuropathy (DPN group); group 4 DM type 2 without painful neuropathy (DN). All subjects were evaluated for pain threshold and neuropathy using an ischemia-induced pain model and biothesiometer respectively. Their beta-endorphin, glycated hemoglobin, fasting plasma insulin, and HOMA values were determined and means compared using ANOVA.
    Result: Serum beta-endorphin is significantly reduced in DN and DPN (∗p < 0.001) compared with the control and DM group. Also, DPN and DN patients have significantly increased insulin resistance compared to those without neuropathy (∗p < 0.001; ∗p < 0.0001 respectively). There is a significant positive correlation between the pain threshold and beta-endorphin in all the groups except DN group. The correlation between beta-endorphin and insulin resistance was negative and significant in control and DM groups only. Suggestive that the fact that insulin resistance plays an important role in diabetes polyneuropathy, does not alone explain the chronic pain perception noticed in the DPN patients.
    Conclusion: The present study demonstrates that diabetic neuropathy patients have a poor endogenous opioid peptide system which is associated with increased pain perception and high insulin resistance. However, insulin resistance alone does not explain the chronic pain perception noticed in the DPN patients. Thus, further study is required.
    Language English
    Publishing date 2020-07-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2020.e04377
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Diabetic neuropathy is associated with increased pain perception, low serum beta-endorphin and increase insulin resistance among Nigerian cohorts in Ekiti State

    Akintoye, Olabode O / Owoyele, Bamidele V / Fabunmi, Oyesanmi A / Raimi, Taiwo H / Oniyide, Adesola A / Akintoye, Abimbola O / Ajibare, Ayodeji J / Ajayi, David D / Adeleye, Gbenga S

    Heliyon. 2020 July, v. 6, no. 7

    2020  

    Abstract: There has been an increase in the global prevalence of diabetic polyneuropathy and research evidence suggests that insulin resistance plays an important role in its development and prognosis. However, there seem to be a dearth of information in ... ...

    Abstract There has been an increase in the global prevalence of diabetic polyneuropathy and research evidence suggests that insulin resistance plays an important role in its development and prognosis. However, there seem to be a dearth of information in understanding the likely interplay between beta endorphin, insulin resistance and pain perception especially in the setting of painful diabetic neuropathy.This study recruited 120 volunteers divided into four groups (30 per group): group 1 healthy volunteer (control); group 2 DM type 2 without neuropathy (DM group); group 3 DM type 2 with painful neuropathy (DPN group); group 4 DM type 2 without painful neuropathy (DN). All subjects were evaluated for pain threshold and neuropathy using an ischemia-induced pain model and biothesiometer respectively. Their beta-endorphin, glycated hemoglobin, fasting plasma insulin, and HOMA values were determined and means compared using ANOVA.Serum beta-endorphin is significantly reduced in DN and DPN (∗p < 0.001) compared with the control and DM group. Also, DPN and DN patients have significantly increased insulin resistance compared to those without neuropathy (∗p < 0.001; ∗p < 0.0001 respectively). There is a significant positive correlation between the pain threshold and beta-endorphin in all the groups except DN group. The correlation between beta-endorphin and insulin resistance was negative and significant in control and DM groups only. Suggestive that the fact that insulin resistance plays an important role in diabetes polyneuropathy, does not alone explain the chronic pain perception noticed in the DPN patients.The present study demonstrates that diabetic neuropathy patients have a poor endogenous opioid peptide system which is associated with increased pain perception and high insulin resistance. However, insulin resistance alone does not explain the chronic pain perception noticed in the DPN patients. Thus, further study is required.
    Keywords blood serum ; diabetic neuropathy ; endorphins ; glycohemoglobin ; insulin ; insulin resistance ; models ; pain ; prognosis
    Language English
    Dates of publication 2020-07
    Publishing place Elsevier Ltd
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2020.e04377
    Database NAL-Catalogue (AGRICOLA)

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  6. Article: Metabolic Syndrome and Framingham Risk Score: Observation from Screening of Low-Income Semi-Urban African Women.

    Dada, Ayokunle S / Ajayi, Daisi D / Areo, Peter O / Raimi, Taiwo H / Emmanuel, Eyitayo E / Odu, Olusola O / Aremu, Olusegun A

    Medicines (Basel, Switzerland)

    2016  Volume 3, Issue 2

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2016-06-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2777965-8
    ISSN 2305-6320
    ISSN 2305-6320
    DOI 10.3390/medicines3020015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Performance of waist circumference and proposed cutoff levels for defining overweight and obesity in Nigerians.

    Okafor, Christian I / Raimi, Taiwo H / Gezawa, Ibrahim D / Sabir, Anas A / Enang, Ofem / Puepet, Fabian / Fasanmade, Olufemi A / Ofoegbu, Esther N / Odusan, Olatunde

    Annals of African medicine

    2016  Volume 15, Issue 4, Page(s) 185–193

    Abstract: Background: Waist circumference (WC) is a simple tool for measuring central obesity in routine clinic settings. Gender- and ethnic-specific optimal cutoff points for WC are encouraged for populations lacking such data.: Objectives: To derive WC ... ...

    Abstract Background: Waist circumference (WC) is a simple tool for measuring central obesity in routine clinic settings. Gender- and ethnic-specific optimal cutoff points for WC are encouraged for populations lacking such data.
    Objectives: To derive WC cutoff values, predictive of overweight and obesity in Nigerians and to evaluate the performance of currently recommended values.
    Subjects and methods: Apparently, healthy urban dwellers from six cities spread across Nigeria were selected for this cross-sectional study. Biophysical profiles such as blood pressure and anthropometric indices were measured according to the World Health Organization's STEPs instrument protocol. Receiver operating characteristics curve analysis was used to determine the optimal cutoff levels using the decision rule of maximum (sensitivity + specificity). The level of significance was set at P< 0.05.
    Results: A total of 6089 subjects (3234 males and 2855 females) were recruited for the study. WC demonstrated a high area under the curve in both genders. Selected cutoff points ranged from 83 to 96 cm with high sensitivities and specificities.
    Conclusions: The currently recommended gender-specific WC cutoff values proved inappropriate in this study group, but WC remains a reliable tool for measuring obesity.
    MeSH term(s) Adult ; African Continental Ancestry Group ; Area Under Curve ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Nigeria ; Obesity/diagnosis ; Obesity, Abdominal/diagnosis ; Overweight/diagnosis ; Reference Values ; Sensitivity and Specificity ; Thinness/diagnosis ; Urban Population ; Waist Circumference ; Young Adult
    Language English
    Publishing date 2016-10
    Publishing country India
    Document type Journal Article ; Multicenter Study ; Observational Study
    ZDB-ID 2165792-0
    ISSN 0975-5764 ; 1596-3519
    ISSN (online) 0975-5764
    ISSN 1596-3519
    DOI 10.4103/1596-3519.194275
    Database MEDical Literature Analysis and Retrieval System OnLINE

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