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  1. Article ; Online: Seq'ing the origins of cells in the developing spinal cord.

    Rajebhosale, Prithviraj / Talmage, David A

    The Journal of biological chemistry

    2022  Volume 298, Issue 11, Page(s) 102602

    Abstract: In the developing central nervous system, neurogenesis precedes gliogenesis; however, when and how progenitors are specified for a neuronal versus glial fate and the temporal regulation of this process is unclear. Progenitors within the motor neuron ... ...

    Abstract In the developing central nervous system, neurogenesis precedes gliogenesis; however, when and how progenitors are specified for a neuronal versus glial fate and the temporal regulation of this process is unclear. Progenitors within the motor neuron progenitor domain in the developing spinal cord give rise to cholinergic motor neurons and cells of the oligodendroglial lineage sequentially. In a recent study, Xing et al. used single cell RNA-seq to identify previously unknown heterogeneity of these progenitors in zebrafish and to delineate the trajectories that distinct pools of these progenitors take. These data help integrate existing evidence and inform new hypotheses regarding how populations of neural progenitors in the same spatial domain commit to distinct fates.
    MeSH term(s) Animals ; Oligodendrocyte Transcription Factor 2 ; Zebrafish ; Basic Helix-Loop-Helix Transcription Factors ; Spinal Cord ; Oligodendroglia ; Motor Neurons ; Cell Differentiation
    Chemical Substances Oligodendrocyte Transcription Factor 2 ; Basic Helix-Loop-Helix Transcription Factors
    Language English
    Publishing date 2022-10-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1016/j.jbc.2022.102602
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.108: Show issues Location:
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  2. Article ; Online: Basal forebrain cholinergic signalling: development, connectivity and roles in cognition.

    Ananth, Mala R / Rajebhosale, Prithviraj / Kim, Ronald / Talmage, David A / Role, Lorna W

    Nature reviews. Neuroscience

    2023  Volume 24, Issue 4, Page(s) 233–251

    Abstract: Acetylcholine plays an essential role in fundamental aspects of cognition. Studies that have mapped the activity and functional connectivity of cholinergic neurons have shown that the axons of basal forebrain cholinergic neurons innervate the pallium ... ...

    Abstract Acetylcholine plays an essential role in fundamental aspects of cognition. Studies that have mapped the activity and functional connectivity of cholinergic neurons have shown that the axons of basal forebrain cholinergic neurons innervate the pallium with far more topographical and functional organization than was historically appreciated. Together with the results of studies using new probes that allow release of acetylcholine to be detected with high spatial and temporal resolution, these findings have implicated cholinergic networks in 'binding' diverse behaviours that contribute to cognition. Here, we review recent findings on the developmental origins, connectivity and function of cholinergic neurons, and explore the participation of cholinergic signalling in the encoding of cognition-related behaviours.
    MeSH term(s) Humans ; Acetylcholine/physiology ; Basal Forebrain ; Cholinergic Agents/pharmacology ; Cognition ; Signal Transduction
    Chemical Substances Acetylcholine (N9YNS0M02X) ; Cholinergic Agents
    Language English
    Publishing date 2023-02-23
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Intramural
    ZDB-ID 2034150-7
    ISSN 1471-0048 ; 1471-0048 ; 1471-003X
    ISSN (online) 1471-0048
    ISSN 1471-0048 ; 1471-003X
    DOI 10.1038/s41583-023-00677-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 47: Show issues

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  3. Article ; Online: Functionally refined encoding of threat memory by distinct populations of basal forebrain cholinergic projection neurons.

    Rajebhosale, Prithviraj / Ananth, Mala R / Kim, Ronald / Crouse, Richard / Jiang, Li / López-Hernández, Gretchen / Zhong, Chongbo / Arty, Christian / Wang, Shaohua / Jone, Alice / Desai, Niraj S / Li, Yulong / Picciotto, Marina R / Role, Lorna W / Talmage, David A

    eLife

    2024  Volume 13

    Abstract: Neurons of the basal forebrain nucleus basalis and posterior substantia innominata (NBM/ ... ...

    Abstract Neurons of the basal forebrain nucleus basalis and posterior substantia innominata (NBM/SI
    MeSH term(s) Mice ; Animals ; Basal Forebrain/physiology ; Cholinergic Neurons/physiology ; Memory/physiology ; Learning/physiology ; Acetylcholine/metabolism ; Cholinergic Agents
    Chemical Substances Acetylcholine (N9YNS0M02X) ; Cholinergic Agents
    Language English
    Publishing date 2024-02-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.86581
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  4. Article: Functionally refined encoding of threat memory by distinct populations of basal forebrain cholinergic projection neurons.

    Rajebhosale, Prithviraj / Ananth, Mala R / Kim, Ronald / Crouse, Richard / Jiang, Li / López-Hernández, Gretchen / Zhong, Chongbo / Arty, Christian / Wang, Shaohua / Jone, Alice / Desai, Niraj S / Li, Yulong / Picciotto, Marina R / Role, Lorna W / Talmage, David A

    Research square

    2024  

    Abstract: Neurons of the basal forebrain nucleus basalis and posterior substantia innominata (NBM/ ... ...

