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  1. Article: Mesenchymal Hamartoma of the Chest Wall in an Infant - A Benign Entity Masquerading as Malignancy.

    Mahalingam, Harshavardhan / Ramasundaram, Madhu / Rajendiran, Swaminathan / Jayaraman, Dhaarani

    Journal of Indian Association of Pediatric Surgeons

    2021  Volume 26, Issue 3, Page(s) 184–187

    Abstract: Mesenchymal hamartoma of the chest wall is a rare tumor-like lesion encountered in neonates and infants. Although typically benign with no metastatic potential, it has alarming imaging and pathological features that mimic malignancy. We describe the ... ...

    Abstract Mesenchymal hamartoma of the chest wall is a rare tumor-like lesion encountered in neonates and infants. Although typically benign with no metastatic potential, it has alarming imaging and pathological features that mimic malignancy. We describe the imaging, surgical, and pathological features of this rare entity in a 1-month-old infant.
    Language English
    Publishing date 2021-05-17
    Publishing country India
    Document type Case Reports
    ZDB-ID 2164528-0
    ISSN 1998-3891 ; 0971-9261
    ISSN (online) 1998-3891
    ISSN 0971-9261
    DOI 10.4103/jiaps.JIAPS_84_20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Traveling with ROSE in EBUS-TBNA - Experience from a Tertiary Care Hospital in South India.

    Vasugi, Gramani Arumugam / Mathivanan, Koushik Muthuraja / Rajendiran, Swaminathan / Sundaram, Sandhya / Ayub, Irfan I

    Journal of cytology

    2021  Volume 38, Issue 4, Page(s) 175–179

    Abstract: Aims and objectives: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has emerged as a precise modality for tissue sampling of mediastinal and hilar lesions adjacent to the proximal airway. This study aims to determine the ... ...

    Abstract Aims and objectives: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has emerged as a precise modality for tissue sampling of mediastinal and hilar lesions adjacent to the proximal airway. This study aims to determine the diagnostic efficacy, sensitivity, and specificity of rapid-on site evaluation (ROSE) in EBUS-TBNA.
    Materials and methods: This is a retrospective study that included 100 patients who underwent EBUS-TBNA of paratracheal and mediastinal lymph nodes in a tertiary care hospital in South India between March 2018 and March 2020. After the procedure, the diagnostic yield from the nodes sampled was transferred to slides that were stained with rapid hematoxylin and eosin (H and E), and then onsite evaluation was done. The tissue derived was also processed for histopathologic examination in all cases. ROSE was performed to assess sample adequacy and to arrive at a preliminary diagnosis. In patients suspected of tuberculosis, the sample was collected for GeneXpert evaluation as well.
    Results: Of the 100 cases studied, 51 were males and 49 were females. The age distribution was between 3 and 78 years. Forty-seven cases were diagnosed as granulomatous lymphadenitis, 13 as metastatic malignancies, 33 as reactive lymphadenitis, 3 as atypical cells, and 1 case was diagnosed as a cystic lesion. The diagnostic yield was not adequate for evaluation in three cases. Diagnostic yield was obtained in the first two passes where the lymph nodes were more than 2 cm in size. More diagnostic passes were required in lymph nodes less than 2 cm and those located between and adjacent to major vessels. The onsite diagnosis was correlated with the final histopathologic diagnosis.
    Conclusion: ROSE serves as a useful adjunct to reduce procedure time and enhance sample collection and triaging, and reduces the need for further invasive testing.
    Language English
    Publishing date 2021-11-20
    Publishing country India
    Document type Journal Article
    ZDB-ID 645018-0
    ISSN 0970-9371
    ISSN 0970-9371
    DOI 10.4103/JOC.JOC_60_21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Sclerosing Pneumocytoma of the Lung

    Leena Dennis Joseph / Periyasamy Thangavel / Rajendiran Swaminathan / Ramya Rathinam Sunderaj

    Journal of Clinical and Diagnostic Research, Vol 11, Iss 2, Pp ED12-ED

    A Case Report

    2017  Volume 14

    Abstract: Pulmonary Sclerosing Pneumocytoma (PSP) is a rare tumour of the lung and is always benign. Diagnosis is made incidentally following chest X-ray or chest CT scan performed for other clinical conditions. We report a case of PSP in a seven-year-old girl who ...

