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  1. Article ; Online: An IMiD-inducible degron provides reversible regulation for chimeric antigen receptor expression and activity.

    Carbonneau, Seth / Sharma, Sujata / Peng, Liaomin / Rajan, Vaisakh / Hainzl, Dominik / Henault, Martin / Yang, Chian / Hale, Jacob / Shulok, Janine / Tallarico, John / Porter, Jeff / Brogdon, Jennifer L / Dranoff, Glenn / Bradner, James E / Hild, Marc / Guimaraes, Carla P

    Cell chemical biology

    2021  Volume 28, Issue 4, Page(s) 583

    Language English
    Publishing date 2021-04-16
    Publishing country United States
    Document type Published Erratum
    ISSN 2451-9448
    ISSN (online) 2451-9448
    DOI 10.1016/j.chembiol.2021.02.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: An IMiD-inducible degron provides reversible regulation for chimeric antigen receptor expression and activity.

    Carbonneau, Seth / Sharma, Sujata / Peng, Liaomin / Rajan, Vaisakh / Hainzl, Dominik / Henault, Martin / Yang, Chian / Hale, Jacob / Shulok, Janine / Tallarico, John / Porter, Jeff / Brogdon, Jennifer L / Dranoff, Glenn / Bradner, James E / Hild, Marc / Guimaraes, Carla P

    Cell chemical biology

    2020  Volume 28, Issue 6, Page(s) 802–812.e6

    Abstract: The recent development of successful CAR (chimeric antigen receptor) T cell therapies has been accompanied by a need to better control potentially fatal toxicities that can arise from adverse immune reactions. Here we present a ligand-controlled CAR ... ...

    Abstract The recent development of successful CAR (chimeric antigen receptor) T cell therapies has been accompanied by a need to better control potentially fatal toxicities that can arise from adverse immune reactions. Here we present a ligand-controlled CAR system, based on the IKZF3 ZF2 β-hairpin IMiD-inducible degron, which allows for the reversible control of expression levels of type I membrane proteins, including CARs. Testing this system in an established mouse xenotransplantation model for acute lymphoblastic leukemia, we validate the ability of the CAR19-degron to target and kill CD19-positive cells displaying complete control/clearance of the tumor. We also demonstrate that the activity of CAR19-degron can be regulated in vivo when dosing a US Food and Drug Administration-approved drug, lenalidomide.
    MeSH term(s) Adolescent ; Animals ; Cell Line ; Cell Proliferation/drug effects ; Female ; Humans ; Ikaros Transcription Factor/chemistry ; Ikaros Transcription Factor/immunology ; Immunologic Factors/chemistry ; Immunologic Factors/pharmacology ; Male ; Mice ; Mice, Congenic ; Mice, Inbred NOD ; Mice, SCID ; Middle Aged ; Molecular Structure ; Neoplasms, Experimental/drug therapy ; Neoplasms, Experimental/immunology ; Neoplasms, Experimental/pathology ; Receptors, Chimeric Antigen/genetics ; Receptors, Chimeric Antigen/immunology ; T-Lymphocytes/immunology ; Young Adult
    Chemical Substances IKZF3 protein, human ; Immunologic Factors ; Receptors, Chimeric Antigen ; Ikaros Transcription Factor (148971-36-2)
    Language English
    Publishing date 2020-12-16
    Publishing country United States
    Document type Journal Article
    ISSN 2451-9448
    ISSN (online) 2451-9448
    DOI 10.1016/j.chembiol.2020.11.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

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    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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