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  1. Article ; Online: The management of osteoarthritis symptomatology through nanotechnology: a patent review.

    Santos, Mariana Mendonça / Santos, Anamaria Mendonça / Nascimento Júnior, José Adão Carvalho / Andrade, Tatianny De Araujo / Rajkumar, Gomathi / Frank, Luiza Abrahão / Serafini, Mairim Russo

    Journal of microencapsulation

    2023  Volume 40, Issue 7, Page(s) 475–490

    Abstract: Osteoarthritis is considered a degenerative joint disease that is characterised by inflammation, chronic pain, and functional limitation. The increasing development of nanotechnology in drug delivery systems has provided new ideas and methods for ... ...

    Abstract Osteoarthritis is considered a degenerative joint disease that is characterised by inflammation, chronic pain, and functional limitation. The increasing development of nanotechnology in drug delivery systems has provided new ideas and methods for osteoarthritis therapy. This review aimed to evaluate patents that have developed innovations, therapeutic strategies, and alternatives using nanotechnology in osteoarthritis treatment. The results show patents deposited from 2015 to November 2021 in the online databases European Patent Office and World Intellectual Property Organisation. A total of 651 patents were identified for preliminary assessment and 16 were selected for full reading and discussion. The evaluated patents are focused on the intraarticular route, oral route, and topical route for osteoarthritis treatment. The intraarticular route presented a higher patent number, followed by the oral and topical routes, respectively. The development of new technologies allows us to envision a promising and positive future in osteoarthritis treatment.
    MeSH term(s) Humans ; Drug Delivery Systems ; Nanotechnology ; Osteoarthritis/drug therapy
    Language English
    Publishing date 2023-09-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 843632-0
    ISSN 1464-5246 ; 0265-2048
    ISSN (online) 1464-5246
    ISSN 0265-2048
    DOI 10.1080/02652048.2023.2258955
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2267: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: The use of natural extracts with photoprotective activity: a 2015-2023 patent prospection.

    Oliveira, Ana Maria Santos / de Souza Batista, Daniel / de Castro, Tailaine Nascimento / Alves, Izabel Almeida / Souto, Ricardo Bizogne / Mota, Milleno Dantas / Serafini, Mairim Russo / Rajkumar, Gomathi / Cazedey, Edith Cristina Laignier

    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology

    2024  

    Abstract: Synthetic sunscreen offers protection against excessive exposure to ultraviolet (UV) radiation from the sun, and protects the skin from possible damage. However, they have low efficacy against the formation of reactive oxygen species (ROS), which are ... ...

    Abstract Synthetic sunscreen offers protection against excessive exposure to ultraviolet (UV) radiation from the sun, and protects the skin from possible damage. However, they have low efficacy against the formation of reactive oxygen species (ROS), which are highly reactive molecules that can be generated in the skin when it is exposed to UV radiation, and are known to play a role in oxidative stress, which can contribute to skin aging and damage. Thus, there is an ongoing search for sunscreens that do not have these negative effects. One promising source for these is natural products. Therefore, the current patent review summarizes topical formulations made from natural compounds that have antioxidant properties and can be used as photoprotective or anti-aging agents, either using a single natural extract or a combination of extracts. The review reports basic patent information (applicant country, type of applicant, and year of filing) and gives details about the invention, including its chemical composition, and the in vitro and in vivo tests performed. These patents describe natural products that can be used to protect the skin and validate their efficacy, and safety, in addition to standardizing their formulations. The compositions described illustrate the consistent innovation in the use of natural products to protect against UV damage and photoaging disorders, a promising field which is receiving growing global recognition.
    Language English
    Publishing date 2024-04-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2072584-X
    ISSN 1474-9092 ; 1474-905X
    ISSN (online) 1474-9092
    ISSN 1474-905X
    DOI 10.1007/s43630-024-00559-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Comparative evaluation of volatile profile of tomato subjected to hot air, freeze, and spray drying

    Rajkumar, Gomathi / Rajan, Murugan / Araujo, H.C. / Jesus, M.S. / Leite Neta, M.T.S. / Sandes, R.D.D. / Narain, Narendra

    Drying technology. 2020 Nov. 5, v. 39, no. 3

    2020  

    Abstract: Tomato (Lycopersicon esculentum Mill.) is an important vegetable crop cherished all over the world for consumption as a raw vegetable or as processed products. They are subjected to various drying processes to increase product stability and decrease ... ...

    Abstract Tomato (Lycopersicon esculentum Mill.) is an important vegetable crop cherished all over the world for consumption as a raw vegetable or as processed products. They are subjected to various drying processes to increase product stability and decrease postharvest loss. However, this can cause a loss in volatile compounds due to process conditions. Present study aims to gain an insight into the volatile profile of tomatoes when subjected to hot air, freeze, and spray drying processes. In this regard, the analysis of headspace - solid phase microextraction (HS-SPME) in conjunction with gas chromatography–mass spectroscopy (GC–MS) revealed that the volatile profile, namely compounds belonging to aldehydes, alcohols, terpenes, ketones, and furans varied greatly between the fresh and dehydrated tomatoes. The aroma of dehydrated tomato products that retained volatiles followed the following order: freeze-drying >/≥spray drying > hot air drying. An increase in contents of compounds such as dimethyl sulfide, 2-ethyl furan, hydroxymethyl furfural, acetaldehyde, and α-terpineol was found in all dehydrated products. Interestingly, compounds such as 3-methyl furan, hexanol and terpinyl acetate were found to occur only in dehydrated products. The presence of γ-undecalactone (fruity odor note) is identified for the first time in our study in fresh and all dehydrated tomatoes. From the results obtained and with chemometric analysis as principal component analysis and hierarchical cluster analysis on the volatile profile, it could be concluded that dehydrated tomatoes serve suitable products that could be extensively commercialized world-wide to achieve overall consumer acceptability.
    Keywords Solanum lycopersicum var. lycopersicum ; acetaldehyde ; acetates ; air ; chemometrics ; cluster analysis ; consumer acceptance ; dimethyl sulfide ; freeze drying ; headspace analysis ; hexanols ; hydroxymethylfurfural ; odors ; postharvest losses ; principal component analysis ; solid phase microextraction ; tomatoes ; vegetable crops ; volatile compounds
    Language English
    Dates of publication 2020-1105
    Size p. 383-391.
    Publishing place Taylor & Francis
    Document type Article
    ZDB-ID 2049461-0
    ISSN 1532-2300 ; 0737-3937
    ISSN (online) 1532-2300
    ISSN 0737-3937
    DOI 10.1080/07373937.2020.1842441
    Database NAL-Catalogue (AGRICOLA)