    Abstract Pulmonary Sclerosing Pneumocytoma (PSP) is a rare tumour of the lung and is always benign. Diagnosis is made incidentally following chest X-ray or chest CT scan performed for other clinical conditions. We report a case of PSP in a seven-year-old girl who got admitted for evaluation of an anterior mediastinal mass. Clinically, thought of teratoma or other germ cell tumour the mass was excised and sent for histopathological examination. Grossly, we received a pneumonectomy specimen measuring 13x11x8 cm with a nodular firm grey white lesion in the medial aspect of lower and middle lobe measuring 7.5x5.5x5 cm. Macroscopically, pleura was involved and adherent to the lung. Microscopy showed, an ill-defined lesion in the lung with extensive fibrosis and lymphoplasmacytic infiltrate. The lesion was composed of round to oval cells with ill defined cell border, moderate eosinophilic cytoplasm and bland nuclei. A panel of Immunohistochemical (IHC) markers was performed and the lesional cells were positive for Epithelial Membrane Antigen (EMA) and Thyroid Transcription Factor-1 (TTF-1). The prognosis after surgical resection is good and the patient is doing well.
    Keywords fibrosis ; pulmonary ; thyroid transcription factor-1 ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2017-02-01T00:00:00Z
    Publisher JCDR Research and Publications Private Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Quality Measures in Pre-Analytical Phase of Tissue Processing

    Shalinee Rao / Suresh Masilamani / Sandhya Sundaram / Prathiba Duvuru / Rajendiran Swaminathan

    Journal of Clinical and Diagnostic Research, Vol 10, Iss 1, Pp EC07-EC

    Understanding Its Value in Histopathology

    2016  Volume 11

    Abstract: Introduction: Quality monitoring in histopathology unit is categorized into three phases, pre-analytical, analytical and post-analytical, to cover various steps in the entire test cycle. Review of literature on quality evaluation studies pertaining to ... ...

    Abstract Introduction: Quality monitoring in histopathology unit is categorized into three phases, pre-analytical, analytical and post-analytical, to cover various steps in the entire test cycle. Review of literature on quality evaluation studies pertaining to histopathology revealed that earlier reports were mainly focused on analytical aspects with limited studies on assessment of preanalytical phase. Pre-analytical phase encompasses several processing steps and handling of specimen/sample by multiple individuals, thus allowing enough scope for errors. Due to its critical nature and limited studies in the past to assess quality in pre-analytical phase, it deserves more attention. Aim: This study was undertaken to analyse and assess the quality parameters in pre-analytical phase in a histopathology laboratory. Materials and Methods: This was a retrospective study done on pre-analytical parameters in histopathology laboratory of a tertiary care centre on 18,626 tissue specimens received in 34 months. Registers and records were checked for efficiency and errors for pre-analytical quality variables: specimen identification, specimen in appropriate fixatives, lost specimens, daily internal quality control performance on staining, performance in interlaboratory quality assessment program {External quality assurance program (EQAS)} and evaluation of internal nonconformities (NC) for other errors. Results: The study revealed incorrect specimen labelling in 0.04%, 0.01% and 0.01% in 2007, 2008 and 2009 respectively. About 0.04%, 0.07% and 0.18% specimens were not sent in fixatives in 2007, 2008 and 2009 respectively. There was no incidence of lost specimen. A total of 113 non-conformities were identified out of which 92.9% belonged to the pre-analytical phase. The predominant NC (any deviation from normal standard which may generate an error and result in compromising with quality standards) identified was wrong labelling of slides. Performance in EQAS for pre-analytical phase was satisfactory in 6 of 9 cycles. Conclusion: A ...
    Keywords anatomic pathology ; pre-analytical quality variables ; quality assurance ; Medicine ; R
    Subject code 796
    Language English
    Publishing date 2016-01-01T00:00:00Z
    Publisher JCDR Research and Publications Private Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Primary dedifferentiated massive mediastinal liposarcoma weighing 5.3 kg.