    Abstract Neurons of the basal forebrain nucleus basalis and posterior substantia innominata (NBM/SI
    Language English
    Publishing date 2024-02-09
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-3938016/v1
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  5. Article ; Online: Acetylcholine is released in the basolateral amygdala in response to predictors of reward and enhances the learning of cue-reward contingency.

    Crouse, Richard B / Kim, Kristen / Batchelor, Hannah M / Girardi, Eric M / Kamaletdinova, Rufina / Chan, Justin / Rajebhosale, Prithviraj / Pittenger, Steven T / Role, Lorna W / Talmage, David A / Jing, Miao / Li, Yulong / Gao, Xiao-Bing / Mineur, Yann S / Picciotto, Marina R

    eLife

    2020  Volume 9

    Abstract: The basolateral amygdala (BLA) is critical for associating initially neutral cues with appetitive and aversive stimuli and receives dense neuromodulatory acetylcholine (ACh) projections. We measured BLA ACh signaling and activity of neurons expressing ... ...

    Abstract The basolateral amygdala (BLA) is critical for associating initially neutral cues with appetitive and aversive stimuli and receives dense neuromodulatory acetylcholine (ACh) projections. We measured BLA ACh signaling and activity of neurons expressing CaMKIIα (a marker for glutamatergic principal cells) in mice during cue-reward learning using a fluorescent ACh sensor and calcium indicators. We found that ACh levels and nucleus basalis of Meynert (NBM) cholinergic terminal activity in the BLA (NBM-BLA) increased sharply in response to reward-related events and shifted as mice learned the cue-reward contingency. BLA CaMKIIα neuron activity followed reward retrieval and moved to the reward-predictive cue after task acquisition. Optical stimulation of cholinergic NBM-BLA terminal fibers led to a quicker acquisition of the cue-reward contingency. These results indicate BLA ACh signaling carries important information about salient events in cue-reward learning and provides a framework for understanding how ACh signaling contributes to shaping BLA responses to emotional stimuli.
    MeSH term(s) Acetylcholine/metabolism ; Animals ; Basolateral Nuclear Complex/metabolism ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/genetics ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism ; Cues ; Female ; Learning/physiology ; Male ; Mice ; Neurons/metabolism ; Optogenetics ; Reward
    Chemical Substances Calcium-Calmodulin-Dependent Protein Kinase Type 2 (EC 2.7.11.17) ; Acetylcholine (N9YNS0M02X)
    Keywords covid19
    Language English
    Publishing date 2020-09-18
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.57335
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  6. Article ; Online: Specific Basal Forebrain-Cortical Cholinergic Circuits Coordinate Cognitive Operations.

    Záborszky, Laszlo / Gombkoto, Peter / Varsanyi, Peter / Gielow, Matthew R / Poe, Gina / Role, Lorna W / Ananth, Mala / Rajebhosale, Prithviraj / Talmage, David A / Hasselmo, Michael E / Dannenberg, Holger / Minces, Victor H / Chiba, Andrea A

    The Journal of neuroscience : the official journal of the Society for Neuroscience

    2018  Volume 38, Issue 44, Page(s) 9446–9458

    Abstract: Based on recent molecular genetics, as well as functional and quantitative anatomical studies, the basal forebrain (BF) cholinergic projections, once viewed as a diffuse system, are emerging as being remarkably specific in connectivity. Acetylcholine ( ... ...

    Abstract Based on recent molecular genetics, as well as functional and quantitative anatomical studies, the basal forebrain (BF) cholinergic projections, once viewed as a diffuse system, are emerging as being remarkably specific in connectivity. Acetylcholine (ACh) can rapidly and selectively modulate activity of specific circuits and ACh release can be coordinated in multiple areas that are related to particular aspects of cognitive processing. This review discusses how a combination of multiple new approaches with more established techniques are being used to finally reveal how cholinergic neurons, together with other BF neurons, provide temporal structure for behavior, contribute to local cortical state regulation, and coordinate activity between different functionally related cortical circuits. ACh selectively modulates dynamics for encoding and attention within individual cortical circuits, allows for important transitions during sleep, and shapes the fidelity of sensory processing by changing the correlation structure of neural firing. The importance of this system for integrated and fluid behavioral function is underscored by its disease-modifying role; the demise of BF cholinergic neurons has long been established in Alzheimer's disease and recent studies have revealed the involvement of the cholinergic system in modulation of anxiety-related circuits. Therefore, the BF cholinergic system plays a pivotal role in modulating the dynamics of the brain during sleep and behavior, as foretold by the intricacies of its anatomical map.
    MeSH term(s) Aging/metabolism ; Aging/pathology ; Aging/psychology ; Animals ; Basal Forebrain/metabolism ; Basal Forebrain/pathology ; Cerebral Cortex/metabolism ; Cerebral Cortex/pathology ; Cholinergic Neurons/metabolism ; Cholinergic Neurons/pathology ; Cognition/physiology ; Dementia/diagnosis ; Dementia/physiopathology ; Dementia/psychology ; Humans ; Nerve Net/metabolism ; Nerve Net/pathology
    Language English
    Publishing date 2018-10-31
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 604637-x
    ISSN 1529-2401 ; 0270-6474
    ISSN (online) 1529-2401
    ISSN 0270-6474
    DOI 10.1523/JNEUROSCI.1676-18.2018
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1668: Show issues Location:
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