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  4. Article: Comparative evaluation of physical properties and aroma profile of carrot slices subjected to hot air and freeze drying

    Rajkumar, Gomathi / Saravanan Shanmugam / Mercia de Sousa Galvâo / Maria Terezinha Santos Leite Neta / Rafael Donizete Dutra Sandes / Arun S. Mujumdar / Narendra Narain

    Drying technology. 2017 Apr. 26, v. 35, no. 6

    2017  

    Abstract: In the present study, carrots were subjected to hot air- and freeze-drying processes and their physical parameters and aromatic profile were compared. Water activity, shrinkage, hardness, springiness, cohesiveness, chewiness, rehydration ratio, and color ...

    Abstract In the present study, carrots were subjected to hot air- and freeze-drying processes and their physical parameters and aromatic profile were compared. Water activity, shrinkage, hardness, springiness, cohesiveness, chewiness, rehydration ratio, and color measurements show that the convective drying of carrot slices lead to major changes in physical and aroma characteristics. The volatiles from air-drying of carrots contain terpenes, aldehydes, and alcohols which contribute to their aroma. The terpene, patchoulene imparting a spicy odor is reported for the first time in fresh carrots and it gets completely degraded during air dehydration. The key flavor components of fresh carrots were mostly retained during drying. The analytical results confirm that freeze-dried products had higher aroma retention.
    Keywords air ; air drying ; alcohols ; aldehydes ; carrots ; chewiness ; cohesion ; color ; flavor compounds ; freeze drying ; hardness ; odors ; rehydration ; shrinkage ; terpenoids ; water activity
    Language English
    Dates of publication 2017-0426
    Size p. 699-708.
    Publishing place Taylor & Francis
    Document type Article
    ZDB-ID 2049461-0
    ISSN 1532-2300 ; 0737-3937
    ISSN (online) 1532-2300
    ISSN 0737-3937
    DOI 10.1080/07373937.2016.1206925
    Database NAL-Catalogue (AGRICOLA)

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  5. Article: Comparative evaluation of physical properties and volatiles profile of cabbages subjected to hot air and freeze drying

    Rajkumar, Gomathi / Shanmugam, Saravanan / Galvâo, Mercia de Sousa / Dutra Sandes, Rafael Donizete / Leite Neta, Maria Terezinha Santos / Narain, Narendra / Mujumdar, Arun Sadashiv

    Lebensmittel-Wissenschaft + [i.e. und] Technologie. 2017 July, v. 80

    2017  

    Abstract: The aim of the present study was to evaluate the physical parameters, volatiles profile and sensory quality of the cabbage pieces subjected to hot air drying and freeze drying processes. Physical properties such as water activity, shrinkage, hardness, ... ...

    Abstract The aim of the present study was to evaluate the physical parameters, volatiles profile and sensory quality of the cabbage pieces subjected to hot air drying and freeze drying processes. Physical properties such as water activity, shrinkage, hardness, springiness, cohesiveness, chewiness, rehydration ratio and color measurements were measured using standard procedures while the volatile compounds were determined by the SPME-GC-MS method. The results showed that convective drying of cabbages lead to major adverse changes in physical and volatile compounds characteristics. Hot air and freeze drying of cabbages display different volatiles profile containing aldehydes, alcohols, terpenes, ketones and furans. Better retention of character impact cabbage green and pungent aroma compounds viz. allyl isothiocyanate, dimethyl sulfide, dimethyl disulfide, 1-octen-3-ol and (Z)-2-penten-1-ol was found in freeze dried cabbage. The presence of 3-(methylthio)-propyl isothiocyanate, methyl benzene isothiocyante and phenyl ethyl isothiocyanate is reported here for the first time in fresh cabbages. The flavor components of fresh cabbage were largely retained in the freeze dried product. Freeze drying also leads to positive sensory effects and better overall acceptability by consumers compared to the hot air dried product.
    Keywords air ; air drying ; aldehydes ; allyl isothiocyanate ; benzene ; cabbage ; chewiness ; cohesion ; color ; dimethyl disulfide ; dimethyl sulfide ; flavor compounds ; freeze drying ; furans ; gas chromatography-mass spectrometry ; hardness ; ketones ; octenol ; odor compounds ; rehydration ; sensory properties ; shrinkage ; solid phase microextraction ; terpenoids ; water activity
    Language English
    Dates of publication 2017-07
    Size p. 501-509.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 241369-3
    ISSN 0460-1173 ; 0023-6438
    ISSN 0460-1173 ; 0023-6438
    DOI 10.1016/j.lwt.2017.03.020
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 2634: Show issues

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