    Muthukumar, Sivasubramanian / Rajendiran, Swaminathan / Damodharan, Jayachandran

    Asian cardiovascular & thoracic annals

    2016  Volume 25, Issue 6, Page(s) 472–473

    MeSH term(s) Biopsy ; Cell Dedifferentiation ; Humans ; Liposarcoma, Myxoid/complications ; Liposarcoma, Myxoid/diagnostic imaging ; Liposarcoma, Myxoid/pathology ; Liposarcoma, Myxoid/surgery ; Male ; Mediastinal Neoplasms/complications ; Mediastinal Neoplasms/diagnostic imaging ; Mediastinal Neoplasms/pathology ; Mediastinal Neoplasms/surgery ; Middle Aged ; Tomography, X-Ray Computed ; Tumor Burden
    Language English
    Publishing date 2016-05-25
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1400468-9
    ISSN 1816-5370 ; 0218-4923
    ISSN (online) 1816-5370
    ISSN 0218-4923
    DOI 10.1177/0218492316652058
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5193: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Incidental Detection of Neuroendocrine Carcinoma of Rectum During Staging Workup of Renal Cell Carcinoma.

    Athiyappan, Kumaresh / Ramachandran, Rajoo / Rajendiran, Swaminathan / Thangam, Vinoth

    World journal of oncology

    2015  Volume 6, Issue 6, Page(s) 491–494

    Abstract: Malignancies of rectum and kidneys are common pathologies in clinical practice; however, the incidence of these malignancies coexisting together is unclear. The main purpose of this article was to show the usefulness of computed tomography (CT) in ... ...

    Abstract Malignancies of rectum and kidneys are common pathologies in clinical practice; however, the incidence of these malignancies coexisting together is unclear. The main purpose of this article was to show the usefulness of computed tomography (CT) in diagnosing these rare synchronous tumors. We report a case of neuroendocrine carcinoma of the rectum in a 57-year-old male patient who came for staging workup of renal cell carcinoma (RCC) of the left kidney. To our knowledge, this is the first case of synchronous RCC and rectal neuroendocrine carcinoma coexisting in the same patient.
    Language English
    Publishing date 2015-12-31
    Publishing country Canada
    Document type Case Reports
    ZDB-ID 2548989-6
    ISSN 1920-454X ; 1920-4531
    ISSN (online) 1920-454X
    ISSN 1920-4531
    DOI 10.14740/wjon949w
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  7. Article ; Online: Mucinous Cystadenocarcinoma in a Horse Shoe Kidney Masquerading as Giant Hydronephrosis – A Case Report

    Leena Dennis Joseph / Sriram Krishnamoorthy / Rajendiran Swaminathan / Gokul Kripesh / Hariharasudhan Sekar

    Journal of Clinical and Diagnostic Research, Vol 10, Iss 11, Pp PD12-PD

    Diagnostic Challenges, Lessons Learnt and Review of Literature

    2016  Volume 14

    Abstract: Primary epithelial tumour of the renal pelvis is a rare entity. So far, very few cases are reported in literature. Of these, mucin secreting adenocarcinomas are distinctly rare. However, mucinous cystadenocarcinoma, that too arising in a horse shoe ... ...

    Abstract Primary epithelial tumour of the renal pelvis is a rare entity. So far, very few cases are reported in literature. Of these, mucin secreting adenocarcinomas are distinctly rare. However, mucinous cystadenocarcinoma, that too arising in a horse shoe kidney is extremely rare to be reported. Mucinous cystadenomas and carcinomas arising from the renal pelvis are regarded to be secondary to a metaplastic change in the urothelium. Here, we present a case of a 51-year-old male, who complained of abdominal pain, palpable abdominal mass, haematuria along with passage of mucoid material in the urine, with a very poorly functioning kidney. A pre-operative diagnosis of horse shoe kidney with pelvi ureteric junction obstruction and a poorly functioning kidney was made. Intraoperative findings and frozen section biopsy were suggestive of mucin secreting cystic mass and a right heminephrectomy was done. The final histopathology was suggestive of mucinous cystadenocarcinoma of the renal pelvis of the right moiety. This case is presented for its rarity, diagnostic challenges faced and the lessons learnt, stressing on the need for having a high index of clinical suspicion in making such diagnosis.
    Keywords haematuria ; heminephrectomy ; primary epithelial tumour ; Medicine ; R
    Subject code 616
    Language English
    Publishing date 2016-11-01T00:00:00Z
    Publisher JCDR Research and Publications Private Limited
    Document type Article ; Online
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  8. Article: A rare case of primary malignant pericardial mesothelioma.

    Ramachandran, Rajoo / Radhan, Prabhu / Santosham, Roy / Rajendiran, Swaminathan

    Journal of clinical imaging science

    2014  Volume 4, Page(s) 47

    Abstract: Primary malignant pericardial mesothelioma (PMPM) is a rare tumor of the pericardium. The cause of this tumor is unknown and it has a very poor prognosis. Exposure to asbestos is correlated with the onset of pleural and peritoneal mesothelioma; however, ... ...

    Abstract Primary malignant pericardial mesothelioma (PMPM) is a rare tumor of the pericardium. The cause of this tumor is unknown and it has a very poor prognosis. Exposure to asbestos is correlated with the onset of pleural and peritoneal mesothelioma; however, the role of asbestos in pericardial mesothelioma is unclear. Here we highlight the radiological features of this rare tumor and its correlative pathological confirmation with the help of new immunohistochemical (IHC) markers.
    Language English
    Publishing date 2014-08-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2601233-9
    ISSN 2156-5597 ; 2156-7514
    ISSN (online) 2156-5597
    ISSN 2156-7514
    DOI 10.4103/2156-7514.139737
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  9. Article ; Online: Assessing capabilities in India today and the role of "outside" opinions.

    Jayaram, Gita / Dewar, Rajan / Raman, Ratna / Rajendiran, Swaminathan / Parkash, Vinita

    Indian journal of medical ethics

    2014  Volume 11, Issue 4, Page(s) 1–2

    MeSH term(s) Female ; Humans ; Mass Screening/economics ; Uterine Cervical Neoplasms/mortality ; Uterine Cervical Neoplasms/prevention & control
    Language English
    Publishing date 2014-10
    Publishing country India
    Document type Comment ; Journal Article
    ISSN 0975-5691
    ISSN (online) 0975-5691
    DOI 10.20529/IJME.2014.061
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  10. Article ; Online: Inflammatory myofibroblastic tumor of spermatic cord.

    Rafeek, Noora / Joseph, Leena Dennis / Rajendiran, Swaminathan / Narayanan, Cunnigaiper Dhanasekaran

    International journal of surgery case reports

    2012  Volume 3, Issue 12, Page(s) 618–621

    Abstract: Introduction: Inflammatory myofibroblastic tumor (IMT) is a neoplasm of intermediate biologic potential. Only a few cases of IMT in the spermatic cord have been reported. It was earlier included in a wide spectrum of reactive and neoplastic lesions ... ...

    Abstract Introduction: Inflammatory myofibroblastic tumor (IMT) is a neoplasm of intermediate biologic potential. Only a few cases of IMT in the spermatic cord have been reported. It was earlier included in a wide spectrum of reactive and neoplastic lesions called "inflammatory pseudotumors". It commonly presents as a painless scrotal mass, usually in children and young adults.
    Presentation of case: We present a case of IMT in the spermatic cord who based on clinical, radiological and cytological findings underwent surgical exploration of left scrotal sac. The mass was separate from the left testis and left epididymis, and was closely adherent to pampiniform plexus of veins. Wide excision of the mass was done. Histology and immunohistochemistry suggested IMT.
    Discussion: IMT is a myofibroblastic spindle cell proliferation with chronic inflammatory infiltrate. Surgical exploration is essential as clinically and radiologically benign or malignant nature of mass cannot be distinguished. The diagnosis of IMT is based on the histological features and is substantiated by immunomarkers.
    Conclusion: In clinically distinct masses, based on frozen section, either tumor excision or radical orchidectomy can be performed. The prognosis is excellent after complete surgical excision of spermatic cord IMT. Careful long-term follow-up is essential, because of the possibility of recurrence, though rare in this site.
    Language English
    Publishing date 2012-09-05
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2210-2612
    ISSN (online) 2210-2612
    DOI 10.1016/j.ijscr.2012.08.010
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